Category: 110-73-6

Related Products of 110-73-6, Adding some certain compound to certain chemical reactions, such as: 110-73-6, name is 2-(Ethylamino)ethanol,molecular formula is C4H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110-73-6.

General procedure: All compounds were prepared according our previous works[12]. The general procedure: Amines (1 mmol) was dissolved in20 mL of MeOH. Equal molar NaOH aqueous solution was added to the methanol solution. Excess CS2 was slowly dropped into thereaction flask in an ice bath. The reaction was completed at roomtemperature for 8 h. The solution was then evaporated and theresidue was precipitated three times with diethyl ether and filtered and dried to give a white powder product. All sodium dithiocarbamate(A1-22) are white solid. A1-22 and equal molar Mn(CO)5Brwere dissolved in 15mL of methanol. The solution immediately became yellow and was stirred at room temperature for 3 h. Thesolution was then evaporated and the yellow residue was dissolved in Ether. The solution was placed in 2-4 C for 2 h and the supernatant was evaporated to give a yellow solid. After recrystallization three times with DCM and CYH, the final product was obtained.

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bai, Zhongjie; Zhang, Jinlong; Zhang, Qiuping; Zhang, Taofeng; Li, Jili; Zhao, Quanyi; Wang, Zhen; He, Dian; Cheng, Jie; Zhang, Jingke; Liu, Bin; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 339 – 356;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 110-73-6, 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

18a. Ethyl(2-(nitrooxy)ethyl)ammonium nitrate Ethyl(2-(hydroxy)ethyl)amine (5 g, 56 mmol) in EtOAc (60 mL) was added drop-wise to a mixture of fuming HNO3 (17.7 g, 11.8 mL, 280 mmol) and Ac2O (45.8 g, 42.3 mL, 448 mmol) at -10 C. The reaction mixture was stirred at -10 C. for 30 minutes and diluted with EtOAc and hexane. The oil layer was separated and dried in high vacuo to give the title compound (8.4 g, 76% yield) as a pale green oil. 1H NMR (300 MHz, d6-DMSO) delta 8.60-8.95 (bs, 2H), 4.84 (m, 2H), 3.37-3.49 (m, 2H), 3.02-3.16 (m, 2H), 1.24 (t, J=7.2 Hz, 3H). 13C NMR (75 MHz, d6-DMSO) delta 69.1, 43.6, 42.6, 11.0. Mass spectrum (API-TIS) m/z 135 (MH+).

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NitroMed, Inc.; US2004/24057; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 110-73-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 110-73-6 as follows.

[0284] To the solution of compound of Example 1 (120 mg, 0.136 mmol) and catalytic amount of dimethylaminopyridine in CH2Cl2 (2 mL) at 0 C. was added pyridine (0.20 mL, 2.48 mmol) and diphosgen (0.08 mL, 0.66 mmol). The reaction was warmed to room temperature and stirred for 20 h. 2-(Ethylamino)ethanol (0.2 mL, 2.05 mmol) was added to the reaction and the mixture was stirred for another 16 h before being diluted with ethyl acetate (50 mL). The organic solution was washed with sat. aq. NH4Cl (5 mL¡Á2), sat. aq. NaHCO3 (5 mL) and brine, dried over MgSO4, and concentrated. The crude product was purified by chromatography (silica gel, 94:6:0.3 dichloromethane/methanol/conc. NH4OH). The purified product was dissolved in methanol (5 mL) and stirred at room temperature for 72 h. Concentration and purification by chromatography (silica gel, 92:8:0.3 dichloromethane/methanol/conc. NH4OH) yielded 17 mg (13%) of the title compound. MS 954 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin; US2004/18994; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 8This example illustrates the preparation of certain compounds of the present invention. The amines used were commercial samples supplied by Fisher Scientific or Sigma Aldrich. Amines were reacted with one of the following: (-)-Ethyl(S)-2-hydroxypropionate (Ethyl-5-lactate, Ex Sigma Aldrich, 98%) (-)-Ethyl(S)-2-hydroxypropionate (Ethyl-L-lactate, Ex Fluka, >99%) 3,6-dimethyl-1,4-dioxane-2,5-dione (Lactide, Ex Aldrich, 99%) Initially reactions were performed in a microwave reactor under the conditions listed in Table 5. Due to the restricted volumes possible and in light of the rapid reactions seen, further reactions were carried out under ambient conditions and over an increased timescale. Reactions were monitored using FT-IR spectroscopy via the reduction in the ester band from ethyl-lactate at ~1750 cm-1 and the corresponding increase in the amide bands at ~1630 cm-1 and ~1550 cm-1. Selected samples were purified via preparatory HPLC and the compounds were identified via GC-MS and NMR. A cleaner, novel synthetic route was later utilised where the amines were reacted with lactide (3,6-dimethyl-1,4-dioxane-2,5-dione). TABLE 5 Reacted Amine Moles With Moles Reaction Conditions Yield Ethylamine 0.126 Ethyl-S- 0.126 Microwave Reactor, 200 C., 20 >75% lactate Bar, 3 minutes Ethanolamine 0.164 Ethyl-S- 0.164 Microwave Reactor, 200 C., 15 >95% lactate Bar, 30 minutes Isopropylamine 0.116 Ethyl-S- 0.116 Microwave Reactor, 200 C., 18 >75% lactate Bar, 30 minutes Diethanolamine 0.104 Ethyl-S- 0.104 Microwave Reactor, 200 C., 15 >75% lactate Bar, 30 minutes Morpholine 0.114 Ethyl-S- 0.114 Microwave Reactor, 200 C., 9 Bar, >75% lactate 30 minutes Benzylamine 0.091 Ethyl-S- 0.091 Microwave Reactor, 200 C., 13 >75% lactate Bar, 30 minutes Diethylamine 0.096 Ethyl-S- 0.096 Microwave Reactor, 200 C., >50% lactate 15 Bar, 30 minutes N-methyl-tert- 0.037 Ethyl-S- 0.037 Microwave Reactor, 200 C., >25% butylamine lactate 12 Bar, 30 minutes N-ethylisopropylamine 0.037 Ethyl-S- 0.037 Microwave Reactor, 175 C., 8 >25% lactate Bar, 30 minutes sec-Butylamine 0.098 Ethyl-S- 0.098 Microwave Reactor, 200 C., >75% lactate 14 Bar, 30 minutes 1-ethylpropylamine 0.085 Ethyl-S- 0.085 Microwave Reactor, 200 C., >75% lactate 12 Bar, 30 minutes N- 0.096 Ethyl-S- 0.096 Microwave Reactor, 150 C., 3 >25% isopropylmethylamine lactate Bar, 30 minutes tert-Butylamine 0.095 Ethyl-S- 0.095 Microwave Reactor, 200 C., >95% lactate 17 Bar, 30 minutes Pyrrolidine 0.119 Ethyl-S- 0.119 Microwave Reactor, 200 C., >75% lactate 14 Bar, 30 minutes 1,3-dimethylbutylamine 0.030 Ethyl-S- 0.030 Microwave Reactor, 200 C., >50% lactate 10 Bar, 30 minutes 2-(ethylamino)ethanol 0.204 Ethyl-L- 0.183 4 days at Ambient >75% lactate Temperature & Pressure 2-amino-1-butanol 0.208 Ethyl-L- 0.188 4 days at Ambient >75% lactate Temperature & Pressure allylamine 0.267 Ethyl-L- 0.240 4 days at Ambient >75% lactate Temperature & Pressure Isobutylamine 0.199 Ethyl-L- 0.179 4 days at Ambient >75% lactate Temperature & Pressure 1-ethylpropylamine 0.171 Ethyl-L- 0.154 4 days at Ambient >25% lactate Temperature & Pressure tert-amylamine 0.170 Ethyl-L- 0.153 3 days at Ambient <25% lactate Temperature & Pressure Dipropylamine 0.146 Ethyl-L- 0.131 2 days at Ambient Negligible lactate Temperature & Pressure Hexylamine 0.151 Ethyl-L- 0.136 3 days at Ambient >75% lactate Temperature & Pressure DL-2-amino-1-pentanol 0.044 Ethyl-L- 0.039 3 days at Ambient >75% lactate Temperature & Pressure N-hexylmethylamine 0.130 Ethyl-L- 0.117 2 days at Ambient >50% lactate Temperature & Pressure N-methylpropylamine 0.047 Ethyl-L- 0.042 4 days at Ambient >50% lactate Temperature & Pressure Dipropylamine 0.047 Lactide 0.025 2 hours at 50 C. <10% Benzylamine 0.053 Lactide 0.028 1 hour at 40 C. >95% 2-benzylaminoethanol 0.069 Lactide 0.035 5 hours at 55 C. >25% N-methylbenzylamine 0.074 Lactide 0.038 12 days at Ambient >50% Temperature & Pressure N-methylbutylamine 0.078 Lactide 0.040 12 days at Ambient >50% Temperature & Pressure 3-diethylamino-propylamine 0.065 Lactide 0.033 12 days at Ambient >75% Temperature & Pressure 2-Ethyl-1-Hexylamine 0.166 Lactide 0.108 4 days at Ambient >95% Temperature & Pressure 3-N-Butoxy Propylamine 0.056 Lactide 0.034 4 days at Ambient >25% Temperature & Pressure 3-Pentylamine 0.059 Lactide 0.040 4 days at Ambient >95% Temperature & Pressure N-(3-Aminopropyl)Morpholine 0.067 Lactide 0.035 4 days at Ambient >95% Temperature & Pressure N-Methylaniline 0.081 Lactide 0.042 4 days at Ambient >25% Temperature & Pressure

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; US2009/227453; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 110-73-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 110-73-6 as follows.

2-Bromothiophene (1.19 mL, 12.3 mmol, CAS 1003-09-4), copper(I) iodide (350 mg, 15 mol %), copper powder (117 mg, 15 mol %, CAS 7440-50-8) and potassium phosphate tribasic (5.22 g, 24.6 mmol) were suspended in 2-(ethylamino)ethanol (12 mL) and heated at 80 C. for 20 h under Ar. After this time, the reaction mixture was allowed to cool to room temperature and water (40 mL) added. The solution was extracted with diethyl ether (3¡Á40 mL), and the combined organic fractions washed with brine (1¡Á60 mL), dried over MgSO4 and the solvent removed in vacuo. Purification was undertaken by silica gel column chromatography (column loaded using 3% Et3N/hexane) using 2:1 hexane/ethyl acetate to elute the product as an orange oil (1.02 g, 5.96 mmol, 48%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; University of Notre Dame du Lac; Smith, Bradley; US2015/5501; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Synthetic Example 19 tert-Butyl ethyl(2-hydroxyethyl)carbamate To a mixture of 2-(ethylamino)ethanol (8.91 g) and ethyl acetate (100 mL) was added di-tert-butyl dicarbonate (21.8 g) under ice-cooling. The reaction mixture was stirred at room temperature for 3 days, and washed with saturated brine, then, dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give title compound as colorless oil (19.0 g). 1H-NMR (CDCl3): 1.11 (3H, t, J=7.0Hz), 1.47(9H,s), 3. 27 (2H, q, J=7. 0Hz), 3. 37 (2H, t, J=5.2Hz), 3. 73 (2H, q, J=5. 2Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 110-73-6, 2-(Ethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1602362; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

110-73-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below.

Compounds 1 and 2 were prepared by the following procedure: 2-(4-chloro-3-nitrophenyl)-2-oxoethyl 2-aminobenzoate or 2-(4-amino-3-nitrophenyl)-2-oxoethyl 2-aminobenzoate (44.8 mmol) was suspended in polyphosphoric acid (167.3 g). The reaction mixture was heated to 100 C and stirred for 90 min. The mixture was then poured into H2O/crushed ice (700 ml). The precipitated product was filtered, washed with H2O, dried and recrystallized from 2-methoxyethanol. Compounds 3-17 were prepared by the following general procedure: quinolinone 1 (200 mg, 0.63 mmol) was added to a solution of amine (6.3 mmol) and N-methylpyrrolidone (1.0 ml) and the mixture was stirred at 110 C for 2 h. After cooling to room temperature, H2O (20 ml) was added and the pH adjusted to 7 with dilute HCl (1:3). The precipitated solid was collected by suction, washed thoroughly with H2O and dried at 80 C. The crude product was recrystallized from 2-methoxyethanol.

Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.

Reference:
Article; Motyka, Kamil; Hlava?, Jan; Soural, Miroslav; Hradil, Pavel; Krej?i, Petr; Kvapil, Lubomir; Weiss, Milo?; Tetrahedron Letters; vol. 52; 6; (2011); p. 715 – 717;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.110-73-6

2-(ethyl(2-hydroxyethyl)amino)benzenesulfonamideTo the solution of 2-fluorobenzenesulfonamide (1051 mg, 6 mmol) in 2-(ethylamino)ethanol (2.93 mL, 30.0 mmol) was heated with microwave irradiation at 130 C for 30 min, heated again with microwave at 130 C for 30 min (71-1), heated again with microwave at 150 C for 30 min. To the reaction mixture was added DMSO (2 mL) and water (0.2 mL) then heated with microwave irradiation at 130 C for 2 h, heated again with microwave at 140 C for 1 h, heated again with microwave at 150 C for 1 h, heated again at 150 C for 5 h. The reaction mixture was diluted with H20 (30 mL), adjusted pH to ~5 with HCI (6 N then 1 N), extracted with EtOAc (3 x 30 mL). The organic layer was washed with brine (30 mL), dried over MgSO4, filtered, concentrated under reduced pressure, purified by silica gel chromatography, to afford the desired product 2-(ethyl(2-hydroxyethyl)amino)benzenesulfonamide (923.0 mg, 3.78 mmol, 63.0 % yield). LC-MS m/z 245 (M + H)+, 0.94 (ret. time).

Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; BOEHM, Jeffrey Charles; DAVIES, Thomas Glanmor; WOOLFORD, Alison Jo-anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; NORTON, David; SAXTY, Gordon; HEIGHTMAN, Thomas Daniel; LI, Tindy; KERNS, Jeffrey K.; DAVIS, Roderick S.; YAN, Hongxing; WO2015/92713; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

110-73-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of 1.0 mmol of amino alcohol [ethanolamine (0.06 mL), N-methylethanolamine (0.08 mL), or N-ethylethanolamine (0.10 mL)], 1.0 mmol of paraformaldehyde (0.03 g), and 1.0 mmol of >P(O)H reagent [diethyl phosphite (0.13 mL), dibutyl phosphite (0.20 mL), or ethylphenyl-H-phosphinate (0.17 g)] was irradiated in a sealed tube at 80 C for 20 min in a CEM Discover Microwave reactor equipped with a pressure controller. The crude product was purified by flash column chromatography using silica gel and dichloromethane-methanol 9:1 as the eluent.Thus, the following products were prepared:

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Article; Tajti, Adam; Szatmari, Enik; Perdih, Franc; Keglevich, Gyoergy; Balint, Erika; Molecules; vol. 24; 8; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 474-[ethyl(2-hydroxyethyl)amino]-/V-methyl-3-(1 /-/-purin-6-ylamino)benzenesulfonamidea) 4-[ethyl(2-hydroxyethyl)amino]-/V-methyl-3-nitrobenzenesulfonamideA solution of 4-fluoro-/V-methyl-3-nitrobenzenesulfonamide (500 mg, 2.14 mmol) in (2-ethylamino)ethanol (951 mg, 10.67 mmol) in a microwave reaction tube was sealed and heated at 1 10 C for 18 h. The mixture was concentrated and purified by flash column chromatography (0-3% MeOH/CHCI3 containing 0.1 % NuEta3¡¤Eta20) to afford the title compound (620 mg, 96%) as a yellow oil. LCMS (ES) m/z 304 (M+H)+; 1H NMR (400 MHz, DMSO-de) delta ppm 1 .10 (t, J=7.07 Hz, 3 H) 2.42 (d, J=4.55 Hz, 3 H) 2.50 (br. s, 2 H) 3.23 – 3.30 (m, 2 H) 3.54 (d, J=5.56 Hz, 2 H) 4.73 (s, 1 H) 7.44 (d, J=9.09 Hz, 2 H) 7.73 (s, 1 H) 8.03 (d, J=2.27 Hz, 1 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; GLAXOSMITHKLINE LLC; HAMMOND, Marlys; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne; SARPONG, Martha, A.; SEEFELD, Mark, Andrew; WO2011/149827; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts