Category: 115-20-8

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115-20-8, name is Trichloroethanol, molecular formula is C2H3Cl3O, molecular weight is 149.4, as common compound, the synthetic route is as follows.SDS of cas: 115-20-8

A mixture of CLTAM (1.0 g, 2.59 mmol) and K2C03 (0.39 g, 2.85 mmol) in 2.2,2-trichloroethanol (5 mL) was stirred at room temperature for 16 hours. Water (70 mL) was added, then product was extracted to MeTHF (3 x 20 mL), combined organic layers ware dried over MgS04, and then concentrated to afford crude product, which was purified by chromatography (Si02, hexane:EtOAc) to afford title compound as white powder (1.00 g, 78% yield). MP 1 18C; MS (ESI) mlz: 498 [MH]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,115-20-8, Trichloroethanol, and friends who are interested can also refer to it.

Reference:
Patent; LEK PHARMACEUTICALS D.D.; ZUPANCIC, Borut; MARAS, Nenad; STERK, Damjan; WO2013/60837; (2013); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-20-8, name is Trichloroethanol. A new synthetic method of this compound is introduced below., COA of Formula: C2H3Cl3O

3alpha-Hydroxy-7-oxo-5beta-cholanoic acid (39.0 g, 100 mmol),beta,beta,beta-Trichloroethanol (16.4 g, 110 mmol)Soluble in 150 ml of methylene chlorideStir and cool to 0C.DCC (dicyclohexylcarbodiimide) (24.7 g) was slowly added dropwise.120mmol) dichloromethane solution,After dripping, the reaction was incubated for 6 hours.Filtered, concentrated under reduced pressure, recrystallized from acetonitrile, filtered,Trichloroethyl 3alpha-hydroxy-7-oxo-5beta-cholanoic acid (50.4 g, yield 86.7%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-20-8, Trichloroethanol.

Reference:
Patent; Hangzhou Heze Pharmaceutical Technology Co., Ltd.; Ni Sheng; Yang Zhenghe; Chen Jie; Cai Liefeng; Zhou Yinglei; Zhou Liang; Chen Hongxiang; (23 pag.)CN107383139; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 115-20-8, Trichloroethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C2H3Cl3O, blongs to alcohols-buliding-blocks compound. Formula: C2H3Cl3O

4.2.2.14 3,17beta-dimethoxy-17alpha-[2′,2′,2′-trichloroethyl-1′-N-tosylacetimidate]estra-1,3,5(10)-triene (4w) The general procedure was followed using 3,17beta-dimethoxy-17alpha-ethynyl-estra-1,3,5(10)-triene 1f and 2,2,2-trichloroethanol 3l, affording compound 4w (76 mg, 59%) as a white solid, mp 68-70 C, [alpha]D26 = +24 (? 0.98, CHCl3).

The synthetic route of 115-20-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Volkova, Yulia A.; Kozlov, Andrey S.; Kolokolova, Marya K.; Uvarov, Denis Y.; Gorbatov, Sergey A.; Andreeva, Olga E.; Scherbakov, Alexander M.; Zavarzin, Igor V.; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 694 – 706;,
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Related Products of 115-20-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115-20-8 as follows.

To a suspension of 7-acetoxycoumarin-4-acetic acid 5 (945 mg, 3.6 mmol, 1 eq) in 47 mL of anhydrous dichloromethane at room temperature under nitrogen was added 2,2,2-trichloroethanol (431 muL, 4.5 mmol, 1.25 eq). A solution of Lambda^Lambdaf’-dicyclohexylcarbodiimide (818 mg, 4 mmol, 1.1 eq) in 10 mL of anhydrous dichloromethane was added. The reaction mixture was stirred for 15 min, after which it was diluted with dichloromethane and filtered. The filtrate was concentrated under vacuum. Column chromatography on silica gel (CH2Cl2 then CH2Cl2^tOAc, 10:1) afforded product 6a (1.37 g, 96 %): Rf 0.78 (CH2Cl2:Et0Ac, 5:1); 1H NMR (300 MHz, CDCl3): delta 7.61 (d, 1 H, J5,6 8.7 Hz, H-5), 7.15 (d, 1 H, J6,8 2.1 Hz, H-8), 7.07 (dd, 1 H, J6,8 2.3, J5,6 8.7 Hz, H-6), 6.42 (s, 1 H, H-3), 4.77 (s, 2 H, CH2CCl3), 3.91 (2 s, 2 Eta, CH2CO2), 2.33 (s, 3 Eta, OAc); 13C NMR (75 MHz, CDCl3): delta 168.6, 167.0, 154.5, 153.5, 146.5, 125.5, 118.5, 117.0, 116.5, 110.9, 74.6, 37.7, 21.2; ESI-MS: m/z 393 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.

Reference:
Patent; UNIVERSITY OF WASHINGTON; GELB, Michael, H.; BLANCHARD, Sophie; WO2010/81163; (2010); A2;,
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Related Products of 115-20-8 ,Some common heterocyclic compound, 115-20-8, molecular formula is C2H3Cl3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirring solution of 5-chloro-2-(quinolin-6-yl)benzoic acid (0.201 g, 0.708 mmol) and TEA (0.148 ml, 1.06 mmol) in 1 ,4-dioxane (10 ml) at RT, was added DPPA (0.191 ml, 0.244 mmol). After stirring for 30 min at RT, 2,2,2-trichloroethanol (0.680 ml, 7.08 mmol) was added and the reaction was stirred with heating at 100 C for 2 h. The completed reaction was diluted with brine (10 ml) and extracted with EtOAc (3×25 ml). The combined organics were washed with 5% citric acid (10 ml), sat’d. NaHC03 (10 ml) and brine (10 ml), dried (MgSO^, concentrated in vacuo and purified by chromatography to afford 2,2,2-trichloroethyl 5-chloro-2-(quinolin-6- yl)phenylcarbamate (0.25 g, 82% yield) as a white solid. MS (ESI) m/z: 431.0 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.

Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.; WO2013/36232; (2013); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 115-20-8

Compound 1 (2g, 13.4mmol) was dissolved intetrahydrofuran (15ml) was added triethylamine (176mg), Was added dropwise to asolution of compound 2 (2.1g, 24.8mmol), dropwise addition was heated to 60 C under reflux, stirringStirred overnight. The reaction was stopped, after the reaction mixture wascooled added saturated citric acid (20ml), extracted with methylene chloride,The organic layer was washed with water, brine, dried over anhydrous NaSO 4,isolated by column chromatography to give compound 3 (2.2g, 71% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-20-8, Trichloroethanol.

Reference:
Patent; ARROMAX PHARMATECH SUZHOU CO LTD; JIAN, HONG; XU, XIN; (12 pag.)CN104230792; (2016); B;,
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Reference of 115-20-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115-20-8 as follows.

Preparation of 12′- (2, 2,2-Trichloroethylcarbonyl) vinblastine Trifluoroacetate [00125] Carbon monoxide was bubbled through a solution of 12′- iodovinblastine (53 mg, 0.057 mmol), triethylamine (57 mg, 0.565 mmol) and bis (triphenylphosphine) palladium (II) dichloride (8 mg, 0.011 mmol) in a mixture of DMF/2,2, 2-trichloroethanol (2 mL, 1 : 1) for 5 min, then the reaction mixture was heated at 50 C for 9 h under one atmosphere of carbon monoxide (balloon). The solution was diluted with ethyl acetate (15 mL) then washed with saturated aqueous NaHC03 (2 x 5 mL) and brine (5 mL), dried over MgS04 and evaporated to dryness in vacuo. The residue was purified by reverse phase chromatography (C18, acetonitrile/water, 0.05% trifluoroacetic acid) to provide 12′- (2, 2,2- trichloroethylcarbonyl) vinblastine trifluoroacetate (33 mg, 48%) as a white powder after lyophilization

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.

Reference:
Patent; AMR TECHNOLOGY, INC.; WO2005/55939; (2005); A2;,
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115-20-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of a dicyclohexyl carbodiimide (3.26 g, 15.8 mmol), 4-n-butylbenzoic acid (2.35 g, 13.2 mmol) and 4-dimethylaminopyrridine (806.3 mg, 6.6 mmol) in anhydrous CH2Cl2 (100 mL), 2,2,2-trichloroethanol (1.5 mL, 15.8 mmol) was added dropwise at 0 C. The mixture was stirred at room temperature for 21 h. The reaction mixture was filtrated through funnel padded with cotton. The mixture was extracted with CH2Cl2 (30 mL), 1 mol/L HCl (25 mL¡Á2), then aqueous NaHCO3 solution (50 mL¡Á2), dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash silica gel columun chromatography (n-hexane/EtOAc=20/1) to give 3i as a colorless oil (3.39 g, 82%); IR (ATR, cm-1) : 2956, 2931, 2860, 1731, 1610, 1576, 1509; 1H NMR (500 MHz; CDCl3): delta8.04 (d, 2H, J = 8.0 Hz), 7.29 (d, 2H, J = 8.0 Hz), 4.96 (s, 2H), 2.69 (t, 2H, J = 7.8 Hz), 1.65-1.59(m, 2H), 1.38-1.34 (m, 2H), 0.93 (t, 3H, J = 7.5 Hz); 13C NMR (125 MHz; CDCl3): delta 165.1, 149.8,130.3, 128.8, 126.2, 95.3, 74.5, 35.9, 33.4, 22.4, 14.0; MS (EI) m/z (%). [M+], 308 (17) 273 (9) 267(19) 230 (5) 161 (99) 135 (14) 125 (15) 118 (30) 103 (18) 95 (6) 91 (72) 77 (19) 65 (10) 51 (6) 41(21). HRMS (EI): calcd for C13H15O2Cl3 [M+]: 308.0138; found: 308.0140.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115-20-8, Trichloroethanol.

Reference:
Article; Sawama, Yoshinari; Imanishi, Takahiro; Nakatani, Ryosuke; Fujiwara, Yuta; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 70; 30; (2014); p. 4540 – 4546;,
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115-20-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115-20-8 as follows.

Carbon monoxide was bubbled through a solution of 11′- iodovinorelbine (151 mg, 0.167 mmol), triethylamine (169 mg, 1.67 mmol) and bis (triphenylphosphine) palladium (II) dichloride (23 mg, 0.033 mmol) in a mixture of DMF/2,2, 2-trichloroethanol (4 mL, 1 : 1) for 5 min. The reaction mixture was heated at 50 C for 14 h under one atmosphere of carbon monoxide (balloon). The solution was diluted with ethyl acetate (35 mL) then washed with saturated NaHC03 (2 x 20 mL) and brine (20 mL), dried over MgS04, and evaporated to dryness in vacuo. The residue was purified by reverse phase chromatography (C18, acetonitrile/water, 0.05% TFA) to provide 11′- (2,2, 2-trichloroethoxycarbonyl) lvinorelbine Trifluoroacetate (78 mg, 40% yield) as a white powder after lyophilization

The chemical industry reduces the impact on the environment during synthesis 115-20-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AMR TECHNOLOGY, INC.; WO2005/55943; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 115-20-8, Trichloroethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115-20-8, blongs to alcohols-buliding-blocks compound. 115-20-8

General procedure: 3-Hydroxy-2-((S)-1-phenylethyl)isoindolin-1-one 1 (150 mg, 0.592 mmol, Entries 1-3, Table 1) or (100 mg, 0.395 mmol, (Entries 4-11, Table 1) was dissolved in dichloromethane (3.0 mL) under an inert atmosphere (N2) while stirring followed by the addition diethylaminosulfur trifluoride (DAST, 240 L, 1.776 mmol, 3 eq). Stirring was continued overnight (16 hr) and the alcohol (10 or 5 eq) was added and stirring was continued until the reaction was complete as indicated by TLC (4-8 hr). The crude reaction mixture was directly submitted to gravity-column chromatography and the entire series of products were eluted with hexane/ethyl acetate, 4:1. Combination and concentration of the individual fractions gave the pure products detailed in Table 1.

With the rapid development of chemical substances, we look forward to future research findings about 115-20-8.

Reference:
Article; Ronnebaum, Jarrid M.; Luzzio, Frederick A.; Arkivoc; vol. 2019; 5; (2019);,
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