Category: 111-90-0

Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H14O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C6H14O3

[00150] Copper (I) iodide (FW 190.45, 0.90 grams, 4.72 mmol), 1,10-phenanthroline (FW 180.21, 0.83 grams, 4.62 mmol), cesium carbonate (FW 325.82, 19.00 grams, 58.30 mmol), 1 ,2-diiodobenzene (FW 329.90, 7.50 grams, 22.70 mol), di(ethylene glycol) ethyl ether (FW 134.17, 9.18 grams, 68.40 mol) and 100 milliliters of dry xylene were charged in a 350 milliliter three necked round bottom flask. The reaction mixture was heated with stirring at reflux temperature for 20 hours under nitrogen. The resulting suspension was cooled to room temperature by adding 50 milliliters of toluene. Then reaction mixture was filtered through celite and alumina. The low boiling (xylene and toluene) component was removed by a rotary evaporator and high boiling component di(ethylene glycol) ethyl ether by air bath oven at 200C under high vacuum for 2 hours. The residue was purified by flask chromatography on silica gel. The final dark yellow product yielded 7.00 grams (90%). The product I and C NMR analysis shows the formation of aryl ether product. IR: neat (cm” FontWeight=”Bold” FontSize=”10″ ): 745, 843, 931, 1052, 1 1 16, 1219, 1256, 1325, 1350, 1373, 1453, 1501, 1593, 2869, 2929, 2973. 1H NMR (CDC13): delta 6.76 (m, 4H, Ph), 4.02 (t, 4H, -OCH2-), 3.71 (m, 4H, -CH2O-) 3.57 (m, 4H, -OCH2), 3.45(m, 4H, -OCH2-), 3.37(t, 4H, -OCH2-), 1.06 (t, 6H, -CH3). 13C NMR (CDC13): 149.42, 121.61, 1 15.04, 70.89, 69.89, 69.76, 68.93, 66.59, 15.14.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Patent; EXXONMOBIL RESEARCH AND ENGINEERING COMPANY; PATIL, Abhimanyu, Onkar; BODIGE, Satish; WO2015/60985; (2015); A1;,
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Electric Literature of 111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

59-1) Synthesis of 2-(2-ethoxyethoxy)ethyl 4-methylbenzenesulfonate 432 mg (3.22 mmol) of 2-(2-ethoxyethoxy)ethanol was dissolved in 40 ml of dichloromethane, and 0.6 ml (4.19 mmol) of triethylamine and 614 mg (3.22 mmol) of p-toluenesulfonyl chloride were added thereto. The mixture was stirred at room temperature for 15 hours. After the solvent was removed under reduced pressure, 40 ml of water was added thereto. The mixture was extracted with 30 ml of ethyl acetate. The solvent was removed under reduced pressure to give 760 mg (2.64 mmol) of the title compound in a yield of 82%. 1H NMR (CDCl3, ppm): delta 1.20(3H, t), 2.35(3H, s), 3.35(2H, q), 3.52(2H, t), 3.57-3.60(4H, m), 4.08(2H, t), 7.33(2H, d), 7.78(2H, d) FAB MS(m/e)=289 [M+1]

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; Lee, Jin-Ho; Hong, Chang-Yong; Park, Tae-Sik; Kim, Jong-Hyun; Choi, Sei-Hyun; Yoon, Sook-Kyung; Chung, Hyun-Ho; Jeong, Shin-Wu; Hwang, Kwang-Yeon; Shin, Dong-Kyu; US2003/149034; (2003); A1;,
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Synthetic Route of 111-90-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A. 3-(3-(2-(2-Ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-4-yl)pyridine To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

According to the analysis of related databases, 111-90-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Muhlhauser; Mark A.; Shannon; Harlan E.; Thor; Karl B.; US5565475; (1996); A;,
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Related Products of 111-90-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-90-0, name is Diethylene Glycol Monoethyl Ether. A new synthetic method of this compound is introduced below.

In a round bottom flask NaH (3.9 g, 0.163 mol) was dispersed in 150 ml of anhydrous THF. Anhydrous di(ethylene glycol) ethyl ether (20 g, 0.149 mol) was dissolved in THF (50 ml) and added dropwise to the NaH suspension. The reaction mixture was stirred for 2 hours. The solution of ethyl 3-bromopropionate (17.5 ml, 0.140 mol) in THF (20 ml) was added to a pre-cooled reaction mixture (t=-10 C.). The reaction mixture was stirred overnight, and the solvent was evaporated completely. [00150] Ethylacetate was added to the residue and a mixture was washed with a solution of 10% NaCl and deionized water. The ethylacetate solution was dried over MgSO4, filtered, and the solvent was evaporated. The residue was dried using a vacuum pump. The crude material was chromatographed on a silica gel column. Fractions containing the Compound III were collected, concentrated and characterized by TLC, HPLC, MS and NMR.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; Nobex Corporation; US6713454; (2004); B1;,
Alcohol – Wikipedia,
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Reference of 111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of DCM, diethylene glycol mono ethyl ether (21.0 ml_, 150 mmol), and triethylamine (34.7 ml_, 250 mmol) under a nitrogen atmosphere at -78 0C was added dropwise bromo acetyl bromide (17.2 ml_, 200 mmol). After stirring at -78 0C for 3 h, the reaction mixture was allowed to warm up to -20 0C and quenched by addition of water (50 ml_). The organic phase was washed with distilled water (3 x 50 ml_), saturated ammonium chloride (3 x 50 ml_), saturated sodium bicarbonate (3 x 50 ml_) and brine (2 x 50 ml_). The organic phase was then dried over magnesium sulfate, filtered and solvents removed via rotary evaporation to yield a crude product in 87 % yield. This crude product was distilled (bp 105 – 115 0C) to give a colourless liquid at RT in 71 % yield.

According to the analysis of related databases, 111-90-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DUBLIN CITY UNIVERSITY; WO2009/24607; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of DCM, diethylene glycol mono ethyl ether (21.0 ml_, 150 mmol), and triethylamine (34.7 ml_, 250 mmol) under a nitrogen atmosphere at -78 0C was added dropwise bromo acetyl bromide (17.2 ml_, 200 mmol). After stirring at -78 0C for 3 h, the reaction mixture was allowed to warm up to -20 0C and quenched by addition of water (50 ml_). The organic phase was washed with distilled water (3 x 50 ml_), saturated ammonium chloride (3 x 50 ml_), saturated sodium bicarbonate (3 x 50 ml_) and brine (2 x 50 ml_). The organic phase was then dried over magnesium sulfate, filtered and solvents removed via rotary evaporation to yield a crude product in 87 % yield. This crude product was distilled (bp 105 – 115 0C) to give a colourless liquid at RT in 71 % yield.

According to the analysis of related databases, 111-90-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DUBLIN CITY UNIVERSITY; WO2009/24607; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 111-90-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-90-0, name is Diethylene Glycol Monoethyl Ether. A new synthetic method of this compound is introduced below.

In a round bottom flask NaH (3.9 g, 0.163 mol) was dispersed in 150 ml of anhydrous THF. Anhydrous di(ethylene glycol) ethyl ether (20 g, 0.149 mol) was dissolved in THF (50 ml) and added dropwise to the NaH suspension. The reaction mixture was stirred for 2 hours. The solution of ethyl 3-bromopropionate (17.5 ml, 0.140 mol) in THF (20 ml) was added to a pre-cooled reaction mixture (t=-10 C.). The reaction mixture was stirred overnight, and the solvent was evaporated completely. [00150] Ethylacetate was added to the residue and a mixture was washed with a solution of 10% NaCl and deionized water. The ethylacetate solution was dried over MgSO4, filtered, and the solvent was evaporated. The residue was dried using a vacuum pump. The crude material was chromatographed on a silica gel column. Fractions containing the Compound III were collected, concentrated and characterized by TLC, HPLC, MS and NMR.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; Nobex Corporation; US6713454; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows. Safety of Diethylene Glycol Monoethyl Ether

EXAMPLE 14 10.7 g (0.08 mole) of ethyl carbitol was added dropwise to a mixture consisting of 1.5 g (0.04 mole) of sodium borohydride and 15 ml of xylene at 120 C. for 1.5 hours. The mixture was agitated at 120 C. for one hour. A mixture consisting of 3 g (0.02 mole) of N,N-dimethyl benzamide and 10 ml of xylene was added dropwise to the mixture over 0.5 hours. Subsequently, the resulting mixture was agitated at 120 C. for 20 hours. After cooling to room temperature, the mixture was neutralized with dilute sulfuric acid. As a result, N,N-dimethylbenzylamine was obtained in 51% yield and benzyl alcohol in 47% yield, respectively.

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

Reference:
Patent; Kao Corporation; US5196601; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 111-90-0, blongs to alcohols-buliding-blocks compound. SDS of cas: 111-90-0

To a solution of 3 (0.5 g, 1.78 mmol), DMAP (0.22 g, 1.78 mmol), and diethylene glycol monoethyl ether (0.24 g, 1.78 mmol) in dichloromethane (15 mL) was added portionwise EDCI (0.34 g, 1.78 mmol) at room temperature. After stirring for 2 hrs, the product was extracted with ether (45 mL). The ether solution was washed with water (50 mL), a solution of 1N HCl (10 mL), and water (40 mL), dried over MgSO4, and concentrated. The residue was purified with silica gel column chromatography eluting with ethyl acetate to give compound 8 (0.18 g) as an oil in 25% yield. 1H NMR delta (CDCl3) 1.21 (3H, t, J = 6.9 Hz), 1.75 (6H, brs) 1.84 (2H, quint, J = 6.9 Hz), 1.95 (6H, brs), 2.05 (3H, brs), 2.38 (2H, t, J = 6.9 Hz), 3.18 (2H, q, J = 6.9 Hz), 3.53 (2H, q, , J = 6.9 Hz), 3.61 (2H, t, J = 6.9 Hz), 3.67 (2H, t, J = 6.9 Hz), 3.74 (2H, t, J = 6.9 Hz), 4.25 (2H, t, J = 6.9 Hz), 4.47 (1H, s), 4.62 (1H, s). LC-MS (ESI) m/z calcd for C21H36N2O5 [M + H]+ 397.26, found [M + H]+ 397.32.

The synthetic route of 111-90-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kim, In-Hae; Nishi, Kosuke; Kasagami, Takeo; Morisseau, Christophe; Liu, Jun-Yan; Tsai, Hsing-Ju; Hammock, Bruce D.; Bioorganic and medicinal chemistry letters; vol. 22; 18; (2012); p. 5889 – 5892,4;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.COA of Formula: C6H14O3

A. Preparation of 1-Allyloxy-2-(2′-ethoxyethoxy) ethanol (4A) All procedures were the same as for preparation of 1A except that diethylene glycol monoethyl ether (39.0 mL, 0.288 mmoles) was used. After filtering the sodium bromide precipitate and concentrating the filtrate, the product was chromatographed on silica gel (eluents: toluene, 15% ethyl acetate in toluene, then 50% ethyl acetate in toluene) and then purified by fractional distillation to produce an 80% yield of colorless liquid, b.p. 78-79 C. at 0.2 torr. 1 H NMR:delta1.02 (t, J=7.0 Hz, –O–C–CH3); 3.28 (q, J=6.5 Hz, –O–CH2 C); 3.30 [m, W1/2 =4 Hz (CH2 CH2 O)2 ]; 3.77 (d, J=5.0 Hz, CH2 allyloxy); 4.69-5.22 (m, CH2 vinyl); 5.29-6.02 (m, CH vinyl).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Patent; Northeastern University; US4778909; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts