Category: 12080-32-9

Computed Properties of C8H12Cl2Pt. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about An Antitumor Bis(N-Heterocyclic Carbene)Platinum(II) Complex That Engages Asparagine Synthetase as an Anticancer Target. Author is Hu, Di; Yang, Chen; Lok, Chun-Nam; Xing, Fangrong; Lee, Pui-Yan; Fung, Yi Man Eva; Jiang, Haibo; Che, Chi-Ming.

New anticancer platinum(II) compounds with distinctive modes of action are appealing alternatives to combat the drug resistance and improve the efficacy of clin. used platinum chemotherapy. Herein, we describe a rare example of an antitumor PtII complex targeting a tumor-associated protein, rather than DNA, under cellular conditions. Complex [(bis-NHC)Pt(bt)]PF6 (1a; Hbt=1-(3-hydroxybenzo[b]thiophen-2-yl)ethanone) overcomes cisplatin resistance in cancer cells and displays significant tumor growth inhibition in mice with higher tolerable doses compared to cisplatin. The cellular Pt species shows little association with DNA, and localizes in the cytoplasm as revealed by nanoscale secondary ion mass spectrometry. An unbiased thermal proteome profiling experiment identified asparagine synthetase (ASNS) as a mol. target of 1a. Accordingly, 1a treatment reduced the cellular asparagine levels and inhibited cancer cell proliferation, which could be reversed by asparagine supplementation. A bis-NHC-ligated Pt species generated from the hydrolysis of 1 a forms adducts with thiols and appears to target an active-site cysteine of ASNS.

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Fukunaga, Toshiya M.; Sawabe, Chizuru; Matsuno, Taisuke; Takeya, Jun; Okamoto, Toshihiro; Isobe, Hiroyuki published the article 《Manipulations of Chiroptical Properties in Belt-Persistent Cycloarylenes via Desymmetrization with Heteroatom Doping》. Keywords: cycloarylene preparation dipole moment fluorescence UV spectrum CD; chirality; circular dichroism; cylinders; macrocycles; nanotubes.They researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Category: alcohols-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12080-32-9) here.

A desymmetrization strategy has been devised in the design of mol. cylinders to maximize the dissymmetry factor relevant to circularly polarized light. Although the highest dissymmetry factor of organic mols. was previously achieved with a chiral belt-persistent cycloarylene having magnetic and elec. transition dipole moments in parallel, we noticed that an unbalanced magnitude of two moments was detrimental for higher dissymmetry factors. In this study, a mol. cylinder was desymmetrized by arraying doped and undoped panels via stereoselective cross-coupling macrocyclization. The desymmetrization succeeded in balancing two moments by reducing the elec. transition moment at the global min. but failed to maximize the dissymmetry factor. Structural studies revealed that the dissymmetry factor is sensitive to subtle structural fluctuations, while the rotatory strength is not affected. This study is important for the development of chiroptical materials.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 12080-32-9, is researched, Molecular C8H12Cl2Pt, about A Germylene Supported by Two 2-Pyrrolylphosphane Groups as Precursor to PGeP Pincer Square-Planar Group 10 Metal(II) and T-Shaped Gold(I) Complexes, the main research direction is pyrrolylphosphino germylene pincer platinum gold preparation crystal mol structure; planar T shaped gold pyrrolylphosphino germylene preparation crystal structure; nickel palladium pyrrolylphosphino germylene complex preparation mol structure; Group 10 elements; T-shaped gold; germylenes; phosphorus; pincer complexes.SDS of cas: 12080-32-9.

An efficient synthesis of 2-di-tert-butylphosphinomethylpyrrole (HpyrmPtBu2), by treating 2-dimethylaminomethylpyrrole (HpyrmNMe2) with tBu2PH at 135° in the absence of any solvent, has allowed the preparation of the new PGeP germylene Ge(pyrmPtBu2)2 (1), by treating [GeCl2(dioxane)] with LipyrmPtBu2, in which the Ge atom is stabilized by intramol. interactions with one (solid state) or both (solution) of its phosphine groups. Reactions of germylene 1 with Group 10 metal dichlorido complexes containing easily displaceable ligands have led to [MCl{κ3P,Ge,P-GeCl(pyrmPtBu2)2}] [M = Ni (2), Pd (3), Pt (4)], which have an unflawed square-planar metal environment. Treatment of germylene 1 with [AuCl(tht)] (tht = tetrahydrothiophene) rendered [Au{κ3P,Ge,P-GeCl(pyrmPtBu2)2}] (5), which is a rare case of a T-shaped gold(I) complex. The hydrolysis of 5 gave the linear gold(I) derivative [Au(κP-HpyrmPtBu2)2]Cl (6). Complexes 2-5 contain a PGeP pincer chloridogermyl ligand that arises from the insertion of the Ge atom of germylene 1 into a M-Cl bond of the corresponding metal reagent. The bonding in these mols. has been studied by DFT/NBO/QTAIM calculations These results demonstrate that the great flexibility of germylene 1 makes it a better precursor to PGeP pincer complexes than the previously known germylenes of this type.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 12080-32-9, is researched, Molecular C8H12Cl2Pt, about Novel tetranuclear PdII and PtII anticancer complexes derived from pyrene thiosemicarbazones, the main research direction is tetranuclear palladium platinum cyclometalated pyrene thiosemicarbazone preparation antitumor activity; crystal mol structure cyclometalated pyrene thiosemicarbazone platinum tetranuclear complex.HPLC of Formula: 12080-32-9.

Cyclometalated palladium(II) and platinum(II) pyrenyl-derived thiosemicarbazone (H2PrR) complexes of the type [M4(μ-S-PrR-κ3-C,N,S)4] (M = PdII, PtII; R = Et, cyclohexyl) have been synthesized in good yields and fully characterized. X-ray crystallog. showed that the tetranuclear complex [Pt4(μ-S-PrCh-κ3-C,N,S)4](CH3)2COCHCl3 contains an eight-membered ring of alternating M-S atoms. The Et derivatives [M4(μ-S-PrEt-κ3-C,N,S)4] exhibit potent antiproliferative activity towards A2780 human ovarian cancer cells, with IC50 values of 1.27μM (for M = PdII) and 0.37μM (for M = PtII), the latter being an order of magnitude more potent than the anticancer drug cisplatin (IC50 1.20μM). These promising complexes had low toxicity towards non-cancerous human MRC5 cells, which points towards an early indication of differential toxicity between cancer and normal cells. Experiments that investigated the effects of these tetranuclear complexes on the cell cycle, integrity of the cell membrane, and induction of apoptosis, suggested that their mechanism of action of does not involve DNA targeting, unlike cisplatin, and therefore could be promising for combating cisplatin resistance.

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Yuan, Ming; Zhu, Wenxian; Lv, Jiaxing; Zhang, Panpan; Tang, Huadong published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Name: Dichloro(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

In this work, a series of hydrosilanes including phenylsilane, diphenylsilane, triethylsilane (TES), and tris(trimethylsilyl)silane combined with catalytical amount of platinum complex such as dichloro(1,5-cyclooctadiene)platinum (COD) and dichloro(dicyclopentadienyl)platinum have been used to initiate the polymerization of vinyl acetate (VAc) at 70-95°C. An ultrahigh mol. weight PVAc with number-average mol. weight (Mn) up to 1.17 X 106 Da and polydispersity index (PDI) of 2.59 has been synthesized using TES as an initiator in the presence of 9.7 ppm of COD. A kinetic study indicates that the polymerization at VAc/TES/COD molar ratio = 3.0 X 105 : 60 : 1 smoothly reached 81.0% conversion in 28.0 h at 85°C, producing PVAc with Mn increasing linearly from 1.41 X 105 to 6.01 X 105 Da with the increase of monomer conversion. A mechanistic investigation revealed that COD was firstly reduced by reductive TES, producing Pt nanoparticles and corresponding silane radicals to initiate the polymerization of VAc.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The water-solubilisation of the metalloligand [Pt2(μ2-S)2(PPh3)4] using 1,3,5-triaza-7-phospha-adamantane (PTA), published in 2020-06-01, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, COA of Formula: C8H12Cl2Pt.

The synthesis of the platinum(II) μ2-sulfide complex [Pt2(μ2-S)2(PTA)4] (PTA = phosphatriazaadamantane), as a water-soluble analog of the known triphenylphosphine complex [Pt2(μ2-S)2(PPh3)4], was explored through a range of synthetic routes. A direct synthesis, from cis-[PtCl2(PTA)2] and Na2S·9H2O in benzene is the most effective, while attempted ligand substitution of the PPh3 ligands of [Pt2(μ2-S)2(PPh3)4] with PTA resulted in rearrangement of the {Pt2S2} core, and formation of a series of PTA-substituted trinuclear species of the general composition [Pt3(μ3-S)2(PPh3)x(PTA)6-x]2+. The fully-substituted complex [Pt3(μ3-S)2(PTA)6]2+ was also obtained when cis-[PtCl2(PTA)2] was reacted with a sulfide ion-exchange resin. Reaction of [PtCl2(cod)] (cod = 1,5-cyclooctadiene) with Na2S·9H2O in benzene gave a red solid identified as crude [Pt2(μ2-S)2(cod)2]. Reaction of this labile {Pt2S2} precursor with PTA gave [Pt2(μ2-S)2(PTA)4] along with PTA -oxide and -sulfide. ESI mass spectrometry was widely employed as a convenient tool for exploring this chem., in conjunction with 31P{1H} NMR spectroscopy. These PTA-Pt-sulfide species, especially those containing {Pt2S2} cores, have a tendency to decompose in solution Addnl. confirmation of the formation of [Pt2(μ2-S)2(PTA)4] was provided by its reaction with [Rh2(μ2-Cl)2(cod)2], giving the adduct [Pt2(μ3-S)2(PTA)4Rh(cod)]+, identified using ESI MS.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called C-C* Platinum(II) Complexes with Electron-Withdrawing Groups and Beneficial Auxiliary Ligands: Efficient Blue Phosphorescent Emission, published in 2021-08-02, which mentions a compound: 12080-32-9, mainly applied to platinum cyclometalated aryl imidazolylidene complex diketonate borate preparation photoluminescence; crystal mol structure platinum cyclometalated aryl imidazolylidene diketonate borate; redox potential platinum cyclometalated aryl imidazolylidene diketonate borate; phosphorescence platinum cyclometalated aryl imidazolylidene diketonate borate, Synthetic Route of C8H12Cl2Pt.

Cyclometalated arylimidazolylidene platinum complexes with diketonate and dipyrazolylborate auxiliary ligands were prepared and examined for photoluminescence and photophys. properties. The combination of strong electron-withdrawing groups in cyclometalated N-heterocyclic carbene ligands (C-C*) with known beneficial auxiliary ligands in phosphorescent platinum(II) complexes leads to efficient light-to-deep-blue emission with quantum yields of up to 92%. All compounds were characterized and investigated regarding their photophys., electrochem., and thermal properties, and three complexes could addnl. be characterized by solid-state structures. D. functional theory calculations (PBE0/6-311G* with dispersion correction) are reported.

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Kobayashi, Atsushi; Imada, Shin-ichiro; Shigeta, Yasuhiro; Nagao, Yuki; Yoshida, Masaki; Kato, Masako published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Related Products of 12080-32-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

Two luminescent and highly proton-conductive Pt(II) complexes [PtCl(tpypy)]Cl and [PtCl(tpypyH)]Cl2 (1 and 1·HCl, resp.; tpypy = 2,2′: 6′,2”-terpyridine-4′,4”’-pyridine) were successfully synthesized. X-ray anal. revealed that the intermol. Pt···Pt interaction was ineffective in the monohydrated form of 1·H2O but effective in dihydrate and hexahydrate forms, 1·HCl·nH2O (n = 2 and 6). Yellow luminescence (λem = 519 nm and Φ = 0.016) assigned to intraligand 3π-π* phosphorescence was observed for 1·H2O, whereas a stronger red emission ascribable to the phosphorescence from the triplet metal-metal-to-ligand charge transfer (3MMLCT) state was observed for the HCl adduct 1·HCl·nH2O (λem = 741 nm, Φ = 0.06 for n = 2, λem = 642 nm, and Φ = 0.10 for n = 6). Both complexes exhibited strong relative humidity (RH)-dependent proton conductivity, while surprisingly high conductivity was observed for 1·HCl (6.8 × 10-3 S cm-1) at 95% RH at 298 K. The reversible transformation between 1 and 1·HCl was achieved upon exposure to humid HCl gas and heating and their vapochromic behavior was completely different owing to the presence of acidic N-H protons and the addnl. hydrophilic Cl- counteranions in 1·HCl. To the best of the authors’ knowledge, these complexes are the first switchable vapochromic and highly proton conductive materials that can be employed to visualize the proton conducting state by color and luminescence.

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Deziel, Anthony P.; Hoffbauer, Melissa R.; Iluc, Vlad M. published the article 《Square Planar Nucleophilic and Radical Pt(II) Carbenes》. Keywords: planar nucleophilic radical platinum carbene preparation crystal mol structure; crystal mol structure planar nucleophilic radical platinum carbene complex; phosphinophenylmethylene platinum carbene complex preparation mol structure calculation.They researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Application of 12080-32-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12080-32-9) here.

A square planar platinum(II) carbene complex [{PC(sp2)P}HPt(PMe3)] ([PC(sp2)P]H = (bis[2-(di-iso-propylphosphino)phenyl]methylene)) was synthesized through the dehydrohalogenation of [{PC(sp3)HP}HPtCl] in a microwave reactor. The tert-Bu substituted analog, [{PC(sp2)P}tBuPt(PMe3)] ([PC(sp2)P]tBu = bis[2-(di-iso-propylphosphino)-4-tert-butylphenyl]methylene), was synthesized via an analogous route. The nucleophilic nature of the carbene carbon was confirmed through DFT calculations and reactivity with HCl. Addnl., [{PC(sp2)P}HPt(PMe3)] was treated with 0.5 equiv of I2 to generate a paramagnetic product, [{PC(sp2)P}HPtI]. The Evans method and EPR spectroscopy revealed that a one-electron oxidation occurred at the carbene carbon, thus generating a persistent radical carbene.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Artem’ev, Alexander V.; Rogovoy, Maxim I.; Samsonenko, Denis G.; Rakhmanova, Mariana I. researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Electric Literature of C8H12Cl2Pt.They published the article 《Heterobimetallic PtII-AgI complex supported by diphenyl(2-pyrimidyl)phosphine: Synthesis and thermochromic photoluminescence》 about this compound( cas:12080-32-9 ) in Inorganic Chemistry Communications. Keywords: platinum silver phenylpyrimidylphosphine heterobimetallic preparation thermochromic photoluminescence; crystal structure heterobimetallic silver platinum palladium phenylpyrimidylphosphine. We’ll tell you more about this compound (cas:12080-32-9).

The reaction of diphenyl(2-pyrimidyl)phosphine (L) derived complex [Pt(L)2Cl2] with AgNO3 (1:3 M ratio, resp.) results in assembly of heterobimetallic complex [AgPt(L)2(NO3)3], wherein Pt → Ag dative bond of 2.9088(2) Å is formed. This complex features thermochromic photoluminescence that appears as ∼40 nm red shift of an emission maximum upon cooling from 300 to 77 K. The related PdII/AgI complex, [AgPd(L)2(NO3)3], showing Pd → Ag dative bond of 2.9098(5) Å, also was synthesized and structurally attested.

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