Category: 111-87-5

Albu, Paul Constantin published the artcilepH and Design on n-Alkyl Alcohol Bulk Liquid Membranes for Improving Phenol Derivative Transport and Separation, Safety of n-Octanol, the main research area is alkyl alc bulk liquid membrane transport separation; bulk liquid membranes; liquid membrane design; n–decanol membranes; n–octanol membranes; pH operational parameter; permeation module design; phenol derivative separation; phenol derivative transports.

Regardless of the type of liquid membrane (LM) (Bulk Liquid Membranes (BLM), Supported Liquid Membranes (SLM) or Emulsion Liquid Membranes (ELM)), transport and separation of chem. species are conditioned by the operational (OP) and constructive design parameters (DP) of the permeation module. In the present study, the pH of the aqueous source phase (SP) and receiving phase (RP) of the proposed membrane system were selected as operational parameters. The mode of contacting the phases was chosen as the convective transport generator. The experiments used BLM-type membranes with spheres in free rotation as film contact elements of the aqueous phases with the membrane. The target chem. species were selected in the range of phenol derivatives (PD), 4-nitrophenol (NP), 2,4-dichlorophenol (DCP) and 2,4-dinitrophenol (DNP), all being substances of tech.-economic and environmental interest. Due to their acid character, they allow the evaluation of the influence of pH as a determining operational parameter of transport and separation through a membrane consisting of n-octanol or n-decanol (n-AlcM). The comparative study performed for the transport of 4-nitrophenol (NP) showed that the module based on spheres (Ms) was more performant than the one with phase dispersion under the form of droplets (Md). The sphere material influenced the transport of 4-nitrophenol (NP). The transport module with glass spheres (Gl) was superior to the one using copper spheres (Cu), but especially with the one with steel spheres (St). In all the studied cases, the sphere-based module (Ms) had superior transport results compared to the module with droplets (Md). The extraction efficiency (EE) and the transport of 2,4-dichlorophenol (DCP) and 2,4-dinitrophenol (DNP), studied in the module with glass spheres, showed that the two phenolic derivatives could be separated by adjusting the pH of the source phase. At the acidic pH of the source phase (pH = 2), the two derivatives were extracted with good results (EE > 90%), while for pH values ranging from 4 to 6, they could be separated, with DCP having doubled separation efficiency compared to DNP. At a pH of 8 in the source phase, the extraction efficiency halved for both phenolic compounds

Membranes (Basel, Switzerland) published new progress about Contact angle. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Viola, Arnaud published the artcileOn the importance of the crystalline surface structure on the catalytic activity and stability of tailored unsupported cobalt nanoparticles for the solvent-free acceptor-less alcohol dehydrogenation, Application of n-Octanol, the main research area is surface structure dehydrogenation catalysts cobalt nanoparticle; Acceptorless dehydrogenation of alcohols; Cobalt; Molecular hydrogen; Nanoparticles; PM-IRRAS.

Unsupported nanoparticles are now recognized as model catalysts to evaluate the intrinsic activity of metal particles, irresp. of that of the support. Co nanoparticles with different morphologies, rods, diabolos and cubes have been prepared by the polyol process and tested for the acceptorless catalytic dehydrogenation of alcs. under solvent-free conditions. Rods crystallize with the pure hcp. structure, diabolos with a mixture of hcp. and fcc. phases, while the cubes crystallize in a complex mixture of hcp., fcc. and ε-Co phases. All the cobalt particles are found to be highly selective towards the oxidation of a model secondary alc., octan-2-ol, into the corresponding ketone while no significant activity is found with octan-1-ol. Our results show the strong influence of particle shape on the activity and catalytic stability of the catalysts: Co nanorods display the highest conversion (85%), selectivity (95%) and recyclability compared to Co diabolos and Co cubes. We correlate the nanorods excellent stability with a strong binding of carboxylate ligands on their {1 1 2̅ 0} facets, preserving their crystalline superficial structure, as evidenced by phase modulation IR reflection absorption spectroscopy.

Journal of Colloid and Interface Science published new progress about Crystallinity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Weixiao published the artcileEffective Control of Particle Size and Electron Density of Pd/C and Sn-Pd/C Nanocatalysts for Vanillin Production via Base-Free Oxidation, Formula: C8H18O, the main research area is nanocatalyst palladium carbon tin vanillyl alc oxidation vanillin preparation.

The effective control of particle size and electron d. of metal active sites is challenging yet important for supported nanoparticles, as size effects and promoter effects play vital roles in heterogeneous catalysis on the nanoscale. In this work, we report Pd/C and Sn-Pd/C nanocatalysts for the base-free aerobic oxidation of vanillyl alc. to vanillin, a challenging reaction not only in the fundamental research of selective oxidation of alcs. but also for the practical transformation of bio-based alcs. to value-added chems. We effectively tuned the mean size of Pd nanoparticles from 1.8 to 6.7 nm by varying the temperature used for catalyst preparation and further modified the electron d. of the Pd/C catalyst by adding a SnO2 promoter with different loadings. TEM, HAADF-STEM, XPS, CO chemisorption, and in situ DRIFT-IR of CO adsorption characterizations allowed us to get insight into the unique catalytic properties of Pd nanocatalysts. It was conjectured that the base-free aerobic oxidation of vanillyl alc. to vanillin over the Pd/C catalyst can be a structure-sensitive reaction and the Pd particle size was decisive for the dispersion of Pd, the proportion of catalytically active Pd0 sites, and the intrinsic turnover frequency (iTOF). The 1 weight % Pd/C (1.8 nm) catalyst showed an iTOF value of 268 h-1 and 100% yield to vanillin at 120°C, 5 bar of O2, and 20 mg of the catalyst within 9 h. We further demonstrated that Sn4+ ions in SnO2 as an electronic promoter can promote Pd/C activity by the formation of highly active, electron-sufficient Pd0 sites which significantly lowered the apparent activation energy of reaction. The 0.1Sn-Pd/C catalyst showed a higher iTOF value of 458 h-1 and a yield of 100% to vanillin at 120°C, 3 bar of O2 and 15 mg of the catalyst within 6 h. Moreover, we verified a satisfying reusability and an adequate substrate scope over the 0.1Sn-Pd/C catalyst.

ACS Catalysis published new progress about Electron density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Roulet, Julia published the artcileModification of PapA5 acyltransferase substrate selectivity for optimization of short-chain alcohol-derived multimethyl-branched ester production in Escherichia coli, COA of Formula: C8H18O, the main research area is acyltransferase Mycobacterium tuberculosis Escherichia coli; Acyltransferase; Mutant variants; Polyketide-associated protein; Substrate selectivity.

Abstract: Plant waxes are interesting substitutes of fossil-derived compounds; however, their limited sources and narrow structural diversity prompted the development of microbial platforms to produce esters with novel chem. structures and properties. One successful strategy was the heterologous expression of the mycocerosic polyketide synthase-based biosynthetic pathway (MAS-PKS, PapA5 and FadD28 enzymes) from Mycobacterium tuberculosis in Escherichia coli. This recombinant strain has the ability to produce a broad spectrum of multimethyl-branched long-chain esters (MBE) with novel chem. structures and high oxidation stability. However, one limitation of this microbial platform was the low yields obtained for MBE derived of short-chain alcs. In an attempt to improve the titers of the short-chain alc.-derived MBE, we focused on the PapA5 acyltransferase-enzyme that catalyzes the ester formation reaction. Specific amino acid residues located in the two-substrate recognition channels of this enzyme were identified, rationally mutated, and the corresponding mutants characterized both in vivo and in vitro. The phenylalanine located at 331 position in PapA5 (F331) was found to be a key residue that when substituted by other bulky and aromatic or bulky and polar amino acid residues (F331W, F331Y or F331H), gave rise to PapA5 mutants with improved bioconversion efficiency; showing in average, 2.5 higher yields of short-chain alc.-derived MBE compared with the wild-type enzyme. Furthermore, two alternative pathways for synthesizing ethanol were engineered into the MBE producer microorganism, allowing de novo production of ethanol-derived MBE at levels comparable with those obtained by the external supply of this alc. Key points: • Mutation in channel 2 changes PapA5 acyltransferase bioconversion efficiency. • Improved production of short-chain alc. derived multimethyl-branched esters. • Establishing ethanologenic pathways for de novo production of ethanol derived MBE. • Characterization of a novel phenylethanol-derived MBE.

Applied Microbiology and Biotechnology published new progress about Escherichia coli. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sprakel, Lisette M. J. published the artcileImproving understanding of solvent effects on intermolecular interactions in reactive liquid-liquid extraction with Isothermal Titration Calorimetry and molecular modeling, Category: alcohols-buliding-blocks, the main research area is trioctylamine acetic acid solvent effect intermol interaction liquid extraction.

Isothermal Titration Calorimetry (ITC) and mol. modeling (MM) were combined with liquid-liquid equilibrium data to obtain better understanding of solvent effects on complexation in reactive liquid-liquid extraction Two examples with ample extraction literature available were studied, acetic acid extraction and phenol extraction Interactions with binary solvents were studied. Based on the insight and quantification of complexation with MM and ITC, models describing the liquid-liquid equilibrium (LLE) were formulated and validated with experiments, showing that ITC can predict LLE. ITC together with MM indeed can yield addnl. insight in complexation behavior in reactive liquid-liquid extraction and may guide solvent selection procedures.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Binary solutions. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gray, Geoffrey M. published the artcileSecondary structure of peptides mimicking the Gly-rich regions of major ampullate spidroin protein 1 and 2, Synthetic Route of 111-87-5, the main research area is spider silk dope secondary structure helix simulation; 3(1)-helices; Dope; Secondary structure; Simulation; Spider silk.

Spider dragline silk has highly desirable material properties, possessing high extensibility, strength, and biocompatibility. Before it is spun, the constituent proteins are stored in a concentrated dope that is void of fibrils. To investigate the structural properties of the amorphous fiber regions in the dope, computer simulations were performed on model peptides representing the N. clavipes Gly-rich regions. Anal. of the secondary structure found predominantly turns, bends and coils; a small 31-helical population decreased with increasing concentration Interestingly, the population of 31-helixes saw a large increase in octanol. These results indicate that the unusual 31-helical secondary structure of the Gly-rich region of the fiber is a consequence of the spinning process, and that the low dielec. environment of the fiber may assist in favoring this structure.

Biophysical Chemistry published new progress about Biocompatibility. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vieira, Nicole S. M. published the artcileHuman cytotoxicity and octanol/water partition coefficients of fluorinated ionic liquids, Name: n-Octanol, the main research area is fluorinated ionic liquid cytotoxicity octanol water partition coefficient; 1-Octanol/water partition coefficient; Cytotoxicity; Fluorinated ionic liquids; Hydrophilic/lipophilic balance.

The use of fluorinated ionic liquids (FILs) as novel materials in biol. and pharmaceutical applications is an emerging research field. The knowledge of their cytotoxicity and that of 1-octanol/water partition coefficients are essential to assess their environmental risks, to estimate their toxicity and activity, or the hydrophilic/lipophilic balance, as well as to explore their properties as solvents in extraction processes or for successful drug design. The study of the cytotoxicity in four different human cell lines and the exptl. measurement of the partition coefficient between 1-octanol and water (Po/w), using the slow-stirring method, were carried out for several FILs. In both studies, the effect of the cation ([C2C1Im]+, [C2C1py]+, [C4C1pyr]+, [N1112(OH)]+, or [N4444]+), the cationic alkyl side-chain length ([CnC1Im]+, with n = 2, 6, 8 or 12), and the anionic fluorinated chain length/anionic fluorinated domain size ([C4F9SO3] ̅, [C8F17SO3] ̅, or [N(C4F9SO3)2] ̅) were analyzed. The results reveal that both toxicity and partition properties are mainly influenced by the size of the cationic hydrogenated alkyl side-chain and that of the anionic fluorinated domain. The intrinsic tuneability of the FILs allows for their selection according to the lipophilic or hydrophilic character of the target biol. system under consideration. The toxicity studies corroborate the biocompatible nature of some FILs tested in this work. Along, for all the FILs under study Po/w < 1.00. Accordingly, a decadic logarithm of the bioconcentration factor in fish of 0.5 would be estimated, which is below the regulatory endpoint used by regulatory agencies. Chemosphere published new progress about Biocompatibility. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hamdi, Assia published the artcileCytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4 #, SDS of cas: 111-87-5, the main research area is Haplophyllum tuberculatum essential oil cytotoxicity antiviral coxsackievirus.

Haplophyllum tuberculatumis a plant commonly used in folk medicine to treat several diseases including vomiting, nausea, infections, rheumatism, and gastric pains. In the current study, H. tuberculatumessential oils, hydrosols, the pure compounds R-(+)-limonene, S-(-)-limonene, and 1-octanol, as well as their combinations R-(+)-limonene/1-octanol and S-(-)-limonene/1-octanol, were screened for their cytotoxicity on HEp-2 cells after 24, 48, and 72 h, and then tested for their activity against Coxsackievirus B3 and B4 (CV-B3 and CV-B4) at 3 different moments: addition of the plant compounds before, after, or together with virus inoculation. Results showed that the samples were more cytotoxic after 72 h than after 24 h or 48 h cell contact. However, the combinations R-(+)-limonene/1-octanol and S-(-)-limonene/1-octanol showed less effect on HEp-2 cells than pure R-(+)-limonene and S-(-)-limonene after 24 h, 48 h, and 72 h. 1-octanol exhibited the highest concentration causing 50% cytotoxicity (CC50) on HEp-2 cells after 24 h (CC50 = 93 μg/mL) and 48 h (CC50 = 83 μg/mL). The antiviral assays showed that the tested samples exhibited potent inhibition of CV-B. IC 50values ranged from 0.66 μg/mL to 28.4 μg/mL. In addition, CV-B3 was more sensitive than CV-B4. Both CV-B strains are more inhibited when cells were pretreated with the plant compounds The hydrosols have no effect, neither on HEp-2 cells nor on the virus. 1-octanol, S-(-), and R-(+)-limonene/1-octanol had important selectivity indexes over time. Although essential oils had potent antiviral activity, they can be considered for application in the pretreatment of cells. However, 1-octanol and the combinations are within the safety limits, and thus, they can be used as an active natural antiviral agent for CV-B3 and CV-B4 inhibition.

Planta Medica published new progress about Antiviral agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhimaneni, SaiPriyanka published the artcileAbscisic acid and aloe-emodin against NS2B-NS3A protease of Japanese encephalitis virus, Recommanded Product: n-Octanol, the main research area is Japanese encephalitis virus protease abscisic acid aloe emodin; Molecular docking studies; Molecular dynamics simulations; NS2B-NS3A protease; Pharmacokinetics prediction; Target specific assay.

There are no specific drugs for the treatment of Japanese Encephalitis. Thus, new chem. entities or exploration of existing mols. is required. We have tested the antiviral potential of abscisic acid and aloe-emodin against protease of the Japanese encephalitis virus (JEV) using the computational and target-based assay. Maestro Schrodinger glide suite 2019 was used for mol. docking and dynamic studies, and NS2B-NS3A JEV protease kit was used to confirm protease inhibitory activity of abscisic acid and aloe-emodin. The abscisic acid and aloe-emodin have shown optimum binding affinity towards NS2B-NS3A protease of JEV. Furthermore, mol. dynamic simulation results have also shown the stability of abscisic acid and aloe-emodin within the binding pocket of NS2B-NS3A protease. The ADME parameters of both compounds were also found in an acceptable range. The IC50 values were found to be 100μg/mL and 7.3μg/mL for abscisic acid and aloe-emodin resp. which indicate more potency of aloe-emodin over the abscisic acid. However, the toxicity prediction results have shown a good safety profile of abscisic acid as compared to aloe-emodin. Thus, further, more detailed exptl. studies are required to develop abscisic acid and aloe-emodin as a specific protease inhibitor of JEV.

Environmental Science and Pollution Research published new progress about Antiviral agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Chan published the artcileNovel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study, HPLC of Formula: 111-87-5, the main research area is SN38 PA liposome anticancer; CPT-11; SN38; biodistribution; lipophilic prodrug; long-circulating liposome; pharmacodynamics; pharmacokinetics.

Background: Many novel drug delivery systems have been extensively studied to exploit the full therapeutic potential of SN38, which is one of the most potent antitumor analogs of camptothecins (CPTs), whose clin. application is seriously hindered by poor water solubility, low plasmatic stability, and severe toxicity, but results are always unsatisfactory. Methods: In this study, combining the advantages of prodrug and nanotechnol., a lipophilic prodrug of SN38, SN38-PA, was developed by conjugating palmitic acid to SN38 via ester bond at C10 position, and then the lipophilic prodrug was encapsulated into a long-circulating liposomal carrier by film dispersion method. Results: The SN38-PA liposomes were characterized as follows: an average particle size of 80.13 nm, an average zeta potential of -33.53 mv, and the entrapment efficiency of 99%. Compared with CPT-11, SN38-PA liposome was more stable in close lactone form, more efficient in conversion rate to SN38, and more potent in cytotoxicity against tumor cells. Pharmacokinetic study showed that SN38-PA liposome had significantly enhanced plasma half-life (t1/2) value of SN38 and increased area under the curve (AUC) of SN38, which was 7.5-fold higher than that of CPT-11. Biodistribution study showed that SN38-PA liposome had more active metabolite SN38 in each tissue. Finally, the pharmacodynamic study showed that SN38-PA liposome had higher antitumor effect with the antitumor inhibition rate of 1.61 times than that of CPT-11. Conclusion: These encouraging data merit further investigation on this novel SN38-PA liposome.

International Journal of Nanomedicine published new progress about Antitumor agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts