Category: 111-45-5

Related Products of 111-45-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 111-45-5 as follows.

The compound of formula (J2) (20.0 g), 2-allyloxy ethanol (300 g), a 10 weight % ethanol solution of potassium acetate (0.5 g) and an isopropyl alcohol solution of chloroplatinic acid (0.2 weight % as platinum, 0.5 g) were introduced into a 300 mL eggplant type flask equipped with a reflux condenser and magnetic rotor, and a reaction was carried out for 3.5 hours in an oil bath of 90C as the mixture was being stirred. The low boiling point components were removed with a rotary vacuum evaporator. Purification was performed by silica gel column chromatography (developing solvent, ethyl acetate/hexane) and a pale yellow transparent liquid was obtained. The proton nuclear magnetic resonance spectrum of this liquid was analyzed. As a result, peaks were detected in the vicinity of 0.1 ppm (18H), in the vicinity of 0.5 ppm (8H), in the vicinity of 1.6 ppm (8H), in the vicinity of 1.9 ppm (3H), in the vicinity of 2.5 ppm (3H), in the vicinity of 3.4 ppm (6H), in the vicinity of 3.5 ppm (6H), in the vicinity of 3.7 ppm (6H), in the vicinity of 4.1 ppm (2H), in the vicinity of 5.5 ppm (1H) and in the vicinity of 6.1 ppm (1H). From these findings, it was confirmed that this was the compound represented by formula (M4).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-45-5, its application will become more common.

Reference:
Patent; Johson & Johnson Vision Care Inc.; EP1424339; (2004); A1;,
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Adding a certain compound to certain chemical reactions, such as: 111-45-5, 2-(Allyloxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 111-45-5, blongs to alcohols-buliding-blocks compound. Product Details of 111-45-5

Reactions under ambient pressure: In a glove box, a 4 ml_ vial equipped with a magnetic stirring bar and a screw cap was charged with the substrate (0.1 mmol) and 2 mg of hexamethylbenzene (internal standard). Then a solution of the catalyst (5×10″3 mmol, 5 mol %) dissolved in the right amount of toluene to achieve the final concentration of 1 M in substrate, was added to the vial containing the substrate and the internal standard. The vial was closed and the reaction mixture was stirred at room temperature (22 SC). Samples (about 10 mu_) of the reaction mixture were withdrawn at regular time intervals, and quenched with an excess of ethyl vinyl ether. Determination of conversions, yields, and Z-selectivities were carried out by comparing the integrals of the peaks due to the olefinic protons of substrates and products, identified by comparison with literature data,( 20, 37-41 ) with that of the internal standard.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-45-5, 2-(Allyloxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; BERGEN TEKNOLOGIOVERFØRING AS; JENSEN, Vidar Remi; OCCHIPINTI, Giovanni; (64 pag.)WO2017/9232; (2017); A1;,
Alcohol – Wikipedia,
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Electric Literature of 111-45-5, Adding some certain compound to certain chemical reactions, such as: 111-45-5, name is 2-(Allyloxy)ethanol,molecular formula is C5H10O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111-45-5.

A solution of 2-allyloxiethanol (112 g; 1.1 mol) in THF (100 ml) was dripped in a suspension of sodium hydride (60% in oil) (88 g; 2.2 mol) in THF (250 ml) under mechanic stirrer. After 20 h at room temperature, a solution of bromoacetic acid (138.9 g; 1.0 mol) in THF (150 ml) was added dropwise, causing the spontaneous reflux of the solvent. The solution was kept under reflux for 2 hours, then diluted with ethanol (50 ml) and, after 30 min, the suspension was concentrated. The residue was solved on water (400 ml) and the solution was washed with ethyl ether (3*100 ml), dichloromethane (2*100 ml); the aqueous phase was acidified to pH 1 with hydrochloride acid 37% and the product was extracted with dichloromethane (300 ml+4 50 ml). The organic phase was washed with water (4*50 ml), brine (40 ml) and evaporated to a liquid residue that was distilled under vacuum, at a pressure of 67 Pa, to obtained 3,6-dioxa-8-nonenoic acid (I) as colourless liquid (119.5 g; 0.746 mol). Yield 75%. p.eb67-pa 98-100 C. Title 93.5%.

According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRACCO IMAGING S.P.A.; AIME, Silvio; DELLI CASTELLI, Daniela; FEDELI, Franco; LONGO, Dario Livio; TERRENO, Enzo; UGGERI, Fulvio; (37 pag.)US2019/209713; (2019); A1;,
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Electric Literature of 111-45-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-45-5, name is 2-(Allyloxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In the fume hood, a 3 mL vial equipped with a screw cap and a magnetic stirring bar was charged with thecatalyst (0.01 mmol), and with 1 mmol of allylbenzene (stored under air). THF (stored under air) was added to the flaskto obtain 0.25 mL of a 4 M solution. The cap was closed and the reaction mixture was stirred and heated in an oil bathat 35 C. Conversions, yields, and Z-selectivities were determined from analysis of the 1H NMR spectrum.(28)

According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bergen Teknologioverf°ring AS; Jensen, Vidar Remi; Occhipinti, Giovanni; EP2826783; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 111-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-45-5, name is 2-(Allyloxy)ethanol, molecular formula is C5H10O2, molecular weight is 102.13, as common compound, the synthetic route is as follows.

Sodium hydroxide (2.56 g, 63.99 mmol) was completely dissolved in distilled water and a solution of THF and Allyloxy ethanol (5.83 ml, 54.55 mmol) was added at 0 C. After stirring for 30 minutes, a solution of 4-Toluenesulfonyl chloride (10 g, 52.45 mmol) in THF at 0 C was slowly added. After that, the temperature was raised to room temperature and then stirred for 1 hour. The reaction was terminated by adding cold distilled water and extracted with hexane. The extracted organic layer was washed with water and aqueous NaCl solution, and dried over MgSO4. The reaction product (1EO-OTs) was dried in a vacuum oven (Yield = 33%).

Statistics shows that 111-45-5 is playing an increasingly important role. we look forward to future research findings about 2-(Allyloxy)ethanol.

Reference:
Patent; Korea Research Institute of Chemical Technology; Han Mi-jeong; Kang Yeong-gu; Seok Jeong-don; Kwak Hyeon-ju; (29 pag.)KR101826496; (2018); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 111-45-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-45-5, name is 2-(Allyloxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of alcohol 4A (5.1 g, 1.0 eq) in DCM (50 mL) cooled to 0 C was added a solution of Et3N (7 g, 1.4 eq) followed by dropwise addition of MsCl (6.9 g, 1.2 eq). The reaction was stirred at 0 C for 2 hrs. The reaction mixture was quenched with water and the organic layer was washed with NaHC03 (10 mL) and brine, dried over Na2S04. The crude mixture was filtered and evaporated under reduced pressure to afford the compound 4B, which was used for next step reaction without further purification.

According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; MA, Jingyuan; EMAYAN, Kumaraswamy; ADLER, Marc; (327 pag.)WO2018/9417; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 111-45-5 ,Some common heterocyclic compound, 111-45-5, molecular formula is C5H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The designated donor (i.e. 19, 0.025 mmol) and the acceptor (2-2.5eq.) were dissolved in dry DCM (2-3 mL) under N2 in presence of freshly activated 4 A molecular sieves. The mixture was stirred for 1-1.5 h at rt and then cooled to -20 C. TMSOTf (0.5-1.0 eq.~10muL neat, or as a solution of 50 muL dissolved in 0.5 mL DCM) was added to the reaction and the mixture was allowed to warm to rt over a period of 2h. Upon completion, as monitored by TLC, the reaction was neutralized by adding TEA (50 muL) and filtered. The solvent was removed under reduced pressure and the crude material was purified by column chromatography using 4:1 Hex:EtOAc as eluent to obtain the product glycosides

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-45-5, 2-(Allyloxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Saha, Jaideep; Peczuh, Mark W.; Tetrahedron Letters; vol. 53; 42; (2012); p. 5667 – 5670;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 111-45-5, 2-(Allyloxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-45-5, blongs to alcohols-buliding-blocks compound. name: 2-(Allyloxy)ethanol

10065] In a one-liter flask equipped with a stirring device, a dimroth condenser, a thermometer and a dropping thnnel, put were 38.25 g (0.375 mol) of ethylene glycol monoallyl ether represented by the following formula (8) and 100 g oftoluene, and heated to 70 degrees C. 0.38 Gram of a solution of a catalyst, complex of alkali-neutralized chloroplatinic acid with vinyl siloxane, in toluene, containing 0.5% of platinum, was added in the flask. Then, 185 g (0.25 mol) of the compound represented by the aforesaid formula (7) was added dropwise in the flask with the dropping funnel over one hout The reaction mixture was held at 100 degrees C. for one hour and, then, analyzed in GC. The peak of the compound representedby the aforesaid formula (7) disappeared, which means that the reaction completed. 100 Grams of ion exchanged water were added to the reaction mixture with stirring to wash it and, then, left standing to cause phase separation. The aqueous phase containing the excessive ethylene glycol monoallyl ether was removed. The organic phase was similarly washed twice with each 100 g of ion exchanged water and, then, the toluene in the organic phase was stripped off under a reduced pressure to obtain 193.7 g (0.23 mol) of a colorless and transparent liquid, silicone compound representedby the following formula (9). The yield was 92%. The ratio of the silicone compound represented by the following formula (9) in the obtained product was 98.1 mass %, as determined in GC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-45-5, its application will become more common.

Reference:
Patent; SHIN-ETSU CHEMICAL CO., LTD.; KUDO, Muneo; ICHINOHE, Shoji; GOTO, Tomoyuki; US2015/266905; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-45-5, name is 2-(Allyloxy)ethanol, molecular formula is C5H10O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-(Allyloxy)ethanol

30.6 g (0.3 mol) of allyloxyethanol was dissolved in 100 ml of methylene chloride,Further, a solution prepared by adding 33.4 g (0.33 mol) of triethylamine and 1.8 g (0.015 mol) of N, N-dimethylaminopyridine was prepared.next,The obtained solution was cooled with ice,To this solution,A solution of 31.4 g (0.3 mol) of methacrylic acid chloride in 50 ml of methylene chloride was added dropwise.After completion of the dropwise addition,After stirring at room temperature for 3 hours,100 ml of distilled water was added,It was extracted three times with methylene chloride.Next, the obtained methylene chloride layer was removed using a rotary evaporator to remove the solvent, and the residue obtained was dissolved in 100 ml of toluene to obtain a toluene solution.Then, this toluene solution was washed three times with 0.5 N hydrochloric acid solution,Washed three times with saturated saline solution,And dried with magnesium sulfate solution.After drying, the magnesium sulfate solution was filtered off,The filtrate was concentrated on a rotary evaporator to obtain a concentrate.further,The concentrate was vacuum dried,Methacrylic acid-allyloxyethyl 46.0 g (yield 90%).

With the rapid development of chemical substances, we look forward to future research findings about 111-45-5.

Reference:
Patent; TOKUYAMA DENTAL CORPORATION; AKIZUMI, HIRONOBU; SAKATA, EIBU; (52 pag.)JP2017/141212; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-45-5, name is 2-(Allyloxy)ethanol. A new synthetic method of this compound is introduced below., Product Details of 111-45-5

In a one-liter flask equipped with a stirring device, a dimroth condenser, a thermometer and a dropping funnel, put were 38.25 g (0.375 mol) of ethylene glycol monoallyl ether represented by the following formula (7) and 100 g of toluene, and heated to 70 degrees C. 0.38 Gram of a solution of a catalyst, complex of alkali-neutralized chloroplatinic acid with vinyl siloxane, in toluene, containing 0.5% of platinum, was added in the flask. Then, 185 g (0.25 mol) of the compound represented by the aforesaid formula (6) was added dropwise in the flask with the dropping funnel over one hour. The reaction mixture was held at 100 degrees C. for one hour and, then, analyzed in GC. The peak of the compound represented by the aforesaid formula (6) disappeared, which means that the reaction completed. 100 Grams of ion exchanged water were added to the reaction mixture with stirring to wash it and, then, left standing to cause phase separation. The aqueous phase containing the excessive ethylene glycol monoallyl ether was removed. The organic phase was similarly washed twice with each 100 g of ion exchanged water and, then, the toluene in the organic phase was stripped off under a reduced pressure to obtain 193.7 g (0.23 mol) of a colorless and transparent liquid, silicone compound represented by the following formula (8). The yield was 92%. The ratio of the silicone compound represented by the following formula (8) in the obtained product was 98.1 mass %, as determined in GC. In a one-liter flask equipped with a stirring device, a dimroth condenser, a thermometer and a dropping funnel, put were 210.5 g (0.25 mol) of the silicone compound represented by the formula (8), 0.02 g (0.01 mass %) of dioctyl tin oxide, 0.01 g of Ionol, i.e. 2,6-di-tert-butyl-4-methylphenol, ex Japan Chemtech Co. Ltd., and 0.01 g of 4-methoxyphenol to prepare a mixture. 40.3 Grams (0.26 mol) of a methacryl group-containing isocyanate compound represented by the following formula (9) was added dropwise to the mixture over one hour. The internal temperature rose from 20 degrees C. up to 40 degrees C. The mixture was held at 40 degrees C., while monitoring the peak of the silicone compound represented by the formula (8) in GC. Four hours later, the intensity of the peak of the silicone compound fell down below the detection limit by GC and, then, 4.0 g (0.125 mol) of methanol was added to the reaction mixture. Further, 180 g of hexane and 180 g of ion exchanged water were added to the reaction mixture to wash it. The reaction mixture was left standing to cause phase separation. The aqueous phase was removed and, subsequently, the organic phase was washed twice with ion exchanged water. The solvent, hexane, was stripped off from the organic phase under a reduced pressure to obtain 204.3 g of a colorless and transparent liquid product. 1H-NMR analysis showed that the obtained compound in the product was a silicone compound represented by the following formula (10), hereinafter referred to as silicone compound 1. The yield was 82% and the aforesaid amount (204.3 g) was 0.20 mol. The ratio of the silicone compound represented by the following formula (10) in the product was 97.1 mass %, as determined in GC, the viscosity was 112.9 mm2/s at 25 degrees C., the specific gravity was 1.165 at 25 degrees C. and the refraction index was 1.4131.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111-45-5, 2-(Allyloxy)ethanol.

Reference:
Patent; SHIN-ETSU CHEMICAL CO., LTD.; KUDO, Muneo; ICHINOHE, Shoji; GOTO, Tomoyuki; US2015/361113; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts