Category: 1122-71-0

Creation of a Nonsymmetric Dimethanolpyridine Ligand: A Rare Zn(salphen) Template Effect was written by Escudero-Adan, Eduardo C.;Benet-Buchholz, Jordi;Kleij, Arjan W.. And the article was included in Inorganic Chemistry in 2008.HPLC of Formula: 1122-71-0 This article mentions the following:

An interesting reversible, templated synthesis of unsym. pyridine-ligated Zn complexes was observed in solution and solid-state phases when Zn(salphen) complexes are reacted with MeOH-substituted pyridine substrates. The x-ray mol. structure of an unusual Zn₃ supramol. assembly is reported, in which the central Zn atom is embedded in a distorted octahedral geometry and each of the single anionic O atoms of the pyridine groups coordinates to a Zn(salphen) unit. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0HPLC of Formula: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 1122-71-0

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Alcohol – Wikipedia,
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Base-induced Sommelet-Hauser rearrangement of N-(pyridinylmethyl) tetraalkylammonium salts was written by Tayama, Eiji;Shimizu, Goshu;Nakao, Ryo. And the article was included in Tetrahedron in 2022.Formula: C7H9NO This article mentions the following:

The base-induced Sommelet-Hauser (S-H) rearrangement of various types of N-(pyridinylmethyl) tetraalkylammonium salts to produce N,N-dialkyl-伪-pyridinylamino acid esters were investigated. For example, a treatment of N-(2-pyridinylmethyl) glycine tert-Bu ester-derived tetraalkylammonium salt with 1.2 equiv of potassium tert-butoxide in THF at -40掳C gave the corresponding S-H product, I [R = Obut; R¹ = R² = Me; R³= H] in 93% yield. Method was an efficient C-H functionalization of pyridines under simple and mild conditions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Formula: C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C7H9NO

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Reaction of 2,6-lutidine 1-oxide with acetic anhydride was written by Kobayashi, Goro;Furukawa, Sunao;Kawada, Yuitsu. And the article was included in Yakugaku Zasshi in 1954.Application of 1122-71-0 This article mentions the following:

2,6-Lutidine 1-oxide (4 g.) in 15 ml. Ac₂O heated 2 hrs. at 130-40掳, the Ac₂O removed in vacuo, the residue with water concentrated in vacuo, made alk. with K₂CO₃, extracted with CHCl₃ and distilled, gave 4 g. oil, b₄ 100-5掳. The oil in 10 ml. 10% HCl refluxed 30 min., the product concentrated in vacuo, made alk. with K₂CO₃, extracted with CHCl₃ and distilled, gave 1.8 g. oil, and oxidation of the oil with KMnO₄ gave 6,2-Me(HOH₂C)C₅H₃N (I), m. 96掳; picrate, m. 129-32掳. I in C₆H₆ treated with PCl₃ gave 6,2-Me(ClH₂C)C₅H₃N (picrate, m. 162-3掳). The residue after distillation of I recrystallized from AcOEt gave 0.2 g. 2,6,3-Me₂(HO)C₅H₂N, columns, m. 210-12掳. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Application of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 1122-71-0

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Alcohol – Wikipedia,
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Hydroxymethylpyridine containing half-sandwich complexes of Rh(III), Ir(III) or Ru(II) was written by Carmona, Daniel;Lamata, Pilar;Sanchez, Antonio;Pardo, Pilar;Rodriguez, Ricardo;Ramirez, Paola;Lahoz, Fernando J.;Garcia-Orduna, Pilar;Oro, Luis A.. And the article was included in Dalton Transactions in 2014.Recommanded Product: 6-Methyl-2-pyridinemethanol This article mentions the following:

Complexes of the formula [(畏ⁿ-ring)M(NOH){(R)-P1}][SbF₆]₂ ((畏ⁿ-ring)M = (畏⁵-C₅Me₅)Rh, (畏⁵-C₅Me₅)Ir, (畏⁶-p-MeC₆H₄ⁱPr)Ru; NOH = hydroxymethylpyridine ligand; {(R)-P1} = (R)-monophos) have been prepared from the corresponding dimers [{(畏ⁿ-ring)MCl}₂(渭-Cl)₂] through routes involving [(畏⁵-C₅Me₅)RhCl₂{(R)-P1}] or [(畏ⁿ-ring)MCl(NOH)][SbF₆] intermediates. The new complexes have been characterized by anal. and spectroscopic means, including the determination of the crystal structures of [(畏⁵-C₅Me₅)IrCl₂{(R)-P1}] (1b), [(畏⁶-p-MeC₆H₄iPr)RuCl(NOH-1)][SbF₆] (2c), [(畏⁵-C₅Me₅)IrCl{(R)-NOH-2}][SbF₆] ((R)-3b), [(畏⁵-C₅Me₅)Rh(NOH-1){(R)-P1}][SbF₆]₂ (4a) and [(畏⁶-p-MeC₆H₄iPr)Ru{(R)-NOH-2}{(S)-P1}][SbF₆]₂ ((R)-5c’) by x-ray diffractometric methods. From NMR and x-ray data, the absolute configuration of the new chiral compounds was established. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 6-Methyl-2-pyridinemethanol

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Plants as a green alternative for alcohol preparation from aromatic aldehydes was written by Suarez-Franco, Gabriela;Hernandez-Quiroz, Teresa;Navarro-Ocana, Arturo;Oliart-Ros, Rosa Maria;Valerio-Alfaro, Gerardo. And the article was included in Biotechnology and Bioprocess Engineering in 2010.Product Details of 1122-71-0 This article mentions the following:

A general methodol. for the efficient reduction of aromatic aldehydes and three ketones to their corresponding alcs. (interesting as cosmetic fragrances in their majority) with moderate to excellent chem. yield was achieved by using homogenates of broccoli (B. oleracea var. italica), cauliflower (B. oleracea var. botrytis), beet (B. vulgaris var. cicla), and spinach (S. oleraceae) in aqueous suspension and mild reaction conditions. B. oleracea var. italica and B. oleracea var. botrytis gave the maximum bioconversion yields within short reaction times. Vegetables assayed exhibited an excellent yield (鈮?99%) after 24 h for aromatic aldehydes. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Product Details of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 1122-71-0

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Alcohol – Wikipedia,
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Some high-potential trithioether chelates of copper was written by Kanters, Rene P. F.;Yu, Ru;Addison, Anthony W.. And the article was included in Inorganica Chimica Acta in 1992.SDS of cas: 1122-71-0 This article mentions the following:

The linear quadridentate ligand 1,8-bis(2′-quinolyl)-3,6-dithiaoctane and the 3 quinquedentate ligands 1,9-bis(2′-pyridyl)-2,5,8-trithianonane, 1,9-bis(6′-methyl-2′-pyridyl)-2,5,8-trithianonane and 1,11-bis(2′-quinolyl)-3,6,9-trithiaundecane were prepared The deep green-blue Cu(II) chelates were characterized by optical and ESR spectroscopy and cyclic voltammetry. The 2 pyridyl chelates had similar tetragonal coordination about the Cu, with an equatorial N₂S₂ donor set, plus the 3rd thioether S bound axially. The most marked consequence of the pyridine 伪-methylation was that the Cu²⁺/⁺ reduction potential was raised by 鈭?00 mV; otherwise, the E_1/2 was consonant with previously advanced models for correlating redox potentials with ligand structural features. The pyridyl Cu(II) complexes were isolated as the tetrafluoroborate salts, whereas the quinolyl-Cu(II) chelates were rather redox unstable, in association with even more pos. Cu²⁺/⁺聽E_1/2 values, similar to that for dibromine reduction In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 1122-71-0

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Lewis base-catalyzed Mukaiyama-aldol reaction of trimethylsilyl enolates with aldehydes was written by Zhang, Xingxian;Shi, Junchen;Hu, Shenghui. And the article was included in Journal of Chemical Research in 2010.Related Products of 1122-71-0 This article mentions the following:

An efficient Mukaiyama-type aldol reaction of three silyl enolates, such as 1-[(trimethylsilyl)oxy]-1-methoxy-2-methyl-2-propene [i.e., [(1-methoxy-2-methyl-1-propen-1-yl)oxy]trimethylsilane], 1-phenyl-1-[(trimethylsilyl)oxy]ethene [i.e., [1-[(trimethylsilyl)oxy]ethenyl]silane] and 1,2-bis[(trimethylsilyl)oxy]cyclobutene with aryl aldehydes and 伪,尾-unsaturated aldehydes catalyzed by 5 mol% Lewis base catalyst (4-nitrophenoxy)magnesium iodide [i.e., 4-O₂NPhOMgI] in CH₂Cl₂ solvent is described. The reaction proceeds under mild reaction conditions and the synthesis of the target compounds was achieved in good yield. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Related Products of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 1122-71-0

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors was written by Lacotte, Pierre;Puente, Celine;Ambroise, Yves. And the article was included in ChemMedChem in 2013.Product Details of 1122-71-0 This article mentions the following:

The sodium iodide symporter (NIS) is responsible for the accumulation of iodide in the thyroid gland. This transport process is involved in numerous thyroid dysfunction and is the basis for human contamination in the case of exposure to radioactive iodine species. 4-Aryl-3,4-dihydro-2(1H)-pyrimidinone derivatives were recently discovered by high-throughput screening as the first NIS inhibitors. Described herein are the synthesis and evaluation of 115 derivatives with structural modifications at five key positions on the pyrimidone core. This study provides extensive structure-activity relationships for this new class of inhibitors that will serve as a basis for further development of compounds with in vivo efficacy and adequate pharmacokinetic properties. In addition, the SAR investigation provided a more potent compound, which exhibits an IC₅₀ value of 3.2 n in a thyroid cell line (FRTL5, animal model, rat model). The title compounds thus formed included analogs and derivatives of 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenyl-5-pyrimidinecarboxylic acid (4-methoxyphenyl)methyl ester (I), such as thiophene derivatives, pyridine derivatives, imidazole derivatives, naphthalene derivatives, etc. The synthesis of the target compounds was achieved using Meldrum’s acid, amines aldehydes and alcs. as simple starting materials. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Product Details of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 1122-71-0

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Selective Zinc Sensor Molecules with Various Affinities for Zn²⁺, Revealing Dynamics and Regional Distribution of Synaptically Released Zn²⁺ in Hippocampal Slices was written by Komatsu, Kensuke;Kikuchi, Kazuya;Kojima, Hirotatsu;Urano, Yasuteru;Nagano, Tetsuo. And the article was included in Journal of the American Chemical Society in 2005.Synthetic Route of C7H9NO This article mentions the following:

The authors have developed a series of fluorescent Zn²⁺ sensor mols. with distinct affinities for Zn²⁺, because biol. Zn²⁺ concentrations vary over a wide range from sub-nanomolar to millimolar. The new sensors have K_d values in the range of 10^-8-10^-4 M, compared with 2.7 nM for ZnAF-2. They do not fluoresce in the presence of other biol. important metal ions such as calcium or magnesium, and they can detect Zn²⁺ within 100 ms. In cultured cells, the fluorescence intensity of ZnAF-2 was saturated at low Zn²⁺ concentration, while that of ZnAF-3 (K_d = 0.79 渭M) was not saturated even at relatively high Zn²⁺ concentrations In hippocampal slices, the authors measured synaptic release of Zn²⁺ in response to high-potassium-induced depolarization. ZnAF-2 showed similar levels of fluorescence increase in dentate gyrus (DG), CA3 and CA1, which were indistinguishable. However, ZnAF-3 showed a fluorescence increase only in DG. Thus, by using a combination of sensor mols., it was demonstrated for the first time that a higher Zn²⁺ concentration is released in DG than in CA3 or CA1 and that the authors can easily visualize Zn²⁺ concentration over a wide range. The authors believe that the use of various combinations of ZnAF family members will offer unprecedented versatility for fluorescence-microscopic imaging of Zn²⁺ in biol. applications. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Synthetic Route of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C7H9NO

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Alcohol – Wikipedia,
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Noncovalent ligand strands for transition-metal helicates: The straightforward and stereoselective self-assembly of dinuclear double-stranded helicates using hydrogen bonding was written by Telfer, Shane G.;Sato, Tomohiro;Kuroda, Reiko. And the article was included in Angewandte Chemie, International Edition in 2004.Recommanded Product: 1122-71-0 This article mentions the following:

A genuinely supramol. approach to transition-metal helicates is presented in which eight simple components (four ions and four small mols.) self-assemble to form dinuclear double helicates, where the ligand strands are built up through hydrogen-bonding interactions. The complexes [Co₂(L)₂(L-H)₂Cl₂] (L = 6-methylpyridin-2-ylmethanol, R-1-(6-methylpyridin-2-yl)ethanol and (6-methylpyridin-2-yl)nitromethanol) self-assembled and were characterized by x-ray crystallog. The self-assembly process is highly stereoselective. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 1122-71-0

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Alcohol – Wikipedia,
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