Category: 119-47-1

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Extracts of endophytic fungi from leaves of selected Nigerian ethnomedicinal plants exhibited antioxidant activity》 was published in 2021. The authors were Ibrahim, Mutiat;Oyebanji, Elizabeth;Fowora, Muinah;Aiyeolemi, Ayobami;Orabuchi, Chiamaka;Akinnawo, Babajide;Adekunle, Adedotun A., and the article was included in《BMC Complementary Medicine and Therapies》. The author mentioned the following in the article:

Plants with an ethnobotanical history are known to harbor diverse group of endophytic fungi, which constitute major natural sources of bioactive compounds In the present study, we evaluated the antioxidant activity of endophytic fungi from eight Nigerian ethnomedicinal plants. Endophytic fungi were isolated from the leaves of Acalypha ornata, Albizia zygia, Alchornea cordifolia, Chrysophyllum albidum, Ficus exasperata, Gomphrena celosioides, Millettia thonningii, and Newbouldia laevis. Endophytic fungi were isolated from the leaves of selected plants via surface sterilization. Isolated fungi were identified by internal transcribed spacer (ITS-rDNA) sequence anal. Pure fungal strains were subjected to fermentation process on solid rice medium and metabolites extracted using ethyl-acetate. Fungal crude extracts were screened for antioxidant activity using 2, 2- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and reduction of ferric ion assays. Gas chromatog./mass spectrometry (GC/MS) anal. was used to identify the major chem. constituents in active fungal extracts A total of eighteen fungal endophytes with fungal codes CU (061 and 062); ZA (161, 162, 163, and 164); LO (261); CA (041, 042, and 043); FE (081, 082, and 084); GE (091); MO (211 and 212); and NA (021 and 022) were isolated from the eight ethnomedicinal plants A. ornata, A. zygia, A. cordifolia, C. albidum, F. exasperata, G. celosioides, M. thonningii, and N. laevis resp. ZA 163 and MO 211 fungal extracts showed significant (p < 0.05) radical scavenging activity with IC50 values of 50.53 ± 0.01 and 86.69 ± 0.02μg/mL resp. Fungal extract CA 041 demonstrated significantly (p < 0.01) higher iron chelating activity than standard gallic acid with absorbance values of 0.803 and 1.107 at 250 and 500μg/mL concentrations resp. Pyrogallol, phenol, 2,6-dimethoxy-, phytol, dl-alpha-tocopherol, alpha-tocospiro, oleamide, Me stearate, oleic acid, palmitic acid, campesterol, stigmasterol, β-sitosterol, urs-12-en-24-oic acid, 3-oxo-, Me ester, lup-20(29)-en-3-one, and lupeol were detected in the selected active extracts These results showed that leaves of the selected Nigerian plants harbor diverse group of endophytic fungi, which can be potential antioxidant resource. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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HPLC of Formula: 119-47-1《Metabolome-microbiome signatures in the fermented beverage, Kombucha》 was published in 2020. The authors were Villarreal-Soto, Silvia Alejandra;Bouajila, Jalloul;Pace, Mauro;Leech, John;Cotter, Paul D.;Souchard, Jean-Pierre;Taillandier, Patricia;Beaufort, Sandra, and the article was included in《International Journal of Food Microbiology》. The author mentioned the following in the article:

Kombucha is a fermented tea. Here we investigate the fermentation kinetics, metabolite production, microbiome and potential health promoting properties of three different kombucha consortia. Shotgun metagenomic sequencing revealed several dominant bacterial genera such as Komagataeibacter, Gluconacetobacter and Gluconobacter. Brettanomyces and Schizosaccharomyces were the most dominant yeasts identified. Species distribution reflected different patterns of sugar consumption, with S. pombe being present in samples with the highest sugar conversion. Liquid-liquid extractions were performed with organic solvents in order to obtain dried extracts, which were later characterized. HPLC-DAD and GC-MS anal. revealed differences in the production of organic acids, sugars, alcs. and phenolic compounds, where the presence of caffeine, propanoic acid and 2,3 butanediol differ greatly across the three kombuchas. Metabolomic anal. exhibited a link between the microbiota and the production of bioactive compounds in kombucha fermentation In vitro assays were carried out in order to evaluate potential health-promoting features of the fermented teas, with notable outcomes including antioxidant ability against DPPH radical and against the 15-lipoxygenase enzyme, indicating a potential anti-inflammatory activity. These investigations considerably enhance our understanding of the relationship between the microbiota and metabolites as well as health promoting potential of kombucha and have the potential for the development of future generations of kombucha products in which these relationships are optimized. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

HPLC of Formula: 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Wang, Wanyi;Wang, Xin;Zhu, Qingqing;Zhou, Qunfang;Wang, Yawei;Liao, Chunyang;Jiang, Guibin published 《Occurrence of synthetic phenolic antioxidants in foodstuffs from ten provinces in China and its implications for human dietary exposure》. The research results were published in《Food and Chemical Toxicology》 in 2022.Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:

Synthetic phenolic antioxidants (SPAs) are widely used as food additives to delay the oxidation rate of oils and oil products. The concentrations and compositions of SPAs in Chinese residents most popular daily foods and the resulting exposure risk of SPAs are not clear. Therefore, this study collected food samples in 13 food categories (n = 289) from 10 provinces in China. At least one of the SPAs was detected in approx. 99.7% of foodstuffs, and the concentration of ∑SPAs ranged from not detected to 7830 (geometric mean (GM): 296 ng/g wet weight). 2,6-2 tert Bu p-1,4-benzoquinone (BHT-Q) was the main transformation product, but SPAs in food tend to exist in the parent form. A significant difference between food categories was analyzed. The highest GM of ΣSPAs occurred in cereals and cereal products, which was approx. 8 times higher than that in beverages. The estimated daily intakes of ΣSPAs in Chinese preschoolers, school-age children, adults and elderly individuals were 22200, 9970, 7540 and 7700 ng/kg bw/day, resp. The exposure risks of SPAs decreased with age. This is the first simultaneous anal. of SPAs in multiple provinces and multiple categories of foodstuffs. To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Grand, Caroline;Cogen, Jeffrey M.;Wills, Scott T. published 《Stability of phenolic antioxidants in the presence of sulfonic acid: model compound studies for moisture-crosslinked polyethylene》. The research results were published in《Polymer Degradation and Stability》 in 2021.Formula: C23H32O2 The article conveys some information:

Alkoxysilane-functionalized polyethylene can be crosslinked in the presence of acid catalysts, including Bronsted acids, to yield durable pipe and cable insulation materials. To provide guidelines for the selection of stable phenolic antioxidants in the presence of Bronsted acids, reactions of 4 model alkylphenol compounds in the presence of p-dodecylbenzenesulfonic acid (DBSA) in dodecane were studied as a solution model for polyethylene-based systems. The results point to increasing stability towards DBSA of phenolic compounds when: (i) alkyl groups have less substitution (tertiary carbon compared to quaternary carbon), (ii) they have alkyl-substitution in the para position, and (iii) they have a reduced number of alkyl substituents around the phenol ring. Antioxidants with alkyl or isocyanurate bridges had reaction rates comparable to butylated hydroxytoluene (BHT) and followed the trend outlined in model alkylphenols. The sulfur-bridged antioxidant stood out as rapidly consumed under the reaction conditions. Therefore, selection of phenolic antioxidants for formulations containing strong Bronsted acids should generally favor phenolic compounds with alkyl-substituted para positions and limited number of alkyl substituents in non-para positions, and without quaternary carbon substituents. Moreover, stability of alternate sulfur-containing antioxidants should be assessed if used with sulfonic acids, given the rapid decomposition of the sulfur-bridged antioxidant observed in this work. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Formula: C23H32O2《Comparative analysis of volatile profiles in four pine-mushrooms using HS-SPME/GC-MS and E-nose》 was published in 2022. The authors were Guo, Qiyong;Adelina, Nadya Mara;Hu, Jintao;Zhang, Ligang;Zhao, Yuhong, and the article was included in《Food Control》. The author mentioned the following in the article:

Pine-mushrooms is rich in bioactive compounds, possess a unique aroma profile for culinary art. In China, pine-mushroom has been produced in Southwest and Northeast area. However, the discrepancy of volatile profiles in pine-mushrooms from two regions was unclear due to different extraction and detection method applied in research. This study attempted to compare the volatile profiles of four pine-mushrooms from Southwest (LS) and Northeast (HEB, SY, MDJ) using Headspace Solid Phase Microextraction coupled with Gas Chromatog. Mass Spectrometry (HS-SPME/GC-MS) and Electronic nose (E-nose). showed a significant difference in aroma profiles among samples. A total of 100 volatile compounds were identified, and separated into 11 classes. Benzaldehyde and hexanal were detected in all samples, which could be the pivotal aroma components in pine-mushrooms. Aromatic components, were present in LS pine-mushroom from Southwest China, including abundant of Me (Z)-N-hydroxybenzenecarboximidate, benzaldehyde, and Me 3-phenylprop-2-enoate. Meanwhile, some alcs. (such as oct-1-en-3-ol, hexan-1-ol) were characteristic compounds present in HEB, SY and MDJ samples. Principal component anal. (PCA) of E-nose data showed a clear distinction among samples. In addition, this study also highlighted the correlation between key volatile compounds detected by GC-MS and E-nose sensors, which could be benefit for further explanation to the origin of differences in sensory quality of pine-mushrooms. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Hatairaktham, Suneerat;Masaratana, Patarabutr;Hantaweepant, Chattree;Srisawat, Chatchawan;Sirivatanauksorn, Vorapan;Siritanaratkul, Noppadol;Panichkul, Narumol;Kalpravidh, Ruchaneekorn W. published 《Curcuminoids supplementation ameliorates iron overload, oxidative stress, hypercoagulability, and inflammation in non-transfusion-dependent β-thalassemia/Hb E patients》 in 2021. The article was appeared in 《Annals of Hematology》. They have made some progress in their research.Recommanded Product: 119-47-1 The article mentions the following:

Curcuminoids, polyphenol compounds in turmeric, possess several pharmacol. properties including antioxidant, iron-chelating, and anti-inflammatory activities. Effects of curcuminoids in thalassemia patients have been explored in a limited number of studies using different doses of curcuminoids. The present study aims to evaluate the effects of 24-wk curcuminoids supplementation at the dosage of 500 and 1000 mg/day on iron overload, oxidative stress, hypercoagulability, and inflammation in non-transfused β-thalassemia/Hb E patients. In general, both curcuminoids dosages significantly lowered the levels of oxidative stress, hypercoagulability, and inflammatory markers in the patients. In contrast, reductions in iron parameter levels were more remarkable in the 1000 mg/day group. Subgroup anal. revealed that a marker of hypercoagulability was significantly decreased only in patients with baseline ferritin ≤ 1000 ng/mL independently of curcuminoids dosage. Moreover, the alleviation of iron loading parameters was more remarkable in patients with baseline ferritin > 1000 ng/mL who receive 1000 mg/day curcuminoids. On the other hand, the responses of oxidative stress markers were higher with 500 mg/day curcuminoids regardless of baseline ferritin levels. Our study suggests that baseline ferritin levels should be considered in the supplementation of curcuminoids and the appropriate curcuminoids dosage might differ according to the required therapeutic effect. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Recommanded Product: 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Cao, Bili;Lv, Xue;Chen, Zijing;Xu, Kun published 《Supplementing green light under strong sunlight improves growth and functional ingredients of ginger (Zingiber officinale Rosc.) in summer》 in 2021. The article was appeared in 《Industrial Crops and Products》. They have made some progress in their research.Electric Literature of C23H32O2 The article mentions the following:

The green light for ginger growth may not be as unimportant as often assumed, but still now the roles of green light in ginger remain poorly understood. To investigate this issue, the ‘Shandong Number 1’ginger cultivar was grown and treated with two contrasting light environments: sunlight (CK treatment), supplementing green light under strong sunlight (T1 treatment), and this study explored morphol. alterations, photosynthetic responses and gene expression of ginger in response to supplementing green light under strong sunlight, based on ginger’s own species characteristics. The results showed as follows. One hand, supplementing green light under strong sunlight promoted expression of gibberellin biosynthesis gene and altered the morphol. characteristics of ginger. In response to supplementing green light under strong sunlight, ginger presented not only shade avoidance symptoms characteristics, but also promotion of number of shoots, and thus rendered higher crown d. and greater crown volume When exposed to supplementing green light under strong sunlight condition, the strategies implemented by ginger to deal with stem elongation and branching increase seemed to be a species-specific response. On the other hand, the pos. effect of supplementing green light under strong sunlight on ginger also depends on the growth conditions. Previous research confirmed that ginger did not grow well under green light only treatment. In contrast, supplementing green light under strong sunlight resulted in higher crown d. and greater crown volume, which played a role in shading for the inner leaves and young pseudostems under summer sunlight, although strong summer light posed a threat to ginger growth. In addition, supplementing green light under strong sunlight led to upregulation of chlorophyll metabolism gene and an increase in Chlorophyll a content. Also, the enhancement of green light radiation effectively increased expressions of photosynthetic genes and photosynthesis rate. These all contributed to the improvement of photosynthetic efficiency of ginger leaves, as a way to increase light energy consumption, and thus reduced chloroplast senescence caused by excess light energy in summer. Furthermore, higher photosynthesis rate contributed to accumulation of photosynthetic products, and supported the material requirements for increasing biomass and improving rhizome functional ingredients. Taken together, this study will lay the foundations of a better understanding of the importance of green light to ginger. To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Electric Literature of C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Ma, Xue-feng;Ru, Chao;Liu, Yu-qing;Song, Xue;Lu, Zhou-min published 《Ultrasonic-assisted solvent extraction of essential oil and main components of Citrus reticulata Blanco cv. Manau Gan》. The research results were published in《Shipin Yanjiu Yu Kaifa》 in 2021.Quality Control of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:

The extraction solvent and material-liquid ratio were selected to optimize the essential oil extraction process of Citrus reticulata Blanco cv. Manau Gan. Results showed that the most suitable solvent for the essential oil extraction of Citrus reticulata Blanco cv. Manau Gan was petroleum ether, with a material-to-liquid ratio of 1:15 (g/mL). Three factors-ultrasonic time, temperature, and power were selected for a single-factor experiment An orthogonal condition optimization experiment was carried out for the ultrasonic extraction parameters of the essential oil of Citrus reticulata Blanco cv. Manau Gan. The optimization results were as follows: ultrasound time, 120 min; ultrasound temperature, 50 °C; and ultrasonic power, 60 W. The essential oil extraction rate of Citrus reticulata Blanco cv. Manau Gan reached 2.47% under these conditions. A total of 19 compounds were identified from the essential oil of Citrus reticulata Blanco cv. Manau Gan by gas chromatog.-mass spectrometry analyses, accounting for 97.60% of total volatiles. Thus, the optimized process could be used to extract the essential oil of Citrus reticulata Blanco cv. Manau Gan. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Quality Control of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2020, Gautier, Francoise;Tourneix, Fleur;Assaf Vandecasteele, Hind;van Vliet, Erwin;Bury, Dagmar;Alepee, Nathalie published 《Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: A case study with resorcinol》. 《Regulatory Toxicology and Pharmacology》published the findings. The article contains the following contents:

Historically skin sensitization risk assessment for cosmetic ingredients was based on animal models, however regulatory demands have led to Next Generation Risk Assessment (NGRA), using data from New Approach Methodologies (NAM) and Defined Approaches (DA). This case study was meant to investigate if the use of resorcinol at 0.2% in a face cream was safe and a maximum use concentration could be defined. The NAM data and DA predictions could not provide sufficient confidence to determine a point of departure (POD). Therefore, the application of read-across was explored to increase the level of confidence. Analog searches in various tools and databases using “mode of action” and “chem. structural features” retrieved 535 analogs. After refinement by excluding analogs without a defined structure, similar reactivity profile and skin sensitization data, 39 analogs remained. A final selection was made based on three approaches: expert judgment, chem. similarity or Local Lymph Node Assay data (LLNA). All read-across approaches supported a moderate potency. A POD derived from the LLNA EC3 of 3.6% was determined leading to a favorable NGRA conclusion and a maximum use concentration of 0.36%. This was supported by a traditional risk assessment based on the available animal data for resorcinol. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Analysis of the volatile components of Polygonum chinense L. extracted with different solvents by GC-MS》 was published in 2021. The authors were Wei, Anda;Zhu, Hua;Xie, Fengfeng;Zhang, Miao;Huang, Piaoiing;Yang, Wenqi, and the article was included in《Agricultural Biotechnology》. The author mentioned the following in the article:

This study was conducted to investigate the volatile components of Polygonum chinense L. The volatile components of the methanol extract, Et acetate extract, chloroform extract and petroleum ether extract of P. chinense were analyzed and determined by gas chromatog. The volatile components of the methanol extract from P. chinense were the most, and phenolic acids and ketones accounted for a relatively high proportion, among which pyrogallic acid had the highest content. The Et acetate extract contained the second most volatile components, mostly acids and esters, of which ss-sitosterol had the highest content; the chloroform and petroleum ether extracts had relatively few types of volatile components, most of which were alkanes, and the content of -sitosterol shared by the two was the highest. The common substances of the four extracts were palmitic acid and phytol. This study provides a theor. basis for the quality evaluation of P. chinense and a scientific basis for its resource development. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
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