Category: 117284-59-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 117284-59-0, name is 2-(2,2-Difluorocyclopropyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 117284-59-0

Methanesulfonyl chloride (1.35 mL) was added to a solution of 2- (2 , 2-difluorocyclopropyl) ethanol (1.42 g) and triethylamine (3.24 mL) in THF (20 mL) dropwise at 0 C. The mixture was stirred at room temperature overnight. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography(hexane/ethyl acetate) to give the title compound (1.31 g) as a pale yellow oil.XH NMR (300 MHz, DMSO-d6) delta 1.17-1.30 (1H, m) , 1.44-1.98 (4H, m) , 3.19 (3H,. s) , 4.16-4.36 (2H, m)

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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YASUMA, Tsuneo; KAMATA, Makoto; YAMASHITA, Tohru; HIROSE, Hideki; MURAKAMI, Masataka; KINA, Asato; YONEMORI, Kazuko; MIZOJIRI, Ryo; FUJIMORI, Ikuo; FUJIMOTO, Takuya; IKEDA, Zenichi; WO2012/74126; (2012); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 117284-59-0, name is 2-(2,2-Difluorocyclopropyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(2,2-Difluorocyclopropyl)ethanol

5.41 g (54.1 mmol) of chromium trioxide was dissolved in 90.2 mL of 1.5 M sulfuric acid solution, and cooled at with stirring 0 C. 3.3g (27.1 mmol) of 2-(2,2-difluorocyclopropyl)ethanol was dissolved in 90.2 mL of acetone. The mixture was added dropwise to a chromium trioxide-sulfuric acid solution with stirring at 0 C. After the addition was completed, the reaction solution was stirred at 0 C for 4 hours. The organic layer was extracted with diethyl ether (50 mL34). The combined organic layers were washed with brine. It was then extracted with 2M sodium hydroxide solution (50 mL34) and the aqueous layers were combined. The aqueous layer was acidified to pH < 1 with sulfuric acid with stirring in an ice bath. The organic layer was extracted with diethyl ether (50 mL 3 4), and the combined organic layers were washed with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated to give 3.4g colorless liquid 2-(2,2-difluorocyclopropyl)acetic acid in 92% yield. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol. Reference:
Patent; Shanghai Institute Of Materia Medica Chinese Academy of Sciences; LIU, Hong; ZHOU, Yu; XIA, Wenjing; ZHANG, Dong; JIANG, Hualiang; CHEN, Kaixian; (49 pag.)EP3459948; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 117284-59-0, blongs to alcohols-buliding-blocks compound. Recommanded Product: 117284-59-0

At 0C, to a solution of Cr03 (5.70 g, 57.00mmol) in sulfuric acid (8.3 mL) was added water (92 mL). Then a solution of 2-(2,2- difluorocyclopropyl)ethan-1-ol (180 mg, 1.47 mmol) in acetone (30 mL) was added dropwise over 20 mm period. The resulting mixture was stirred for 4 h at room temperature. Whe the reaction was done, the reaction mixture was extracted with ether (50 mL x 4). The organic layers were combined, washed with 2 M sodium hydroxide solution (50 mL x 4) and the aqueous layers were combined. The pH value of the resulting aqueous solution was adJusted to 1 using sulfuric acid and extracted with ether (50 mL x 4). The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to yield 2-(2,2- difluorocyclopropyl)acetic acid as colorless oil (117 mg, 58%). GCMS: m/z = 136 [Mj.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian A.; BRUGGER, Nadia; (546 pag.)WO2017/106607; (2017); A1;,
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