Category: 111-29-5

On August 1, 2020, Toyooka, Genki; Fujita, Ken-ichi published an article.Quality Control of Pentane-1,5-diol The title of the article was Synthesis of Dicarboxylic Acids from Aqueous Solutions of Diols with Hydrogen Evolution Catalyzed by an Iridium Complex. And the article contained the following:

A catalytic system for the synthesis of dicarboxylic acids e.g., glutaric acid from aqueous solutions of diols e.g., pentane-1,5-diol accompanied by the evolution of hydrogen was developed. An iridium complex bearing a functional bipyridonate ligand with N,N-dimethylamino substituents exhibited a high catalytic performance for this type of dehydrogenative reaction. For example, adipic acid was synthesized from an aqueous solution of 1,6-hexanediol in 97% yield accompanied by the evolution of four equivalent of hydrogen by the present catalytic system. It should be noted that the simultaneous production of industrially important dicarboxylic acids and hydrogen, which is useful as an energy carrier, was achieved. In addition, the selective dehydrogenative oxidation of vicinal diols CH3(CH2)nCH(OH)CH2OH (n = 0, 1, 2, 3) to give α-hydroxycarboxylic acids CH3(CH2)nCH(OH)COOH was also accomplished. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Quality Control of Pentane-1,5-diol

The Article related to dicarboxylic acid preparation, diol hydrogen evolution iridium catalyst, dehydrogenation, dicarboxylic acids, diols, iridium, α-hydroxycarboxylic acids, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of Pentane-1,5-diol

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On June 30, 2021, Lagerspets, Emi; Valbonetti, Evelyn; Eronen, Aleksi; Repo, Timo published an article.Recommanded Product: 111-29-5 The title of the article was A new catalytic approach for aerobic oxidation of primary alcohols based on a Copper(I)-thiophene carbaldimines. And the article contained the following:

Novel Cu(I) thiophene carbaldimine catalysts for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to lactones or lactols was reported. In the presence of the in-situ generated Cu(I) species, a persistent radical (2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO)) and N-methylimidazole (NMI) as an auxiliary ligand, the reaction proceeds under aerobic conditions and at ambient temperature Especially the catalytic system of 1-(thiophen-2-yl)-N-(4-(trifluoromethoxy)phenyl)methanimine with copper(I)-iodide showed high reactivity for all kind of alcs. (benzylic, allylic and aliphatic). In the case of benzyl alc. even 2.5 mol% of copper loading gave quant. yield. Beside high activity under aerobic conditions, the catalysts ability to oxidize 1,5-pentadiol to the corresponding lactol (86% in 4 h) and N-phenyldiethanolamine to the corresponding morpholine derivate lactol (86% in 24 h) is particularly noteworthy. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to thiophenyl methanimine preparation, primary alc copper thiophenyl methanimine catalyst oxidation, diol copper thiophenyl methanimine catalyst oxidation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 111-29-5

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On April 15, 2020, Iliopoulos, Fotis; Sil, Bruno C.; Monjur Al Hossain, A. S. M.; Moore, David J.; Lucas, Robert A.; Lane, Majella E. published an article.Synthetic Route of 111-29-5 The title of the article was Topical delivery of niacinamide: Influence of neat solvents. And the article contained the following:

Niacinamide (NIA) has been widely used in cosmetic and personal care formulations for several skin conditions. Permeation of topical NIA has been confirmed in a number of studies under infinite dose conditions. However, there is limited information in the literature regarding permeation of NIA following application of topical formulations in amounts that reflect the real-life use of such products by consumers. The aim of the present work was therefore to investigate skin delivery of NIA from single solvent systems in porcine skin under finite dose conditions. A secondary aim was to probe the processes underlying the previously reported low recovery of NIA following in vitro permeation and mass balance studies. The solubility and stability of NIA in various single solvent systems was examined The solvents investigated included Transcutol P (TC), propylene glycol (PG), 1-2 hexanediol (HEX), 1-2 pentanediol (1-2P), 1-5 pentanediol (1-5P), 1-3 butanediol (1-3B), glycerol (GLY) and di-Me isosorbide (DMI). Skin permeation and deposition of the mol. was investigated in full thickness porcine skin in vitro finite dose Franz-type diffusion experiments followed by mass balance studies. Stability of NIA for 72 h in the solvents was confirmed. The solubility of NIA in the solvents ranged from 82.9 ± 0.8 to 311.9 ± 4.5 mg/mL. TC delivered the highest percentage permeation of NIA at 24 h, 32.6 ± 12.1% of the applied dose. Low total recovery of NIA after mass balance studies was observed for some vehicles, with values ranging from 55.2 ± 12.8% to 106.3 ± 2.3%. This reflected the formation of a number of NIA degradation byproducts in the receptor phase during the permeation studies. Identification of other vehicles for synergistic enhancement of NIA skin delivery will be the subject of future work. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Synthetic Route of 111-29-5

The Article related to skin topical formulation solvent niacinamide, finite dose, in vitro, niacinamide, permeation, porcine skin, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 111-29-5

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On February 8, 2022, Jeong, Jaeyoung; Fujita, Ken-ichi published an article.Computed Properties of 111-29-5 The title of the article was Selective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway. And the article contained the following:

A new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any addnl. organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to bisdimethylamine green preparation, diol aqueous dimethylamine bisdimethylamination iridium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 111-29-5

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On September 10, 2020, Nakamura, Sho; Sayama, Misa; Uwamizu, Akiharu; Jung, Sejin; Ikubo, Masaya; Otani, Yuko; Kano, Kuniyuki; Omi, Jumpei; Inoue, Asuka; Aoki, Junken; Ohwada, Tomohiko published an article.Name: Pentane-1,5-diol The title of the article was Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors. And the article contained the following:

Lysophosphatidylserine (LysoPS), an endogenous ligand of G protein-coupled receptors, consists of L-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages, resp. An ester linkage of phosphatidylserine can be hydrolyzed at the 1-position or at the 2-position to give 2-acyl lysophospholipid or 1-acyl lysophospholipid, resp. 2-Acyl lysophospholipid is in nonenzymic equilibrium with 1-acyl lysophospholipid in vivo. On the other hand, 3-acyl lysophospholipid is not found, at least in mammals, raising the question of whether the reason for this might be that the 3-acyl isomer lacks the biol. activities of the other isomers. Here, to test this idea, we designed and synthesized a series of new 3-acyl lysophospholipids. Structure-activity relationship studies of more than 100 “glycol surrogate” derivatives led to the identification of potent and selective agonists for LysoPS receptors GPR34 and P2Y10. Thus, the non-natural 3-acyl compounds are indeed active and appear to be biol. orthogonal with respect to the physiol. relevant 1- and 2-acyl lysophospholipids. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Name: Pentane-1,5-diol

The Article related to structure activity agonist lysops receptor lysophospholipid phosphatidylserine glycol surrogate, human calcium mobilization agonist amino acid lysophospholipid glycerol, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Name: Pentane-1,5-diol

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On February 21, 2020, Tang, Yidan; Meador, Rowan I. L.; Malinchak, Casina T.; Harrison, Emily E.; McCaskey, Kimberly A.; Hempel, Melanie C.; Funk, Timothy W. published an article.Electric Literature of 111-29-5 The title of the article was (Cyclopentadienone)iron-Catalyzed Transfer Dehydrogenation of Symmetrical and Unsymmetrical Diols to Lactones. And the article contained the following:

Air-stable iron carbonyl compounds bearing cyclopentadienone ligands with varying substitution were explored as catalysts in dehydrogenative diol lactonization reactions using acetone as both the solvent and hydrogen acceptor. Two catalysts with trimethylsilyl groups in the 2- and 5-positions, [2,5-(SiMe3)2-3,4-(CH2)4(η4-C4C=O)]Fe(CO)3 and [2,5-(SiMe3)2-3,4-(CH2)3(η4-C4C=O)]Fe(CO)3, were found to be the most active, with 2 being the most selective in the lactonization of diols containing both primary and secondary alcs. Lactones containing five-, six-, and seven-membered rings were successfully synthesized, and no over-oxidations to carboxylic acids were detected. The lactonization of unsym. diols containing two primary alcs. occurred with catalyst 1, but selectivity was low based on alc. electronics and modest based on alc. sterics. Evidence for a transfer dehydrogenation mechanism was found, and insight into the origin of selectivity in the lactonization of 1°/2° diols was obtained. Addnl., spectroscopic evidence for a trimethylamine-ligated iron species formed in solution during the reaction was discovered. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Electric Literature of 111-29-5

The Article related to lactone preparation, diol transfer dehydrogenation iron catalyst, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Electric Literature of 111-29-5

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Chaudhari, Shivshankar; Shin, HyeonTae; Choi, SeoungYong; Cho, KieYong; Shon, MinYoung; Nam, SeungEun; Park, YouIn published an article in 2021, the title of the article was Hydrophilic and organophilic pervaporation of industrially important α,β and α,ω-diols.Recommanded Product: 111-29-5 And the article contains the following content:

The distillation-based purification of α,β and α,ω-diols is energy and resource intensive, as well as time consuming. Pervaporation separation is considered to be a remarkable energy efficient membrane technol. for purification of diols. Thus, as a core pervaporation process, hydrophilic polyvinyl alc. (PVA) membranes for the removal of water from 1,2-hexanediol (1,2-HDO) and organophilic polydimethylsiloxane-polysulfone (PDMS-PSF) membranes for the removal of isopropanol from 1,5 pentanediol (1,5-PDO) were employed. For 1,2-HDO/water separation using a feed having a 1 : 4 weight ratio of 1,2-HDO/water, the membrane prepared using 4 vol% glutaraldehyde (GA4) showed the best performance, yielding a flux of 0.59 kg m-2 h-1 and a separation factor of 175 at 40°C. In the organophilic pervaporation separation of the 1,5-PDO/IPA feed having a 9 : 1 weight ratio of components, the PDMS membrane prepared with a molar ratio of TEOS alkoxy groups to PDMS hydroxyl groups of 70 yielded a flux of 0.12 kg m-2 h-1 and separation factor of 17 638 at 40°C. Long term stability anal. found that both hydrophilic (PVA) and organophilic (PDMS) membranes retained excellent pervaporation output over 18 days’ continuous exposure to the feed. Both the hydrophilic and organophilic membranes exhibited promising separation performance at elevated operating conditions, showing their great potential for purification of α,β and α,ω-diols. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to pva pdms polysulfone membrane diol hydrophilic organophilic pervaporation, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Recommanded Product: 111-29-5

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Santiago-Calvo, Mercedes; Naji, Haneen; Bernardo, Victoria; Martin-de Leon, Judith; Saiani, Alberto; Villafane, Fernando; Rodriguez-Perez, Miguel Angel published an article in 2021, the title of the article was Analysis of the Foaming Window for Thermoplastic Polyurethane with Different Hard Segment Contents.Recommanded Product: 111-29-5 And the article contains the following content:

A series of thermoplastic polyurethanes (TPUs) with different amounts of hard segments (HS) (40, 50 and 60 weight%) are synthesized by a pre-polymer method. These synthesized TPUs are characterized by Shore hardness, gel permeation chromatog. (GPC), differential scanning calorimetry (DSC), wide angle X-ray diffraction (WAXD), dynamic mech. thermal anal. (DMTA), and rheol. Then, these materials are foamed by a one-step gas dissolution foaming process and the processing window that allows producing homogeneous foams is analyzed. The effect of foaming temperature from 140 to 180°C on the cellular structure and on d. is evaluated, fixing a saturation pressure of 20 MPa and a saturation time of 1 h. Among the TPUs studied, only that with 50 weight% HS allows obtaining a stable foam, whose better features are reached after foaming at 170°C. Finally, the foaming of TPU with 50 weight% HS is optimized by varying the saturation pressure from 10 to 25 MPa at 170°C. The optimum saturation and foaming conditions are 25 MPa and 170°C for 1 h, which gives foams with the lowest relative d. of 0.74, the smallest average cell size of 4μm, and the higher cell nucleation d. of 8.0 x 109 nuclei/cm3. As a final conclusion of this investigation, the TPU with 50 weight% HS is the only one that can be foamed under the saturation and foaming conditions used in this study. TPU foams containing 50 weight% HS with a cell size below 15μ and porosity of 1.4-18.6% can be obtained using foaming temperatures from 140 to 180°C, saturation pressure of 20 MPa, and saturation time of 1 h. Varying the saturation pressure from 10 to 25 MPa and fixing the foaming temperature of 170°C and saturation pressure of 1 h results in TPU foams with a cell size of below 37μ and porosity of 1.7-21.2%. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to thermoplastic polyurethane hard segment foaming window, foaming window, foams, gas dissolution foaming, hard segment, thermoplastic polyurethane, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Recommanded Product: 111-29-5

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Bertolini, Federico A.; Soccio, Michelina; Weinberger, Simone; Guidotti, Giulia; Gazzano, Massimo; Guebitz, Georg M.; Lotti, Nadia; Pellis, Alessandro published an article in 2021, the title of the article was Unveiling the enzymatic degradation process of biobased thiophene polyesters.Application of 111-29-5 And the article contains the following content:

In the past 20 years, scientific research focused on the identification of valid alternatives to materials of fossil origin, in particular, related to biobased polymers. Recently, the efforts led to the synthesis of thiophene-based polymers (TBPs), a new class of polyesters based on 2,5-thiophenedicarboxylic acid (TPCA) that can be industrially produced using biomass-derived mols. In this study, TBPs were synthesized using diols with different chain length (from C4 to C6) leading to poly(butylene 2,5- thiophenedicarboxylate) (PBTF), poly(pentamethylene 2,5-thiophenedicarboxylate) (PPeTF), and poly(hexamethylene 2,5-thiophenedicarboxylate) (PHTF), resp., that were processed to thin films. To investigate enzymic hydrolysis of these polymer films, cutinase 1 (Thc_cut1) and cutinase 2 (Thc_cut2) from Thermobifida cellulosilytica were recombinantly expressed in the host E. coli and purified. The SEM anal. showed that tiny holes were formed on the surface of the films and after 72 h PPeTF was completely degraded. After 72 h of incubation at 65°C with 5μM Thc_cut1, weight loss and HPLC anal. indicated 9, 100, and 80% degradation of PBTF, PPeTF, and PHTG with a concomitant release of 0.12, 2.70, and 0.67 mM of TPCA. The LC-TOF/MS anal. indicated that Thc_cut2 in particular released various oligomers from the polymer during the reaction. In addition, the FTIR anal. showed the formation of novel acid and hydroxyl groups on the polymer surfaces. The results showed that the two used thermostable cutinases are promising biocatalysts for the environmentally friendly degradation of TPCA-based polyesters, in view of a possible sustainable recycling of plastic waste through resynthesis processes. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application of 111-29-5

The Article related to thiophene polyester enzymic degradation, biodegradability, circular economy, circular materials, cutinases, polyesters, thiophene-based polymers, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application of 111-29-5

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Sanchez-Calderon, Ismael; Bernardo, Victoria; Santiago-Calvo, Mercedes; Naji, Haneen; Saiani, Alberto; Rodriguez-Perez, Miguel Angel published an article in 2021, the title of the article was Effect of the Molecular Structure of TPU on the Cellular Structure of Nanocellular Polymers Based on PMMA/TPU Blends.Category: alcohols-buliding-blocks And the article contains the following content:

In this work, the effects of thermoplastic polyurethane (TPU) chem. and concentration on the cellular structure of nanocellular polymers based on poly(methyl-methacrylate) (PMMA) are presented. Three grades of TPU with different fractions of hard segments (HS) (60%, 70%, and 80%) were synthesized by the prepolymer method. Nanocellular polymers based on PMMA were produced by gas dissolution foaming using TPU as a nucleating agent in different contents (0.5 wt%, 2 wt%, and 5 wt%). TPU characterization shows that as the content of HS increases, the d., hardness, and mol. weight of the TPU are higher. PMMA/TPU cellular materials show a gradient cell size distribution from the edge of the sample toward the nanocellular core. In the core region, the addition of TPU has a strong nucleating effect in PMMA. Core structure depends on the HS content and the TPU content. As the HS or TPU content increases, the cell nucleation d. increases, and the cell size is reduced. Then, the use of TPUs with different characteristics allows controlling the cellular structure. Nanocellular polymers have been obtained with a core relative d. between 0.15 and 0.20 and cell sizes between 220 and 640 nm. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Category: alcohols-buliding-blocks

The Article related to mol structure nanocellular pmma tpu blend, gas dissolution foaming, nanocellular polymer, poly(methyl-methacrylate), thermoplastic polyurethane, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Category: alcohols-buliding-blocks

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