Category: 1123172-89-3

《Reversible and Tunable Photoswitching of Protein Function through Genetic Encoding of Azobenzene Amino Acids in Mammalian Cells》 was published in ChemBioChem in 2018. These research results belong to Luo, Ji; Samanta, Subhas; Convertino, Marino; Dokholyan, Nikolay V.; Deiters, Alexander. SDS of cas: 1123172-89-3 The article mentions the following:

The genetic encoding of three different azobenzene phenylalanines with different photochem. properties was achieved in human cells by using an engineered pyrrolysyl tRNA/tRNA synthetase pair. In order to demonstrate reversible light control of protein function, azobenzenes were site-specifically introduced into firefly luciferase. Computational strategies were applied to guide the selection of potential photoswitchable sites that lead to a reversibly controlled luciferase enzyme. In addition, the new azobenzene analogs provide enhanced thermal stability, high photoconversion, and responsiveness to visible light. These small-mol. photoswitches can reversibly photocontrol protein function with excellent spatiotemporal resolution, and preferred sites for incorporation can be computationally determined, thus providing a new tool for investigating biol. processes. The experimental process involved the reaction of (3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3SDS of cas: 1123172-89-3)

(3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3) belongs to nitro compounds. Nitro compounds have very different half-wave potentials. They depend on the type, number and position of the substituents and rise.SDS of cas: 1123172-89-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides》 was written by Rueeger, Heinrich; Lueoend, Rainer; Rogel, Olivier; Rondeau, Jean-Michel; Mobitz, Henrik; Machauer, Rainer; Jacobson, Laura; Staufenbiel, Matthias; Desrayaud, Sandrine; Neumann, Ulf. Application In Synthesis of (3,5-Difluoro-4-nitrophenyl)methanol And the article was included in Journal of Medicinal Chemistry on April 12 ,2012. The article conveys some information:

Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by mol. modeling studies and by x-ray anal. of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochem. property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, highly potent compounds were obtained, such as I, with enzymic and cellular IC50 values of 2 and 50 nM, resp., and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels. In addition to this study using (3,5-Difluoro-4-nitrophenyl)methanol, there are many other studies that have used (3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3Application In Synthesis of (3,5-Difluoro-4-nitrophenyl)methanol) was used in this study.

(3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3) belongs to nitro compounds.Application In Synthesis of (3,5-Difluoro-4-nitrophenyl)methanol Nitro compounds have very different half-wave potentials. They depend on the type, number and position of the substituents and rise.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts