Category: 110-73-6

Related Products of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of(Intermediate 3) 60ml of N, N-dimethylacetamide Intermediate 2 was added 21.1 g(50 mmol), and stirred in an ice bath, was added dropwise so as to keep the following 10 C N- ethyl ethanolamine 8.9 g (100 mmol) . After completion ofthe dropwise addition, stirring under an ice bath for 2 hours, ethyl acetate100ml reaction solution, ion-exchanged water 100ml, and extracted concentratedhydrochloric acid was added to 3 ml. The organic layer was washed with asaturated sodium chloride aqueous solution, dried over anhydrous magnesiumsulfate, and the solvent was evaporated. Then purified by silica gel columnchromatography (hexane / ethyl acetate = 1/1), Intermediate 3 19.0 g: yield(yield: 80%).

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM Corporation; Takasaki, Yuta; Ishiwata, Yasuhiro; Morozumi, Kazuma; (58 pag.)JP2015/124376; (2015); A;,
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Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 14; test-butyl [2-(4-{1-(2,4-dichlorophenyl)-4-methyl-3-[(piperidin-1-ylamino)carbonyl]-1H- pyrazol-5-vl} phenoxy . ethyllethvlcarbamate; Step A: tert-butyl ethyl(2-hydroxyethyl)carbamate; Di-tert-butyl dicarbonate (3.19 g, 14.6 mmol) in THF (10 ml) was added to 2- (ethylamino) ethanol (1.00 g, 11.2 mmol) and reacted at room temperature for 3 hours. The solvent was evaporated at reduced pressure to give the crude product (2.28 g). 1H NMR (499.961 MHz) 8 3.71-3. 65 (br, 2H), 3.55-3. 35 (br, 1H), 3.35-3. 30 (br, 2H), 3. 30- 3.20 (br, 2H), 1.43 (s, 9H), 1.07 (t, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 110-73-6, 2-(Ethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/80343; (2005); A2;,
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Reference of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 2-(chloromethyl)-4-(cyclohexylmethoxy)-1Hbenzo[d]imidazole 7 (0.72 mmol) in DMF (5 mL), K2CO3(0.79 mmol) and appropriate amine 8 or 9 or 10 (0.79 mmol) wereadded. The resulting solution was stirred at 60 C for 3 h. Themixture was cooled, diluted with water, and then extracted withEtOAc. The combined organic extracts were washed with water,brine solution, dried over anhydrous Na2SO4 and then concentratedunder reduced pressure. The crude mixture was subjected to flashsilica gel (230-400 mesh) column chromatography (eluting with0e2% MeOH in dichloromethane) to afford the title compounds 5.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Article; Boggu, Pulla Reddy; Kim, Youngsoo; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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Application of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (10.4 g, 75.4 mmol) and 2-(ethylamino)ethanol (6.72 g, 75.4 mmol) were added to a solution of 2-bromo-1-phenylethanone (5.00 g, 25.1 mmol) in acetonitrile (150 ml), and the mixture was stirred at RT overnight. The solids were then removed by filtration, and the filtrate was concentrated under reduced pressure to afford the crude title compound which was used in the next step without further purification. Yield: 5.00 g (85% purity, 82% yield). LC/MS [Method 3]: Rt = 0.44 min; MS (ESIpos): m/z = 208 [M+H]+. 1H-NMR (400 MHz, DMSO-d6): d [ppm] = 7.55-7.48 (m, 2H), 7.37-7.23 (m, 3H), 4.11-4.03 (m, 1H), 3.67-3.59 (m, 1H), 3.48-3.36 (m, 1H), 2.76-2.67 (m, 2H), 2.36-2.26 (m, 1H), 2.16-2.06 (m, 1H), 2.01 (d, 1H), 0.99 (t, 3H).

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; MUeLLER, Steffen; SCHOHE-LOOP, Rudolf; ORTEGA, HERNANDEZ, Nuria; SUeSSMEIER, Frank; JIMENEZ NUNEZ, Eloisa; BRUMBY, Thomas; LINDNER, Niels; GERDES, Christoph; POOK, Elisabeth; BUCHMUeLLER, Anja; GAUGAZ, Fabienne, Zdenka; LANG, Dieter; ZIMMERMANN, Stefanie; EHRMANN, Alexander, Helmut, Michael; GERISCH, Michael; LEHMANN, Lutz; TIMMERMANN, Andreas; SCHAeFER, Martina; SCHMIDT, Georg; SCHLEMMER, Karl-Heinz; FOLLMANN, Markus; KERSTEN, Elisabeth; WANG, Vivian; GAO, Xiang; WANG, Yafeng; (801 pag.)WO2019/219517; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 110-73-6, 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

The compound represented by the above formula (4) 20.3-parts, 60 parts sulfolane and 2-(ethylamino)ethanol (Tokyo Kasei Kogyo Co., Ltd.) 17.8 parts, were placed in a four-necked 200ml flask, and the mixture was stirred for 3 h at 80 C. When the liquid temperature of the reaction solution had fallen to 30 C, the reaction mixture was poured into 20% aqueous sodium chloride solution, and 35% hydrochloric acid was added to set the pH to 6. The precipitated crystals were collected by filtration, washed, and dried, dye intermediate represented by the following formula (101) was obtained, 22.3 parts.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110-73-6, 2-(Ethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; OHTANI, KOHEI; (19 pag.)JP2016/65219; (2016); A;,
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Synthetic Route of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a flask under a nitrogen atmosphere15 g (1 eq) of 4,4-difluorobenzophenone and 31.1 g of 2-ethylamino ethanol (5 eq) was added thereto,And the temperature was raised while stirring at 160 C.The reaction was carried out at 160 DEG C for 48 hours and then cooled to room temperature.Distilled water was added thereto, followed by extraction with methylene chloride or ethyl acetate, followed by drying under reduced pressure.The residue was recrystallized from ethyl acetate at room temperature to obtain an off-white Compound A. (20 g, 82% yield)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; LG CHEM, LTD.; Lee, Dami; Park, Jong-Ho; (30 pag.)KR2017/3170; (2017); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(Ethylamino)ethanol

1.0 g (11.22 mmol) of 2- (ethylamino) ethanol,10 mL of acetonitrile,0.77 g (5.61 mmol) of potassium carbonate was added to the reaction flask,Warmed to 60 C,A solution of 1.98 g (11.22 mmol) of benzyl bromide and 10 mL of acetonitrile was added dropwise for 15 min.Continue to react for 30 minutes,HPLC detection reaction was complete,After treatment, the reaction solution was evaporated to dryness,Add 20mL water,Extraction with ethyl acetate,The combined organic phases were dried over anhydrous sodium sulfate,Of 1.47 g of a brown oil (II)Yield 75.0%.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kebeiyuan (Beijing) Bio-pharmaceutical Technology Co., Ltd.; Beijing Zhiyuan Technology Co., Ltd.; Liu Qi; Cheng Zengjiang; (46 pag.)CN107468685; (2017); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 110-73-6

The synthesis of INI-12 : [Show Image] 8 g (26 mmol) 2-(3-chloropropoxy)-9H-thioxanthen-9-one was dissolved in 80 mL acetonitrile. The mixture was heated to reflux and 13.2 mL (130 mmol) 2-(ethylamino)-ethanol was added. The reaction was allowed to continue for 24 hours at reflux. 0.7 g sodium iodide was added and the reaction was allowed to continue for another 24 hours at reflux. The precipitated salts were removed by filtration and the solvent was removed under reduced pressure. The residue was dissolved in 150 mL t.butyl methyl ether and extracted 4 times with 100 mL 0.1 N hydrochloric acid. The aqueous fractions were pooled and the pH was adjusted to 12, using a 5 N NaOH solution. The mixture was extracted with 200 mL t.butyl methyl ether. The organic fraction was dried over MgSO4 and evaporated under reduced pressure. 7.6 g (82 %) of the intermediate was isolated.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGFA Graphics NV; EP2130817; (2009); A1;,
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Electric Literature of 110-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below.

To a vial containing 6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]nicotinic acid (63.07 mg, 0.15 mmol) was added 0.375 mL of DMA, EDC (31.6 mg, 0.16 mmol), HOBt (20.3 mg, 0.15 mmol), NMM (0.04 mL, 0.37 mmol) and 2-(ethylamino)ethanol (13.4 mg, 0.15 mmol). The reaction mixture was stirred at room temperature for 12 hours and then diluted with water and ethyl acetate. The layers were separated and the organic layer collected and concentrated to give an oil, which was purified by RP-HPLC to give N-ethyl-6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]-N-(2-hydroxyethyl)nicotinamide (32 mg, 43%). HRMS (TOF, ES+) calculated for C27H30FN50 +H: 492.2333; observed 492.2611.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110-73-6, 2-(Ethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Blake, Tanisha D.; Hamper, Bruce C.; Huang, Wei; Kiefer, James R.; Moon, Joseph B.; Neal, Bradley E.; Olson, Kirk L.; Pelc, Matthew J.; Schweitzer, Barbara A.; Thorarensen, Atli; Trujillo, John I.; Turner, Steven R.; US2008/146569; (2008); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 110-73-6

General procedure: (A) 2-(Alkylamino)ethanol2a or 2b (6 mmol) and Et3N (1.0 ml) were added with stirring tothe solution of diferrocenylcyclopropenylium tetrafluoroborate 1 (3 mmol)in dry benzene or acetonitrile (70 ml). After stirring for 6-12 h at ~80C,the volatiles were removed in vacuo; the residue was chromatographed ona column with Al2O3 (activity III) (hexane-diethyl ether, 3 :1) to affordthe reaction products 3a,b (30-32%) and 4a,b (43-44%), respectively.(B) Following the general procedure, reaction of 1b (1 mmol) in MeCN(30 ml, 80C, 6-12 h) in the presence of Et3N (0.3 ml) with amino alcohols2a,b (1 mmol) afforded compounds 3a (62-71%) or 3b (67-74%) and4a,b (3-10%).(C) Reaction of 1b (1 mmol) in dry benzene (30 ml, 80C, 6-12 h) inthe presence of Et3N (0.3 ml) with amino alcohols 2a,b (3 mmol) affordedcompounds 3a,b (5-7%) and 4a (58-77%), 4b (61-80%)

With the rapid development of chemical substances, we look forward to future research findings about 110-73-6.

Reference:
Article; Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Chirinos Flores, Denis E.; Klimova, Elena I.; Mendeleev Communications; vol. 27; 1; (2017); p. 26 – 28;,
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