Category: 1117-86-8

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1117-86-8, name is 1,2-Octanediol, molecular formula is C8H18O2, molecular weight is 146.23, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: The reactions were performed in a 50 ml autoclave with a Teflon vessel inside equipped with magnetic stirring under 3.0 MPa CO2. After introducing DBU (60.8 mg, 0.4 mmol), propylene glycol (76.1 mg, 1 mmol), 2-methyl-3-butyn-2-ol (126.2 mg, 1.5 mmol), DMF (2 ml), the autoclave was sealed and filled with CO2 to keep thepressure of CO2 under 3.0 MPa. Then, the reaction mixture was stirred at 120 C for 10 h. When the reaction completed, the autoclave was cooled to ambient temperature and residual CO2 was carefully released. Subsequently, the mixture was flushed with DMF and analyzed by GC using biphenyl as an internal standard.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1117-86-8, 1,2-Octanediol, and friends who are interested can also refer to it.

Reference:
Article; Han, Li-Hua; Li, Jing-Yuan; Song, Qing-Wen; Zhang, Kan; Zhang, Qian-Xia; Sun, Xiao-Fang; Liu, Ping; Chinese Chemical Letters; vol. 31; 2; (2020); p. 341 – 344;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1117-86-8, name is 1,2-Octanediol, molecular formula is C8H18O2, molecular weight is 146.23, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: The reactions were performed in a 50 ml autoclave with a Teflon vessel inside equipped with magnetic stirring under 3.0 MPa CO2. After introducing DBU (60.8 mg, 0.4 mmol), propylene glycol (76.1 mg, 1 mmol), 2-methyl-3-butyn-2-ol (126.2 mg, 1.5 mmol), DMF (2 ml), the autoclave was sealed and filled with CO2 to keep thepressure of CO2 under 3.0 MPa. Then, the reaction mixture was stirred at 120 C for 10 h. When the reaction completed, the autoclave was cooled to ambient temperature and residual CO2 was carefully released. Subsequently, the mixture was flushed with DMF and analyzed by GC using biphenyl as an internal standard.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1117-86-8, 1,2-Octanediol, and friends who are interested can also refer to it.

Reference:
Article; Han, Li-Hua; Li, Jing-Yuan; Song, Qing-Wen; Zhang, Kan; Zhang, Qian-Xia; Sun, Xiao-Fang; Liu, Ping; Chinese Chemical Letters; vol. 31; 2; (2020); p. 341 – 344;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1117-86-8, name is 1,2-Octanediol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1,2-Octanediol

General procedure: 2.2.1. General protocol A. The acylation of 1,2-alkanediols withacid chloride1,2-Alkanediol was dissolved in pyridine on slight heating;petroleum ether (PE) was added and the mixture was shaken untilhomogenization. Acid chloride was added dropwise on efcientmagnetic stirring. The mixture was stirred at RT for 0.25-16 hdepending on the target compound. Reaction was monitored byTLC. Methanol (0.5 ml) was added to the mixture when excessof acid chloride was used and stirring was continued for addi-tional 10 min. The reaction mixture was diluted with ethyl acetate(EtOAc) and aqueous NaHCO3 (10%) was added. Following the neutralization the water layer was separated, and the organic layerwashed twice with brine, dried over anhydrous MgSO4, ltered,concentrated and puried by ash chromatography over silica gel.(NB 1,2-Alkanediol bisbutyrates were used in preparative-scalelipase-catalyzed cleavage without previous purication.) The tar-get products were gained in 91-96% yields.;

With the rapid development of chemical substances, we look forward to future research findings about 1117-86-8.

Reference:
Article; Parve, Jaan; Reile, Indrek; Aid, Tiina; Kudrja?ova, Marina; Mueuerisepp, Aleksander-Mati; Vallikivi, Imre; Villo, Ly; Aav, Riina; Pehk, Tonis; Vares, Lauri; Parve, Omar; Journal of Molecular Catalysis B: Enzymatic; vol. 116; (2015); p. 60 – 69;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts