Category: 116-02-9

Reference of 116-02-9, Adding some certain compound to certain chemical reactions, such as: 116-02-9, name is 3,3,5-Trimethylcyclohexanol,molecular formula is C9H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 116-02-9.

a) 426g (3,00 Mol) of Homomenthol is added to the above-mentioned filtrate, the temperature is raised to 60C and under stirring and a vacuum of 100mbar the Ethyl acetate is distilled off the reaction mixture. Then 56g of Sulfuric acid are added at a temperature of 50C within 20minutes, stirring is continued for 6h. For work-up 500g of Toluene are added to the reaction mixture and after cooling to 5-10C the dosage of 500g of iced water follows. After separation of the water layer the organic layer is washed to neutral with aqueous Sodium hydroxide solution (10% w/w) and finally with saturated aqueous Sodium chloride solution. After separation of the water layer the organic layer is distilled resulting 250g (0,93 Mol) of product. Yield (overall): 58% of theory.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 116-02-9, 3,3,5-Trimethylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Symrise AG; Stuhlmann, Dominik; Meyer, Imke; Koch, Oskar; Oertling, Heiko; Herrmann, Martina; Goemann, Claudia; EP2810934; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 116-02-9 ,Some common heterocyclic compound, 116-02-9, molecular formula is C9H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1, equipped with a stirrer, condensate return pipe, thermometer, N.2The four-necked flask was purged with nitrogen and the addition of acrylic acid and 3,3,5-trimethylcyclohexanol, the molar ratio of acrylic acid to 3,3,5-trimethylcyclohexanol was 1: 1.2, , Stirring speed of 300 r / min, heating up; 2, continue to heat up to 118 , stable condensate reflux, adding catalyst, incubation reaction 4h; and then remove the condenser, install the water separator, at 125 reaction 3h, stop And then distilled at a temperature of 80 C and a pressure of -0.099 MPa to obtain a pale yellow transparent product with an acrylic acid conversion of 94.6% and a yield of 85.14%.The catalyst is p-toluenesulfonic acid in an amount of 1.0% by weight based on the total weight of the total reactants.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 116-02-9, 3,3,5-Trimethylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SOUTH CHINA UNIVERSITY OF TECHNOLOGY; PAN, CHAOQUN; ZHANG, JIN; KANG, YINGZI; (6 pag.)CN104151159; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116-02-9, name is 3,3,5-Trimethylcyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C9H18O

a) 426g (3,00 Mol) of Homomenthol is added to the above-mentioned filtrate, the temperature is raised to 60C and under stirring and a vacuum of lOOmbar the Ethyl acetate is distilled off the reaction mixture. Then 56g of Sulfuric acid are added at a tempera- ture of 50C within 20minutes, stirring is continued for 6h. For work-up 500g of Toluene are added to the reaction mixture and after cooling to 5-10C the dosage of 500g of iced water follows. After separation of the water layer the organic layer is washed to neutral with aqueous Sodium hydroxide solution (10% w/w) and finally with saturated aqueous Sodium chloride solution. After separation of the water layer the organic layer is distilled resulting 250g (0,93 Mol) of product. Yield (overall): 58% of theory.

With the rapid development of chemical substances, we look forward to future research findings about 116-02-9.

Reference:
Patent; SYMRISE AG; STUHLMANN, Dominik; MEYER, Imke; KOCH, Oskar; OERTLING, Helko; HERRMANN, Martina; GOeMANN, Claudia; WO2014/198602; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 116-02-9 ,Some common heterocyclic compound, 116-02-9, molecular formula is C9H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis 4 Synthesis of 3-(3,3,5-trimethylcyclohexyloxy)phenol In a four necked flask (1 L) sufficiently dried, substituted with nitrogen, and equipped with a dropping funnel, Dimroth condenser tube, thermometer and stirring blade, resorcinol (42 g, 0.38 mol), 3,3,5-trimethylcyclohexanol (54 g, 0.57 mol) and triphenylphosphine (150 g, 0.57 mol) were dissolved in dried tetrahydrofuran (200 ml) under a nitrogen gas stream, and a mixed solution of diisopropyl azodicarboxylate (100 g, 0.5 mol) and dried tetrahydrofuran (150 ml) was dropped for 1 hour while cooling with an iced saline solution. Next, it was stirred at room temperature for 12 hours. After the reaction terminated, 30 % hydrogen peroxide (75 ml) was dropped through the dropping funnel for 10 minutes, then the reaction solution was dissolved in 1 L toluene, and washed three times with 500 ml water. Toluene was distilled away by evaporation, and the residue was purified by column chromatography using hexane and ethyl acetate as developing solvents, to obtain a red brown objective product (hereinafter, referred to as R-4A) (19.5 g, 22 % yield, 99 % GC purity). The chemical shift value (delta ppm, TMS standard) of 1H-NMR of this compound in a heavy dimethyl sulfoxide solvent was 0.7 (m, 1H), 0.9 to 1.0 (m, 9H), 1.2 to 2.0 (m, 6H), 4.1 (m, H), 6.5 (m, 3H), 7.0 (m, H), 8.9 (b, H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116-02-9, its application will become more common.

Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; EP2505576; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts