Category: 110-99-6

Reed, Kristi J. published the artcileDiethylene glycol and its metabolites induce cell death in SH-SY5Y neuronal cells in vitro, Application of 2,2′-Oxydiacetic acid, the main research area is diethylene glycol neuronal cell death neurotoxicity diglycolic acid HEAA; Diethylene glycol; Diglycolic acid; Hydroxyethoxyacetate; Neurotoxicity; SH-SY5Y cell death.

Diethylene glycol (DEG) intoxication results in metabolic acidosis, renal and hepatic dysfunction, and late-stage neurotoxicity. Though the renal and hepatic toxicity of DEG and its metabolites 2-hydroxyethoxyacetic acid (2-HEAA) and diglycolic acid (DGA) have been well characterized, the resultant neurotoxicity has not. SH-SY5Y neuroblastoma cells were incubated with all 3 compounds at increasing concentrations for 24, 48, or 120 h. At all 3 time points, 50 mmol/L DGA and 100 mmol/L DEG showed significant Annexin V and propidium iodide (PI) staining with addnl. concentrations showing similar staining patterns at 24 h (100 mmol/L DGA) and 48 h (50 mmol/L DEG, 100 mmol/L DGA). Only the 200 mmol/L 2-HEAA concentration induced SH-SY5Y cell death. Interestingly at 24 and 48 h, 100 mmol/L DEG induced significant increases in apoptotic cell death markers, which progressed to necrosis at 120 h. Similar to DEG, 50 mmol/L DGA induced significant increases in SH-SY5Y cell apoptosis and necrosis markers at both 24 and 48 h. As expected, high DGA concentrations (100 mmol/L) at 120 h induced significant SH-SY5Y cell necrosis with no apoptosis detected. However, at 120 h lower DGA concentrations (20 mmol/L) significantly increased oligonucleosome formation alone and in combination with 2-HEAA or DEG. Taken together, these results indicate that DGA and DEG at threshold concentrations induce neurotoxicity in SH-SY5Y cells.

Toxicology In Vitro published new progress about Apoptosis. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Application of 2,2′-Oxydiacetic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Hyun-Jung published the artcilePerformance improvement of slot-die-deposition based perovskite solar cells using diglycolic acid additives, COA of Formula: C4H6O5, the main research area is diglycolic acid slot die deposition perovskite solar cell.

In slot-die-coating process, novel approaches for better perovskite film formation were continuously required. Here, we studied additive processes for better slot-die-processed perovskite fabrication. As a novel additive, we introduced diglycolic acid (DA) material having a carboxyl group, well known as an effective functional group. With adding optimal amount of DA in the perovskite precursor solution, device efficiency and stability were all improved; DA-based perovskite device showed the best PCE of 14.63%. Moreover, the DA-based devices showed superior long-term stability guaranteeing 80% of initial efficiency during 95 days.

Materials Letters published new progress about Annealing. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Van Damme, Ryan published the artcileChemical reversible crosslinking enables measurement of RNA 3D distances and alternative conformations in cells, Synthetic Route of 110-99-6, the main research area is RNA 3D measurement reversible crosslinking cell conformation.

Three-dimensional (3D) structures dictate the functions of RNA mols. in a wide variety of biol. processes. However, direct determination of RNA 3D structures in vivo is difficult due to their large sizes, conformational heterogeneity, and dynamics. Here we present a method, Spatial 2-Hydroxyl Acylation Reversible Crosslinking (SHARC), which uses chem. crosslinkers of defined lengths to measure distances between nucleotides in cellular RNA. Integrating crosslinking, exonuclease (exo) trimming, proximity ligation, and high throughput sequencing, SHARC enables transcriptome-wide tertiary structure contact maps at high accuracy and precision, revealing heterogeneous RNA structures and interactions. SHARC data provide constraints that improves Rosetta-based RNA 3D structure modeling at near-nanometer resolution Integrating SHARC-exo with other crosslinking-based methods, we discover compact folding of the 7SK RNA, a critical regulator of transcriptional elongation. These results establish a strategy for measuring RNA 3D distances and alternative conformations in their native cellular context.

Nature Communications published new progress about Acylation. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Synthetic Route of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Waheed, K. published the artcileDiglycolamide Based Mono and Di-Ionic Liquids Having Imidazolium Cation for Effective Extraction and Separation of Pb(II) and Co(II), Recommanded Product: 2,2′-Oxydiacetic acid, the main research area is lead cobalt diglycolamide ionic liquid imidazolium cation extraction separation.

Two glycolamide based functionalized ionic liquids (ILs) having imidazolium cations namely LI (mono-ionic) and LII (di-ionic) were synthesized for the extraction of Pb(II) and Co(II) from waste water. The synthesized ligands were characterized by FTIR and NMR spectroscopy. The extraction efficiency of both mono- and di-ionic liquids was evaluated in terms of contact time, pH of the aqueous phase and metal ion concentration The metal extraction was carried out at various pH values viz. 2, 4, 6, 8, and 10 whereas, at contact time of 15, 30, 45, 60, and 75 min. The optimized pH of 4 and equilibration time of 75 min was further utilized for extraction at various metal ions concentration (50, 100, 150, 200, and 250 ppm). LI exhibited low equilibration time as compared to LII whereas, both ligands showed maximum extraction at a pH of 4. A very high extraction efficiency of up to 99% for both metals was observed with LI and LII under optimized conditions. In addition to that effective separation of Co(II) and Pb(II) was observed at pH 10.

Russian Journal of Inorganic Chemistry published new progress about Extraction. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Recommanded Product: 2,2′-Oxydiacetic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Santibanez, Luis published the artcileCuII- and CoII-based MOFs: {[La2Cu3(μ-H2O)(ODA)6(H2O)3]·3H2O}n and {[La2Co3(ODA)6(H2O)6]·12H2O}n. The relevance of physicochemical properties on the catalytic aerobic oxidation of cyclohexene, Application In Synthesis of 110-99-6, the main research area is lanthanum copper cobalt cyclohexene catalytic aerobic oxidation pore size.

The aerobic oxidation of cyclohexene was done using the heterometallic metal organic frameworks (MOFs) {[La2Cu3(μ-H2O)(ODA)6(H2O)3]·3H2O}n and {[La2Co3(ODA)6(H2O)6]·12H2O}n (LaCoODA) (2) as catalysts, in solvent free conditions (ODA, oxydiacetic acid). After 24 h of reaction, the catalytic system showed that LaCoODA had a better catalytic performance than that of LaCuODA (conversion 85% and 67%). The structures of both catalysts were very similar, showing channels running along the c axis. The physicochem. properties of both MOFs were determined to understand the catalytic performance. The Langmuir surface area of LaCoODA was shown to be greater than that of LaCuODA, while the acid strength and acid sites were greater for LaCuODA. On the other hand, the redox potential of the active sites was related to CoII/CoIII in LaCoODA and CuII/CuI in LaCuODA. Therefore, it is concluded that the Langmuir surface area and the redox potentials were more important than the acid strength and acid sites of the studied MOFs, in terms of the referred catalytic performance. Finally, the reaction conditions were also shown to play an important role in the catalytic performance of the studied systems. Especially, the type of oxidant and the way to supply it to the reaction medium influenced the catalytic results.

Catalysts published new progress about Adsorption. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Application In Synthesis of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yang published the artcileHighly selective and sensitive probes for the detection of Cr(VI) in aqueous solutions using diglycolic acid-functionalized Au nanoparticles, Formula: C4H6O5, the main research area is diglycolic acid functionalized gold nanoparticle probe synthesis chromium detection.

In this study, a variety of diglycolic acid-functionalized gold nanoparticle (Au NP) probes are reported, which are highly sensitive for the detection of chromium ions, Cr(VI) ions, at low concentrations in aqueous solutions based on the application of surface plasmon resonance (SPR) theory. Due to its outstanding affinity for Cr(VI) ions, the capped diglycolic acid would induce the aggregation of the NP probes upon encountering them; this was evidenced by the obvious red-shifting of the SPR peak and the enlarged size of the NPs. For the same reason, the selectivity of the probe for Cr(VI) against other heavy metal ions was found to be remarkable. Under optimized conditions, the probe showed the limit of detection (LOD) of 0.32 ppb for Cr(VI) and a linear detection scale ranging from 0.32 ppb to 0.1 ppm. To the best of our knowledge, this is probably the lowest LOD reported for Cr(VI) detection among those of the methods based on SPR.

RSC Advances published new progress about Adsorption. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nawaz, Tehreema published the artcileSynthesis of diglycolic acid functionalized core-shell silica coated Fe3O4 nanomaterials for magnetic extraction of Pb(II) and Cr(VI) ions, Category: alcohols-buliding-blocks, the main research area is diglycolic acid functionalized magnetite lead chromium adsorption magnetic WWT.

Abstract: Amine-terminated core-shell silica coated magnetite nanoparticles were functionalized with diglycolic acid for the first time to create acid moiety on the surface of the nanoparticles. The formation of magnetite nanoparticles was scrutinized through XRD, SEM, EDS, TEM, VSM and FTIR spectroscopy. The BET surface area of nano-sorbent was found to be 4.04 m2/g with pore size 23.68 nm. These nanomaterials were then utilized to remove the Pb(II) and Cr(VI) ions from their aqueous media and uptake of metal ions was determined by at. absorption spectroscopy (AAS). A batch adsorption technique was applied to remove both ions at optimized pH and contact time with maximum adsorption efficiency for Pb(II) ions at pH 7 while for Cr(VI) ions at pH 3. Adsorption mechanism was studied using Langmuir and Freundlich isotherms and equilibrium data fitted well for both the isotherms, showing complex nature of adsorption comprising both chemisorption as well as physio-sorption phenomena. The nanosorbents exhibited facile separation by applying external magnetic field due to the ferrimagnetic behavior with 31.65 emu/g saturation magnetization. These nanosorbents were also found to be used multiple times after regeneration.

Scientific Reports published new progress about Adsorption. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pereao, Omoniyi published the artcileAdsorption of Ce3+ and Nd3+ by diglycolic acid functionalized electrospun polystyrene nanofiber from aqueous solution, Computed Properties of 110-99-6, the main research area is cerium neodymium adsorption diglycolate functionalized electrospun polystyrene nanofiber wastewater.

Highly selective and stable ligands with fast kinetics for rare earth element extraction are not well developed. Durable attachment of ligands to the support would make regeneration possible. Polystyrene nanofiber supports (PS-nF) were prepared using the electrospinning method. Thereafter, PS-nf were chem. modified with diglycolic anhydride (DGA) to produce novel electrospun polystyrene diglycolic acid nanofiber (PS-DGAnf) adsorbents. The immobilization reaction proceeded via an electrophilic aromatic substitution of the ligand onto the PS nanofiber. The maximum gravimetric loading of DGA on PS nanofiber was 0.827 g g-1. The unmodified and modified nanofibers were characterized by ATR-FTIR, HR-SEM, BET and TGA. After optimizing pH, time and concentration, the equilibrium adsorption and binding kinetics of cerium (Ce3+) and neodymium (Nd3+) ions on the nanofibers surface were examined at pH 6. The adsorption capacity of PS-DGAnf for Ce3+ and Nd3+ at pH 6.0 was 152.5 mg g-1 (1.09 mmol/g) and 146.2 mg g-1 (1.01 mmol/g) resp. Selectivity of Ce3+ over Ni2+, Co2+ and Sr3+ was also studied at pH 6. The amount of Ce3+ adsorbed even in the presence of interfering ions was 100.3 mg g-1, which was only a little lower than 119.4 mg g-1 obtained in a single ion solution The rapid adsorption kinetics of Ce3+ and Nd3+ ions were achieved within 15 mins. The desorption and regeneration was carried out with 1 M nitric acid and the developed PS-DGAnf adsorbent could be reused for 4 cycles without any substantial loss to its adsorption abilities.

Separation and Purification Technology published new progress about Adsorbents. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Computed Properties of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liao, Lieqiang published the artcileSupramolecular organogels fabricated with dicarboxylic acids and primary alkyl amines: controllable self-assembled structures, Related Products of alcohols-buliding-blocks, the main research area is supramol organogel dicarboxylic acid primary alkyl amine.

Supramol. organogels are soft materials comprised of low-mol.-mass organic gelators (LMOGs) and organic liquids Owning to their unique supramol. structures and potential applications, LMOGs have attracted wide attention from chemists and biochemists. A new “”superorganogel”” system based on dicarboxylic acids and primary alkyl amines (R-NH2) from the formation of organogels is achieved in various organic media including strong and weak polar solvents. The gelation properties of these gelators strongly rely on the mol. structure. Their aggregation morphol. in the as-obtained organogels can be controlled by the solvent polarity and the tail chain length of R-NH2. Interestingly, flower-like self-assemblies can be obtained in organic solvents with medium polarity, such as THF, pyridine and dichloromethane, when the gelators possess a suitable length of carbon chain. Moreover, further analyses of Fourier transformation IR spectroscopy and 1H NMR spectroscopy reveal that the intermol. acid-base interaction and van der Waals interaction are critical driving forces in the process of organogelation. In addition, this kind of organogel system displays excellent mech. properties and thermo-reversibility, and its forming mechanism is also proposed.

RSC Advances published new progress about Aggregation. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Seong-Yun published the artcileSelective Separation of Trivalent Europium(III) from Americium(III) using N,N’-Dimethyl-N,N’-di-2-phenylethyl-diglycol Amide (MPEDGA) Extractant in Ionic Liquid, HPLC of Formula: 110-99-6, the main research area is americium europium dimethyl diphenylethyl diglycol amide IL extractant separation.

A diglycolamide based N,N”-Dimethyl-N,N”-di-2-phenylethyl-diglycol amide (MPEDGA) extractant was synthesized and dissolved into 1-butyl-3-methylimidazolium nonafluorobutanesulfonate ([C4mim][NfO]) to prepare the extraction phase. Its separation performance of Am-241 with Eu-152 in nitric acid solution was investigated. The extraction kinetics were fast and could reach equilibrium within 15 min. When [HNO3] = 0.1 M, the maximum SFEu-152/Am-241 was obtained as 124. Moreover, with increase in the concentration of HNO3, the extraction ability decreased gradually, and SFEu-152/Am-241 decreased as 3 when [HNO3] reached 4 M. Back extraction was successfully completed by using 1 M guanidine carbonate with 0.5 M EDTA or 1 M guanidine carbonate with 0.5 M diethylenetriaminepentaacetic acid (DTPA), resp. Slope anal. revealed a 1:3 complex was formed. Effect of temperature further clarified the extraction process was exothermic.

Solvent Extraction Research and Development, Japan published new progress about Complexation. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, HPLC of Formula: 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts