Category: 111-90-0

Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-90-0, blongs to alcohols-buliding-blocks compound. Recommanded Product: Diethylene Glycol Monoethyl Ether

Example 89b; Sodium hydride (60% in oil, 40 mg) was added to a mixture of 2-chloro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidine-5-carbaldehyde (150 mg) obtained in Example 89a), 2-(2-ethoxyethoxy)ethanol (134 mg) and N,N-dimethylformamide (3 ml), and the resulting mixture was stirred for one hour at room temperature. Furthermore, 2-(2-ethoxyethoxy)ethanol (134 mg) and sodium hydride (60% in oil, 40 mg) were sequentially added thereto, and the resulting mixture was stirred for 15 hours at 100 C. The reaction mixture was returned to room temperature, and then the solvent was distilled off under reduced pressure. The residue was diluted with ethyl acetate, and the dilution was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by chromatography, and was recrystallized from a mixed solvent of ethyl acetate/hexane. Thus, the title compound (85 mg) was obtained as a white powder.1H NMR (300 MHz, CHLOROFORM-d) delta ppm 1.18 (3H, t, J=8.2 Hz), 3.36-3.52 (6H, m), 3.68 (2H, dd, J=5.7, 3.8 Hz), 4.40 (2H, q, J=8.2 Hz), 4.45-4.52 (2H, m), 6.33-6.41 (1H, m), 7.04(2H, d, J=9.1 Hz), 7.17-7.25 (3H, m), 9.51 (1H, br. s.).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; Suzuki, Hideo; Fujimoto, Takuya; Yamamoto, Takeshi; US2010/190747; (2010); A1;,
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111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 10 43 g (0.32 mole) of diethylene glycol monoethyl ether was added dropwise to a mixture consisting of 6 g (0.16 mole) of sodium borohydride, 25 ml of xylene and 10 g (0.097 mole) of benznitrile at 110 C. over two hours while agitating the mixture. Subsequently, the mixture was agitated at the same temperature for 16 hours. After cooling to room temperature, the mixture was neutralized with dilute sulfuric acid. As a result, benzylamine was obtained in 74% yield and the benzynitriles remained unreactive in the proportion of 25%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; Kao Corporation; US5196601; (1993); A;,
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111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

The 4,7-dichloroquinazoline used as a starting material was obtained as follows:- A mixture of 4-chloroanthranilic acid (17.2 g) and formamide (10 ml) was stirred and heated to 130C for 45 minutes and to 175C for 75 minutes. The mixture was allowed to cool to approximately 100C and 2-(2-ethoxyethoxy)ethanol (50 ml) was added. The solution so formed was poured into a mixture (250 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 7-chloroquinazolin-4-one (15.3 g, 85%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; ZENECA LIMITED; EP520722; (1992); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-90-0, name is Diethylene Glycol Monoethyl Ether. A new synthetic method of this compound is introduced below., 111-90-0

Diethylene glycol monoethyl ether (1 equiv.) and water (1 mL) were mixed together and stirred on ice before addition of NaOH (2.95 equiv.) and 0.4 M tetrabutylammonium hydroxide (aq) (0.05 equiv.). Once the mixture returned to 0C, epichlorohydrin (2.95 equiv.) was added portion-wise over 3 mm. The mixture was stirred at room temperature for 16 hours. H20 (15 mL) was added and the mixture was extracted with EtOAc (4x 30 mL). The combined extracts were washed with brine (30 mL) and dried over Na2SO4. The extracts were concentrated under reduced pressure. The residue was distilled under vacuum, providing a as a colorless liquid boiling at 110-117C (0.1 mmHg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE BORDEAUX; INSTITUT POLYTECHNIQUE DE BORDEAUX; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; LECOMMANDOUX, Sebastien, Jean, Marie; GARANGER, Elisabeth, Beatrice, Michele; DEMING, Timothy; (40 pag.)WO2017/21334; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-90-0, blongs to alcohols-buliding-blocks compound. 111-90-0

The 7-chloro-4-(3′-methylanilino)-6-nitroquinazoline used as a starting material was obtained as follows:- A mixture of 4-chloroanthranilic acid (17.2 g) and formamide (10 ml) was stirred and heated to 130C for 45 minutes and to 175C for 75 minutes. The mixture was allowed to cool to approximately 100C and 2-(2-ethoxyethoxy)ethanol (50 ml) was added. The solution so formed was poured into a mixture (250 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 7-chloroquinazolin-4-one (15.3 g, 85%).

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

Reference:
Patent; ZENECA LIMITED; EP635498; (1995); A1;,
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111-90-0 , The common heterocyclic compound, 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A. 3-(4-(2-(2-ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-3-yl)pyridine To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

The synthetic route of 111-90-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVO NORDISK A/S; EP384288; (1995); B1;,
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111-90-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 9; 2-rrriig.2,y)-2-r{r(3.R.3a1y.6ai;Vhexahvdrofuror2.3-61furan-3-yloxylcarbonvnamino)-l- { [Cl ,3-benzodioxol-5-ylsulfonylYisobutyl)amino1methyl| -3- (4-IY2-methyl- 1 ,3-thiazol- 4-yl)methoxylphenyl|propyDoxy1 -2-oxoethyl r2-f2-ethoxvethoxv)ethoxvl acetate; EPO Example 9, step 1; [2-(2-ethoxyethoxy)ethoxy] acetic acid; A mixture of tert-butyl chloroacetate (6.00 g, 40.0 mmol), 2-(ethoxyethoxy)ethanol (2.68 g, 20.0 mmol), 18-crown-6 (250 mg), and sodium hydroxide (12.0 g, 0.300 mol) in dioxane (60 mL) was stirred at room temperature for 24 hours. The dark mixture was diluted with water (250 mL) and twice extracted with ether (50 mL). The aqueous phase was acidified with 12N hydrochloric acid (35 mL) and extracted with dichloromethane (3 x 75 mL). The dichloromethane layers, after combining and concentrating under vacuum, were dried by dissolving in dichloromethane (50 ml) and concentrating under vacuum (3x) to afford [2-(2-ethoxyethoxy)ethoxy]acetic acid as a colorless oil (2.8 g, 73%). 1H NMR (400 MHz, DMSO-d6) delta 3.99 (s, 2H), 3.60-3.38 (m, 9H), 3.38 (q, 2H), 1.07 (t, 3H). ES-LCMS m/z 193 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-90-0, Diethylene Glycol Monoethyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/104646; (2006); A1;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 111-90-0 as follows., 111-90-0

A. 3-(4-(2-(2-ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-3-yl)pyridine To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

The chemical industry reduces the impact on the environment during synthesis 111-90-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Novo Nordisk A/S; US5041455; (1991); A;,
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111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

The 6-amino-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]-quinazoline used as a starting material was obtained as follows: A mixture of 4-chloroanthranilic acid (17.2 g) and formamide (10 ml) was stirred and heated to 130 C. for 45 minutes and to 175 C. for 75 minutes. The mixture was allowed to cool to approximately 100 C. and 2-(2-ethoxyethoxy)ethanol (50 ml) was added. The solution so formed was poured into a mixture (250 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 7-chloroquinazolin-4-one (15.3 g, 85%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; Zeneca Limited; US5821246; (1998); A;,
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111-90-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-90-0, name is Diethylene Glycol Monoethyl Ether, the common compound, a new synthetic route is introduced below.

General procedure: TMSOTf (336 mg, 1.51 mmol) is added to a solution of the alcohol (0.755 mmol) in the respective nitrile (3 mL) and the mixture is stirred at rt for 65 h. H2O (25 mL) and brine (25 mL) are added, and the mixture is extracted with EtOAc (3 ¡Á 30 mL). The combined organic layers are dried (Na2SO4) and concentrated. The crude product is purified by flash column chromatography (silica gel).

Statistics shows that 111-90-0 is playing an increasingly important role. we look forward to future research findings about Diethylene Glycol Monoethyl Ether.

Reference:
Article; Pfaff, Dominik; Nemecek, Gregor; Podlech, Joachim; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1572 – 1577;,
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