Category: 1195-59-1

《Exploring solvent dependent catecholase activity in transition metal complexes: an experimental and theoretical approach》 was written by I., Mantasha; Shahid, M.; Kumar, Manjeet; Ansari, Azaj; Akhtar, Muhammad Nadeem; AlDamen, Murad A.; Song, You; Ahmad, Musheer; Khan, Ishaat M.. Application of 1195-59-1 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

In contrast to polynuclear complex models for biomimetic activity, a series of mononuclear complexes are designed in this work in order to assess their catecholase activity and kinetics. Four new complexes, namely, [Mn(pdmH2)(Phen)Cl]Cl·H2O (1), [Mn(pmmH)2(SCN)2] (2), [Ni(pmmH)2(SCN)2] (3) and [Zn(phen)3][(pdm)]·11H2O (4) utilizing an amino alc. ligand, pyridine-2,6-dimethanol (pdmH2) or 2-pyridinemonomethanol (pmmH), and an auxiliary ligand, 1,10-phenanthroline (phen) or thiocyanate (SCN-), are synthesized. The complexes are characterized by elemental anal., FTIR, UV-visible, EPR, fluorescence (solution and solid state), Hirshfeld surface anal., magnetic, single crystal X-ray and DFT/TD-DFT studies. X-ray structures confirm the geometry around the M(II) ions to be octahedral in all the complexes. In 1-3, the primary aminoalc. ligand binds to a metal ion in a neutral (pdmH2 or pmmH) mode while 4 exists as a cation-anion type complex where a deprotonated ligand (pdm2-) is present in the outer sphere having no coordination to the metal. The Zn(II) complex also shows remarkable luminescence in the solid state photoluminescence spectrum. Variable temperature magnetic studies show the presence of antiferromagnetic exchange in 1-3 (θ = -2.8, -1.7 and -5.2, resp.) with the observation of anisotropy (D = 4.0 and E = 3.4) in 3. DFT/TD-DFT results provide ample information regarding the structures, spin densities, charge distribution, and electronic spectra along with the transitions. The spin d. values, ρ = 4.793, 4.792 and 1.676, confirm the presence of five, five and two unpaired electrons on the metal d-orbitals of 1, 2 and 3, resp. Interestingly, solvent dependent catecholase activity has been observed for the first time in mononuclear Mn(II) complexes (1 and 2) with Kcat = 2602.8 h-1 (acetonitrile), 1490.4 h-1 (methanol) for 1, and 1083.6 h-1 (acetonitrile), 806.4 h-1 (methanol) for 2. This can be rationalized in terms of the coordinating powers of the solvent, i.e., DMSO > MeOH > MeCN. Further, the order of activity in 1 and 2 (i.e., 1 > 2) and inactivity of 3 and 4 are very well corroborated by DFT which ascertains the highest charge contribution on the metal in 1 [33% on HOMO and 2% on LUMO of Mn(II)] resulting in the formation of the most stable metal-substrate adduct, thus enhancing the activity. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Jianfeng; Liu, Dan; Yang, Qianqian; Ge, Yan; Tang, Jinkui; Qi, Zhenhui published their research in New Journal of Chemistry in 2021. The article was titled 《Magnetic investigation in di- and tetranuclear lanthanide complexes》.Computed Properties of C7H9NO2 The article contains the following contents:

By using a crab-like hydrazone ligand, dinuclear and tetranuclear dysprosium-based complexes Dy2 and Dy4 have been isolated. Magnetic investigation reveals that complex Dy2 shows typical single-mol. magnet behavior under a zero field, benefiting from the ferromagnetic coupling between the DyIII ions, while Dy4 possesses a diamagnetic ground state with the anisotropy axes of DyIII ions in centripetal arrangement. The magnetic anisotropies and couplings were confirmed by ab initio calculations In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Electrocatalytic water oxidation studies of a tetranuclear Cu(II) complex with cubane-like core Cu4(μ3-O)4》 were Gao, Wei-Song; Wang, Jin-Miao; Shi, Ning-Ning; Chen, Chang-Neng; Fan, Yu-Hua; Wang, Mei. And the article was published in New Journal of Chemistry in 2019. Related Products of 1195-59-1 The author mentioned the following in the article:

To mimic the strategy used by natural photosynthesis in Photosystem II, which adopts the cubic Mn4CaO5 cluster as a natural O-evolving complex, a bio-inspired cubane-like tetranuclear cluster [Cu4(pdmH)4(OAc)2](NO3)2·3H2O (1) was synthesized successfully with pyridine-2, 6-dimethanol as the ideal ligand, and studied by x-ray crystallog., PXRD, in situ UV-visible-NIR spectroelectrochem. anal., and magneto- and electrochem. By x-ray anal., the distorted cubane-like core Cu4(μ3-O)4 is composed of 4 CuII and 4 μ3-O which arrange at the vertexes of a slightly distorted cube. Electrochem. studies indicate that complex 1 presents potential properties as an effective mol. catalyst for electrocatalytic H2O oxidation under aqueous alk. conditions at a potential of ∼1.20 V vs. Normal H electrode with a relatively low overpotential of ∼400-665 mV vs. Normal H electrode, which may result from the unique covalent metal-oxo bonding. Magnetic susceptibility measurements reveal that complex 1 displays overall antiferromagnetic exchanges between the Cu(II) ions within the clusters. Temperature dependence of in-phase (χM′) a.c. susceptibility signals display frequency-dependence, whereas the out-of-phase (χM′′) signals show no significant frequency-dependence for complex 1, which indicates that the complex may not be a SMM. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cobalt-Catalyzed Acceptorless Dehydrogenation of Alcohols to Carboxylate Salts and Hydrogen》 was published in Organic Letters in 2020. These research results belong to Pradhan, Deepak Ranjan; Pattanaik, Sandip; Kishore, Jugal; Gunanathan, Chidambaram. Recommanded Product: 2,6-Pyridinedimethanol The article mentions the following:

The facile oxidation of alcs. to carboxylate salts and H2 is achieved using a simple and readily accessible cobalt pincer catalyst (NNNHtBuCoBr2). The reaction follows an acceptorless dehydrogenation pathway and displays good functional group tolerance. The amine-amide metal-ligand cooperation in cobalt catalyst is suggested to facilitate this transformation. The mechanistic studies indicate that in-situ-formed aldehydes react with a base through a Cannizzaro-type pathway, resulting in potassium hemiacetolate, which further underwent catalytic dehydrogenation to provide the carboxylate salts and H2. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 1195-59-1In 2019 ,《Metal-ligand cooperativity in a ruthenium(II) complex of bis-azoaromatic ligand for catalytic dehydrogenation of alcohols》 was published in Inorganica Chimica Acta. The article was written by Saha, Tanushri; Pramanick, Rajib; Sengupta, Debabrata; Goswami, Sreebrata. The article contains the following contents:

Herein a new Ru-phosphine complex (1) with mol. formula [RuL(PPh3)Cl2] is reported where L is a redox active pincer ligand 2,6-bis(phenylazo)pyridine. The isolated complex was characterized by usual spectroscopic techniques including single crystal x-ray crystallog. anal. Complex 1 efficiently catalyzes aerobic oxidation of a wide range of primary and secondary benzylic, allylic, heterocyclic, alicyclic alcs. under mild conditions and is superior over several other Ru (0, +2 and +3), Ru-H and Ru-PPh3 catalysts. Mechanistic studies indicate that a transient Ru-H intermediate is formed in the catalytic cycle which gets switched into a Ru-hydrazo intermediate via hydrogen-walking mechanism. The catalyst is regenerated by aerial oxidation producing H2O2 as a byproduct. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dermitzaki, Despina; Raptopoulou, Catherine P.; Psycharis, Vassilis; Escuer, Albert; Perlepes, Spyros P.; Mayans, Julia; Stamatatos, Theocharis C. published their research in Dalton Transactions in 2021. The article was titled 《Further synthetic investigation of the general lanthanoid(III) [Ln(III)]/copper(II)/pyridine-2,6-dimethanol/carboxylate reaction system: {CuII5LnIII4} coordination clusters (Ln = Dy, Tb, Ho) and their yttrium(III) analogue》.Quality Control of 2,6-Pyridinedimethanol The article contains the following contents:

In addition to previously studied {CuII3Gd6}, {CuII8Gd4}, {CuII15Ln7} and {CuII4Ln8} coordination clusters (Ln = trivalent lanthanide) containing pdm2- or Hpdm- ligands (H2pdm = pyridine-2,6-dimethanol) and ancillary carboxylate groups (RCO2-), the present work reports the synthesis and study of three new members of a fifth family of such complexes. Compounds [Cu5Ln4O2(OMe)4(NO3)4(O2CCH2But)2(pdm)4(MeOH)2] (Ln = Dy, 1; Ln = Tb, 2; Ln = Ho, 3) were prepared from the reaction of Ln(NO3)3·xH2O (x = 5, 6), CuX2·yH2O (X = ClO4, Cl, NO3; y = 6, 2 and 3, resp.), H2pdm, ButCH2CO2H and Et3N (2 : 2.5 : 2 : 1 : 9) in MeCN/MeOH. Rather surprisingly, the copper(II)/yttrium(III) analog has a slightly different composition, i.e. [Cu5Y4O2(OMe)4(NO3)2(O2CCH2But)4(pdm)4(MeOH)2] (4). The structures of 1·4MeCN·1.5MeOH and 4·2MeOH were solved by single-crystal x-ray crystallog. The five CuII and four DyIII centers in 1 are held together by two μ5-O2-, four μ-MeO-, two syn,syn η1:η1:μ ButCH2CO2-, four η2:η1:η2:μ3 pdm2- (each of these groups chelates a CuII atom and simultaneously bridges two DyIII atoms through its two -CH2O- arms) and two μ-MeOH ligands. The four terminal nitrato groups each chelate (η1:η1) a DyIII center. The five CuII atoms are co-planar (by symmetry) forming a bow-tie arrangement; the four outer CuII atoms form a rectangle with edges of 3.061(1) and 6.076(1) Å. The four DyIII centers also form a rectangle that lies above and below the plane of the CuII centers, with edges of 3.739(1) and 5.328(1) Å. The two strictly planar rectangles are almost perpendicular. Two trigonal bipyramidal μ5-O2- groups link the perpendicular Cu5 and Dy4 frameworks together. The mol. 4 has a very similar structure to that of 1, differences being the replacement of the two chelating nitrato groups of 1 by two chelating ButCH2CO2- ligands in 4 and the coordination polyhedra of the LnIII and YIII atoms (Snub diphenoids in 1 and biaugmented trigonal prisms in 4). Dc magnetic susceptibility data (χM) on anal. pure samples of 1-3, collected in the 300-2 K range, indicate that ferromagnetic exchange interactions dominate leading to large spin ground states. The χMT vs. T data for 4 suggest moderately strong antiferromagnetic CuII···CuII exchange interactions. Studies of the dynamic magnetic properties of the {Cu5Ln4} clusters show that 1 behaves as a SMM at zero field and 2 is a very weak field-induced SMM, while 3 exhibits only weak tails in the χ”Mvs. T plots at various ac frequencies at zero dc field. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Wekesa, Amon K.; Nyamato, George S.; Kowenje, Chrispin O.; Ojwach, Stephen O. published an article in Inorganica Chimica Acta. The title of the article was 《Coordination behavior and binding properties of 2,6-pyridinedimethanol with Cu(II), Zn(II), and Cd(II) cations》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Selective extraction of water-bound metal cations through chelating agents is investigated. Reactions of 2,6-pyridinedimethanol (L1) with Cu(NO3)2·3H2O, Zn(NO3)2·6H2O and Cd(NO3)2·4H2O produced complexes [Cu(L1)2] (1), [Zn(L1)2] (2), and [Cd2(μ-NO3)(L1)2] (3), resp. The solid-state structures of 1, 2, and 3 confirmed that L1 coordinates in a tridentate fashion. The chelating ligand 2,6-pyridinedimethanol (L1) was also used as a model chelating agent for liquid-liquid extraction of copper(II), zinc(II), cadmium(II), and lead(II) cations from water using dichloromethane as the organic solvent. The relative affinities of these chelating ligands for Cu(II), Zn(II), Cd(II), and Pb(II) by liquid-liquid extraction were found to be in the order Cu(II) > Zn(II) > Pb(II) > Cd(II). Extraction efficiencies of 85% for Cu(II), 80% for Zn(II), 58% for Pb(II), and 45% for Cd(II) were observed In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Hall, Ryan C.; Qin, Jingcan; Laney, Victoria; Ayat, Nadia; Lu, Zheng-Rong published an article in ACS Applied Bio Materials. The title of the article was 《Manganese(II) EOB-Pyclen Diacetate for Liver-Specific MRI》.Quality Control of 2,6-Pyridinedimethanol The author mentioned the following in the article:

MRI is increasingly utilized for the diagnosis of liver disease and focal liver lesions. Although liver-targeted gadolinium-based contrast agents (GBCAs) have high efficacy, there continue to be safety concerns regarding release of toxic Gd(III) ions. Herein, Mn(EOB-PC2A) is synthesized as a nongadolinium alternative for liver-specific MRI. Mn(EOB-PC2A) has an r1 relaxivity of 2.8 mM-1 s-1 in Dulbecco’s phosphate-buffered saline (DPBS) and 5.9 mM-1 s-1 in saline containing human serum albumin at 1.5 T. It has a strong uptake in hepatocytes with minimal toxicity and demonstrated robust liver-specific enhancement at a dose of 60 μmol/kg. Mn(EOB-PC2A) is a promising liver-specific contrast agent for liver MRI. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C7H9NO2In 2021 ,《Cobalt complexes of an OSNSO-tetrapodal pentadentate ligand: Synthesis, structures and reactivity》 appeared in Inorganica Chimica Acta. The author of the article were Thevenin, Lucas; Daran, Jean-Claude; Poli, Rinaldo; Fliedel, Christophe. The article conveys some information:

The novel pentadentate tetrapodal proligand 2,6-bis[(2-hydroxyphenyl)thiomethyl]pyridine (1·H2) and its cobalt(II) complex [Co(1)] (2) were synthesized and characterized by several anal. (EA, ESI-MS) and spectroscopic methods (NMR or EPR, FTIR), including x-ray crystallog. for 1·H2. Cyclic voltammetry studies showed that 2 undergoes a reversible metal-based oxidation (CoII/CoIII). Complex 2 was designed to be applied to organometallic mediated radical polymerization (OMRP), however it exhibited an extremely poor solubility in non-coordinating solvents and several vinyl monomers (styrene, vinyl acetate and tert-Bu acrylate), which hampers its potential as moderator. Complex 2 has a high affinity towards Lewis bases, such as pyridine, leading to the clean formation of the mono-pyridine adduct 2·py, as confirmed by x-ray crystallog. In 2·py, ligand 1 is pentacoordinated to the CoII center, with the two thioether-phenolate (S,O) moieties oriented anti to each other, and the only free coordination site of the octahedron is completed by the addnl. pyridine, trans to the central pyridine linker of 1. The equilibrium between 2 and 2·py could be studied by 1H NMR. Complex 2 could be cleanly and quant. oxidized to its diamagnetic iodo cobalt(III) analog [Co(1)I] (3), by simple reaction with iodine. The latter could then be subjected to a halide abstraction reaction, mediated by K[B(C6F5)], affording the cationic complex [Co(1)][B(C6F5)], 4. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Electric Literature of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Electric Literature of C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Efficient Pincer-Ruthenium Catalysts for Kharasch Addition of Carbon Tetrachloride to Styrene》 were Das, Kanu; Dutta, Moumita; Das, Babulal; Srivastava, Hemant Kumar; Kumar, Akshai. And the article was published in Advanced Synthesis & Catalysis in 2019. Application of 1195-59-1 The author mentioned the following in the article:

A series of NNN pincer-ruthenium complexes (R2NNN)RuCl2(PPh3) (R=Cyclohexyl (Cy), t-Bu (tBu), i-Pr (iPr) and Ph (Ph)) have been synthesized and characterized. These pincer-ruthenium complexes have been used to catalyze the Kharasch addition or atom transfer radical addition (ATRA) of carbon tetrachloride to styrene. Among the pincer-ruthenium catalysts screened for the Kharasch addition, the catalytic activity followed the order (Cy2NNN)RuCl2(PPh3)>(iPr2NNN)RuCl2(PPh3)≫(Ph2NNN)RuCl2(PPh3). The oxidation of Ru(II) is easier with (Cy2NNN)RuCl2(PPh3) and (iPr2NNN)RuCl2(PPh3) in comparison with (Ph2NNN)RuCl2(PPh3) as indicated by cyclic voltammetry studies. The catalyst precursor (R2NNN)RuCl2(PPh3) itself is the resting state of the reaction. The rate determining step involves the generation of the five-coordinate 16-electron ruthenium(II) species (R2NNN)RuCl2. Owing to weaker binding of tri-Ph phosphine to ruthenium, the generation of catalytically active 16-electron species (Cy2NNN)RuCl2 and (iPr2NNN)RuCl2 are more favorable. The complex (Cy2NNN)RuCl2(PPh3) demonstrates very high productivity (5670 turnovers after 48 h at 140 °C) in the absence of any co-catalyst radical initiator. To the best of our knowledge, our turnovers (ca. 5670) are much higher than that reported hitherto. Quantum mech. calculations demonstrate that the path involving the activation of carbon tetrachloride by (Cy2NNN)RuCl2 is more favored than the path where carbon tetrachloride is activated by (Cy2NNN)RuCl2(η2-styrene). D. functional theory (DFT) and kinetic studies are in accord with the widely accepted mechanism involving the single electron transfer (SET) from ruthenium(II) to chloride radical with concomitant generation of a benzyl radical which is trapped by the resulting ruthenium(III) species. The experimental process involved the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts