Category: 1202577-61-4

Adding a certain compound to certain chemical reactions, such as: 1202577-61-4, trans-(4-(Trifluoromethyl)cyclohexyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1202577-61-4, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H13F3O

To a solution of 489 trans-4-(trifluoromethyl)cyclohexyl)methanol (209 mg, 1.15 mmol) in 12 DMF (4 mL) was added 490 sodium bis(trimethylsilyl)amide (1.15 mL, 1.0 M, 1.15 mmol) at rt and after stirring at rt for 5 min., 154 6-bromo-3-isopropyl-7-methylimidazo[1,5-a]pyrazin-8(7H)-one (238 mg, 0.88 mmol) was added as a solid. After stirring at rt for 2 h, the mixture was diluted with a 1 M solution of 195 NH4Cl, 18 water and 68 DCM, partitioned and the aqueous layer was extracted with DCM (2×15 mL). The combined organic extracts were dried (MgSO4) and evaporated. The residue was purified (FCC, SiO2, 10-100% EtOAc/heptanes) to provide the 491 title compound (131 mg, 40%) as a white solid. 1H NMR (400 MHz, CDCl3) delta 7.86 (s, 1H), 6.34 (s, 1H), 3.81 (d, J=6.0 Hz, 2H), 3.42 (s, 3H), 3.14 (td, J=6.8, 13.7 Hz, 1H), 2.14-2.02 (m, 5H), 1.92 (dtt, J=3.2, 6.0, 12.0 Hz, 1H), 1.47-1.40 (m, 8H), 1.28-1.12 (m, 2H). [M+H]=372.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1202577-61-4, its application will become more common.

Reference:
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

General procedure: PPh3 (30.75 g, 117.4 mmol) was added slowly to a 0 C solution of (trans-4- (trifluoromethyl)cyclohexyl)methanol (17.8 g, 97.8 mmol) and CBr4 (38.85 g, 117.4 mmol) in dry DCM (200 mL). The reaction was stirred at room temperature overnight and then concentrated. Hexane/EtOAc (9/1, 300 ml) was added and the mixture was stirred for 1 hour and then filtered. The filtrate was concentrated and distilled under vacuum to give trans- 1 – (bromomethyl)-4-(trifluoromethyl)cyclohexane. XH NMR (300 MHz, CDC13): delta 3.30-3.28 (d, 2H), 2.02-1.92 (m, 5H), 1.70-1.59 (m, 1H), 1.40-1.27 (m, 2H), 1.13-1.00 (m, 2H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1202577-61-4, trans-(4-(Trifluoromethyl)cyclohexyl)methanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CHRISTOPHER, Matthew, P.; FRADERA LLINAS, Francesc Xavier; MACHACEK, Michelle; MARTINEZ, Michelle; REUTERSHAN, Michael Hale; SHIZUKA, Manami; SUN, Binyuan; THOMPSON, Christopher Francis; TROTTER, B. Wesley; VOSS, Matthew, E.; YANG, Liping; WO2014/123882; (2014); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-(4-(Trifluoromethyl)cyclohexyl)methanol

[00173] To a mixture of oxalyl chloride (24.96 g, 13.84 mL, 197.7 mmol) in CH2C12 (250 mL) was added dropwise DMSO (20.72 g, 28 mL, 395.4 mmol) at -65 C. The mixture was stirred at -65 C for 30 min. (iraw5,-4-(trifluoromethyl)cyclohexyl)methanol (12 g, 65.9 mmol) dissolved in CH2C12 (50 mL) was added dropwise at -65 C and the mixture was stirred at -65 C for another 30 min. Triethylamine (66.4 g, 91.2 mL, 659 mmol) was added dropwise below -65 C. The mixture was stirred at -65 C for 30 min, then stirred at rt for 1.5 h. The mixture was quenched with water (200 mL) and separated. The aqueous layer was extracted with CH2C12 (2 x 300 mL). The combined organic layers were washed with water (200 mL) and brine (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with petroleum ether: ethyl acetate = 10: 1) to give trans-4- (trifluoromethyl)cyclohexanecarbaldehyde (8.9 g, 75%) as a slight yellow oil. 1H NMR (CDCI3, 400 MHz): delta 9.70 (s, 1H), 2.16-2.65 (m, 3H), 2.04-2.12 (m, 3H), 1.00-1.39 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 1202577-61-4.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; DILLARD, Lawrence, Wayne; DONG, Chengguo; FAN, Yi; JIA, Lanqi; LOTESTA, Stephen, D.; MARCUS, Andrew; SINGH, Suresh, B.; TICE, Colin, M.; YUAN, Jing; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; (102 pag.)WO2016/61160; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol, molecular formula is C8H13F3O, molecular weight is 182.18, as common compound, the synthetic route is as follows.Recommanded Product: 1202577-61-4

(45B) Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionateMethyl (3S)-3-ethoxy-3-(4-hydroxyphenyl)propionate (150 mg, 0.669 mmol) produced in Example 41 (41C) and [trans-4-(trifluoromethyl)cyclohexyl]methanol (183 mg, 1.00 mmol) produced in (45A) were dissolved in tetrahydrofuran (5 mL), and triphenylphosphine (350 mg, 1.34 mmol) and a 40% diethyl azodicarboxylate toluene solution (600 muL, 1.34 mmol) were added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 50 C. for 3 hours.After the reaction solution was cooled to room temperature, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 80:20 (v/v)), whereby the objective title compound was obtained as a colorless oily substance (103 mg, yield: 40%).1H NMR (CDCl3, 400 MHz): delta1.07-1.17 (2H, m), 1.14 (3H, t, J=7.0 Hz), 1.30-1.43 (2H, m), 1.74-1.86 (1H, m), 1.95-2.05 (5H, m), 2.56 (1H, dd, J=5.1, 15.3 Hz), 2.81 (1H, dd, J=9.0, 15.3 Hz), 3.30-3.39 (2H, m), 3.67 (3H, s), 3.77 (2H, d, J=6.3 Hz), 4.68 (1H, dd, J=5.1, 9.0 Hz), 6.86 (2H, d, J=9.0 Hz), 7.25 (2H, d, J=9.0 Hz)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1202577-61-4, trans-(4-(Trifluoromethyl)cyclohexyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2011/53974; (2011); A1;,
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