Category: 124-76-5

Haque, Rafiul Md. published the artcileQuality standard, lipid profile and anti-lipase studies of Zangiber officinale, Related Products of alcohols-buliding-blocks, the main research area is Zingiber camphene pinene lipid profile antilipase.

Zangiber officinale, commonly called as ginger, its rhizome part is a very important for its traditional uses due to presence of oleoresin and volatile oil. It belongs to the family Zangiberaceae. The objectives of current study are to determine the quality and evaluation of anti-lipase activity and lipid profile in Zangiber officinale on obese rat modal. Determination of quality of Zangiber officinale Roscoe rhizome is done with the help of microscopical and physiochem. studies. The composition of ginger oil was analyzed by gas chromatog. (GC) and gas chromatog. mass spectroscopy (GCMS). Zangiber officinale distillate (ZD) was prepared for the study of lipid profile and pancreatic lipase activity. All these physiochem. values and microscopical observations were under pharmacopeia′s limits and observation. Volatile oil content was 1.2 ± 0.03%weight/weight, and 53 components were identified. Camphene (18.28%), para-cineole (10.02%), zingiberene (6.12%), and cuminaldehyde (2.17%) were as major components. After end of the treatment, Zangiber officinale distillate (7.75 mL/kg, twice a day) treatments showed significant reduction in serum lipids. But ZD did not significantly alter the pancreatic lipase activity. These results recommend that ZD have strong hypolipidemic activity without inhibition of pancreatic lipase in HFD induced obese rat model.

Pharma Innovation published new progress about Food quality. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pesesse, R. published the artcileMultimodal chemometric approach for the analysis of human exhaled breath in lung cancer patients by TD-GC × GC-TOFMS, Category: alcohols-buliding-blocks, the main research area is multimodal chemometrics human exhaled breath lung cancer GC TOFMS; Breath analysis; Comprehensive two-dimensional gas chromatography (GC × GC); Lung cancer; Statistics; Thermal desorption (TD); Time-of-flight mass spectrometry (TOFMS); Volatile organic compounds (VOCs).

Lung cancer is the deadliest cancer in developed countries. To reduce its mortality rate, it is important to enhance the authors’ capability to detect it at earlier stages by developing early diagnostic methods. In that context, the anal. of exhaled breath is an interesting approach because of the simplicity of the medical act and its non-invasiveness. Thermal desorption comprehensive two-dimensional gas chromatog. time of flight mass spectrometry (TD-GC × GC-TOFMS) has been used to characterize and compare the volatile content of human breath of lung cancer patients and healthy volunteers. On the sampling side, the contaminations induced by the bags membrane and further environmental migration of VOCs during and after the sampling have also been studied. Over a realistic period of 6 h, the concentration of contaminants inside the bag can increase from 2 to 3 folds based on simulated breath samples. On the data processing side, Fisher ratio (FR) and random forest (RF) approaches were applied and compared in regards to their ability to reduce the data dimensionality and to extract the significant information. Both approaches allow to efficiently smooth the background signal and extract significant features (27 for FR and 17 for RF). Principal component anal. (PCA) was used to evaluate the clustering capacity of the different models. For both approaches, a separation along PC-1 was obtained with a variance score around 35%. The combined model provides a partial separation with a PC-1 score of 52%. This proof-of-concept study further confirms the potential of breath anal. for cancer detection but also underlines the importance of quality control over the full anal. procedure, including the processing of the data.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Homo sapiens. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saadi Saaidpour published the artcileUsing gas chromatography-mass spectrometry in conjunction with chemometrics technique for characterization of iranian essential oils Myrtus communis L., Computed Properties of 124-76-5, the main research area is gas chromatog mass spectrometry chemometrics iranian essential oil component.

Abstract: Myrtus communis L. essential oils were extracted by simultaneous distillation extraction method and studied with gas chromatog.-mass spectrometry (GC-MS). The obtained mass spectra were investigated by searching in NIST library, and 54 components were identified, but due to several problems such as varying baseline due to column bleed, low signal-to-noise ratio of peaks, and co-elution, some of components did not have satisfactory match factors. Chemometric resolution techniques were used to resolve these problems. The number of identified components was expanded to 67 using combination of GC-MS with resolution technique. In addition, the presence of worthful components such as α-Pinene (36.19%), 1,8-Cineole (11.44%), d-Limonene (10.04%), Linalool (7.76%), α-Terpineol (5.51%), linalyl acetate (4.19%) and α-Terpineol acetate (2.61%) in Myrtle essential oils have been verified. The results of this study indicate that joining of hyphenated chromatog. methods and multivariate curve resolution techniques can be useful for comprehensive, rapid, and accurate anal. of complex natural product such as Iranian Myrtle essential oils.

Journal of Analytical Chemistry published new progress about Chemometrics. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Misharina, T. A. published the artcileInhibition of Autoxidation of Polyunsaturated Fatty Acids by Clove and Oregano Essential Oils, SDS of cas: 124-76-5, the main research area is Eugenia Origanum essential oil synergism polyunsaturated fatty acid autoxidation.

Abstract: Inhibition of the autoxidation of polyunsaturated fatty acid Me esters isolated from fish oil by essential oils of clove, oregano and their mixture has been studied. Their content was determined after 1-6 mo of autoxidation by capillary gas chromatog. to assess antioxidant efficiency. It has been shown that the essential oils of clove and oregano and their combination effectively inhibited the autoxidation of polyunsaturated fatty acids. The degree of this inhibition depended on the structure of fatty acids and the composition of their mixtures, as well as on the essential oil content and duration of autoxidation It was shown that an increase in the number of double bonds in unsaturated acid mols. resulted in a decreased resistance of their esters to oxidation In the control, 97% of monounsaturated acids and only 9% of docosahexaenoic acid remained after 3 mo of autoxidation Clove essential oils at concentrations of 2 and 4% inhibited oxidation with equal efficiency; after 3 mo, 86-91% of esters of acids with five and six double bonds remained. Oregano essential oil was less effective as an antioxidant than the clove. Thus, up to 79% of Me eicosapentaenoate and 73% of Me docosahexaenoate remained after 3 mo of autoxidation in its presence. After 6 mo of autoxidation, the Me eicosapentaenoate and docosahexaenoate contents were 67 and 54% in the presence of 4% clove oil and only 11 and 7%, resp., with 1% oil. The inhibitory activity of 4% oregano oil and 2% clove oil turned out to be almost the same, and a similar content of all unoxidized acids was observed in the presence of 1% oils. A mixture of clove and oregano essential oils showed an additive antioxidant effect on arachidonic and eicosapentaenoic acids esters and a synergistic effect on docosahexaenoic acid ester.

Applied Biochemistry and Microbiology published new progress about Autoxidation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Agatonovic-Kustrin, Snezana published the artcileModels for skin and brain penetration of major components from essential oils used in aromatherapy for dementia patients, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is dementia skin blood brain barrier terpenoid essential oil aromatherapy; Alzheimer’s disease; QSAR; blood brain barrier; skin penetration; terpenes.

The aim of this work was to develop quant. structure activity relationships (QSARs), to predict skin and blood barrier penetrative abilities of 119 terpenoids from EOs used in aromatherapy. The first model was based on exptl. measured skin permeability for 162 mols., and the second model on BBB permeability for 138 mols. Each mol. was encoded with 63 calculated mol. descriptors and an artificial neural network was used to correlate mol. descriptors to permeabilities. Developed QSAR models confirm that EOs components penetrate through the skin and across the BBB. Some well-known descriptors, such as log P (lipophilicity), mol. size and shape, dominated the QSAR model for BBB permeability. Compounds with the highest predicted BBB penetration were hydrocarbon terpenes with the smallest mol. size and highest lipophilicity. Thus, mol. size is a limiting factor for penetration. Compounds with the highest skin permeability have slightly higher mol. size, high lipophilicity and low polarity. Our work shows that a major disadvantage of novel multitarget compounds developed for the treatment of Alzheimer’s disease is the size of mols., which cause problems in their delivery to the brain. Therefore, there is a need for smaller compounds, which possess more desirable physicochem. properties and pharmacokinetics, in addition to targeted biol. effects.

Journal of Biomolecular Structure and Dynamics published new progress about Aromatherapy. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jingqin published the artcileGreen synthesis, characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of Curcumae kwangsiensis leaf aqueous extract green-synthesized gold nanoparticles, COA of Formula: C10H18O, the main research area is Curcuma leaf gold nanoparticle antioxidant cytotoxicity green chem.

The present work indicated the green synthesis, characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of gold nanoparticles containing Curcumae Kwangsiensis Folium (Leaf) aqueous extract Characterization of gold nanoparticles was done by Field Emission SEM (FE-SEM), Transmission Electron Microscopy (TEM), Fourier Transformed IR Spectroscopy (FT-IR), and UV-Visible Spectroscopy (UV-Vis). MTT assay was used on common ovarian cancer cell lines i.e., SW-626, PA-1, and SK-OV-3 to survey the cytotoxicity and anti-ovarian cancer effects of gold chloride, Curcumae Kwangsiensis Folium leaf aqueous extract, and gold nanoparticles. The best results of cytotoxicity and anti-ovarian cancer properties were seen in the case of gold nanoparticles. They had very low cell viability and high anti-ovarian cancer activities dose-dependently against PA-1, SW-626, and SK-OV-3 cell lines without any cytotoxicity on the normal cell line (HUVEC). For investigating the antioxidant properties of gold chloride, Curcumae Kwangsiensis Folium leaf aqueous extract, and gold nanoparticles, the DPPH test was used in the presence of butylated hydroxytoluene as the pos. control. The best results of antioxidant properties were seen in the case of gold nanoparticles. They inhibited half of the DPPH mols. in the concentration of 153μg/mL. Maybe significant anti-human ovarian cancer potentials of gold nanoparticles synthesized by Curcumae Kwangsiensis Folium leaf aqueous extract against common human ovarian cancer cell lines are linked to their antioxidant activities.

Arabian Journal of Chemistry published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiang, Yueyue published the artcileSpatial variation of volatile organic compounds and antioxidant activity of turmeric (Curcuma longa L.) essential oils harvested from four provinces of China, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is volatile organic compound antioxidant Curcuma longa essential oil; Antioxidant activity; Curcuma longa L; DPPH; HS-SPME-GC-MS; Turmeric essential oils (TEOs).

The objective of this study was to investigate the spatial variation of volatile organic compounds and antioxidant activity of turmeric essential oils (TEOs) harvested from four provinces of China. The major chem. components of these TEOs were analyzed using headspace solid-phase micro-extraction gas chromatog.-mass spectrometry. More than forty volatile organic compounds in TEOs were identified, which accounted for 82.09-93.64% of the oil components. The relative abundances of the main volatile organic compounds in TEOs at the genus level were visualized by a heat map. The antioxidant activity of the TEOs of five different origins was characterized by the DPPH free radical scavenging activity, in which the antioxidant activity of the TEOs from Guangxi was superior to those of other sources. Furthermore, the IC50 values of the antioxidants TEOs collected from Guangxi, Sichuan, Yunnan, Changting, and Liancheng were 33.30, 42.5, 35.22, 63.27, and 39.96 mg/mL, resp., which indicated the excellent free radical scavenging activity of those TEOs. Therefore, the TEOs might be considered as a natural antioxidant with potential applications in food and pharmaceutical industries.

Current Research in Food Science published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vergine, Marzia published the artcilePhytochemical profiles and antioxidant activity of Salvia species from Southern Italy, Computed Properties of 124-76-5, the main research area is Salvia phytochem antioxidant Southern Italy.

The purpose of this research was to investigate phytochem. profiles and antioxidant activity in four Salvia species growing in Salento (Southern Italy). The hydrodistillation products obtained from the aerial parts of Salvia clandestina, Salvia fruticosa, Salvia officinalis and Salvia sclarea were characterized by GC-MS and 50 compounds were detected. With the exception of S. clandestina, that did not produce essential oils, the other species shared different amounts of monoterpenes oxygenated (camphor 2.13%-9.16%) and sesquiterpenes hydrocarbons (caryophyllene 4.65%-18.33%; humulene 1.87%-12.39%). The phenolic profiling, analyzed by HPLC ESI/MS-TOF, highlights that S. clandestina is a rich source of danshensu (4.76 mg/g DW) while S. sclarea of rosmarinic acid (15.57 mg/g DW). Mutivariate statistical anal. (PCA) of hitherto studied Salvia phenols have shown similarities in profiles between S. fruticosa and S. officinalis, while S. clandestina and S. sclarea showed distinctive profiles. Otherwise, essential oil profiles analyzed by PCA are clearly different among the three productive species. The extracts from collected plants were found to be effective antioxidant in three different in vitro assays (DPPH, ABTS, FRAP and Superoxide anion scavenging activity). Thus, they can be proposed as natural ingredients in functional foods, herbal medicines or as sources of bioactive mols.

Records of Natural Products published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caser, Matteo published the artcileDrought stress adaptation modulates plant secondary metabolite production in Salvia dolomitica Codd, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Salvia secondary metabolite drought stress adaptation.

Sage is an important medicinal and aromatic plant. While Salvia officinalis and S. miltiorrhiza have been widely studied, little information regarding S. dolomitica exists, although it has recently attracted attention due to its anti-plasmodial and anti-inflammatory properties. This study investigated the performance and metabolic profile of this species in response to two drought treatments (moderate or severe) relative to well-watered control plants. Changes in growth and ecophysiol. traits, as well as in bioactive and volatile compounds and essential oil production were determined Given that terpenoids are the most representative class of secondary metabolites, the gene expression of key enzymes of terpenoid biosynthesis was also investigated. Moderate drought stimulated a decline in leaf water potential, growth and stomatal conductance, as well as an increase in deyhdrin expression. Serious stress symptoms occurred only in severe drought-stressed plants, where a decline in net photosynthesis and transpiration and an increase in endogenous abscisic acid was observed Both drought stress conditions led to modulate the expression of some genes involved in biogenic volatile organic compound and essential oil biosynthesis and metabolic profile. In particular, drought induced an increase in sesquiterpene production, a class of terpenoids that is important in the food, cosmetics, and pharmaceutical industries. Thus, controlled drought, in addition to water savings during cultivation, can be applied to improve the production of secondary metabolites in S. dolomitica.

Industrial Crops and Products published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghanbariasad, Ali published the artcileNanoformulating Cinnamomum zeylanicum essential oil with an extreme effect on Leishmania tropica and Leishmania major, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Leishmania tropica major Cinnamomum zeylanicum essential oil nanoemulsion.

Major causatives for cutaneous leishmaniasis, the most common form of leishmaniasis, in the old world are Leishmania major and Leishmania tropica. Investigating the leishmanicidal effects of essential oils and preparing their nano/formulation is a promising approach for developing new green drugs. In this study, the ingredients of Cinnamomum zeylanicum essential oil were investigated using GC/MS anal., and its antioxidant effect was then evaluated using the DPPH assay. Moreover, the leishmanicidal effect of the essential oil against L. major and L. tropica was investigated; obtained half-maximal inhibitory concentrations (IC50)s were 16.53 and 7.56μg/mL. After that, a practical dosage form of C. zeylanicum, i.e., the nanoemulsion with a 52 ± 4 nm droplet size and a low droplet size distribution index (SPAN = 0.97), was prepared Interestingly, after treatment of both species with nanoemulsion, their viability was reduced to 0%. The prepared nanoformulation could be considered a potent anti-leishmanial agent for other species and in vivo studies.

Journal of Drug Delivery Science and Technology published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts