Category: 111-87-5

Neelakandan, Poovarasan published the artcileVolatile 1-octanol of tea (Camellia sinensis L.) fuels cell division and indole-3-acetic acid production in phylloplane isolate Pseudomonas sp. NEEL19, SDS of cas: 111-87-5, the main research area is Camellia sinensis Pseudomonas octanol indole acetic acid production; phylloplane fuel cell division production.

Tea leaves possess numerous volatile organic compounds (VOC) that contribute to tea’s characteristic aroma. Some components of tea VOC were known to exhibit antimicrobial activity; however, their impact on bacteria remains elusive. Here, we showed that the VOC of fresh aqueous tea leaf extract, recovered through hydrodistillation, promoted cell division and tryptophan-dependent indole-3-acetic acid (IAA) production in Pseudomonas sp. NEEL19, a solvent-tolerant isolate of the tea phylloplane. 1-octanol was identified as one of the responsible volatiles stimulating cell division, metabolic change, swimming motility, putative pili/nanowire formation and IAA production, through gas chromatog.-mass spectrometry, microscopy and partition petri dish culture anal. The bacterial metabolic responses including IAA production increased under 1-octanol vapor in a dose-dependent manner, whereas direct-contact in liquid culture failed to elicit such response. Thus, volatile 1-octanol emitting from tea leaves is a potential modulator of cell division, colonization and phytohormone production in NEEL19, possibly influencing the tea aroma.

Scientific Reports published new progress about Alkalinization. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Pratima published the artcileDauer formation in C. elegans is modulated through AWC and ASI-dependent chemosensation, Recommanded Product: n-Octanol, the main research area is Caenorhabditis EXP1 DAF7 STR2 olfaction neuron chemotaxis TGFbeta plasticity; ASI neuron; C. elegans; EXP-1; STR-2; chemotaxis; dauer.

The perception of our surrounding environment is an amalgamation of stimuli detected by sensory neurons. In Caenorhabditis elegans, olfaction is an essential behavior that determines various behavioral functions such as locomotion, feeding and development. Sensory olfactory cues also initiate downstream neuroendocrine signaling that controls aging, learning, development and reproduction Innate sensory preferences toward odors (food, pathogens) and reproductive pheromones are modulated by 11 pairs of amphid chemosensory neurons in the head region of C. elegans Amongst these sensory neurons, the ASI neuron has neuroendocrine functions and secretes neuropeptides, insulin-like peptide (DAF-28) and the TGF-β protein, DAF-7. Its expression levels are modulated by the presence of food (increased levels) and population d. (decreased levels). A recent study has shown that EXP-1, an excitatory GABA receptor regulates DAF-7/TGF-β levels and participates in DAF-7/TGF-β-mediated behaviors such as aggregation and bordering. Here, we show that exp-1 mutants show defective responses toward AWC-sensed attractive odors in a non-autonomous manner through ASI neurons. Our dauer experiments reveal that in daf-7 mutants, ASI expressed EXP-1 and STR-2 (a G-protein-coupled receptor; GPCR) that partially maintained reproductive growth of animals. Further, studies suggest that neuronal connections between ASI and AWC neurons are allowed at least partially through ASI secreted DAF-7 or through alternate TGF- β pathway/s regulated by EXP-1 and STR-2. Together, our behavioral, genetic and imaging experiments propose that EXP-1 and STR-2 integrate food cues and allow the animals to display DAF-7/TGF-β neuroendocrine dependent or independent behavioral responses contributing to chemosensensory and developmental plasticity.

eNeuro published new progress about Caenorhabditis elegans. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caterino, Marco published the artcileSelective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter, Computed Properties of 111-87-5, the main research area is cervical cancer KRAS porphyrin G quadruplex photosensitizer photodynamic therapy; Biophysics; Chlorins; G-quadruplex; Ligands; Photodynamic activity; Singlet oxygen generation.

The G-quadruplex-forming sequence within the KRAS proto-oncogene P1 promoter is a promising target for anticancer therapy. Porphyrin derivatives are among the most rewarding G-quadruplex binders. They can also behave as photosensitizers. Three water-soluble, pos. charged porphyrin-like compounds were synthesized and tested for their interaction with the KRAS G-quadruplex by CD, fluorescence, and mol. docking calculations For a comparison of ligands binding affinity and selectivity, TMPyP4 was taken as a reference One out of the three tested compounds proved biol. activity and selectivity for G-quadruplex over duplex DNA. It also showed to discriminate between different G-quadruplex topologies, with a preference for the parallel over antiparallel conformation. Mol. docking studies suggested a preferential binding to the 3′-end of the KRAS G-quadruplex driven through π-π stacking interactions. Biol. assays also revealed a good photodynamic-induced cytotoxicity on HeLa cells. The reported results show that these porphyrin-like compounds could actually give the basis for the development of G-quadruplex ligands with effective photodynamic-induced cytotoxicity on cancer cells. The possibility of obtaining photosensitizers with improved physico-chem. features and able to selectively target G-quadruplexes is a very interesting perspective to develop new therapeutic agents.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Kai published the artcileUncovering abnormal changes in logP after fluorination using molecular dynamics simulations, Recommanded Product: n-Octanol, the main research area is mol dynamics simulations; Fluorination; Molecular dynamics; Solvation free energy calculation; logP.

The fluorination-induced changes in the logP (1-octanol/water partition coefficient) of ligands were examined by mol. dynamics simulations. The protocol and force field parameters were first evaluated by calculating the logP values for n-alkanes, and their monofluorinated and monochlorinated analogs. Then, the logP values of several test sets (1-butanol, 3-propyl-1H-indole, and analogs fluorinated at the terminal Me group) were calculated The calculated results agree well with experiment, and the root mean square error values are 0.61 and 0.68 log units for the GAFF and GAFF2 force fields, resp. Finally, the logP estimation was extended to a drug mol., TAK-438, for which fluorination-induced abnormal logP reduction has been observed exptl. This abnormal change was qual. reproduced by the mol. dynamics simulations. We found that the abnormal logP reduction can be mainly attributed to the effect of fluorination-induced dipole change. Our results suggest that mol. simulation is a useful strategy to predict the fluorination-induced change in logP for drug discovery applications.

Journal of Computer-Aided Molecular Design published new progress about Dipole. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

John, Gerald F. published the artcileEnhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions, SDS of cas: 111-87-5, the main research area is water oil emulsion stability dispersant.

Oil impacting the northern Gulf of Mexico shoreline from the 2010 Deepwater Horizon accident was predominantly in the form of water-in-oil emulsions (WOE), a chem. weathered, highly viscous, neutrally buoyant material. Once formed, WOE are extremely difficult to destabilize. Com.-available oil dispersants are largely ineffective de-emulsifiers as a result of the inability of dispersant surfactants to displace asphaltenes stabilizing the oil-water interface. This study investigated the effectiveness of the com.-available dispersant Corexit 9500A, modified to enhance its polar fraction, in destabilizing WOE. Results suggest that Corexit modified to include between 20-60% fractional amount of either polar additive (1-octanol or hexylamine) will produce a modest increase in WOE instability, with a Corexit to hexylamine ratio of approx. 80/20 providing the most effective enhanced destabilization. Results support the hypothesis that modifying the fraction of polar constituents in com. dispersants will increase asphaltene solubility, decrease oil-water interface stability, and enhance WOE instability.

PLoS One published new progress about Coalescence. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jukic, Ivo published the artcileUniversal features in the lifetime distribution of clusters in hydrogen-bonding liquids, Related Products of alcohols-buliding-blocks, the main research area is universal lifetime distribution hierarchy cluster liquid hydrogen bond.

Hydrogen-bonding liquids, typically water and alcs., are known to form labile structures (network, chains, etc.); hence, the lifetime of these structures is an important microscopic parameter, which can be calculated via computer simulations. Since these cluster entities are mostly statistical in nature, one would expect that, in the short-timescale regime, their lifetime distribution would be a broad Gaussian-like function of time, with a single maximum representing their mean lifetime, and be weakly dependent on criteria such as the bonding distance and angle, much similar to non-hydrogen-bonding simple liquids, while the long-timescale regime is known to have some power law dependence. Unexpectedly, all the hydrogen-bonding liquids studied herein, namely water and alcs., display three highly hierarchical specific lifetimes, in the sub-picosecond range 0-0.5 ps. The dominant lifetime depends very strongly on the bonding-distance criterion and is related to hydrogen-bonded pairs. This mode is absent in non-H-bonding simple liquids The secondary and tertiary mean lifetimes are related to clusters and are nearly independent of the bonding criterion. Of these two lifetimes, only the first one can be related to that of simple liquids, which poses the question of the nature of the third lifetime. The study of alcs. reveals that this third lifetime is related to the topol. of the H-bonded clusters and that its distribution may also be affected by the alkyl tail surrounding the “”bath””. This study shows that hydrogen-bonding liquids have a universal hierarchy of hydrogen-bonding lifetimes with a timescale regularity across very different types, and which depend on the topol. of the cluster structures.

Physical Chemistry Chemical Physics published new progress about Aliphatic alcohols, C1-8 Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Hwa-Jin published the artcileMechanism for Transition of Reverse Cylindrical Micelles to Spherical Micelles Induced by Diverse Alcohols, HPLC of Formula: 111-87-5, the main research area is reverse micelle lecithin calcium chloride propanol pentanol hexanol octanol.

Herein, the effects of various alcs. on lecithin/CaCl2 organogels are investigated. Mixtures of lecithin and CaCl2 form reverse cylindrical micelles, resulting in optically transparent organogels. The addition of various alcs. to a mixture of lecithin and CaCl2 induces a decrease in viscosity through which reverse cylindrical micelles are transformed into spherical micelles (or short cylindrical micelles). Long-hydrocarbon-chain alcs. decrease the viscosity of lecithin/CaCl2 mixtures more efficiently. Hydrogen bonding and hydrocarbon chain interactions between lecithin and alc. play important roles in the morphol. transition. More importantly, isothermal titration calorimetry was conducted to obtain thermodn. variables such as the enthalpy, equilibrium constant, Gibbs free energy, entropy, and stoichiometry of the associated mols. observed in the transition. It was found that the transition is an entropically driven process, in which the endothermic and exothermic behaviors were observed depending on the hydrocarbon chain length in the alc. In addition, the enthalpy for the association of the alc. with lecithin showed a linear relationship depending on the hydrocarbon chain length, in which the magnitude of hydrogen bonding and hydrocarbon chain interactions was obtained quant. To the best of our knowledge, this is the first study reporting the thermodn. properties of the morphol. transition observed in a reverse self-assembly process.

Langmuir published new progress about Enthalpy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kikuchi-Taura, Akie published the artcileGap junction-mediated cell-cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke, HPLC of Formula: 111-87-5, the main research area is cell gap junction communication stemcell transplantation vascular endothelium stroke; COVID-19; cell therapy; gap junction; immunosuppression; mesenchymal stem cell.

We have shown previously that transplanted bone marrow mononuclear cells (BM-MNC), which are a cell fraction rich in hematopoietic stem cells, can activate cerebral endothelial cells via gap junction-mediated cell-cell interaction. In the present study, we investigated such cell-cell interaction between mesenchymal stem cells (MSC) and cerebral endothelial cells. In contrast to BM-MNC, for MSC we observed suppression of vascular endothelial growth factor uptake into endothelial cells and transfer of glucose from endothelial cells to MSC in vitro. The transfer of such a small mol. from MSC to vascular endothelium was subsequently confirmed in vivo and was followed by suppressed activation of macrophage/microglia in stroke mice. The suppressive effect was absent by blockade of gap junction at MSC. Furthermore, gap junction-mediated cell-cell interaction was observed between circulating white blood cells and MSC. Our findings indicate that gap junction-mediated cell-cell interaction is one of the major pathways for MSC-mediated suppression of inflammation in the brain following stroke and provides a novel strategy to maintain the blood-brain barrier in injured brain. Furthermore, our current results have the potential to provide a novel insight for other ongoing clin. trials that make use of MSC transplantation aiming to suppress excess inflammation, as well as other diseases such as COVID-19 (coronavirus disease 2019).

Stem Cells (Durham, NC, United States) published new progress about Adhesion G protein-coupled receptor E1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bolle, Jennifer published the artcileIsomeric effects in structure formation and dielectric dynamics of different octanols, Related Products of alcohols-buliding-blocks, the main research area is octanol cluster aggregate hydrogen bond supramol structure.

The understanding of the microstructure of associated liquids promoted by hydrogen-bonding and constrained by steric hindrance is highly relevant in chem., physics, biol. and for many aspects of daily life. In this study we use a combination of X-ray diffraction, dielec. spectroscopy and mol. dynamics simulations to reveal temperature induced changes in the microstructure of different octanol isomers, i.e., linear 1-octanol and branched 2-, 3- and 4-octanol. In all octanols, the hydroxyl groups form the basis of chain-, cyclic- or loop-like bonded structures that are separated by outwardly directed alkyl chains. This clustering is analyzed through the scattering pre-peaks observed from X-ray scattering and simulations. The charge ordering which pilots OH aggregation can be linked to the strength of the Debye process observed in dielec. spectroscopy. Interestingly, all methods used here converge to the same interpretation: as one moves from 1-octanol to the branched octanols, the cluster structure evolves from loose large aggregates to a larger number of smaller, tighter aggregates. All alcs. exhibit a peculiar temperature dependence of both the pre-peak and Debye process, which can be understood as a change in microstructure promoted by chain association with increased chain length possibly assisted by ring-opening effects. All these results tend to support the intuitive picture of the entropic constraint provided by branching through the alkyl tails and highlight its capital entropic role in supramol. assembly.

Physical Chemistry Chemical Physics published new progress about Clusters. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khedri, Zohrab published the artcileThermodynamic Properties of 1-Hexyl-3-methylimidazolium Nitrate and 1-Alkanols Mixtures: PC-SAFT Model, Category: alcohols-buliding-blocks, the main research area is thermodn property PCSAFT hexylmethylimidazolium nitrate binary mixture alkanol.

To study the type, nature, and amount of interactions in binary systems including 1-hexyl-3-methylimidazolium nitrate ([Hmim][NO3]) ionic liquid and a homologous series of 1-alkanols (1-hexanol up to 1-decanol), some thermophys. properties via d. and viscosity measurements were calculated at temperatures of 293.15-323.15 K. Also, to study the behavior of systems with temperature, values of the thermal expansion coefficient, α, excess thermal expansion coefficient, αE, isothermal coefficient of excess molar enthalpy, (∂HEm/∂P)T,x, and partial molar volume, V̅i, for five binary mixtures at various temperatures were calculated Findings demonstrate that strong interactions between the mixture components occur and intermol. forces become weaker with the increase in the length of the alc. chain and temperature For a theor. study of mentioned mixtures, perturbed-chain statistical associating fluid theory was implemented. The d. and partial molar volume of mixtures were correlated and predicted by this theory, and the results show that outcomes are fairly consistent with the exptl. data.

Journal of Chemical & Engineering Data published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts