Category: 124-76-5

Ranarivelo, Lalasoa R. published the artcileChemical Composition and Antimicrobial Activity of Leaf Essential Oil of Tetradenia nervosa Codd from Madagascar, Collected at Different Stages of Vegetative Growth and Age, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Tetradenia nervosa leaf essential oil chem composition antimicrobial activity.

The chem. composition and antimicrobial activities of the essential oil isolated from the leaves of Tetradenia nervosa, a medicinal shrub from Madagascar have been investigated. The essential oil from the fresh leaves was obtained using hydrodistillation in a Clevenger-type apparatus, and characterized by gas chromatog./mass spectrometry (GC/MS) and gas chromatog./flame ionization detection (GC/FID). Eighty-one components that are 93.68-98.61% of the total composition were quantified and identified. The essential oil composition was dominated by sesquiterpenes (68.69-79.87%) represented by β-Caryophyllene, Bicycloelemene, Bicyclogermacrene, (-)-Spathulenol, and Caryophyllene oxide. Monoterpenes (15.51-24.99%) were characterized by α-Pinene, β-Pinene, 1,8-Cineole, and (+)-Fenchone. β-Caryophyllene remains the major component according to vegetative growth and plant age. The essential oils of T. nervosa tested were active against 16 Gram-pos. and 2 Gram-neg. bacteria strains. The vegetative growth and the plant age did not have any influence on the antimicrobial activity.

ACS Symposium Series published new progress about Aging, plant. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahmoudabadi, Samane Zarei published the artcileApplication of PC-SAFT EOS for Pharmaceuticals: Solubility, Co-Crystal, and Thermodynamic Modeling, Related Products of alcohols-buliding-blocks, the main research area is pharmaceuticals solubility cocrystal thermodn modeling PCSAFT EOS; Co-crystal; PC-SAFT EOS; Solubility; Thermodynamic; Thermodynamic modeling.

In this study, the applicability of the perturbed chain statistical associating fluid theory (PC-SAFT) was evaluated for pharmaceutical compounds For this purpose, the parameters of the PC-SAFT equation of state (EOS) were regressed by applying the exptl. solubility data of 54 pharmaceuticals in pure solvents. The reported errors for train and test data show the suitability of the PC-SAFT EOS. The applicability of the PC-SAFT EOS was explored by its prediction accuracy for the ternary system of medicine in solvent mixtures The model errors were 23 and 26% for two ternary systems of salicylic acid and lidocaine HCl in solvent mixtures of ethanol and water, resp. The co-crystal formation of salicylic acid-sulfamethazine in methanol was investigated by the PC-SAFT EOS. Finally, the reaction and crystallization sections for acetaminophen production from p-aminophenol were simulated by accompanying the PC-SAFT EOS and equilibrium assumption. The purification efficiencies for acetaminophen were obtained to be 93-98% for different temperatures

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Crystals (Co). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khebri, Souad published the artcilePhytochemical Profile, Antimicrobial and Antioxidant Activities of Cistus clusii Essential oil From Algeria, Quality Control of 124-76-5, the main research area is Pseudomonas Staphylococcus essential oil phytochem antimicrobial antioxidant property Algeria.

Cistus clusii essential oil has been extracted using hydrodistillation method and characterized by GC/MS. The antioxidant activity was evaluated by two different methods DPPH free radical scavenging, and β-carotene bleaching test. The antimicrobial activity was carried out using disk diffusion method against reference strains; Pseudomonas aeruginosa (ATCC 27865), Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), clin. bacterial (Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus) and fungal (Candida albicans) isolates. The chem. profile of the oil showed 31 compounds This profile was dominated by the presence of monoterpene hydrocarbons (78.4%), oxygenated derivatives (18.8%) and sesquiterpene hydrocarbons as minor constituents of this essential oil (1.9%). The major constituents were Camphene (20.6%), γ-Terpinene (16.5%), Sabinene (12.8%), and Terpineol-4 (13.5%). Other compounds were found in moderately good amounts like α-Terpinene (8.9%), α-Thujene (5.9%), α-Pinene (4.2%), and α- Terpinolene (3.1%). The results of the antimicrobial activity showed that the highest activity was observed against C. albicans and it was higher than pos. control Fluconazole. Conclusion: This study indicates that Cistus clusii essential oil showed potent antioxidant and moderate antimicrobial activities which could be used to explain the use of this species in traditional medicine.

Current Bioactive Compounds published new progress about Candida albicans. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Wen-Juan published the artcileAntagonistic storage potential of Tagetes minuta, Eupatorium fortunei and Ocimum basilicum oils with volatile secondary metabolites against Tribolium castaneum and Lasioderma serricorne, Computed Properties of 124-76-5, the main research area is Tagetes Eupatorium Ocimum Tribolium Lasioderma volatile secondary metabolite.

Antagonistic storage potential of Tagetes minuta Linnaeus, Eupatorium fortunei Turcz. and Ocimum basilicum L. volatile oils hydrodistillated with main secondary metabolites against two storage pests, Tribolium castaneum and Lasioderma serricorne adults were evaluated. More than 95% volatile secondary metabolites obtained at different hydrodistillation time were identified by gas chromatog.-mass spectrometry (GC-MS), and analyzed with principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA). Further insecticidal assay exhibited interesting results that T. minuta oil showed the strongest fumigant toxicity against both T. castaneum (LC50 = 6.68 mg/L air) and L. serricorne (LC50 = 3.13 mg/L air) among the three essential oils. As one of the main volatile secondary metabolites, methylthymol was found to possess more powerful fumigant (LC50 = 2.42 mg/L air) and contact toxicity (LD50 = 5.43 μg/adult) against T. castaneum. While, precocene I exhibited the strongest insecticidal toxicity on L. serricorne with the LC50 value of 0.88 mg/L air and LD50 of 3.46 μg/adult, resp. During the repellent assay, T. minuta oil showed the same repellent rate against both T. castaneum and L. serricorne at the highest concentration of 78.63 nL/cm2. The results proved that the essential oils as well as the main volatile secondary metabolites have potential to be developed into novel natural botanical resources on antagonistic storage with traditional Chinese medicine (TCM).

Industrial Crops and Products published new progress about Chinese medicine. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pinto, Joana published the artcileCharacterization of chemical compounds susceptible to be extracted from cork by the wine using GC-MS and 1H NMR metabolomic approaches, Application In Synthesis of 124-76-5, the main research area is wine maturation cork extractable compound geog origin; 1-Terpinen-4-ol (PubChem CID: 11230); Camphene (PubChem CID: 6616); Castalagin (PubChem CID: 168165); Cork; Friedelin (PubChem CID: 91472); GC-MS; Geographical origin; Metabolomics; NMR spectroscopy; Polyphenols; Pyrogallol (PubChem CID: 1057); Quinic acid (PubChem CID: 6508); Sitost-4-en-3-one (PubChem CID: 5484202); Vescalagin (PubChem CID: 5458626); Volatile compounds; o-Cymene (PubChem CID: 10703); trans-3-Pinanone (PubChem CID: 11038); trans-Squalene (PubChem CID: 638072).

This work presents a metabolomic study of cork by GC-MS and 1H-NMR spectroscopy to characterize compounds susceptible to be extracted from cork by the wine in an attempt to find a relationship between the content of these compounds and the geog. origin of cork. Cork from eleven geog. regions was studied, five from Portugal and six from Spain. Unsupervised pattern recognition techniques unveiled three main clusters of regions according to their chem. similarity but not related with geog. proximity. Nineteen compounds were found to be responsible for the clusters, including terpenes (trans-squalene, friedelin, camphene, trans-3-pinanone, 1-terpinen-4-ol, two sesquiterpenes), polyphenols (vescalagin, castalagin), among others (pyrogallol, glucosan, sitost-4-en-3-one, o-cymene, quinic acid, five unknowns). These preliminary results unveiled the potential for a more efficient selection of cork planks for stoppers production based on the compounds susceptible to be extracted from cork by the wine.

Food Chemistry published new progress about Cluster analysis. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Portella, Roberto de Oliveira published the artcileKinetin establish the volatile chemical profile after rhizome dormancy is released in Curcuma zedoaria (Christm.) Roscoe, Synthetic Route of 124-76-5, the main research area is Curcuma rhizome dormancy volatile chem profile kinetin; Metabolic pattern; bud dormancy; monoterpene; terpenes; volatile substances.

The aim of this work was to provide information about kinetin effects on chem. volatile profile of Curcuma zedoaria (Christm.) Roscoe after several days of plant dormancy release. Rhizomes of C. zedoaria were immersed in four kinetin concentrations (0, 50, 100, 150 mg ml-1, n = 12 by each concentration) for 30 min. After 240 h of treatment, root length (mm), bud break (%) and bud speed index (BSI) were measured, and three rhizomes at 24 h and 240 h were collected for chem. volatile profile anal. by application of headspace solid-phase microextraction (HS-SPME) coupled with gas chromatog.-mass spectrometry (GC-MS). Kinetin does not alter morphol. aspects of the bud dormancy releasing, but drastically changes metabolic aspects of volatile production on C. zedoaria rhizomes, by the selection of several monoterpenes, such as camphene, sabinene, isoborneol, borneol, 1,8-cineole. We assume that kinetin application maintain monoterpene production as a consequence of its signaling over dormancy release.

Natural Product Research published new progress about Curcuma zedoaria. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dessy, V. J. published the artcileGC-MS analysis of bioactive compounds present in different extracts of rhizome of Curcuma aeruginosa Roxb., Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Curcuma rhizome bioactive compound GCMS.

To analyze and characterize the chem. composition of the different crude extracts from the rhizome of Curcuma aeruginosa Roxb a medicinal plant. The air-dried rhizomes were powd. and subjected to Soxhlet extraction using solvent n-hexane and Supercritical fluid extraction Then, each of the extracts was further subjected to gas chromatog.-mass spectrometry. Qual. determination of the different biol. active compounds from crude extracts of C aeruginosa Roxb using gas chromatog.-mass spectrometry revealed different types of high and low mol. weight chem. entities with varying quantities present in each of the extracts These chem. compounds are considered biol. and pharmacol. important. Furthermore, the two different extracts SCF and n-hexane possess unique physicochem. characteristics. The two extracts possess major bioactive compounds that were identified and characterized spectroscopically. Thus, identification of different biol. active compounds in the extracts of C aeruginosa Roxb warrants further biol. and pharmacol. studies.

Journal of Drug Delivery and Therapeutics published new progress about Bioactive agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murthy, Sushma S. published the artcileMolecular docking studies of phytocompounds with transcriptional factors in hepatocellular carcinoma, Category: alcohols-buliding-blocks, the main research area is mol docking anticancer agent hepatocellular carcinoma.

Hepatocellular carcinoma is one of the majorly categorized forms of human malignancy and is the prime cause of cancer-related mortality. Transcription factors and co-factors play an important role in the cellular process performing as key regulators in the normal cell and in the cancerous cell. The present study investigates the potential interaction between the potent phytocompounds and key transcriptional factors involved in hepatocellular carcinoma (HCC) by using mol. docking studies. In the area of drug designing and development, computational modeling and simulation play a significant role. Screening of potent phytocompounds against targets by means of conventional methods is tedious and requires more time when compared to computational modeling and simulation studies. In the present study, the application of computational screening of phytocompounds against transcriptional factors was effectively used to determine their binding strength with the pythocompounds. Ten potential phytocompounds linalool, p-cymene, pelargonidin, harpagoside, 1, 8-cineole, afzelin, ginkgolide B, theophylline, bromelain and isoborneol and five transcription factors p53, AP-1, c-Myc, β-catenin and HIF-1α were selected for docking studies. The 3D structures of both phytocompounds and transcription factors were obtained from Pubchem and PDB databases resp. Docking studies were carried out by using AutoDockVina. On evaluating the docking results, it was found that phytocompounds Harpagoside, Bromelain and Afzelin showed strong binding affinity against their targets. These phytocompounds showed the binding free energy more than 6 kcal/mol and RMSD value between 4-7 A0 with targets and can be potential ligands against the selected targets for further mol. investigations.

Rasayan Journal of Chemistry published new progress about Antitumor agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sokolova, Anastasiya S. published the artcileMonoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process, Computed Properties of 124-76-5, the main research area is preparation monoterpenoid filovirus entry inhibitor glycoprotein structure; Borneol; Camphor; Ebola virus; Glycoprotein; Marburg virus; Mutagenesis study.

In this study, we screened a large library of (+)-camphor and (-)-borneol derivatives to assess their filovirus entry inhibition activities using pseudotype systems. Structure-activity relationship studies revealed several compounds exhibiting submicromolar IC50 values. These compounds were evaluated for their effect against natural Ebola virus (EBOV) and Marburg virus. Compound 3b (As-358) exhibited the good antiviral potency (IC50 = 3.7 μM, SI = 118) against Marburg virus, while the hydrochloride salt of this compound 3b·HCl had a strong inhibitory effect against Ebola virus (IC50 = 9.1 μM, SI = 31) and good in vivo safety (LD50 > 1000 mg/kg). The results of mol. docking and in vitro mutagenesis analyses suggest that the synthesized compounds bind to the active binding site of EBOV glycoprotein similar to the known inhibitor toremifene.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cotchakaew, Nuttavich published the artcileToxicity of several botanical essential oils and their combinations against females of Aedes albopictus (Skuse) and Anopheles minimus (theobald): oviposition deterrent, ovicidal and adulticidal efficacies, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Aedes albopictus Anopheles minimus essential oil oviposition adulticidal toxicity.

To investigate the efficacies of 12 essential oil (EO) formulations from three Zingiberaceae plants (Alpinia galanga, Curcuma zedoaria, and Zingiber cassumunar) individually and in combination with an augmenting Eucalyptus globulus (E. globulus) EO against females of Aedes albopictus (Ae. albopictus) and Anopheles minimus (An. minimus). These formulations were evaluated for their ovicidal, oviposition deterrent and adulticidal activities against Ae. albopictus and An. minimus by a topical method, a double-choice method and a WHO susceptibility test, resp. It was found that all formulations of Zingiberaceae plants EOs augmented with E. globulus EO were more effective in oviposition deterrent, ovicidal, and adulticidal activities against the two mosquito species than all of the formulations used without E. globulus EO. Their oviposition deterrent, ovicidal and adulticidal activities were equivalent to those of 10% w/v cypermethrin. In contrast, 70% volume/volume Et alc. as a control alone was not effective at all. The highest synergistic effect in effective repellency against Ae. albopictus was achieved by 5% Alpinia galanga EO + 5% E. globulus EO and against An. minimus was 5% Zingiber cassumunar EO + 5% E. globulus EO. Moreover, the highest synergistic effects in ovicidal activities against Ae. albopictus and An. minimus were achieved by 10% Zingiber cassumunar EO + 10% E. globulus EO and 5% Curcuma zedoaria EO + 5% E. globulus EO, resp. For the adulticidal activities, the highest synergistic effect against two mosquitoes was achieved by 5% Curcuma zedoaria EO + 5% E. globulus EO. These results suggest that Zingiberaceae plant EOs augmented with E. globulus EO have a high potential to be developed into oviposition deterrent, ovicidal, and adulticidal agents for controlling populations of Ae. albopictus and An. minimus.

Asian Pacific Journal of Tropical Biomedicine published new progress about Aedes albopictus. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts