Revisiting Iodine-Mediated N-tert-Butoxycarbonylation of Amines was written by Murthia, Ponugubati R. K.;Kumar, Gondrala P.;Rambabua, Dandela;Rao, Mandava V. B.;Pal, Manojit. And the article was included in Current Catalysis in 2014.Reference of 121282-70-0 This article mentions the following:
The revisiting of iodine-mediated N-Boc (N-tert-butoxycarbonyl) protection of RNH2 (R = C6H5, 4-FC6H4, 2-HOC6H4, etc.) revealed that the reaction can be performed using a lower quantity of iodine as a catalyst within a shorter reaction time. In addition to various aliphatic and aromatic amines, the reaction was found to be equally effective and selective for the N-Boc protection of amino acid, guanidine, thiourea and N-(diaminomethylene)-1,1,1-trifluoromethanesulfonamide. The operational simplicity, high yield, mild and solvent-free nature are the other features of this process. In the experiment, the researchers used many compounds, for example, tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0Reference of 121282-70-0).
tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 121282-70-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts