Category: 1124-63-6

Synthetic Route of 1124-63-6, Adding some certain compound to certain chemical reactions, such as: 1124-63-6, name is 3-Cyclohexylpropan-1-ol,molecular formula is C9H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1124-63-6.

The crude mixture was reacted with phthalimide (15.0 mmol) in THF (20 mL) under reflux for 2 h to get a the phthalimide intermediate as white powder. It was filtered and further reacted with hydrazine (98%, 63 mmol) in absolute ethanol (15 mL) at 60 C for 30 min. The reaction mixture was diluted with water and extracted using ethyl acetate to get the 3-cyclohexylpropan-1-amine 47. The amine 47 was reacted with phenethylisocyanate according to the general procedure to get 23. Yield 87%; White solid; mp 84-86 C; Rf 0.40 (1: 2 Ethylacetate: Hexane), IR (neat): 3359, 3307, 2911, 2849, 1625, 1560, 1496 cm-1; 1H NMR (CDCl3) delta 0.81-0.89 (m, 2H), 1.11-1.26 (m, 6H), 1.41-1.49 (m, 2H), 1.62-1.69 (m, 5H), 2.81 (t, J = 8.00 Hz, 2H), 3.05-3.10 (m, 2H), 3.41-3.46 (m, 2H), 4.26-4.33 (m, 2H), 7.19-7.24 (m, 3H), 7.28-7.33 (m, 2H). 13C NMR (CDCl3) delta 26.24, 26.53, 27.45, 33.24, 34.51, 36.37, 37.33, 40.82, 41.57, 126.40, 128.59, 128.86, 139.30, 158.31. HRMS Calcd for C18H28N2O2 m/z [M+H] 289.2281, found 289.2308.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1124-63-6, 3-Cyclohexylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Manickam, Manoj; Jalani, Hitesh B.; Pillaiyar, Thanigaimalai; Sharma, Niti; Boggu, Pulla Reddy; Venkateswararao, Eeda; Lee, You-Jung; Jeon, Eun-Seok; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 134; (2017); p. 379 – 391;,
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Synthetic Route of 1124-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1124-63-6, name is 3-Cyclohexylpropan-1-ol, molecular formula is C9H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 125 5-(3-Cyclohexyl-propoxy)-1-(4-nitro-phenyl)-1H-tetrazole Cyclohexylpropyl alcohol (237 mL, 1.58 mol) was added to a suspension of NaH (66.0 g, 1.65 mol) in tetrahydrofuran (1.40 L). A solution of 5-Chloro-1-(4-nitro-phenyl)-1 H-tetrazole (320 g, 1.42 mol) in tetrahydrofuran (900 mL) was added dropwise over 1.5 hours. The reaction was allowed to cool to room temperature and stirred overnight. The mixture was concentrated in vacuo to a solid. The solid was dissolved in ethyl acetate, washed with saturated aqueous sodium chloride solution (2x), dried (Na2SO4), and filtered through silica gel (700 g). The red filtrate was concentrated in vacuo until product began to precipitate from solution. Hexane was added and the slurry filtered to provide a tan solid (320 g, 64 %). Mp 82-88C (dec); 1H NMR (CDCl3, 300 MHz) delta 8.43 (d, 9.2 Hz, 2 H), 8.04 (d, 9.2 Hz, 2 H), 4.70 (t, 7.0 Hz, 2 H), 1.96 (m, 2 H), 1.75-1.64 (m, 5 H), 1.39-1.13 (m, 6 H), 0.97-0.87 (m, 2 H); MS (CI) mlz 332 (MH+); Anal. calcd for C16H21N5O3: C, 57.99; H, 6.39; N, 21.13. Found: C, 57.80; H, 6.35; N, 21.02; Rf = 0.43 (N).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; BAYER CORPORATION; EP1054881; (2008); B1;,
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Adding a certain compound to certain chemical reactions, such as: 1124-63-6, 3-Cyclohexylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1124-63-6, blongs to alcohols-buliding-blocks compound. Formula: C9H18O

3-Cyclohexylpropan-1-ol (10 mmol) was refluxed overnight with bromic acid (10 mmol). After adding ice water, the reaction mixture was extracted with ethyl acetate to obtain 3- (bromopropyl) cyclohexane. The crude mixture was reacted with phthalimide (15 mmol) in THF solution (20 ml) to obtain a white solid phthalimide derivative. This was filtered and then reacted with hydrazine (98%, 63 mmol) in anhydrous ethanol (15 ml) at 60 C for 10 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate to give a 3-cyclohexylpropylamine compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1124-63-6, its application will become more common.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
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Related Products of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.

To a stirred solution of 4-nitrophenol (4) (1.30 g, 8.35 mmol) and PPh3 (3.20 g, 12.2 mmol) in THF (30.0 mL) were added diisopropyl azodicarboxylate (2.40 mL, 12.2 mmol) and 3-cyclohexyl-1-propanol (1.91 mL, 12.2 mmol) at 0 C. After stirring for 2 h at ambient temperature, the reaction mixture was quenched with H2O and then extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (EtOAc : n-hexane = 1 : 24 to 1 : 15) to afford 2.23 g (91%) of 18 as a colorless oil: 1H NMR (CDCl3, 400 MHz) delta 8.15 (d, 2H, J= 7.0 Hz), 6.91 (d, 2H, J = 7.0 Hz), 3.99 (t, 2H, J = 6.6 Hz), 1.80 (quintet, 2H, J = 7.2 Hz), 1.67 (m, 5H), 1.31 (m, 2H), 1.18 (m, 4H), 0.89 (m, 2H); 13C NMR (CDCl3, 100 MHz) delta 164.3, 141.3, 125.9, 114.4, 69.3, 37.4, 33.6, 33.3, 26.7, 26.4, 26.4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Jo, Jeyun; Kim, Heegyu; Oh, Ji Youn; Kim, Soyeong; Park, Yeong Hye; Choi, Hyeonjin; Jeong, Jee-Yeong; Jung, Young-Suk; Yun, Hwayoung; Bioorganic and Medicinal Chemistry Letters; vol. 29; 24; (2019);,
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Electric Literature of 1124-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1124-63-6, name is 3-Cyclohexylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

3-Cyclohexyl-1-propanol (3.96 g, 27.8 mmol) was dissolved in DCM (90 mL) at 0 C. and treated sequentially with dimethyl sulfoxide (3.25 g, 41.7 mmol), N,N-diisopropylethylamine (8.98 g, 69.6 mmol) and sulfur trioxide pyridine complex (11 g, 69.6 mmol). After one hour, the reaction mixture was diluted with DCM (100 mL) and washed with 1N aqueous HCl (3×50 mL), saturated sodium bicarbonate (3×50 mL), and brine. The organic layer was dried over MgSO4, filtered, and concentrated to yield the title intermediate as a light yellow oil (3.8 g). 1H NMR (d6-DMSO, 300 MHz) delta (ppm): 9.72 (s, 1H), 3.65-3.72 (m, 2H), 2.46 (t, 2H), 1.65-1.73 (m, 3H), 1.51-1.56 (m, 2H), 1.14-1.48 (m, 4H), 0.85-0.96 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; Long, Daniel D.; Church, Timothy J.; Jacobsen, John R.; Jiang, Lan; Saito, Daisuke Roland; Stergiades, Ioanna; Van Dyke, Priscilla M.; Dalziel, Sean; Preza, Leticia Maria; US2007/219278; (2007); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1124-63-6, 3-Cyclohexylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

3-Cyclohexylpropan-1-ol (10 mmol) was refluxed overnight with bromic acid (10 mmol). After adding ice water,The reaction mixture was extracted with ethyl acetate to give 3- (bromopropyl) cyclohexane. The crude mixture was reacted with phthalimide (15 mmol) in THF solution (20 ml) to obtain a white solid phthalimide derivative. This was filtered and then reacted with hydrazine (98%, 63 mmol) in anhydrous ethanol (15 ml) at 60 C for 10 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate to give a 3-cyclohexylpropylamine compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below., COA of Formula: C9H18O

General procedure: DMSO (14.0 mmol) was added dropwise to a stirred solution of oxalyl chloride (5.0 mmol) in DCM (20.0 mL) at -78 C and the resulting reaction mixture was stirred for 20 min at this temperature. Then 3-cyclohexyl-propanol or 3-pyridinepropanol (4.0 mmol) was added dropwise and stirred for 1 h followed by the addition of Et3N (1.0 mL). The reaction was gradually brought to room temperature and H2O was added. The separated DCM phase was washed with brine and purified by flash chromatography (Hexane/ethyl acetate (EtOAc) = 10/1) to give a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Article; Liu, Kai; Rao, Wei; Parikh, Hardik; Li, Qianbin; Guo, Tai L.; Grant, Steven; Kellogg, Glen E.; Zhang, Shijun; European Journal of Medicinal Chemistry; vol. 47; 1; (2012); p. 125 – 137;,
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Application of 1124-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1124-63-6, name is 3-Cyclohexylpropan-1-ol, molecular formula is C9H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10 g of Fmoc-TentaGel-S-RAM resin (0.25 mmol/g, 2.5 mmol) was treated with 25% PIP in DMF for 30 min. The resin was washed with DMF (2x) , MeOH (2x) and DMF (2x) and subsequently acylated with Fmoc-gamma-Abu-OH/DIC/HOBt (3 eq) in DMF. The completeness of the reaction was assessed with Kaiser’s ninhydrine test. The Fmoc group was removed followed by resin washing as described above . The o-NBS group was introduced by treatment with o-NBS-Cl (4 eq) /collidine (6 eq) in DCM for 1 h at rt . The resin was then suspended in dry DME (15 ml) and 3- cyclohexyl-1-propanol (3.8 ml, 25 mmol, 10 eq) was added. The TPP/DIAD complex was preformed at 00C by dissolving TPP (6.55 g, 25 mmol, 10 eq) in dry DME (30 ml) and adding DIAD (4.92 ml, 25 mmol, 10 eq) . The complex was then added to the suspension and the reaction was carried out overnight. An aliquot of the resin was cleaved and analysed by HPLC (column: Vydac C18, 5mu, 250 x 4.6 mm; solvents: A-O.1% TFA (aq) , B-80% CH3CN/0.1% TFA (aq) ; a linear gradient of B was used) . The content of the non-alkylated substrate was below 2%. The o-NBS group was subsequently removed by treatment with 1 M 2-mercaptoethanol/DBU in DMF (25 ml) for 1 h (2x) . The resin was then treated with PhNCO (10.9 ml, 25 mmol, 10 eq) in DMF for 4 h. The completeness of the reaction was confirmed by a negative chloranil test. The compound was cleaved from the resin by treatment with TFA/TIS/H2O 96/2/2 (100 ml) for 1.5 h at rt . The resin was filtered off and the solvents were evaporated. The crude product was purified by preparative HPLC. The fractions containing the pure compound were combined and lyophilised. The obtained product was treated with isopropyl ether, whereby crystalline compound was provided. Yield: 442.8 mg (51%, 1.28 mmol); Mp. 104- 1060C; MS (ion spray): [M + H]+ expected 346.2, observed 346.2; 1H NMR (500 MHz, CDCl3) data was consistent with the structure of compound 17.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; FERRING B.V.; WO2006/116399; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.

(9-1) Synthesis of 3-bromopropylcyclohexane (compound 9-1) [Show Image] 3-Cyclohexyl-1-propanol (5.00 g) was dissolved in methylene chloride (50 ml), triphenylphosphine (10.2 g) and N-bromosuccinimide (6.90 g) were added under ice-cooling, and the mixture was stirred under ice-cooling for 1 hr, and further at room temperature for 1 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. Diethyl ether (100 ml) was added, and the precipitated triphenylphosphine oxide was filtered off. The concentrate of the filtrate was purified by silica gel column chromatography (hexane alone) to give the object product (7.17 g) as a colorless oil. 1H-NMR(CDCl3) delta (ppm): 0.81-0.96(2H, m), 1.10-1.45(6H, m), 1.60-1.78(5H, m), 1.82-1.92(2H, quint, J=7.0Hz), 3.39(2H, t, J=7.0Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
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Application of 1124-63-6 ,Some common heterocyclic compound, 1124-63-6, molecular formula is C9H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Cyclohexylpropanal To a solution of commercially available 3-cyclohexylpropanol (45.5 g, 0.32 mol) in CH2C12 (1000 mL) was added PCC (103.5 g, 0.48 mol), Celite 545 (50 g) and stirred at room temperature for 3 h. The reaction mixture was diluted with ethyl ether (1000 mL), stirred at rt for 1 h, before it was filtered through Celite and silica gel (1 : 1) pad. The filtrate was concentrated to give crude residue. Crude product was purified by silica gel flash chromatography (0-30% EtOAc/hexanes) to give the title compound as oil (50.7 g), which contained residual hexanes as judged by NMR analysis. lH NMR (300 MHz, CDCb) delta 0.83 – 0.98 (m, 3 H), 1.15 – 1.31 (m, 4 H), 1.49 – 1.56 (m, 2 H), 1.61 – 1.73 (m, 4 H), 2.41 – 2.46 (m, 2 H), 9.77 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1124-63-6, its application will become more common.

Reference:
Patent; RESEARCH TRIANGLE INSTITUTE; RUNYON, Scott, P.; MAITRA, Rangan; NARAYANAN, Sanju; THOMAS, James, Barnwell; REHDER, Kenneth, S.; OLEPU, Srinivas; (194 pag.)WO2017/100558; (2017); A1;,
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