Category: 1261524-75-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1261524-75-7

A solution of (3 -bromo-2- chlorophenyl)methanol (600 mg, 2.71 mmol), (2-chloro-3 -(4,4,5,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)phenyl)methanol (728 mg, 2.71 mmol), K2C03 (936 mg, 6.77 mmol) in 1,4-dioxane (9 mL) and water(2.3 mL) was purged with nitrogen for 5 mi Pd(dppf)C12.DCM (198 mg, 0.27 mmol) was added and the reaction mixture was heated at 100 C for 12 h. The reaction mixture was filtered through a pad of celite and the pad was washed with MeOH. The filtrate was concentrated to dryness and the residue was purified by silica gel column with 0-30% EtOAc in hexanes to give a product.

With the rapid development of chemical substances, we look forward to future research findings about 1261524-75-7.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
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Electric Literature of 1261524-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol, molecular formula is C7H6BrClO, molecular weight is 221.48, as common compound, the synthetic route is as follows.

To a solution of (3-bromo-2-chlorophenyl)methanol(4.57 g, 20.63 mmol, 1 equiv.) in DCM(200 mL) were added DMF(45.2 mg, 0.62 mmol, 0.03 equiv.) and SOCl2(61.4 g, 516.10 mmol, 25.01 equiv.) dropwise at 0 degrees C under nitrogen atmosphere. The resulting mixture was stirred for 2 days at ambient temperature. The desired product could be detected by LCMS. The mixture was concentrated to get crude product. The crude product was added water(400mL) and extracted with EA (400mLx2). The organic layers was washed with saturated brine (200ml), dried over anhydrous Na2SO4, filtered and concentrated to give desired product. The residue was purified by silica gel column chromatography, eluted with EtOAc / PE (1:50 to 1:40) to afford 1-bromo-2-chloro-3-(chloromethyl)benzene (4.9 g, 98.98%) as a yellow liquid.

The chemical industry reduces the impact on the environment during synthesis 1261524-75-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1261524-75-7, Adding some certain compound to certain chemical reactions, such as: 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1261524-75-7.

To (3-bromo-2-chlorophenyl)methanol (CAS 1261524-75-7) (0.253 g, 1.142 mmol) in DCM (1 1.4 mL) at 0 C was added TEA (0.398 mL, 2.86 mmol) followed by MsCI (0.134 mL, 1.713 mmol) and the ice bath was removed and the solution was allowed to stir at room temperature for 30 minutes. At this point, the reaction was placed in an ice bath and diluted with DCM and a saturated solution of sodium bicarbonate. This mixture was passed thorugh a phase separator to remove the water layer. The organics were dried and concentrated to obtain the title compound. 1H NMR (400 MHz, DMSO-c/6) delta ppm 7.85 (dd, J=8.07, 1.47 Hz, 1 H) 7.63 (dd, J=7.70, 1.47 Hz, 1 H) 7.37 (t, J=7.83 Hz, 1 H) 5.37 (s, 2 H) 3.29 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1261524-75-7, 3-Bromo-2-chlorobenzyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; BELANGER, David B.; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; KARKI, Rajeshri Ganesh; MAINOLFI, Nello; POWERS, James J.; RANDL, Stefan Andreas; ROGEL, Olivier; VULPETTI, Anna; YOON, Taeyoung; WO2015/9977; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1261524-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol, molecular formula is C7H6BrClO, molecular weight is 221.48, as common compound, the synthetic route is as follows.

Step D: 5-bromo-4-chloro-2-benzofuran-l(3H)-one: To a flask charged with (3-bromo-2- chlorophenyl)methanol (1.1 g, 4.8 mmol) and a stir bar was added thallium trifluoroacetate (2.9 g, 5.3 mmol) and TFA (6 mL). The mixture was allowed to stir at RT for 16 hours. The volatiles were removed under reduced pressure. The residue was pumped under high vacuum for 15 minutes before palladium (II) chloride (0.085 g, 0.48 mmol), magnesium oxide (0.39 g, 9.6 mmol), lithium chloride (0.20 g, 4.8 mmol), and ethanol (30 mL) were added. The mixture was stirred under an atmosphere of carbon mono-oxide until the reaction turned black. The reaction was diluted with DCM. The suspension was filtered through a pad of celite to remove the solids. The filtrate was adsorbed onto silica gel, and purified by MPLC to afford the title compound.

Statistics shows that 1261524-75-7 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-chlorobenzyl Alcohol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; PIO, Barbara; TEUMELSAN, Nardos; PASTERNAK, Alexander; DEJESUS, Reynalda; WO2013/62892; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts