Category: 1195-59-1

Li, Xiao-Qiang; Duan, Guo-Yi; Chen, Jun-Wu; Han, Li-Jun; Zhang, Suo-Jiang; Xu, Bao-Hua published their research in Applied Catalysis, B: Environmental in 2021. The article was titled 《Regulating electrochemical CO2RR selectivity at industrial current densities by structuring copper/poly(ionic liquid) interface》.Application In Synthesis of 2,6-Pyridinedimethanol The article contains the following contents:

Ionic liquid-based electrocatalytic CO2 reduction faces the challenge of achieving high selectivity toward value-added C2+ products at high reaction rate (≥ 100 mA cm-2). Herein, novel copper@poly(ionic liquid) (Cu@PIL) hybrids demonstrate multi-electron reduction (> 2e-) with current densities ≥ 300 mA cm-2. Remarkably, Cu@PIL with F- anion exhibits high C2+ faradaic efficiency of 58 % with a high partial c.d. of 174 mA cm-2. Further, a highest C2+ partial c.d. of 233 mA cm-2 was also achieved. Exptl. combined theor. investigations reveal that the “”individual”” ionic pairs in the outer PIL layer enrich local CO2 concentration, thereby promoting the CO2 supply. Besides, an interfacial elec. field is induced by the unbonded imidazolium moieties at Cu-PIL interface, which stabilize intermediates. Anions, differing in the electron-donating number to the imidazolium moieties, influence both the enrichment of CO2 and the stabilization of intermediates, thus regulating c.d. and product selectivity.2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application In Synthesis of 2,6-Pyridinedimethanol

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El-Massaoudi, Mohamed; Radi, Smaail; Lamsayah, Morad; Tighadouini, Said; Seraphin, Konan Kouakou; Kouassi, Lazare Kouakou; Garcia, Yann published an article in 2021. The article was titled 《Ultra-fast and highly efficient hybrid material removes Cu(II) from wastewater: Kinetic study and mechanism》, and you may find the article in Journal of Cleaner Production.Computed Properties of C7H9NO2 The information in the text is summarized as follows:

Water pollution by toxic elements represents a significant risk to the environment and human ecosystem, and a number of efforts are developed to find a suitable solution In this work, a new adsorbent based on silica gel as an inert material modified on surface by a pincer ligand was prepared The hybrid material has been synthesized via a simple Schiff base reaction and characterized by several relevant phys. methods. The adsorbent shows an extremely rapid efficiency in removal of copper (less than 8 min) with maximum sorption capacity of 1.90 mmol g-1 and a rapid efficiency for zinc, cadmium and lead (less than 20 min) with adsorption capacities 0.52, 0.49 and 0.43 mmol g-1, resp. A kinetic study shows that the sorption can be described by a pseudo second-order model, and that the process is thermodynamically spontaneous and endothermic. The adsorbent shows a high selectivity to Cu(II) and a great reusability after five adsorption-desorption cycles. Theor., energy dispersive X-ray fluorescence (EDX) and Fourier transform-IR spectroscopy studies demonstrate that the uptake occurs by a coordination reaction between metal ions and the pincer ligand on the surface of the adsorbent. The efficiency of this new hybrid material was confirmed in removal of Cu(II) from real water samples originating from Abidjan Atlantic sea bay, one of the most polluted region in West Africa, as well as from rivers located near Oujda, Morocco. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H9NO2

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Application In Synthesis of 2,6-PyridinedimethanolIn 2020 ,《Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists》 appeared in European Journal of Medicinal Chemistry. The author of the article were Fang, Xiong; Meng, Qian; Zhang, Huijun; Liang, Boqiang; Zhu, Siyu; Wang, Juan; Zhang, Chaozai; Huang, Lina S.; Zhang, Xingquan; Schooley, Robert T.; An, Jing; Xu, Yan; Huang, Ziwei. The article conveys some information:

CXCR4, a well-studied coreceptor of human immunodeficiency virus type 1 (HIV-1) entry, recognizes its cognate ligand SDF-1α (also named CXCL12) which plays many important roles, including regulating immune cells, controlling hematopoietic stem cells, and directing cancer cells migration. These pleiotropic roles make CXCR4 an attractive target to mitigate human disorders. Here a new class of sym. polyamines was designed and synthesized as potential small mol. CXCR4 antagonists. Among them, a representative compound 21 (namely HF50731) showed strong CXCR4 binding affinity (mean IC50 = 19.8 nM) in the CXCR4 competitive binding assay. Furthermore, compound 21 significantly inhibited SDF-1α-induced calcium mobilization and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function. The structure-activity relationship anal., site-directed mutagenesis, and mol. docking were conducted to further elucidate the binding mode of compound 21, suggesting that compound 21 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288. Our studies provide not only new insights for the fragment-based design of small mol. CXCR4 antagonists for clin. applications, but also a new and effective mol. probe for CXCR4-targeting biol. studies. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2,6-Pyridinedimethanol

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《Structural reorganization and crack-healing properties of hydrogels based on dynamic diselenide linkages》 was written by Xu, Hao; Suzuki, Nao; Takahashi, Akira; Ohishi, Tomoyuki; Goseki, Raita; Xie, Xu-Ming; Otsuka, Hideyuki. Recommanded Product: 1195-59-1 And the article was included in Science and Technology of Advanced Materials in 2020. The article conveys some information:

We report the dynamic behavior of diselenide-containing hydrophilic polyurethanes and hydrogels based on diselenide exchange reactions in an aqueous media. Diselenide-containing linear and crosslinked polyurethanes were synthesized via polyaddition reactions using diselenide-containing diol in combination with pyridinium diol that enhances the hydrophilicity of the polymer chains. The obtained linear polyurethanes underwent photo-induced diselenide exchange reactions with small diselenide compounds and degraded to smaller fragments, confirming the dynamicity of the obtained hydrophilic polyurethanes. The prepared hydrogels displayed characteristic large swelling behavior based on the structural reorganization through diselenide exchange either under photo-irradiation at 365 nm or even in the dark at room temperature The diselenide-containing hydrogels also showed crack-healing behavior under the same exchanging conditions, presenting the utility of diselenide linkages as simple and useful units to offer high dynamicity to hydrogels. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 1195-59-1

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Manandhar, Erendra; Johnson, Ashley D. G.; Watson, William M.; Dickerson, Shelby D.; Sahukhal, Gyan S.; Elasri, Mohamed O.; Fronczek, Frank R.; Cragg, Peter J.; Wallace, Karl J. published an article in 2021. The article was titled 《Detection of ferric ions in a gram-positive bacterial cell: Staphylococcus aureus》, and you may find the article in Journal of Coordination Chemistry.Related Products of 1195-59-1 The information in the text is summarized as follows:

A rhodamine-based chemosensor was synthesized and found to selectively bind ferric ions over other metal ions (Na+, K+, Ca2+, Mg2+, Fe2+, Zn2+, Cd2+, Co2+, Hg2+ Cr3+, Al3+) in an organic-aqueous mixture (CH3CN-MES). Upon addition of ferric ions, the spirolactam ring opens, producing a visual color change and a fluorescence intensity increase, i.e. a turn on optical response at 577 nm is observed The chemosensor coordinates to ferric ions in 1:1 stoichiometry with a calculated Ka = 3.5 × 104 mol dm-3 by fluorescence spectroscopy and a LoD of 27 ppb. The chemosensor was reversible upon addition of the Fe3+ chelator desferrioxamine. One- and two-dimensional NMR experiments with Al3+ ions aided in understanding of the coordination environment of the ferric ion with the chemosensor, which were confirmed by mol. modeling calculations X-ray quality crystals of the chemosensor were obtained, and the solid-state structure is reported. Confocal microscopy was used to detect free ferric ions in Staphylococcus aureus. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

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《Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Lumangtad, Liezel A.; Claeys, Elisa; Hamal, Sunil; Intasiri, Amarawan; Basrai, Courtney; Yen-Pon, Expedite; Beenfeldt, Davison; Vermeire, Kurt; Bell, Thomas W.. Recommanded Product: 1195-59-1 The article mentions the following:

CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic substituents into the macrocyclic scaffold of CADA compounds may lead to potent compounds with improved properties, 17 macrocycles were synthesized, 14 with 12-membered rings having an isobutylene head group, two arenesulfonyl side arms, and fused pyridine rings bearing a para substituent. The analogs display a wide range of CD4 down-modulating and anti-HIV potencies, including some with greater potency than CADA, proving that a highly basic nitrogen atom in the 12-membered ring is not required for potency and that hydrophobic substituents enhance potency of pyridine-fused CADA compounds Cytotoxicities of the new compounds compared favorably with those of CADA, showing that incorporation of a pyridine ring into the macrocyclic scaffold can produce selective compounds for potently down-modulating proteins of medicinal interest. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 1195-59-1

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《Palladium-Catalyzed Selective Reduction of Carbonyl Compounds》 was written by Sarkar, Nabin; Mahato, Mamata; Nembenna, Sharanappa. Recommanded Product: 1195-59-1 And the article was included in European Journal of Inorganic Chemistry in 2020. The article conveys some information:

Two new examples of structurally characterized β-diketiminate analogs i.e., conjugated bis-guanidinate (CBG) supported palladium(II) complexes, [LPdX]2; [L= {(ArHN)(ArN)-C=N-C=(NAr)(NHAr)}; Ar = 2,6-Et2-C6H3], X = Cl (1), Br (2) were reported. The synthesis of complexes 1-2 was achieved by two methods. Method A involves deprotonation of LH by nBuLi followed by the treatment of LLi (insitu formed) with PdCl2 in THF, which afforded compound 1 in good yield (75%). In Method B, the reaction between free LH and PdX2 (X = Cl or Br) in THF allowed the formation of complexes 1 (Yield 73%) and 2 (Yield 52%), resp. Moreover, these complexes were characterized thoroughly by several spectroscopic techniques (1H, 13C NMR, UV/Vis, FT-IR, and HRMS), including single-crystal X-ray structural and elemental analyses. In addition, we tested the catalytic activity of these complexes 1-2 for the hydroboration of carbonyl compounds with pinacolborane (HBpin). We observed that compound 1 exhibits superior catalytic activity when compared to 2. Compound 1 efficiently catalyzes various aldehydes and ketones under solvent-free conditions. Furthermore, both inter- and intramol. chemoselectivity hydroboration of aldehydes over other functionalities have been established. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 1195-59-1

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Formula: C7H9NO2In 2018 ,《A Stimuli-Responsive Molecular Capsule with Switchable Dynamics, Chirality, and Encapsulation Characteristics》 was published in Journal of the American Chemical Society. The article was written by Zhiquan, Lei; Xie, Han; Border, Sarah E.; Gallucci, Judith; Pavlovic, Radoslav Z.; Badjic, Jovica D.. The article contains the following contents:

In this study, we report the preparation, conformational dynamics, and recognition characteristics of novel mol. capsule 1 (I) comprising a bowl-shaped framework conjugated to a tris(2-pyridylmethyl)amine (TPA) lid. With the assistance of experiment (1H NMR spectroscopy) and theory (MM and DFT) we found that C3 sym. 1 is poorly preorganized with three pyridines at the rim adopting a propeller-like orientation and undergoing P-to-M (or vice versa) stereoisomerization (ΔG < 8 kcal/mol, VT 1H NMR). Capsule 1 binds CH4, CH3Cl, CH2Cl2, CHCl3, and CCl4 with Ka < 7 M-1. Protonation of 1 with HCl, however, gives [1·H]-Cl, with the solid-state structure showing the TPA lid being ""flattened"" and the +N-H···Cl hydrogen-bonded group residing outside. Importantly, the P-to-M stereoisomerization would for [1·H]-Cl occur with ΔG = 11 kcal/mol (VT 1H NMR). Less dynamic and more preorganized [1·H]-Cl binds CH4, CH3Cl, CH2Cl2, CHCl3, and CCl4 guests with a greater affinity (Ka = 100-400 M-1) than 1. The results of our studies suggest that the complexation of increasingly larger guests takes place in an induced-fit fashion, with [1·H]-Cl (a) elongating along its vertical axis and concurrently potentially (b) twisting pyridines from P into M (and vice versa) orientation. The addition of Et3N to [1·H]-Cl⊂CH2Cl2 causes deprotonation of the capsule and the release of CH2Cl2 with the process being fully reversed after the addition of HCl. Allosteric capsule 1 with unique structural and dynamic characteristics is expected to, in the future, assist the construction of complex mol. machines and smart functional materials. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C7H9NO2

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In 2019,Journal of the American Chemical Society included an article by Zhu, Yuan-Yuan; Wu, Xue-Dan; Gu, Shuang-Xi; Pu, Lin. Synthetic Route of C7H9NO2. The article was titled 《Free Amino Acid Recognition: A Bisbinaphthyl-Based Fluorescent Probe with High Enantioselectivity》. The information in the text is summarized as follows:

A novel fluorescent probe based on a bisbinaphthyl structure was designed and synthesized. This compound in combination with Zn(II) has exhibited highly enantioselective fluorescence enhancement with 13 common free amino acids. For example, its enantiomeric fluorescent enhancement ratios (ef or ΔIL/ΔID) in the presence of the following amino acids are extremely high: 177 for valine, 199 for methionine, 186 for phenylalanine, 118 for leucine, and 89 for alanine. The observed high enantioselectivity and the extent of the substrate scope are unprecedented in the fluorescent recognition of free amino acids. This fluorescent probe can be applied to determine the enantiomeric composition of the structurally diverse chiral amino acids. NMR and mass spectroscopic studies provided clues to elucidate the observed high enantioselectivity. The experimental process involved the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Synthetic Route of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H9NO2

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《Bioinspired Nitroalkylation for Selective Protein Modification and Peptide Stapling》 was written by Mahesh, Sriram; Adebomi, Victor; Muneeswaran, Zilma P.; Raj, Monika. Safety of 2,6-Pyridinedimethanol And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Nitroalkanes react specifically with aldehydes, providing rapid, stable, and chemoselective protein bioconjugation. These nitroalkylated proteins mimic key post-translational modifications (PTMs) of proteins and can be used to understand the role of these PTMs in cellular processes. Demonstrated here is the substrate scope of this bioconjugation by attaching a variety of tags, such as NMR tags, fluorescent tags, affinity tags, and alkyne tags, to proteins. The structure and enzymic activity of modified proteins remain conserved after labeling. Notably, the nitroalkane group leads to easy characterization of proteins by mass spectrometry because of its distinct fingerprint pattern. Importantly, the nitro-alkylated peptides provide a new handle for site-selective fluorination of peptides, thus installing a specific probe to study peptide-protein interactions by 19F NMR spectroscopy. Furthermore, nitroalkane reagents can be used for the late-stage diversification of peptides and for the synthesis of peptide staples. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Safety of 2,6-Pyridinedimethanol

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