Category: 1195-59-1

Wang, Hui-Sheng; Zhang, Ke; Wang, Jia; Hu, Zhao-Bo; Zhang, Zaichao; Song, You; Zhang, Yi-Quan published their research in Inorganic Chemistry in 2021. The article was titled 《Influence of the Different Types of Auxiliary Noncarboxylate Organic Ligands on the Topologies and Magnetic Relaxation Behavior of Zn-Dy Heterometallic Single Molecule Magnets》.Related Products of 1195-59-1 The article contains the following contents:

The authors 1st synthesized a Zn-Dy complex, [Zn6Dy2(L)6(tea)2(MeOH)2]·6MeOH·8H2O (H2L = N-3-methoxysalicylidene-2-amino-3-hydroxypyridine, teaH3 = triethanolamine, 1), by employing H2L, anhydrous ZnCl2, and Dy(NO3)3·5H2O reacting with auxiliary ligand teaH3 in the mixture of MeOH and DMF. When teaH3 and MeOH in the reaction system of 1 were replaced by the auxiliary ligand 2,6-pyridinedimethanol (pdmH2) and the solvent MeCN, another Zn-Dy complex, [Zn4Dy4(L)6(pdm)2(pdmH)4]·10MeCN·5H2O (2), was obtained. The crystal structure of 1 can be seen as a dimer of two Zn3DyIII units. However, for 2, four DyIII form a zigzag arrangement, and each of its terminals linked two ZnII ions. Although the structural topologies of 1 and 2 are different, the coordination geometries of DyIII are all triangular dodecahedron (TDD-8). The difference is that the continuous shape measure (CShM) values of DyIII in 1 are larger than the corresponding values in 2. Magnetic studies revealed that the diluted sample 1@Y exhibits two magnetic relaxation processes, while 2 exhibits a single relaxation process. Ab initio calculations indicated that, in the crystal lattice of 1, two complexes exhibiting slightly different CShM values of DyIII result in the double relaxation behavior of 1@Y. However, for 2, one of two DyIII fragments possesses a fast quantum tunneling of magnetization (QTM), resulting in its magnetic process presented at T < 1.8 K, so 2 exhibits single relaxation behavior. Theor. calculations also clearly indicated that the weak ligation at equatorial sites of DyIII in 1 and 2 ensure that 1@Y and 2 possess SMM behavior, although the coordination geometry of DyIII (TDD-8) in 1 and 2 severely deviates from the ideal polyhedron and its axial symmetry is low. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

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HPLC of Formula: 1195-59-1In 2019 ,《Regulation of magnetic relaxation behavior by replacing 3d transition metal ions in [M2Dy2] complexes containing two different organic chelating ligands》 appeared in Dalton Transactions. The author of the article were Wang, Hui-Sheng; Yin, Cheng-Ling; Hu, Zhao-Bo; Chen, Yong; Pan, Zhi-Quan; Song, You; Zhang, Yi-Quan; Zhang, Zai-Chao. The article conveys some information:

Four tetranuclear 3d-4f complexes, namely [Fe2Ln2(L)2(teaH)2(Cl)2](NO3)2·4CH3CN (H2L = N1,N3-bis(3-methoxysalicylidene)diethylenetriamine, teaH3 = triethanolamine, Ln = Dy for 1 and Ln = Gd for 1′) and [Co2Ln2(L)2(pdm)2(CH3COO)2(CH3OH)2](NO3)2·xCH3OH·yH2O (pdmH2 = 2,6-pyridinedimethanol, Ln = Dy, x = 5 and y = 2.5 for 2 and Ln = Gd, x = 6 and y = 1.5 for 2′), are reported. Two FeIII and two DyIII in 1 formed a zigzag Fe1-Dy1-Dy1a-Fe1a arrangement with a Fe1-Dy1-Dy1a angle of 105.328(3)°. However, in contrast to 1, two CoIII and two DyIII ions in 2 formed a more linear Co1-Dy1-Dy1a-Co1a arrangement with a Co1-Dy1-Dy1a angle of 141.86(2)°. Addnl., two DyIII ions in 1 are eight-coordinated with a triangular dodecahedron geometry, while two DyIII ions in 2 adopt nine-coordination with a muffin geometry. Magnetic studies revealed slow magnetic relaxation behavior for 1, with an energy barrier Ea of 6.9 K. For 2, single mol. magnet behavior was presented under a zero d.c. field with an effective energy barrier Ueff of 64.0(9) K. Ab initio calculations for 1 and 2 indicate that compared to 2, complex 1 has a larger transversal magnetic moment of its ground Kramers doublets (KD) and a larger value of the tunneling parameter (Δt) for the exchanged coupled ground state, which may result in poor single mol. magnet behavior for 1.2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 1195-59-1

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Product Details of 1195-59-1In 2021 ,《Azine-N-oxides as effective controlling groups for Rh-catalyzed intermolecular alkyne hydroacylation》 was published in Chemical Science. The article was written by Moseley, Daniel F.; Kalepu, Jagadeesh; Willis, Michael C.. The article contains the following contents:

Azine N-oxide substituted aldehydes are used as highly effective substrates with good reactivity for intermol. hydroacylation of alkynes. Employing a Rh(I)-catalyst, a mild and scalable aldehyde C-H activation, that permits the coupling with unactivated terminal alkynes was achieved in good yields and with high regioselectivities (up to >20 : 1 l:b). Both substrates can tolerate a broad variety of functional groups. The reaction can also be applied to diazine aldehydes that contain a free N-lone pair. Conversion of the hydroacylation products to the corresponding azine, through a one-pot hydroacylation/deoxygenation sequence was also demonstrated. A one-pot hydroacylation/cyclization, using N-Boc propargylamine, addnl. leads to the synthesis of a bidentate pyrrolyl ligand. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Product Details of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1195-59-1

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In 2022,Valigura, Dusan; Rajnak, Cyril; Titis, Jan; Moncol, Jan; Bienko, Alina; Boca, Roman published an article in Dalton Transactions. The title of the article was 《Unusual slow magnetic relaxation in a mononuclear copper(II) complex》.Related Products of 1195-59-1 The author mentioned the following in the article:

A hexacoordinate Cu(II) complex with the {CuO4O′N} donor set shows an intermol. π-π stacking owing to which a 1D-chain structure is formed. The DC magnetic data at low temperature are consistent with the Curie law. The AC susceptibility shows a field supported slow magnetic relaxation that survives up to 7 K. The relaxation time at T = 2.0 K and BDC = 0.2 T is τ = 0.23 ms and it increases at BDC = 0.6 T to τ = 2.9 ms. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 1195-59-1

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Lagerspets, Emi; Abba, Donatella; Sharratt, Joseph; Eronen, Aleksi; Repo, Timo published an article in 2022. The article was titled 《Water tolerant base free Copper (I) catalyst for the selective aerobic oxidation of primary alcohols》, and you may find the article in Molecular Catalysis.Quality Control of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

Authors report here a base free copper(I) catalyst for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to their corresponding lactones or lactols. In the presence of the in situ generated Cu(I)-catalyst with 2,2′-dipyridylamine (dpa) as a ligand and 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO) as a persistent radical, the oxidation reaction proceeds under true aerobic conditions, at ambient temperature, utilizing air as the oxidant and without added base. High catalytic activity without over oxidation was achieved for numerous primary alcs. (aliphatic, allylic, benzylic and diols) with different substitution patterns. The catalyst’s stability is unique among reported Cu(I)-catalysts. It is not moisture or air sensitive, and is capable of e.g. oxidizing aliphatic and benzyl alcs. in a water/acetonitrile solution in moderate or in quant. yield (> 99%) in 3 h. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 2,6-Pyridinedimethanol

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Lu, Tian-Qi; Wang, Xue-Tao; Cheng, Lan-Tao; Chen, Cheng; Shi, Haiyan; Zheng, Jun; Zheng, Xiu-Ying published an article in 2021. The article was titled 《Soft Metal-Organic Frameworks Based on {Na@Ln6} as a Secondary Building Unit Featuring a Magnetocaloric Effect and Fluorescent Sensing for Cyclohexane and Fe3+》, and you may find the article in Crystal Growth & Design.COA of Formula: C7H9NO2 The information in the text is summarized as follows:

Two series of cluster-based Ln-metal-organic frameworks (MOFs) {[Na@Ln8(EDTA)6(H2O)22]·ClO4·xH2O}n (x ≈ 28, Ln = Gd 1, Ln = Eu 2) and {[Na@Ln9(EDTA)6(H2O)27]·(ClO4)4·xH2O}n (x ≈ 26, Ln = Gd 3, Ln = Eu 4) were prepared by ethylene diamine tetraacetic acid (H4EDTA) to control the hydrolysis of lanthanide ions to form cluster-based secondary building blocks and hydrated metal ions as linkers. Structural anal. showed that all four compounds were formed by using {Na@Ln6} as the node and hydrated [Ln(H2O)5]3+ ion as the linker. Compounds 1-2 and 3-4 featured a two-dimensional (2D) layered structure and a three-dimensional (3D) frame structure, resp. Magnetic studies showed that compounds 1 and 3 displayed a considerable magnetocaloric effect with magnetic entropy values of 32.8 and 33.3 J kg-1 K-1, resp., at low temperature and high field. The magnetic entropy changes of 3 did not increase greatly with the increase of the dimension due to the similar weak magnetic interactions and similar magnetic densities of compounds 1 and 3. Luminescence studies showed that compounds 2 and 4 had a good recognition effect on the cyclohexane mol., and 4 displayed excellent sensitive sensing and a detection effect on Fe3+ ions in MeOH based on the high-sensitivity fluorescence quenching phenomenon. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1COA of Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C7H9NO2

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《A new catalytic approach for aerobic oxidation of primary alcohols based on a Copper(I)-thiophene carbaldimines》 was written by Lagerspets, Emi; Valbonetti, Evelyn; Eronen, Aleksi; Repo, Timo. Application of 1195-59-1This research focused onthiophenyl methanimine preparation; primary alc copper thiophenyl methanimine catalyst oxidation; diol copper thiophenyl methanimine catalyst oxidation. The article conveys some information:

Novel Cu(I) thiophene carbaldimine catalysts for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to lactones or lactols was reported. In the presence of the in-situ generated Cu(I) species, a persistent radical (2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO)) and N-methylimidazole (NMI) as an auxiliary ligand, the reaction proceeds under aerobic conditions and at ambient temperature Especially the catalytic system of 1-(thiophen-2-yl)-N-(4-(trifluoromethoxy)phenyl)methanimine with copper(I)-iodide showed high reactivity for all kind of alcs. (benzylic, allylic and aliphatic). In the case of benzyl alc. even 2.5 mol% of copper loading gave quant. yield. Beside high activity under aerobic conditions, the catalysts ability to oxidize 1,5-pentadiol to the corresponding lactol (86% in 4 h) and N-phenyldiethanolamine to the corresponding morpholine derivate lactol (86% in 24 h) is particularly noteworthy. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application of 1195-59-1

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In 2022,Kardashliev, Tsvetan; Panke, Sven; Held, Martin published an article in Green Chemistry. The title of the article was 《Efficient synthesis of 2,6-bis(hydroxymethyl)pyridine using whole-cell biocatalysis》.Application In Synthesis of 2,6-Pyridinedimethanol The author mentioned the following in the article:

We demonstrate a novel one-pot biocatalytic process for the preparation of a versatile chem. intermediate, 2,6-bis(hydroxymethyl)pyridine, from naturally-occurring 2,6-lutidine using recombinant microbial whole cells as a catalysts. After scale up, the bioconversion enabled titers exceeding 12 g L-1 with a space-time yield of 0.8 g L-1 h-1. This biocatalytic route offers a simpler and more sustainable alternative to multistep organic synthesis protocols.2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2,6-Pyridinedimethanol

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Reference of 2,6-PyridinedimethanolIn 2019 ,《Site-Specific Modification of Proteins through N-Terminal Azide Labeling and a Chelation-Assisted CuAAC Reaction》 appeared in Bioconjugate Chemistry. The author of the article were Inoue, Nozomu; Onoda, Akira; Hayashi, Takashi. The article conveys some information:

Site-specific modification of peptides and proteins is an important method for introducing an artificial function to the protein surface. Recently, we found that new bioconjugation reagents, 6-(azidomethyl)-2-pyridinecarbaldehyde (6AMPC) derivatives, allow specific N-terminal modification and enhance the reaction rate of the subsequent bioconjugation in a chelation-assisted CuAAC reaction. The N-terminal specific azide-labeling of bioactive peptides and proteins occurs under mild reaction conditions with 6AMPC derivatives (angiotensin I: 90%, RNase A: 90%). Kinetic anal. of the CuAAC reaction with azide-labeled proteins reveals that the ligation is promoted in the presence of a copper-chelating pyridine moiety. Importantly, the introduction of an electron-donating methoxy group to the pyridine moiety further accelerates the CuAAC ligation. We demonstrate that this method enables site-specific conjugation of various functional mols. such as fluorophores, biotin, and polyethylene glycol. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Reference of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2,6-Pyridinedimethanol

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In 2018,Schoonen, Lise; Eising, Selma; van Eldijk, Mark B.; Bresseleers, Jaleesa; van der Pijl, Margo; Nolte, Roeland J. M.; Bonger, Kimberly M.; van Hest, Jan C. M. published 《Modular, Bioorthogonal Strategy for the Controlled Loading of Cargo into a Protein Nanocage》.Bioconjugate Chemistry published the findings.Synthetic Route of C7H9NO2 The information in the text is summarized as follows:

Virus capsids, i.e., viruses devoid of their genetic material, are suitable nanocarriers for biomedical applications such as drug delivery and diagnostic imaging. For this purpose, the reliable encapsulation of cargo in such a protein nanocage is crucial, which can be accomplished by the covalent attachment of the compounds of interest to the protein domains positioned at the interior of the cage. This approach is particularly valid for the capsid proteins of the cowpea chlorotic mottle virus (CCMV), which have their N-termini located at the inside of the capsid structure. Here, the authors examined several site-selective modification methods for covalent attachment and encapsulation of cargo at the N-terminus of the CCMV protein. Initially, the authors explored approaches to introduce an N-terminal azide functionality, which would allow the subsequent bioorthogonal modification with a strained alkyne to attach the desired cargo. As these methods showed compatibility issues with the CCMV capsid proteins, a strategy based on 2-pyridinecarboxaldehydes for site-specific N-terminal protein modification was employed. This method allowed the successful modification of the proteins, and was applied for the introduction of a bioorthogonal vinylboronic acid moiety. In a subsequent reaction, the proteins could be modified further with a fluorophore using the tetrazine ligation. The application of capsid assembly conditions on the functionalized proteins led to successful particle formation, showing the potential of this covalent encapsulation strategy. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Synthetic Route of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C7H9NO2

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