Category: 124-76-5

Ribeiro, Rita published the artcileComparing the effect of Thymus spp. essential oils on Candida auris, Product Details of C10H18O, the main research area is Thymus Candida auris essential oil comparing effect.

Candida auris is an emergent yeast pathogen responsible for many invasive fungal infections due to its multidrug-resistant character and its huge transmission ability. Essential oils (EOs) obtained from several aromatic plants have been regarded as an alternative treatment upon to fungal infections. For example, Thymus spp. are known by their antifungal effect due to the presence of some volatile compounds in their EOs, such as carvacrol, thymol, linalool and gamma-terpinene. So, the main goal of this work was to compare the effect of several EOs from Thymus spp. on C. auris biofilm. The antifungal activity of Thymus vulgaris, Thymus zygis, Thymus satureioides and Thymus mastichina against planktonic cells of C. auris NCPF 8971 was assessed by agar disk diffusion method. The effect of these EOs with direct or vapor phases on preformed biofilms was evaluated by colony-forming unitsprime enumeration. Importantly it was noticed a completely different range of action between the EOs from the same genus. While T. vulgaris showed the biggest antifungal effect with a halo of 59.75 plusmn 15.75 mm, T. mastichina for the other side, presented a halo of 13.13 plusmn 1.36 mm, showing a very low activity. In addition, the direct application of T. vulgaris and T. zygis EOs demonstrated higher antifungal activity against C. auris biofilms than vapor phase application. However, T. vulgaris also showed significant action in the vapor phase mode. The chem. composition of Thymus EOs was analyzed by GC and GC-MS, and was demonstrated that they have different chem. profiles, namely in the amount of phenolic compounds, which justify the different antifungal actions.In conclusion, T. vulgaris and T. zygis oils, can be pointed out as a great contribution to the treatment of C. auris infections, being promising alternatives to conventional therapy. However, the efficiency of the EOs differs substantially between the four species of Thymus. Therefore, the selection of natural therapies should always have in account EOs composition

Industrial Crops and Products published new progress about Candida auris. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Lei published the artcileTransition-Metal-Free Photoredox Phosphonation of Aryl C-N and C-X Bonds in Aqueous Solvent Mixtures, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is aryl halide photoredox cross coupling reaction phosphite phenothiazine catalyst; aromatic aryl phosphonate preparation green solvent.

Herein, the authors present an efficient and mild methodol. for the synthesis of aromatic phosphonate esters in good to excellent yields using 10H-phenothiazine, an inexpensive commodity chem., as a photoredox catalyst. The reaction exhibits wide functional group compatibility enabling the transformation in the presence of ketone, amide, ester, amine, and alc. moieties. Importantly, the reaction proceeds using a green solvent mixture primarily composed of H2O, thus lowering the environmental footprint of this transformation compared to current methods. The transformation also proceeds under atm. conditions, which further differentiates it from current methods that require inert atm. Mechanistic work using fluorescence quenching experiments and radical trapping approaches support the proposed mechanism.

ACS Sustainable Chemistry & Engineering published new progress about Green solvents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caputo, Lucia published the artcileImpact of drying methods on the yield and chemistry of Origanum vulgare L. essential oil, Related Products of alcohols-buliding-blocks, the main research area is Origanum essential oil carvacrol drying thermal stress.

Oregano (Origanum vulgare L.) is mainly cultivated, both as fresh and dried herb, for several purposes, such as ailments, drugs, and spices. To evaluate the influence of some drying methods on the chem. composition of the essential oil of oregano, its aerial parts were dehydrated by convective drying techniques (shade, static oven), microwave-assisted heating (three different treatments) and osmotic treatment. The oils were analyzed by GC-FID and GC-MS. The highest essential oil yield was achieved from microwave and shade drying methods. In total, 39 components were found, with carvacrol (ranging from 56.2 to 81.4%) being the main constituent; other compounds present in lower amounts were p-cymene (1.6-17.7%), γ-terpinene (0.8-14.2%), α-pinene (0.1-2.1%), thymol Me ether (0.4-1.8%) and thimoquinone (0.5-3.5%). The essential oil yields varied among the different treatments as well as the relative compositions The percentages of p-cymene, γ-terpinene and α-pinene decreased significantly in the dried sample compared with the fresh sample; on the other hand, carvacrol, isoborneol and linalool increased significantly in the dried materials. The choice of the drying method for obtaining the essential oil therefore appears crucial not only in relation to the higher yield but also and above all in reference to the percentage presence of components that can direct the essential oil toward an appropriate use.

Scientific Reports published new progress about Drying process. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jia-Jia published the artcileGC-MS profile of Hua-Feng-Dan and RNA-Seq analysis of induced adaptive responses in the liver, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Hua Feng Dan RNA sequence liver bioinformatic signaling GCMS; GC-MS; GEO database; Hua-Feng-Dan; RNA-seq; adaptation; bioinformatics.

Hua-Feng-Dan is a patent Chinese medicine for stroke recovery and various diseases. This study used GC-MS to profile its ingredients and RNA-Seq to analyze the induced adaptive response in the liver. Hua-Feng-Dan was subjected to steam distillation and solvent extraction, followed by GC-MS anal. Mice were orally administered Hua-Feng-Dan and its “”Guide drug”” Yaomu for 7 days. Liver pathol. was examined, and total RNA isolated for RNASeq, followed by bioinformatic anal. and quant. real-time PCR (qPCR). Forty-four volatile and fifty liposol. components in Hua-Feng-Dan were profiled and analyzed by the NIST library and their concentrations quantified. The major components (>1%) in volatile (5) and liposol. (10) were highlighted. HuaFeng-Dan and Yaomu at hepatoprotective doses did not produce liver toxicity as evidenced by histopathol. and serum enzyme activities. GO Enrichment revealed that Hua-Feng-Dan affected lipid homeostasis, protein folding, and cell adhesion. KEGG showed activated cholesterol metabolism, bile secretion, and PPAR signaling pathways. Differentially expressed genes (DEGs) were identified by DESeq2 with p < 0.05 compared to controls. Hua-Feng-Dan produced more DEGs than Yaomu. qPCR on selected genes largely verified RNA-Seq results. Ingenuity Pathways Anal. of the upstream regulator revealed activation of MAPK and adaptive responses by Hua-FengDan, and Yaomu was less effective. Hua-Feng-Dan-induced DEGs were highly correlated with the Gene Expression Omnibus database of chem.-induced adaptive transcriptome changes in the liver. GC-MS primarily profiled volatile and liposol. components in Hua-FengDan. Hua-Feng-Dan at the hepatoprotective dose did not produce liver pathol. changes but induced metabolic and signaling pathway activations. The effects of Hua Feng-Dan on liver transcriptome changes point toward induced adaptive responses to program the liver to produce hepatoprotective effects. Frontiers in Pharmacology published new progress about Bioinformatics. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gomez-Ramos, M. M. published the artcileExploration of environmental contaminants in honeybees using GC-TOF-MS and GC-Orbitrap-MS, Application In Synthesis of 124-76-5, the main research area is environmental contaminant honeybee Apis GC TOF MS Orbitrap; pollutant PAH phthalate synthetic musk Apis; Environmental contaminants; GC-EI-TOF-MS; GC-Orbitrap-MS; Honeybee; Non-targeted screening.

This study reports an anal. approach by gas chromatog. and high-resolution mass spectrometry (HRMS) intended to be used for investigation of nontargeted environmental contaminants in honeybees. The approach involves a generic extraction and anal. with two GC-HRMS systems: time-of-flight and Orbitrap analyzers, GC-TOF-MS, and GC-Orbitrap-MS operated in electron-impact ionization (EI) mode. The workflow for screening of non-targeted contaminants consisted of initial peak detection by deconvolution and matching the first-stage mass spectra EI-MS with a nominal mass spectral library. To gain further confidence in the structural characterization of the contaminants under investigation, mol. formula of representative ions (mol. and fragment ions) was provided for those with an accurate mass scoring (error < 5 ppm). This methol. was applied for screening environmental contaminants in 75 samples of adult honeybee. This approach has provided the tentative identification of environmental contaminants belonging to different chem. groups, among them, PAHs, phthalates and synthetic musks. Residues of veterinary treatments used in apiculture were also detected in the honeybee samples. Science of the Total Environment published new progress about Apis mellifera. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caputo, Lucia published the artcileChemical composition and biological activities of essential oils from peels of three Citrus species, Name: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Citrus fruit peelessential oil chem composition phototoxicity biol activity; Citrus limon; Citrus × bergamia; Citrus × myrtifolia; eco-compatibility; essential oil; phytotoxicity.

Fruit peels are generally underutilized byproducts of the food industry, although they are valuable sources of bioactive compounds The aim of this study is to evaluate a new application for three Citrus peel EOs as bio-herbicides. After a micro-morphol. evaluation of Citrus peels by SEM anal., the phytochem. composition of the EOs of Citrus x bergamia Risso & Poit., Citrus x myrtifolia Raf., and Citruslimon (L.) Osbeck was characterized by GC/FID and GC/MS analyses. The in vitro phytotoxicity against germination and initial radical elongation of several crop and weed species was evaluated. Furthermore, the eco-compatibility of these EOs has been assessed by the brine shrimp (Artemia salina) lethality assay. SEM anal. highlighted the morphometric differences of the schizolysigenous pockets among the peels of the three Citrus species. Oxygenated monoterpenes are the main constituents in C. x bergamia (51.09%), whereas monoterpene hydrocarbons represent the most abundant compounds in C. x myrtifolia (82.15%) and C. limon (80.33%) EOs. They showed marked and selective phytotoxic activity in vitro, often at very low concentration (0.1 μg/mL) against all plant species investigated, without showing any toxicity on Artemia salina, opening the perspective of their use as safe bio-herbicides.

Molecules published new progress about Artemia salina. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Name: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miura, Patricia Tidori published the artcileStudy of the chemical composition and ecotoxicological evaluation of essential oils in Daphnia magna with potential use in aquaculture, Synthetic Route of 124-76-5, the main research area is Daphnia essential oil chem composition aquaculture ecotoxicol.

Essential oils have been used in aquaculture due to their wide range of biol. activities. However, even though they have a potentially low risk for fish, it is necessary to assess the risks to nontarget organisms to guarantee their safe use in the environment. Here, we assessed the acute toxicity on the model organism Daphniamagna of seven essential oils of interest in aquaculture (Lippiaalba, Lippiagracilis, Lippiasidoides, Menthaarvensis, Menthapiperita, Ocimumgratissimum and Pipercallosum). Furthermore, we also studied the chem. composition of essential oils using gas chromatog.-mass spectrometry (GC-MS) to relate toxicity to the chem. composition The half maximal effective concentration values during 48 h of exposure (EC50-48 h) of the essential oils for D. magna showed toxicity ranging from moderately (EC50-48 h 3.59 mg/L for L. gracilis, followed by L. sidoides, L. alba and O. gratissimum) to slightly toxic (EC50-48 h 43.74 mg/L for M. piperita as the least toxic, M. arvensis and P. callosum). Thus, for the purpose of establishing ecol. safe therapeutic protocols, the correct use of these substances in aquaculture should be considered, as the toxicity of the essential oils observed indicates potential interference with the nontarget organism D. magna.

Aquaculture Research published new progress about Acute toxicity. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tunnisa, Fitra published the artcileAntioxidant and antidiabetic compounds identification in several Indonesian underutilized Zingiberaceae spices using SPME-GC/MS-based volatilomics and in silico methods, HPLC of Formula: 124-76-5, the main research area is Zingiber eucalyptol fenchone volatiles antioxidant antidiabetic SPME GCMS Indonesia; AC, Amomum compactum Soluble ex Maton; AGI, α-glucosidase inhibitor; AM, Alpinia malaccensis (Burm.f.) Roscoe; Antioxidant; BR, Boesenbergia rotunda L. Mansf.; CA, Curcuma aeruginosa Roxb; CH, Curcuma heyneana Val. & Zijp; CP, Curcuma purpurascens Blume; CT, Curcuma petiolata Roxb; CUPRAC, Cupric ion reducing antioxidant capacity; CZ, Curcuma zedoria Roscoe; DPPH, 2,2-diphenyl-1-picrylhydrazyl; FRAP, Ferric reducing antioxidant property; GC/MS, Gas chromatography/mass spectrometry; Metabolomics; OPLS, Orthogonal projection to the least square; PCA, Principal component analysis; SPME, Solid phase micro extraction; SPME-GC/MS; TFC, Total flavonoid content; TPC, Total phenolic content; Volatiles; ZA, Zingiber aromaticum Val.; ZC, Zingiber purpureum Roscoe; ZO, Zingiber ottensii Val.; ZZ, Zingiber zerumpet L. Roscoe ex Sm.; α-Glucosidase inhibitor.

This study aimed to identify compounds in 12 minor Zingiberaceae spices grown in Indonesia linked with in vitro α-glucosidase inhibitor and antioxidant (DPPH, FRAP, CUPRAC) activities using SPME-GC/MS volatilomics. The results illustrated that Zingiber aromaticum Val., Alpinia malaccensis (Burm.f.) Roscoe, Amomum compactum Soluble ex Maton, and Zingiber purpureum Roscoe had the highest α-glucosidase inhibitor and DPPH, FRAP, CUPRAC antioxidant activities, resp. Also, the total phenolic content pos. influenced DPPH, FRAP, and CUPRAC antioxidant activities. The strongest pos. correlation with α-glucosidase inhibitor and DPPH antioxidant activities was found in eucalyptol; whereas o-cymene and terpinen-4-ol had the strongest correlations with FRAP and CUPRAC antioxidants, resp. Furthermore, the mol. docking anal. revealed that all compounds with a strong correlation with α-glucosidase inhibitor activity (based on their OPLS VIP score) had binding energies (-5.06 – -6.26 kcal/mol) close to Acarbose (-10.11 kcal/mol). Thus, this study provided vital information on the volatile compounds in underutilized spices associated with their health beneficial properties.

Food Chemistry: X published new progress about Adipose tissue. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oswald, Iain W. H. published the artcileIdentification of a New Family of Prenylated Volatile Sulfur Compounds in Cannabis Revealed by Comprehensive Two-Dimensional Gas Chromatography, COA of Formula: C10H18O, the main research area is prenylated volatile sulfur compound Cannabis terpene Allium.

Cannabis sativa L. produces over 200 known secondary metabolites that contribute to its distinctive aroma. Studies on compounds traditionally associated with the scent of this plant have focused on those within the terpenoid class. These isoprene-derived compounds are ubiquitous in nature and are the major source of many plant odors. Nonetheless, there is little evidence that they provide the characteristic “”skunk-like”” aroma of cannabis. To uncover the chem. origins of this scent, we measured the aromatic properties of cannabis flowers and concentrated extracts using comprehensive two-dimensional gas chromatog. equipped with time-of-flight mass spectrometry, flame ionization detection, and sulfur chemiluminescence. We discovered a new family of volatile sulfur compounds (VSCs) containing the prenyl (3-methylbut-2-en-1-yl) functional group that is responsible for this scent. In particular, the compound 3-methyl-2-butene-1-thiol was identified as the primary odorant. We then conducted an indoor greenhouse experiment to monitor the evolution of these compounds during the plant’s lifecycle and throughout the curing process. We found that the concentrations of these compounds increase substantially during the last weeks of the flowering stage, reach a maximum during curing, and then drop after just one week of storage. These results shed light on the chem. origins of the characteristic aroma of cannabis and how volatile sulfur compound production evolves during plant growth. Furthermore, the chem. similarity between this new family of VSCs and those found in garlic (allium sativum) suggests an opportunity to also investigate their potential health benefits.

ACS Omega published new progress about Allium sativum. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Brijesh published the artcileIn Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19, Application In Synthesis of 124-76-5, the main research area is COVID traditional Indian spices antiviral effect; 6LXT; 6YNQ; 6YOR; COVID-19; isovitexin; myricetin; spices.; spike protein.

The global health emergency due to SARS-CoV-2 causing the COVID-19 pandemic emphasized the scientific community to intensify their research work for its therapeutic solution In this study, Indian traditional spices owing to various medicinal properties were tested in silico for their inhibitory activity against SARS-CoV-2 proteins. SARS-CoV-2 spike proteins (SP) and main proteases (Mpro) play a significant role in infection development were considered as potential drug targets. A total of 75 phytochems. present in traditional Indian spices retrieved from the published literature and Dr. Duke’s Phytochem. and Ethnobotanical Database, were docked with Mpro (PDB IDs: 6YNQ), and the SP (PDB IDs: 6LXT and 6YOR). Through the screening process, 75 retrieved phytochems. were docked with spike protein (PDB IDs: 6LXT and 6YOR) and main protease (PDB ID: 6YNQ) of SARS-CoV-2. Among them, myricetin, a flavonoid (rank score: 6LXT: -11.72383; 6YOR: -9.87943; 6YNQ: -11.68164) from Allium sativum L and Isovitexin, an example of flavone (rank score: 6LXT: -12.14922; 6YOR: -10.19443; 6YNQ: -12.60603) from Pimpinella anisumL were the most potent ligands against SP and Mpro of SARS-CoV-2. Whereas, Astragalin from Crocus sativus L.; Rutin from Illicium verum, Oxyguttiferone from Garcinia cambogia; Scopolin from Apium graveolens L, Luteolin from Salvia officinalis, Emodin, Aloe-emodin from Cinnamomum zeylanicium and Apigenin from Allium sativum L showed better inhibition against Mpro than SP of SARS-CoV-2. The amino acid residues like SER, LYS, ASP and TYR were found playing important role in protein-ligand interactions via hydrogen bonding and Vander Waals forces. Optimal use of traditional spices in our daily meals may help fight against COVID-19. This study also paves the path for herbal drug formulation against SARS-CoV-2 after wet lab validation.

Current Pharmaceutical Design published new progress about Acorus calamus. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts