Category: 111-46-6

Related Products of 111-46-6 ,Some common heterocyclic compound, 111-46-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Protocole 2 To a solution of diethylene glycol (31.83 g ; 300.0 mmol ; 7.0 eq) in CH2Cl2 (90 mL) was added Et3N (4.77 g ; 47.1 mmol ; 1.1 eq). The mixture was stirred vigorously. A solution of p-toluenesulfonyl chloride (8.17 g ; 42.8 mmol ; 1.0 eq) in CH2Cl2 (108 mL) was added dropwise. Following the addition, the reaction mixture was stirred for 24 h at room temperature. Then a 1.0 M solution of HCl (50 mL), water (50 mL) and saturated solution of brine (60 mL) were added. The resultant aqueous layers were further extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The product was purified by flash column chromatography on silica gel (99% CH2Cl2/MeOH) to give the desired compound 3b as a colorless oil in 67% yield (7.48 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-46-6, 2,2′-Oxybis(ethan-1-ol), other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ricco, Christophe; Abdmouleh, Fatma; Riccobono, Charlotte; Guenineche, Lena; Martin, Frederique; Goya-Jorge, Elizabeth; Lagarde, Nathalie; Liagre, Bertrand; Ali, Mamdouh Ben; Ferroud, Clotilde; Arbi, Mehdi El; Veitia, Maite Sylla-Iyarreta; Bioorganic Chemistry; vol. 96; (2020);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol). This compound has unique chemical properties. The synthetic route is as follows. Formula: C4H10O3

General procedure: Potassium tert-butoxide (x100 = 11.1 mmol, x1500 = 0.67 mmol, x6000 = 1.42 mmoL) was added to dissolved PEGx (x100 = 21.4 mmol, x1500 = 1.33 mmoL, x6000 = 0.50 mmoL) in dry tetrahydrofuran (20 mL,x100 or x1500) or dimethylformamide (20 mL, x6000, dissolution of PEG by heating) at 0 C. After 15 min,the mixture was allowed to warm to room temperature and stirred for 30 min. Propargyl bromide was added (x100 = 13.4, mmol, x1500 = 0.67 mmoL, x6000 = 1.98 mmol) and the mixture was stirred overnight for 14 h at the same temperature. The fine solids were filtered off through a membrane filter and the solution was concentrated in vacuo to a minimum volume. In the case of the mixture containing PEG 6000, the reaction was stopped by dilution with dichloromethane (30 mL), the residue was precipitated with diethylether (3 × (5-10) mL), diethylether was decanted and the product was dried on an oil pump.2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanol (4a) Yield 2.23 g (91%) of pale yellow liquid. 1H NMR (CDCl3):delta 2.45 (t, J = 2.3, 2H, CH2CCH), 3.58-3.67 (m, 2H, CH2OH), 3.69-3.78 (m, 6H, CH2O), 4.22 (d, J = 2.4,2H, CH2CCH). 13C NMR (CDCl3): delta 58.6 (CH2CCH). 61.9, 69.3, 70.4, 72.6 (CH2O), 74.8 (CH2CCH), 79.6(CH2CCH). The spectroscopic data of 5a are in agreement with [26].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111-46-6, 2,2′-Oxybis(ethan-1-ol).

Reference:
Article; Pomeisl, Karel; Richter, Jan; Golan, Martin; Kratochvilova, Irena; Molecules; vol. 25; 3; (2020);,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. Recommanded Product: 111-46-6

1.122 g of tBuOK (potassium tert-butoxide) was dissolved in 6.5 ml of dry THF (tetrahydrofuran)2.12g of diethylene glycol was added under the protection of ice-water outer bath under argon, the reaction was stirred for 30 minutes, then 1.18g of bromopropyne was added dropwise,The reaction was complete after dropping 1 hour ice water bath, the reaction was carried out at room temperature for 12 hours, the reaction was stopped after diatomaceous earth filter layer, the filtrate evaporated to give a yellow oil, 300-400 mesh silica gel medium pressure separation,The mobile phase of petroleum ether: ethyl acetate = 4: 1, the product fractions were collected and evaporated to give the product 0.976g pale yellow oily product, yield 72.8%.

The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-46-6, name is 2,2′-Oxybis(ethan-1-ol). This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)

In steel esterification reactor with the volume of 15 1 equipped with a heating element and a stirring device, 3550 g of benzoic acid, 1500 g of diethylene glycol are charged, 13 g of titanium (IV) isopropoxide are added. Before the heating treatment, xylene in the amount of 2500 g is added to separator. The reaction is conducted at the constant feed of xylene into the reaction mass by the circulating pump from the separator with the rate of 3 1/hour. The reaction mass is heated to the temperature 200C, in an hour after the beginning of the heating the temperature is raised to 220C, in two hours after the beginning of the heating the temperature is raised to 240C. In 3 hours after the beginning of the heating the pressure in. reactor is reduced to 15 kPa, in 30 min more the pressure in reactor is reduced to 5 kPa. In 4 hours after the beginning of the heating the reaction mass is cooled. From the esterification reactor 4400 g of reaction mass comprising 0.5% by weight of benzoic acid, 0.3 % by weight of diethylene glycol benzoate and 99.0% by weight of diethylene glycol dibenzoate are discharged. From the separator an aqueous phase comprising 785 g of water, 8 g of benzoic acid, as well as organic phase comprising 1720 g of xylene, 365 g of benzoic acid, is discharged.

With the rapid development of chemical substances, we look forward to future research findings about 111-46-6.

Reference:
Patent; PUBLIC JOINT STOCK COMPANY “SIBUR HOLDING”; NOSIKOV, Aleksei Aleksandrovich; BABIN, Ivan Anatolievich; POPOVTSEV, Egor Evgenievich; IGASHEVA, Varvara Petrovna; (28 pag.)WO2019/59801; (2019); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. SDS of cas: 111-46-6

Diethylene glycol (7.0 g, 66.0 mmol) was dissolved in 10 mL of dichloromethane solution, Et3N (13.3 g, 132.2 mmol) was added, and TsCl (15.1 g, 79.1 mmol) in dichloromethane was added dropwise on ice. .After the completion of the dropwise addition, the mixture was transferred to room temperature and stirred overnight.After adjusting the pH of the solution to 7 with 6 mol/L HCl, 10 mL of water was added, and the mixture was extracted three times with 30 mL of dichloromethane, and the organic phases were combined and dried over anhydrous sodium sulfate.Column chromatography (EA) gave 10 g of a yellow liquid product, yield 60%.

The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Zhang Xingxian; He Kailun; Wang Wenbing; Wang Xiaoju; Zheng Xiaoliang; (23 pag.)CN110204532; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 111-46-6, 2,2′-Oxybis(ethan-1-ol), can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 111-46-6, blongs to alcohols-buliding-blocks compound. Recommanded Product: 111-46-6

The preparation of this compound was adapted from a literature procedure. Into a suspension of tBuOK (5.10 g, 45.5 mmol) in dry THF (125 mL) was added die(thylene)glycol (9.55 g, 90.0 mmol) at 0 C under nitrogen atmosphere. The reaction mixture was allowed to stir at room temperature for 30 min then propargyl bromide (6.69 g, 45.0 mmol) in dry THF (25 mL) was added dropwise. The resulting mixture was allowed to stir at room temperature for 12 h. After completion of the reaction as indicated by NMR, the mixture was diluted with THF and filtered through Celite. The filtrate was concentrated and the residue was purified by column chromatography (Si02, EtOAc) to give the product as a pale yellow liquid (4.77 g, 93%). NMR (500 MHz, CDC13) delta 4.22 (d, J = 2.4, 2H, CH2C?C), 3.78 – 3.69 (m, 6Eta, CH2), 3.67 – 3.58 (m, 2Eta, CH2OH), 2.45 (t, J = 2.3, 2H, C?CH, OH). 13C NMR (126 MHz, CDC13) delta 79.6 (CH2C?CH), 74.8 (CH2C?CH), 72.6, 70.4, 69.3, 61.9 (CH2OH), 58.6 (CH2C?CH). The spectroscopic data of 39c are in agreement with those previously reported.

The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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Electric Literature of 111-46-6, Adding some certain compound to certain chemical reactions, such as: 111-46-6, name is 2,2′-Oxybis(ethan-1-ol),molecular formula is C4H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111-46-6.

2-(2-(Prop-2-ynyloxy)ethoxy)ethanol (10) To a stirred suspension of potassium tert-butoxide (1.06 g, 9.42 mmol) in THF (300 mL) cooled to 0 C. in an ice-bath was added a solution of 2,2′-oxydiethanol (4.60 g, 78.0 mmol) in THF (10 mL). The mixture was stirred at 0 C. for 30 min and was then allowed to warm to RT and was treated dropwise with propargyl bromide (1.68 mL of an 80% solution in toluene, 11.30 mmol). The reaction mixture was stirred at RT for 16 hr and diluted with brine and water (5:1, 50 mL) and was extracted with EtOAc (3*500 mL). The combined organic extracts were dried, filtered and evaporated in vacuo. The residue was purified by flash column chromatography, eluting with 25 to 60% EtOAc in heptane, to afford the title compound (10) (410 mg, 30%) as a yellow oil: 1H NMR (250 MHz, CDCl3) delta: 2.22 (1H, s), 2.45 (1H, t), 3.58-3.66 (2H, m), 3.67-3.79 (6H, m), 4.22 (2H, d).

According to the analysis of related databases, 111-46-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; King-Underwood, John; Ito, Kazuhlro; Murray, Peter John; Hardy, George; Brookfield, Frederick Arthur; Brown, Christopher John; US2012/208799; (2012); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. Formula: C4H10O3

General procedure: Preparation of 2-(2-(trityloxyl)ethoxyl)ethanol 3a is used as an example. To a stirring solution ofdiethylene glycol 2a (34.4 g, 324.0 mmol), DMAP (1.3 g, 10.8 mmol) and triethylamine (18.7 mL,130.0 mmol) in CH2Cl2 (200 mL) at 40oC was slowly added a solution of triphenylmethyl chloride(30.1 g, 108.0 mmol) in CH2Cl2 (100 mL) over an hour. After the addition, the mixture was refluxed until no more triphenylmethyl chloride can be detected by TLC (usually 2-3h). Then, the mixture was cooled and poured into brine (300 mL), extracted with CH2Cl2 (150 mL, three times). The combined organic phase was dried over anhydrous Na2SO4, concentrated under vacuum, purified by flash chromatography on silica gel to give 3a as white wax (30.7 g, yield: 82%). 1H NMR (400MHz, CDCl3) delta 3.27 (t, J = 6.0 Hz, 2H), 3.61 (t, J = 4.0 Hz, 2H), 3.66-3.73 (m, 4H), 7.20-7.31 (m,9H), 7.45-7.47 (m, 6H).

The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Yu; Thapa, Bijaya; Zhang, Hua; Li, Xuefei; Yu, Fanghua; Jeong, Eun-Kee; Yang, Zhigang; Jiang, Zhong-Xing; Tetrahedron; vol. 69; 46; (2013); p. 9586 – 9590;,
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Electric Literature of 111-46-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-46-6, name is 2,2′-Oxybis(ethan-1-ol). This compound has unique chemical properties. The synthetic route is as follows.

Sodium metal (64 mg, 0.03 eq) was added to a solution of diethylene glycol (29.5 g, 0.278 mmol) in THF (100 mL). The mixture was stirred for 1 hour to dissolve the sodium, then /cvV-butyl acrylate (12.4 g, 97 mmol) was added. The resulting mixture was stirred for 2 days, then concentrated under reduced pressure and the residue purified by silica chromatography (1 : 1 hexane:EtOAc) to give the title compound (9.1 g, 40%) as a colorless oil. (0315) [00139] NMR (400 MHz, CDCb): d 3.75 (m, 4H), 3.64 (m, 6H), 2.53 (t, 2H), 2.40 (s, 1H), (0316) 1.45 (s, 9H).

According to the analysis of related databases, 111-46-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael S.; SCOTT, David; LI, Zhengnian; PINCH, Benika J.; OLSON, Calla; FISCHER, Eric S.; NOWAK, Radoslaw P.; DONOVAN, Katherine A.; (171 pag.)WO2020/69105; (2020); A1;,
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