Category: 112513-79-8

Adding a certain compound to certain chemical reactions, such as: 112513-79-8, 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol

A solution of racemic 6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol (30 mg), isopropenyl acetate (24-240 mul, 1-30 eq.) and NOV435 (30 mg) in 3.0 mL of solvent (toluene, acetonitrile, tetrahydrofuran or terc-buthyl methyl ester) was stirred gently at 35 C for 7 h in a 4 mL vial. Samples were collected after 3 and 7 h and were directly analyzed by chiral GC for ee of the product and reagent. Conversion (C) was calculated as C = eer/(eer + eep) and enantiomeric ratio (E) was calculated as E = ln[1 – C(1 + eep)]/ln[1 – C(1 – eep)].

The synthetic route of 112513-79-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Miranda, Amanda S.; Gomes, Juliana C.; Rodrigues Jr., Manoel T.; Costa, Ingrid C.R.; Almeida, Wanda P.; Lopes, Raquel De O.; Miranda, Leandro S.M.; Coelho, Fernando; De Souza, Rodrigo O.M.A.; Journal of Molecular Catalysis B: Enzymatic; vol. 91; (2013); p. 77 – 80;,
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Reference of 112513-79-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.112513-79-8, name is 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, molecular formula is C6H8N2O, molecular weight is 124.1405, as common compound, the synthetic route is as follows.

To a mixture of 6,7-dihydro-5H- pyrrolofl,2-a]imidazol-7-ol (1 g, 8.06 mmol) and 3-methyl-4-nitro-lH-pyrazole (1.13 g, 8.87 mmol) in THF (20 mL) was added PPh3 (3.17 g, 12.09 mmol) and then D1AD (2.44 g, 12.09 mmol, 2.4mL) dropwise at 0 C over a period of 30 min under N2. The mixture was warmed to 20 C and stirred for 12 h, then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (gradient PE:EtOAc from 10: 1 to 0: 1) to give the mixture of 7-(3-methyl-4-nitro-pyrazol-l-yl)-6,7-dihydro-5H-pyrrolo[l,2-a]imidazole and 7-(5-methyl- 4-nitro-lH-pyrazol-l -yl)-6,7-dihydro-5H-pyrrolo[l,2-a]imidazole as a white solid. LCMS: RT 0.112 min, m/z —— 234.1 [M + H .] To a solution of 7-(3- methyl-4-nitro-pyrazol-l-yl)-6,7-dihydro-5H-pyrrolo| l,2-a|imidazole and 7-(5-methyl-4-nitro-lH- pyrazol-l-yl)-6,7-dih}’dro-5H-pyrrolo[ l,2-a]imidazole (650 mg, 2.79 mmol) in MeOH (20 mL) was added Pd-C (10%, 0.3 g) under N2. The suspension was degassed under vacuum and purged with H2 several times. The mixture was stirred under H2 (15 psi) at 20 C for 4 h, then filteredand concentrated under reduced pressure, to give the mixture of l-(6,7-dihydro-5H-pyrrolo|T,2- a]imidazol-7-yl)-3-methyl-pyrazol-4-amine and l-(6,7-dihydro-5H-pyrrolo[ l,2-a]imidazol-7-yl)-5- methyl-lH-pyrazol-4-amine as a light yellow solid. LCMS: RT 0.62-0.878 min, m/z = 204.2 [M+H]~.

Statistics shows that 112513-79-8 is playing an increasingly important role. we look forward to future research findings about 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol.

Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
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