Category: 1205037-95-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1205037-95-1, name is trans-3-Aminocyclobutanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-3-Aminocyclobutanol hydrochloride

In an ice bath, 44.5 mg (1 .12 mmol) sodium hydride (60% dispersion in mineral oil) were dispensed in 5 mL of anhydrous THF. 91 .6 mg (0.742 mmol) trans-3- aminocyclobutan-1 -ol (hydrochloride salt) were slowly added. Stirring at 0 C was continued for 15 min. 100 mg (0.371 mmol) of intermediate 2 were added, the ice bath was removed and the resulting mixture was stirred for 5 days at 40 C. The reaction mixture was carefully poured into water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, and concentrated. The crude product was purified by HPLC to give 32 mg of the title compound as a solid material. 1H-NMR (300 MHz ,DMSO-d6), delta [ppm]= 2.49-2.57 (2H), 3.72 (2H), 5.53 (1 H), 7.01 (1 H), 7.31 (2H), 7.58-7.67 (2H), 7.71 -7.77 (1 H), 8.1 1 -8.19 (2H). LC-MS (Method 3): Rt = 0.73 min; MS (ESIpos) m/z = 321 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1205037-95-1, trans-3-Aminocyclobutanol hydrochloride.

Reference:
Patent; Bayer Intellectual Property GmbH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; HITCHCOCK, Marion; WO2013/34570; (2013); A1;,
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Application of 1205037-95-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1205037-95-1, name is trans-3-Aminocyclobutanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

In an ice bath, 25.4 mg (0.635 mmol) sodium hydride (60% dispersion in mineral oil) were dispensed in 2 mL of anhydrous THF. 52.9 mg (0.43 mmol) trans-3- aminocyclobutanol hydrochloride in 2 mL of a 1 : 1 mixture of anhydrous DMF and anhydrous THF were slowly added. After complete addition, stirring at 0C was continued for 15 min. 100 mg (0.287 mmol) of 6-chloro-3-(5-methoxy-1 -benzofuran- 2-yl)imidazo[1 ,2-b]pyridazine were added, the ice bath was removed and the resulting mixture was stirred for 72 h at 40 C. The reaction mixture was cooled to rt and a freshly prepared mixture of 9 mg (0.225 mmol) sodium hydride (60% dispersion in mineral oil) and 18 mg (0.146 mmol) trans-3-aminocyclobutanol hydrochloride in 1 mL of a 1 : 1 mixture of anhydrous DMF and anhydrous THF were added to the reaction mixture. Stirring at 40 C was continued for 18 h. The reaction mixture was carefully poured into water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, and concentrated. The crude product was purified by HPLC to give 54 mg of the title compound as a solid material. 1H-NMR (300 MHz, DMSO-d6), delta [ppm] = 2.53 (4H), 3.68-3.77 (1 H), 3.79 (3H), 5.47- 5.58 (1 H), 6.90 (1 H), 7.00 (1 H), 7.26 (1 H), 7.48-7.57 (2H), 8.09-8.17 (2H). LC-MS (Method 3): Rt = 0.76 min; MS (ESIpos) m/z = 351 [M+H]+.

According to the analysis of related databases, 1205037-95-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Intellectual Property GmbH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; HITCHCOCK, Marion; WO2013/34570; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1205037-95-1, trans-3-Aminocyclobutanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of trans-3-Aminocyclobutanol hydrochloride, blongs to alcohols-buliding-blocks compound. Safety of trans-3-Aminocyclobutanol hydrochloride

General Method C (Amine substitution) A solution of benzoimidazol-2-yl arylpyridinone bistriflate derivate (1 equiv) in MeCN, DCM, or DMF was treated with amine (1.2-3 equiv). In the case where the amine is a salt (e.g. HCl), the amine salt was dissolved in MeOH or DMF and passed through a PoraPak Rxn CX ion exchange column to yield the free base which was added to the reaction mixture. The reaction mixture was stirred at rt or up to 45 C for 1-48 h. Solvent was removed and the crude product was purified by column chromatography or prep-HPLC to give the desired product. General Method D (Global deprotection) A solution of protected benzoimidazol-2-yl arylpyridinone derivate (1 equiv) in TFA/conc. HCl (7: 1 v/v) was heated at 80-100 C for 3-24 h. Solvent was removed and the crude product was purified by column chromatography (free base) or prep-HPLC (TFA salt) to give the desired product. To generate the desired product as a HCl salt, the free base was dissolved in MeOH and 1 M HCl-Et20 (2-4 equiv) was added at rt. The solution was stirred for 5 min and azeotroped twice with MeOH.

The synthetic route of 1205037-95-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; SAMPSON, Peter Brent; PATEL, Narendra Kumar B.; PAULS, Heinz W.; LI, Sze-Wan; NG, Grace; LAUFER, Radoslaw; LIU, Yong; LANG, Yunhui; (93 pag.)WO2016/205942; (2016); A1;,
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