Category: 111-87-5

Wang, Wenying published the artcileHemichannel-mediated volume regulation contributes to IPC-induced cardiomyocyte protection, Related Products of alcohols-buliding-blocks, the main research area is IPC cardiomyocyte protection hemichannel mediated volume regulation contribute; capacity regulation; hemichannels; ischemic preconditioning; myocardial protection.

Cx43 has been documented to be involved in ischemic preconditioning (IPC). However, the participation of Cx43-formed hemichannels in IPC and the potential underlying mechanisms remain unclear. The present study focused on cardiomyocytes’ volume regulation during IPC to investigate the role of hemichannels in the IPC-induced cardioprotection. In the study, mice cardiomyocytes were resp. treated with a hemichannel blocker, octanol or 18a-Glycyrrhizic acid (18a-GA), and a Cx43-silenced lentivirus. They were subsequently cultured in hypotonic solution to simulate ischemic reperfusion (SIR) and systemic ischemic preconditioning (SIP). Cell morphol. and volumetric (area) change were detected by inverted microscopy at 30 min following the addition of hypotonic solution Cardiomyocyte mortality was assessed by trypan blue stain assay. The analyses revealed that regardless of the treatments, hypotonic solution aggravated cell edema: Compared with the initial condition (the moment before the solution addition, 0 min), the volumetric area increased significantly 30 min later (for hypotonic + DMSO, 5,050 ± 1,511 vs. 3,464 ± 723μm2; for hypotonic+scramble lentiviral vector, 5,517 ± 1,128 vs. 2,331 ± 536μm2; P<0.05, resp.). Either treatment alleviated the edematous condition when a comparison was made between 30 min after the hypotonic addition and 0 min (for hypotonic+octanol, 2,990 ± 765 vs. 2,821 ± 773μm2; for hypotonic+18a-GA, 4,817 ± 1,306 vs. 4,762 ± 1,271μm2; for hypotonic + Cx43-silenced, 3,627 ± 688 vs. 3,419 ± 814μm2; P>0.05 for all). Notably, results indicated that the SIP group had lower mortality rates compared with its SIR counterpart; the hypotonic + octanol, hypotonic + 18a-GA, and hypotonic + Cx43-silenced group showed markedly-declined mortality when compared with their resp. control groups (resp., 35.70 ± 1.02, 30.76 ± 2.20 vs. 53.58 ± 2.14%; 30.89 ± 2.37 vs. 54.12 ± 2.55%; P<0.05 for all). The results suggest that ischemic preconditioning may provide cardioprotection by blocking the opening of the hemichannels and further mediating the volume regulation of cardiomyocytes. Experimental and Therapeutic Medicine published new progress about Cardiomyocyte. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bi, Chenyang published the artcileDirect transfer of phthalate and alternative plasticizers from indoor source products to dust: Laboratory measurements and predictive modeling, Computed Properties of 111-87-5, the main research area is direct transfer phthalate alternative plasticizer indoor source product dust.

Phthalate and alternative plasticizers are semivolatile organic compounds (SVOCs) and among the most abundant indoor pollutants. Although ingestion of dust is one of the major exposure pathways to them, migration knowledge from source products to indoor dust is still limited. Systematic chamber measurements were conducted to investigate the direct transfer of these SVOCs between source products and dust in contact with the source. Substantial direct source-to-dust transfer of SVOCs was observed for all tests. The concentration of bis(2-ethylhexyl)phthalate in dust was 12 times higher than the pre-exptl. level after only two days of source-dust contact. A mechanistic model was developed to predict the direct transfer process, and a reasonable agreement between model predictions and measurements was achieved. The octanol/air partition coefficient (Koa) of SVOCs, the emission parameter of the source product (y0), and the characteristics of the dust layer (i.e., porosity and thickness) control the transfer, affecting the SVOC concentration in dust, the kinetics of direct transfer, or both. Dust mass loading has a significant influence on the transfer, while relative humidity only has a limited effect. The findings suggest that minimizing the use of SVOC-containing products and house vacuuming are effective intervention strategies to reduce young children’s exposure to SVOCs.

Environmental Science & Technology published new progress about Airborne dust. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Clemente, Camila M. published the artcileEugenol carbonate activity against Plasmodium falciparum, Leishmania braziliensis, and Trypanosoma cruzi, Quality Control of 111-87-5, the main research area is allyl methoxyphenyl alkylcarbonate preparation antiparasitic activity; antiplasmodial activity; leishmanicidal activity; molecular docking; trypanocidal activity.

Neglected tropical diseases are a major health problem throughout the world, and there are few effective and safe drugs. In this study, we report the design and synthesis of a novel series of carbonates of eugenol using different aliphatic alcs. and N,N-carbonyldiimidazole. Spectroscopic techniques, including 1H NMR (NMR), 13C NMR, Fourier transform IR, and high-resolution mass spectrometry, were used to confirm the structures of the synthesized compounds In vitro and in silico studies of prodrugs of eugenol were performed to determine their antiplasmodial, trypanocidal, and leishmanicidal activities, and also their cytotoxicity. Compounds were highly active against Leishmania braziliensis and Plasmodium falciparum, whereas the activity shown for Trypanosoma cruzi was moderate. Mol. docking was used to determine a possible mode of action of eugenol against the dihydroorotate dehydrogenase of the three parasites (TcDHODH, LbDHODH, and PfDHODH). Notably, the docking results showed that eugenol not only has binding energy similar to that of the natural substrate (-7.2 and -7.1, resp.) but also has interactions with relevant biol. residues of PfDHODH. This result indicates that eugenol could act as a substrate for PfDHODH in the pyrimidine biosynthesis pathway of P. falciparum. In conclusion, the combination of certain aliphatic alcs. and eugenol through a carbonate bond could significantly increase the antiparasitic activity of this class of compounds, which merits further studies.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Antimalarials. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pochec, Michal published the artcileIntermolecular Interactions and Spectroscopic Signatures of the Hydrogen-Bonded System-n-Octanol in Experimental and Theoretical Studies, Recommanded Product: n-Octanol, the main research area is octanol hydrogen bond solvent effect IR spectra; AIM; CPMD; DFT; FTIR; PCM; PIMD; SAPT; classical MD; gas phase; hydrogen bond; isotope effect; liquid phase; n-octanol; snapshot-envelope.

N-Octanol is the object of exptl. and theor. study of spectroscopic signatures and intermol. interactions. The FTIR measurements were carried out at 293 K for n-octanol and its deuterated form. Special attention was paid to the vibrational features associated with the O-H stretching and the isotope effect. D. Functional Theory (DFT) in its classical formulations was applied to develop static models describing intermol. hydrogen bond (HB) and isotope effect in the gas phase and using solvent reaction field reproduced by Polarizable Continuum Model (PCM). The Atoms in Mols. (AIM) theory enabled electronic structure and mol. topol. study. The Symmetry-Adapted Perturbation Theory (SAPT) was used for energy decomposition in the dimers of n-octanol. Finally, time-evolution methods, namely classical mol. dynamics (MD) and Car-Parrinello Mol. Dynamics (CPMD) were employed to shed light onto dynamical nature of liquid n-octanol with emphasis put on metric and vibrational features. As a reference, CPMD gas phase results were applied. Nuclear quantum effects were included using Path Integral Mol. Dynamics (PIMD) and a posteriori method by solving vibrational Schrodinger equation. The latter applied procedure allowed to study the deuterium isotope effect.

Molecules published new progress about Atomic charge. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaneko, Kazuyoshi published the artcileDynamic and static properties of mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate and alcohols with various alkyl chain lengths, Recommanded Product: n-Octanol, the main research area is butyl methylimidazolium tetrafluoroborate ionic liquid alc mixture self diffusion.

The dynamic and static properties of mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) and alcs. with various alkyl chain lengths were investigated. For alc. concentrations of 20 mol% or less, where the alc./ionic liquid system maintains a nano-heterogeneous structure, the self-diffusion coefficient and the chem. shift of anions and cations in the alc./[BMIM][BF4] system were not dependent on the alkyl chain length of the alc., but were almost coincident with each other when comparing the same solvent concentration This indicates that the solution structure of pure [BMIM][BF4] was almost maintained in the alc./ionic liquid system. Moreover, alc. having short alkyl chain length and water moved clearly faster than the IL, but the movement of alc. having long alkyl chain length moved close to that of the IL suggesting that the alcs. may not be able to move significantly in the IL.

Journal of Molecular Liquids published new progress about Hydrophobicity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schoettl, Sebastian published the artcileSolubilization power of surfactant-free microemulsions, Recommanded Product: n-Octanol, the main research area is solubilization microemulsion propane.

Hydrophobe solubilization concepts rely on the shielding of solutes from water in nonpolar domains comprising traditional surfactants. We show how an octanol/ethanol/water surfactant-free microemulsion solvates hydrophobic propane in small octanol/ethanol aggregates similar to traditional micelles. These aggregates have the comparable solvent quality as bulk octanol/ethanol with the same composition

Physical Chemistry Chemical Physics published new progress about Microemulsions. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumari, Bharti published the artcileEfficient Referencing of FSLG CPMAS HETCOR Spectra Using 2D 1H-1H MAS FSLG, Computed Properties of 111-87-5, the main research area is octanol FSLG CPMAS HETCOR spectrum.

FSLG CPMAS HETCOR is a 2D solid-state NMR experiment which provides structural information and conformational correlation between a 1H and an X-nucleus. However, practical application of the experiment suffers from the chem. shift referencing problem on the indirect 1H dimension. In our paper, we present a novel 1H-1H MAS FSLG-based approach and its application to reference the FSLG CPMAS HETCOR which overcomes the 1H referencing in the 2D 1H-X HETCOR experiment This approach works excellently irresp. of the sample type over a wide range of temperature

Applied Magnetic Resonance published new progress about Microstructure. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Carvalho, Ana Claudia Medeiros published the artcileInfluence of synthesis parameters on properties and characteristics of poly (urea-formaldehyde) microcapsules for self-healing applications, Safety of n-Octanol, the main research area is polyurea formaldehyde microcapsule size self healing agitation rate; polymerisation; Microcapsules; factorial design; poly(urea-formaldehyde); self-healing.

Poly(urea-formaldehyde) (PUF) microcapsules filled with dicyclopentadiene (DCPD) were prepared by in situ polymerization and the effect of synthesis parameters, such as pH of the solution and agitation rate, on microcapsules size and shell thickness was evaluated. SEM (SEM) and Fourier transform infra-red spectroscopy (FTIR) were performed. Adjusted pH conditions (pH = 3.5) and agitation rate (1350 RPM) were found using a design of experiments (DOE). SEM results indicated that microcapsule size was directly affected by agitation rate, whereas shell thickness was mostly affected by pH. After obtaining adjusted synthesis conditions, microcapsules presenting mean size of 60μm and mean shell thickness of 4μm were embedded in an epoxy matrix for evaluating the self-healing effect. FTIR and SEM analyses in damaged samples suggested that a healing agent was delivered to the crack location.

Journal of Microencapsulation published new progress about Agglomeration. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Flaviis, Riccardo published the artcileWheat classification according to its origin by an implemented volatile organic compounds analysis, Name: n-Octanol, the main research area is ethanol hexanal acetic acid classification wheat quality; GC–MS; Pedoclimatic conditions; SPME; Volatile organic compounds; Wheat species.

Food volatile organic compounds (VOCs) anal. is a useful tool in authentication and classification processes, but, to date, the anal. of wheat VOCs is still little explored. In this study a method of anal. based on solid phase microextraction coupled with gas chromatog.-mass spectrometry was optimized by testing different types of fibers, sample preparation methods and amounts, extraction temperatures and times, desorption times and oven programs. The anal. was applied to six wheat cultivars harvested in different areas, and permitted to identify 158 VOCs, of which 98 never found before. A principal component anal. performed on the dataset showed that the area of cultivation accounted for the highest source of variability. Partial least squares anal. permitted to correctly classify wheats based on their cultivation area and species, and to identify the most discriminant VOCs. These results are promising for the study of the influence of geog. origin on wheat quality.

Food Chemistry published new progress about Classification. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deshmukh, Sandip published the artcileEffects of using alcohols on the performance and emissions of a diesel engine, Application In Synthesis of 111-87-5, the main research area is alc diesel engine greenhouse gas emission.

Addition of renewable alcs. to diesel is being investigated extensively to reduce greenhouse gas emissions. The objective of this study was to examine the suitability of such renewable alcs. In this study, emissions and performance characteristics of alc./diesel blends were evaluated for a four stroke single cylinder diesel engine test rig. n-octanol and nbutanol were the alcs. considered. Experiments were conducted at different loads up to 4 kW and for alc. contents from 10% to 40% by volume The results indicated that the alc./diesel blends exhibited similar performance characteristics to that possessed by diesel. A slight drop in brake power was observed in all the blends compared to pure diesel. The brake thermal efficiency and brake specific fuel consumption increased in all alc. blends at almost all the loads considered in the study. The emission anal. was also conducted using the AVL DI Test. The results revealed that CO and NO emissions decreased compared to pure diesel. However, HC emissions increased for n-butanol blends but they decreased in case of n-octanol blends. Results are a clear indication that these blends have an excellent potential and detailed investigations in real life conditions can lead to com. usage.

Journal of Physics: Conference Series published new progress about Diesel engines. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts