Category: 110-73-6

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.110-73-6

General procedure: To a solution of 3-formylchromone 5 (1 equiv) in 1,2-dichloroethane was added secondary amine 6a-o (1.2 equiv) and sodium triacetoxyborohydride (1.5 equiv). After stirring at room temperature for 12 h, the reaction mixture was quenched with H2O and extracted with CH2Cl2. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash silica gel chromatography to obtained 4a-n.

Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.

Reference:
Article; Joo, Cheonik; Venkateswararao, Eeda; Lee, Ki-Cheul; Sharma, Vinay K.; Kyung, Min-Sik; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5757 – 5762;,
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Adding some certain compound to certain chemical reactions, such as: 110-73-6, name is 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110-73-6. 110-73-6

General procedure: (A) 2-(Alkylamino)ethanol2a or 2b (6 mmol) and Et3N (1.0 ml) were added with stirring tothe solution of diferrocenylcyclopropenylium tetrafluoroborate 1 (3 mmol)in dry benzene or acetonitrile (70 ml). After stirring for 6-12 h at ~80C,the volatiles were removed in vacuo; the residue was chromatographed ona column with Al2O3 (activity III) (hexane-diethyl ether, 3 :1) to affordthe reaction products 3a,b (30-32%) and 4a,b (43-44%), respectively.(B) Following the general procedure, reaction of 1b (1 mmol) in MeCN(30 ml, 80C, 6-12 h) in the presence of Et3N (0.3 ml) with amino alcohols2a,b (1 mmol) afforded compounds 3a (62-71%) or 3b (67-74%) and4a,b (3-10%).(C) Reaction of 1b (1 mmol) in dry benzene (30 ml, 80C, 6-12 h) inthe presence of Et3N (0.3 ml) with amino alcohols 2a,b (3 mmol) affordedcompounds 3a,b (5-7%) and 4a (58-77%), 4b (61-80%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 110-73-6.

Reference:
Article; Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Chirinos Flores, Denis E.; Klimova, Elena I.; Mendeleev Communications; vol. 27; 1; (2017); p. 26 – 28;,
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Adding some certain compound to certain chemical reactions, such as: 110-73-6, name is 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110-73-6. 110-73-6

into a 500 ml four-necked flask, 26.7 parts of 2- (ethylamino) ethanol (Tokyo Chemical Industry Co., Ltd.) 133 parts of tetrahydrofuran, 1.8 parts of 4-dimethylaminopyridine (manufactured by Tokyo Chemical Industry Co., Ltd.) 33.4 parts of triethylamine and 65.5 parts of di-tert-butyl dicarbonate (manufactured by Tokyo Chemical Industry Co., Ltd.) And refluxed for 2 hours. After cooling the reaction solution to 40 C., Dichloromethane was added to the reaction solution, The organic layer was washed with water, Washed with saturated brine, and dried over anhydrous sodium sulfate. By concentrating the organic layer under reduced pressure, 51.1 parts of an intermediate represented by the following formula (109) was obtained.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 110-73-6.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; OHTANI, KOHEI; KAMEYA, HIROSHI; (24 pag.)JP2017/114996; (2017); A;,
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