Category: 119-47-1

Liu, Kexin;Zhang, Yuxiu;Xu, Weichao published 《Bioaugmentation of quinoline-degrading bacteria for coking wastewater treatment: performance and microbial community analysis》 in 2022. The article was appeared in 《Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering》. They have made some progress in their research.Name: 2,2-Methylenebis(6-tert-butyl-p-cresol) The article mentions the following:

Ochrobactrum sp.XKL1, previously found to have the ability to efficiently degrade quinoline, was bioaugmented into a lab-scale A/O/O system to treat real coking wastewater. During the bioaugmentation stage, the removal of quinoline and pyridine of the O1 tank could be enhanced by 9.88% and 7.96%, resp. High-throughput sequencing anal. indicated that the addition of XKL1 could significantly affect the alteration of microbial community structure in the sludge. In addition, the relative abundance of Ochrobactrum has demonstrated a trend of increasing first followed by decreasing with the highest abundance of 7.87% attained on the 94th day. The bioaugmentation effects lasted for about 14 days after the strains was inoculated into the reactor. Although a decrease in the relative abundance of XKL1 was observed for a rather short period of time, the bioaugmented A/O/O system has been proven to be more effective in the removal of organic pollutants than the control. Hence, the results of this study indicated that the bioaugmentation with XKL1 is a feasible operational strategy that would be able to enhance the removal of NHCs in the treatment of coking wastewater with complex composition and high organic concentrations And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Name: 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Formula: C23H32O2《Evaluation of the antimicrobial activity and compressive strength of a dental cement modified using plant extract mixture》 was published in 2020. The authors were Singer, Lamia;Bierbaum, Gabriele;Kehl, Katja;Bourauel, Christoph, and the article was included in《Journal of Materials Science: Materials in Medicine》. The author mentioned the following in the article:

Literature lacks sufficient data regarding addition of natural antibacterial agents to glass ionomer cement (GICs). Hence, the aim of the study was to increase the antimicrobial properties of GICs through its modification with mixture of plant extracts to be evaluated along with an 0.5% chlorohexidine-modified GIC (CHX-GIC) with regard to biol. and compressive strength properties. Conventional GIC (freeze-dried version) and CHX were used. Alc. extract of Salvadora persica, Olea europaea, and Ficus carcia leaves were prepared using a Soxhlet extractor for 12 h. The plant extract mixture (PE) was added in three different proportions to the water used for preparation of the dental cement (Group 1:1 PE, 2:1 PE, and 1:2 PE). Specimens were then prepared and tested against the unmodified GIC (control) and the 0.5% CHX-GIC. Chem. anal. of the extract mixture was performed using Gas chromatog.-mass spectrometry. Antimicrobial activity was evaluated using agar diffusion assay against Micrococcus luteus and Streptoccocus mutans. Compressive strength was evaluated according to ISO 9917-1:2007 using a Zwick testing machine at a crosshead speed of 0.5 mm/min. Antimicrobial activity against Streptoccocus mutans was significantly increased for all the extract-modified materials compared to the unmodified cement, and the highest concentration was comparable to the CHX-GIC mixture The activity against Micrococcus luteus was also significantly increased, but only for the material with the highest extract concentration, and here the CHX-GIC group showed statistically the highest antimicrobial activity. Compressive strength results revealed that there was no statistically significant difference between the different mixtures and the control except for the highest tested concentration that showed the highest mean values. The plant extracts (PEs) enhanced the antimicrobial activity against S. mutans and also against M. luteus in the higher concentration while compressive strength was improved by addition of the PE at higher concentrations To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Category: alcohols-buliding-blocks《Biomass antioxidant silica supported tea polyphenols with green and high-efficiency free radical capturing activity for rubber composites》 was published in 2022. The authors were Guo, Xiaohui;Luo, Yuanfang;Chen, Lijuan;Zhang, Bowen;Chen, Yongjun;Jia, Demin, and the article was included in《Composites Science and Technology》. The author mentioned the following in the article:

To achieve simultaneous environment protecting, high-efficiency rubber antioxidant is still an enormous and long-term challenge in green rubber industry. Hence, a novel biomass antioxidant (denoted as silica-s-TP) was obtained by silica supported with green tea polyphenols exhibited prominent anti-aging functionality. Silica-s-TP hybrid particles were uniformly dispersed in rubber matrix with remarkable interfacial interaction, and the high-efficiency free radical capturing activity was stem from the construction of polyphenol structure on silica surface. Therefore, silica-s-TP brought to simultaneously enhance the performance of anti-aging property of SBR composites and surpass the achievements of the com. antioxidants. Interesting, the biomass antioxidant silica-s-TP exhibited remarkable free radical-scavenging activities and stability in SBR matrix than the TP directly added in SBR matrix, due to the chem. anchor TP on silica surface. Such clay surface treatment technol. with natural antioxidant may also bring to a new path for the preparation of green and eco-friendly functionalization rubber additives. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Category: alcohols-buliding-blocks2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19)》 was published in 2021. The authors were Upreti, Shobha;Prusty, Jyoti Sankar;Pandey, Satish Chandra;Kumar, Awanish;Samant, Mukesh, and the article was included in《Molecular Diversity》. The author mentioned the following in the article:

Abstract: The pandemic outbreak of coronavirus (SARS-CoV-2) is rapidly spreading across the globe, so the development of anti-SARS-CoV-2 agents is urgently needed. Angiotensin-converting enzyme 2 (ACE-2), a human receptor that facilitates entry of SARS-CoV-2, serves as a prominent target for drug discovery. In the present study, we have applied the bioinformatics approach for screening of a series of bioactive chem. compounds from Himalayan stinging nettle (Urtica dioica) as potent inhibitors of ACE-2 receptor (PDB ID: 1R4L). The mol. docking was applied to dock a set of representative compounds within the active site region of target receptor protein using 0.8 version of the PyRx virtual screen tool and analyzed by using discovery studio visualizer. Based on the highest binding affinity, 23 compounds were short-listed as a lead mol. using mol. docking anal. Among them, β-sitosterol was found with the highest binding affinity – 12.2 kcal/mol and stable interactions with the amino acid residues present on the active site of the ACE-2 receptor. Similarly, luteoxanthin and violaxanthin followed by rutin also displayed stronger binding efficiency. We propose these compounds as potential lead candidates for the development of target-specific therapeutic drugs against COVID-19.2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) were involved in the experimental procedure.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2021, Hayeemasae, Nabil;Ismail, Hanafi published 《Application of silane-treated tea waste powder as a potential filler for natural rubber composites》. 《BioResources》published the findings. The article contains the following contents:

The aim of this work was to develop sustainable composites based on natural rubber (NR) and tea waste (TW) composites. The main concern was the compatibility mismatch between NR and TW. The presence of polar groups in the TW contributes to the weak interaction between relatively hydrophobic NR and TW. Therefore, silane coupling agent was introduced to enhance the properties of the composites. Treating the TW by silane coupling agent greatly influenced the overall properties of the composites. It speeded up the curing process due to its ability to reduce possible adsorption of accelerator by TW. Better interaction between TW and rubber matrix was clearly observed as evidenced by the maximum torque (M_H) and tensile properties of the composites. Such findings can be verified by the Q_f/Q_g values, indicating better rubber-filler interaction when silane was used. Moreover, scanning electron microscope (SEM) images also provided some evidence related to the tensile properties observed It can be concluded that the new composite based on NR and TW was successfully prepared with the contribution of a silane coupling agent. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Song, Xue-Chao;Canellas, Elena;Dreolin, Nicola;Goshawk, Jeff;Nerin, Cristina published 《A Collision Cross Section Database for Extractables and Leachables from Food Contact Materials》 in 2022. The article was appeared in 《Journal of Agricultural and Food Chemistry》. They have made some progress in their research.Electric Literature of C23H32O2 The article mentions the following:

The chems. in food contact materials (FCMs) can migrate into food and endanger human health. In this study, we developed a database of traveling wave collision cross section in nitrogen (^TWCCS_N2) values for extractables and leachables from FCMs. The database contains a total of 1038 ^TWCCS_N2 values from 675 standards including those commonly used additives and nonintentionally added substances in FCMs. The ^TWCCS_N2 values in the database were compared to previously published values, and 85.7, 87.7, and 64.9% [M + H]⁺, [M + Na]⁺, and [M – H]^– adducts showed deviations <2%, with the presence of protomers, post-ion mobility spectrometry dissociation of noncovalent clusters and inconsistent calibration are possible sources of CCS deviations. Our exptl. ^TWCCS_N2 values were also compared to CCS values from three prediction tools. Of the three, CCSondemand gave the most accurate predictions. The ^TWCCS_N2 database developed will aid the identification and differentiation of chems. from FCMs in targeted and untargeted anal. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Electric Literature of C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Marchetti, Sara;Mollerup, Steen;Gutzkow, Kristine Bjerve;Rizzi, Cristiana;Skuland, Tonje;Refsnes, Magne;Colombo, Anita;Oevrevik, Johan;Mantecca, Paride;Holme, Joern Andreas published 《Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells》. The research results were published in《Toxicology In Vitro》 in 2021.Computed Properties of C23H32O2 The article conveys some information:

Combustion-derived particles (CDPs), in particular from traffic, are regarded as a central contributor for adverse health effects linked to air pollution. Recently, also biomass burning has been recognized as an important source for CDPs. Here, the effects of CDPs (PM10) originating from burning of pellet, charcoal and wood on key processes associated to lung carcinogenesis were explored. Human bronchial epithelial cells (HBEC3-KT) were exposed to 2.5μg/cm2 of CDPs for 24 h and biol. effects were examined in terms of cytotoxicity, inflammation, epithelial to mesenchymal transition (EMT)-related effects, DNA damage and genotoxicity. Reduced cell migration, inflammation and modulation of various PM-associated genes were observed mainly after exposure to wood and pellet. In contrast, only particles from pellet burning induced alteration in cell proliferation and DNA damage, which resulted in cell cycle alterations. Charcoal instead, appeared in general less effective in inducing pro-carcinogenic effects. These results illustrate differences in the toxicol. profile due to the CDPs source. The different chem. compounds adsorbed on CDPs seemed to be central for particle properties, leading to an activation of various cellular signaling pathways involved in early steps of cancer progression. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Computed Properties of C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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HPLC of Formula: 119-47-1In 2022, Zhan, Lingxi;Huang, Huanfang;Zhao, Shizhen;Wang, Zuwu;Zhang, Gan;Cheng, Hairong published 《Comparison of atmospheric polycyclic aromatic hydrocarbons (PAHs) over six years at a CAWNET background site in central China: Changes of seasonal variations and potential sources》. 《Chemosphere》published the findings. The article contains the following contents:

Total suspended particles (TSP) and gaseous samples were collected by using a high-volume sampler from March 2012 to March 2013 and Jan. 2018 to Jan. 2019 at a background site (Jinsha, JSH) in central China to study the chem. characteristics, seasonal variations, and potential sources of polycyclic aromatic hydrocarbons (PAHs). The average concentrations of ∑15PAHs were 24.55 ± 9.19 ng m-3 in 2012/2013 and 20.98 ± 9.77 ng m-3 in 2018/2019. Low-ring PAHs were more concentrated in gas phase while high-ring PAHs were prone into particle phase. The concentrations of PAHs in the two sampling years were high in winter but low in summer and autumn. The relationships between the gas concentrations of PAHs and temperature indicated that most PAHs were influenced by long-range atm. transport (LRAT) in 2012/2013 and in 2018/2019, excluding anthracene (Ant) and pyrene (Pyr) were partially affected by air-surface re-volatilization in 2012/2013. The source of atm. PAHs at JSH was similar in 2012/2013 and 2018/2019,which was mainly due to the LRAT of PAHs emitted from biomass/fossil fuel combustion in the northern area of JSH. From 2012/2013 to 2018/2019, there was no significant difference between the concentrations of PAHs in spring and winter, whereas the concentrations of PAHs decreased from 2012/2013 to 2018/2019 in summer. In all, the control of PAHs at the source region was partially effective from 2012/2013 to 2018/2019. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

HPLC of Formula: 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2021, Wang, Jisheng;Bao, Binghao;Meng, Fanchao;Deng, Sheng;Dai, Hengheng;Feng, Junlong;Li, Haisong;Wang, Bin published 《To study the mechanism of Cuscuta chinensis Lam. And Lycium barbarum L. in the treatment of asthenospermia based on network pharmacology》. 《Journal of Ethnopharmacology》published the findings. The article contains the following contents:

Cuscuta chinensis Lam. and Lycium barbarum L.(SC-FL) is a commonly used kidney tonic Chinese medicine combination that is widely used in the clin. treatment of oligoasthenospermia. However, its specific mechanism remains unclear and requires in-depth study. To explore the potential targets of SC-FL in the treatment of oligoasthenospermia using network pharmacol., and to verify the results with in vivo and in vitro experiments A herb-compound-target-disease network and PPI network were constructed with Cytoscape software. The targets of SC-FL for the treatment of male sterility were introduced into a bioinformatics annotation database, and the GO and KEGG databases were used for pathway enrichment anal. Subsequently, Tripterygium wilfordii Hook. f. (GTW) polyglycoside was used to induce a spermatogenic dysfunction model in GC-1 spg cells and SD male rats in in vitro and in vivo experiments, resp. The SC-FL and PI3K pathway inhibitor LY294002 was used to intervene in the spermatogenic dysfunction model to detect the expression of proteins and mRNA related to the PI3K pathway and to detect the indicators related to proliferation and apoptosis. In in vitro experiments, the percentage of spermatogenic cells and the proportion of GC-1 spg cells at G0/G1 and G2/M stages in the model group (GTW group) and the inhibitor group (LY group) were significantly decreased (P < 0.01) compared with the blank control group (NC group). The apoptosis rate of the GTW group was significantly increased (P < 0.01). The ultrastructures of GC-1 spg cells in the GTW group and LY group were obviously destroyed. Compared with the GTW group, the SC-FL group had a significantly reduced apoptosis rate of GC-1 spg cells, reduced percentage of cells in S phase, and a significantly improved mitochondrial membrane potential. SC-FL can repair the ultrastructure of GC-1 spg cells damaged by GTW. The above effects of SC-FL are closely related to up-regulation of GFRa1, RET, PI3K, p-AKT, and Bcl-2 and down-regulation of BAD and BAX proteins and mRNA expression. In vivo, compared with the GTW group, the body mass, testicular mass, and epididymal weight of the GTW + SC-FL group were significantly increased (P < 0.01). Sperm concentrations and the PR + NP of GTW + SC-FL were significantly higher than in the GTW group (P < 0.01 or P < 0.05). FSH, LH, and T levels in the GTW + SC-FL and LY + SC-FL groups were significantly higher than those in the GTW and LY group (P < 0.01 or P < 0.05). HE staining results showed that the morphol. of testicular tissue in the GTW + SC-FL and LY + SC-FL groups was superior to that in the GTW and LY group. The above effects of SC-FL are closely related to the up-regulation of proteins and mRNA expression of PI3K, p-AKT, and Bcl-2. Through the PI3K/Akt signaling pathway, SC-FL up-regulates GFRa1, RET, PI3K, p-AKT, and Bcl-2, and down-regulates the expression of BAD and BAX proteins and mRNA, thus reducing the percentage of GC-1 spg cells in S-phase, significantly increasing the mitochondrial membrane potential, significantly reducing cell apoptosis, and improving sperm counts and viability.2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) were involved in the experimental procedure.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Determination of antioxidants in food and water-based food simulants by supercritical fluid chromatography》 was published in 2021. The authors were Huang, Lin;Xiao, Lei;Zhu, Yan;Shou, Dan;Jin, Micong;Han, Xinghao, and the article was included in《Fenxi Shiyanshi》. The author mentioned the following in the article:

A novel pretreatment method based on syringe for filter solid-phase extraction was developed and combined with supercritical fluid chromatog. (SFC) to determine the migration of antioxidants in packaging materials to two water-based food simulants, and applied to test real sample. The amount of sorbent and SFC conditions were optimized. Under the optimized conditions, all the studied six target antioxidants have good linearity (R²>0.999) in their resp. concentration ranges with limits of detection (LODs) ranging from 25 to 35 ng/mL. Mean recoveries of targets were between 82.0% and 96.0% in ultrapure water, and between 76.2% and 103.0% in 3% acetic acid solution, with the relative standard deviations (RSD) no more than 8.8%. The method is adaptable for analyzing the antioxidants in com. non-alc. beverage and their packaging materials (soaking in different food simulants). The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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