Category: 124-68-5

Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 124-68-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 124-68-5

2-Amino-2-methyl-l-propanol (5 g, 56.1 mmol), (Boc)20 (13.46 g, 61.7 mmol) and triethyl amine (6.24 g, 61.7 mmol) were dissolved in 50 mL of dichloromethane. The reaction mixture was stirred for 4 h at 22 to 25 C. Above mixture was washed with water (25 mL x 2), dried over anhydrous sodium sulfate and concentrated under vacuum to get tert-buty] (1- hydroxy-2-methylpropan-2-yl)carbamate (10.3 g, 97% yield).

The synthetic route of 124-68-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEKTAR THERAPEUTICS (INDIA) PVT.LTD.; NEKTAR THERAPEUTICS (Incorporated under the Laws of Delaware and domiclled in the State of California); DUARTE, FRANCO; ANAND, NEEL; SHARMA, PANKAJ; SINGH, DEVENDRAPRATAP U.; WO2015/79459; (2015); A1;,
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Reference of 124-68-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 124-68-5 as follows.

1) N-Benzyl-2-amino-2-methyl-1-propanol A solution of 2-amino-2-methyl-1-propanol (10.0 g), benzaldehyde (11.98 mL) and p-toluenesulfonic acid (10 mg) in benzene (300mL) was heated to reflux for 4 hours using a Dean-Stark dehydrating apparatus. After air cooling, the reaction solvent was evaporated under reduced pressure, and a residue thus obtained was dissolved in methanol (200 mL). Under ice cooling, sodium cyanoborohydride (8. 89 g) was added to the solution, and the mixture was stirred for 1. 5 hours. The reaction solvent was evaporated under reduced pressure, then a saturated aqueous solution of sodium hydrogen carbonate and ethyl acetate were added to the residue thus obtained, and the resultant mixture was partitioned. The organic layer was washed with saturated brine, and then was dried over anhydrous magnesium sulfate. After separating the organic layer by filtration, the solvent was evaporated under reduced pressure, and a residue thus obtained was purified by silica gel column chromatography (dichloromethane-methanol-aqueous ammonia), to obtain N-benzyl-2-amino-2-methyl-1-propanol (10. 36 g, 52%) as a solid. 1H-NMR (400MHz, CDCl3) delta: 1.15 (6H, s), 1.86 (2H, br s), 3.35 (2H, s), 3.68 (2H, s), 7.30 (5H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1803719; (2007); A1;,
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Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a stirred solution of 2, 4-dichloro-5-methoxypyrimidine (5 g, 27.93 mmol) in 1, 4-dioxane (50 mL) under argon atmosphere were added diisopropylethylamine (7.2 g,55.86 mmol) and 2-amino-2-methylpropan-1-ol (2.4 g, 27.93 mmol) at RT. The reaction mixture was stirred at 130 C for 48 h. After consumption of the starting materials (monitored by TLC), the volatile components were evaporated in vacuo.The residue was diluted with a saturated sodium bicarbonate solution (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 10% EtOAc:hexanes to afford 2-((2-chloro-5 -methoxypyrimidin-4-yl) amino)-2-methylpropan- 1 -ol (5.5 g, 84%) as a white solid. ?H-NMR(DMSO-d6, 500 MHz): oe 7.69 (s, 1H), 6.19 (s, 1H), 6.11 (t, 1H), 3.82 (s, 3H), 3.45 (d, 2H), 1.33 (s, 6H); TLC: 50% EtOAc:hexanes (Rf 0.3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,124-68-5, 2-Amino-2-methyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66696; (2015); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 124-68-5

General procedure: A microwave tube was charged with 2i (1 mmol), NaOH (120 mg, 3 mmol), and EtOH (10 mL). The tube was sealed, placed in a microwaveoven and heated (T = 135 C; t = 10 min). After release, Boc2O(655 mg, 3 mmol) was added at r.t. and the reaction mixture wasstirred for 2 h at 40 C. H2O (10 mL) and Et2O (20 mL) were added andthe layers were separated. The aqueous phase was extracted withEt2O (2 ¡Á 20 mL) and the combined organic layers were dried overMgSO4, filtered, and the solvent was removed in vacuo. The crude residuewas purified on silica gel chromatography (cyclohexane-EtOAc,95:5 to 40:60) to afford the desired N-Boc-protected amino alcohol 4.

With the rapid development of chemical substances, we look forward to future research findings about 124-68-5.

Reference:
Article; Boukattaya, Fatma; Caille, Julien; Ammar, Houcine; Rouzier, Florian; Boeda, Fabien; Pearson-Long, Morwenna S. M.; Bertus, Philippe; Synthesis; vol. 48; 6; (2016); p. 906 – 916;,
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Related Products of 124-68-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.

A 2 L Morton flask equipped with overhead stirring was charged with dichloromethane (200 ml_), 2-amino-2-methylpropan-1-ol (10.71 ml_, 112 mmol) and a saturated solution of sodium bicarbonate (200 ml_) and the reaction mixture was stirred. Benzyl chloroformate (16.61 ml_, 1 18 mmol) was added rapidly via syringe to the reaction mixture and stirring was continued (1H NMR after 6 hours indicated complete conversion). The mixture was poured into a separatory funnel and the layers were separated. The organic layer was washed with water and saturated sodium chloride, dried over sodium sulfate, and concentrated in vacuo to afford a colorless liquid (23.5 g). This liquid was purified by silica gel chromatography, eluting with ethyl acetate: heptane (1 :9 to 1 :1) to afford benzyl (1-hydroxy-2-methylpropan-2-yl)carbamate (13.61 g, 61.0 mmol, 54.3 % yield) as a colorless syrup. NMR (400 MHz, CD3SOCD3) d 1 .16 (s, 6 H), 3.35 (d, J = 6 Hz, 2 H), 4.69 (t, J = 6 Hz, 1 H), 4.97 (s, 2 H), 6.69 (br s, 1 H), 7.26-7.42 (m, 5 H); LC-MS (LC-ES) M+H = 224.

According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CADILLA, Rodolfo; DEATON, David Norman; LARKIN, Andrew L; SCHULTE, Christie; SMALLEY JR, Terrence L.; (237 pag.)WO2020/95215; (2020); A1;,
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Related Products of 124-68-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 124-68-5, name is 2-Amino-2-methyl-1-propanol. A new synthetic method of this compound is introduced below.

(3a) (2-Hydroxy-1,1-dimethylethyl)carbamic acid t-butyl ester 230.4 ml of di-t-butyl dicarbonate (1.00 mol) was added to a solution of 98.05 g of 2-amino-2-methyl-1-propanol (1.10 mol) and 154 ml of triethylamine (1.10 mol) in methylene chloride (500 ml) at room temperature over 20 minutes, and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure and diluted with a 10% citric acid aqueous solution, followed by extraction with ethyl acetate. Then, the organic layer was washed with water and brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain 189.25 g of the crude title compound (yield: quant.). Colorless solid. 1H NMR spectrum (CDCl3, 400 MHz), delta: 4.64 (br s, 1H), 4.01 (br s, 1H), 3.59 (d, 2H, J = 6.3 Hz), 1.43 (s, 9H), 1.25 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,124-68-5, 2-Amino-2-methyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP2036896; (2009); A1;,
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Electric Literature of 124-68-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.

To an oven dried 250 mL round bottomed flask was weighed quinaldic acid (866 mg, 5.0 mmol). A magnetic stir bar was added and the flask was put under N2 atmosphere. The flask was charged with DCM (50 mL) and cooled to 0 C. in an ice bath. The flask was charged with N-methyl morpholine (720 muL, 7.5 mmol) and isobutlychloroformate (752 muL, 5.75 mmol) via syringe addition. The reaction was allowed to stir at 0 C. for 10 min until the solution became cloudy. At which point 2-methyl-2-aminopropanol (550 uL, 5.75 mmol) was added slowly to the flask via syringe. The reaction mixture was allowed to slowly warm to room temperature. The reaction was quenched after 2 h with 1M HCl solution (30 mL) and transferred to a separatory funnel with DCM (50 mL). The layers were partitioned and the organic phase was washed with H2O (2¡Á30 mL) and brine (1¡Á40 mL). After drying over Na2SO4 and filtration, the mixture was concentrated under reduced pressure. The crude mixture was purified by flash chromatography eluting with a 1:1 mixture of EtOAc and hexanes to afford N-(1-hydroxy-2-methylpropan-2-yl)quinoline-2-carboxamide as a colorless oil in 91% yield (1.112 g, 4.55 mmol) according to the following reaction

Statistics shows that 124-68-5 is playing an increasingly important role. we look forward to future research findings about 2-Amino-2-methyl-1-propanol.

Reference:
Patent; Sigman, Matthew Scott; Michel, Brian William; US2011/54176; (2011); A1;,
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Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 124-68-5, blongs to alcohols-buliding-blocks compound. name: 2-Amino-2-methyl-1-propanol

(1) Acetic acid (5.4 ml) was added to a solution of 2-amino-2-methyl-1-propanol (8.4 g) and benzaldehyde (10 g) in 1,2-dichloroethane (140 ml) under ice-cooling. After 30 minutes of stirring at the same temperature, sodium triacetoxyborohydride (26 g) was added by small portions to the solution over 10 minutes. After 2 hours of stirring at room temperature, the mixture was poured into a solution of sodium hydrogen carbonate (48 g) in water (300 ml). The aqueous layer was separated and adjuster to pH 12 with 24% sodium hydroxide aqueous solution. The alkaline solution was extracted with ethyl acetate 12 times. The extract was dried over sodium sulfate and evaporated under reduced pressure to give colorless crystals of 2-benzylamino-2-methyl-1-propanol (13.2 g). mp: 46.0-47.0 C. IR (Nujol): 3330, 3100, 2900, 1450, 1380, 1355 cm-1 NMR (DMSO-d6, delta): 0.99 (6H, s), 3.23 (2H, d, J=3.9Hz), 3.62 (2H, s), 4.50-4.60 (1H, m), 7.16-7.36 (5H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; MIYAKE, HIROSHI; TAKE, KAZUHIKO; SHIGENAGA, SHINJI; AZAMI, HIDENORI; SASAKI, HIROSHI; EIKYU, YOSHITERU; NAKAI, KAZUO; ISHIDA, JUNYA; MANABE, TAKASHI; KONISHI, NOBUKIYO; TERASAKA, TADASHI; US2003/114668; (2003); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. 124-68-5

N-methyl-2-amino-2-methyl-propan-1 -ol (4)2-Amino-2-methylpropanol (3) (10 g, 0.11 mol), Na2CO3 (0.41 g), NaHCO3 (0.41 g) and 3:1 dioxane/water (41 ml) were stirred together at 00C. Boc anhydride (29.4 g, 0.13 mol) was added slowly and the reaction was stirred at room temperature for 6 h. The salts formed were filtered and washed with DCM. The filtrate was diluted with water (50ml) and extracted with DCM (3 x 50 ml), dried (Na2SO4) and evaporated to dryness, giving a white solid. This was dissolved in THF (100 ml) and added dropwise to a mixture of lithium aluminium hydride (12.7 g, 0.33 mol) in THF (200 ml). The mixture was heated to reflux overnight then cooled to room temperature. Water (15 ml) was added slowly with ice-cooling followed by 4 M NaOH (15 ml), and then more water (45 ml). The white solids were filtered, washed with THF, and the filtrate was evaporated to dryness, giving a pink solid (8.9 g, 77%). 1H NMR (400 MHz, CDCI3): 0.97 (6H, s), 2.24 (3H, s), 3.26 (2H, s); 13C NMR (100 MHz, CDCI3): 23.27, 28.41 , 53.62, 68.26.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 124-68-5, 2-Amino-2-methyl-1-propanol.

Reference:
Patent; BIOCOPEA LIMITED; BANNISTER, Robin Mark; WO2010/103312; (2010); A1;,
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Alcohols – Chemistry LibreTexts

Adding some certain compound to certain chemical reactions, such as: 124-68-5, name is 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 124-68-5. 124-68-5

1-a. A mixture of 2-amino-2-methyl-1-propanol (53 g), di-t-butyl dicarbonate (65 g) and water (500 ml) was stirred at room temperature for 1 hour. The reaction mixture was extracted with chloroform, and the chloroform layer was dried over MgSO4. The solvent was evaporated under reduced pressure. The residue was recrystallized from hexane to give 2-(t-butoxycarbonylamino)-2-methyl-1-propanol (44.4 g). NMR (CDCl3)delta: 1.25 (6H, singlet), 1.43 (9H, singlet), 3.20-5.50 (2H, multiplet), 3.56 (2H, singlet).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 124-68-5.

Reference:
Patent; Teikoku Hormone Mfg. Co., Ltd.; US4843072; (1989); A;,
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