Category: 110-73-6

Adding a certain compound to certain chemical reactions, such as: 110-73-6, 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 110-73-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C4H11NO

1-(tert-Butoxycarbonyl)-5-hydroxyindole (2.33 g, 10.0 mmol) and triphenylphosphine (5.25 g, 20.0 mmol) were dissolved in toluene (46.0 mL), and the solution was added with glycidol (1.32 mL, 20.0 mmol) and 40% DEAD-toluene solution (9.10 mL, 20 mmol) at room temperature, followed by stirring at 80C for 4 hours. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (hexane/ethyl acetate=4/1). A crude product (1.28 g) of 1-(tert-butoxycarbonyl)-5-hydroxyindole (1.28 g) was obtained. The obtained crude product was dissolved in N,N-dimethylacetoamide (20.0 mL), and the solution was added with 2- (ethylamino) ethanol (8.60 mL, 87.8 mmol), followed by stirring at 80C for 4 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (chloroform/methanol =9/1) to obtain 1-(tert-butoxycarbonyl)-5-{3-[N-ethyl(2-hydroxyethyl)amino]-2-hy droxypropoxy}indole (1.53 g, 40%). ESI-MS m/z: 379 [M+H]+; 1H-NMR (CDCl3)delta(ppm): 1.07 (t, J = 7.2 Hz, 3H), 1.66 (s, 9H), 2.61-2.80 (m, 6H), 3.61-3.68 (m, 2H), 3.99-4.14 (m, 3H), 6.48 (d, J = 3.9 Hz, 1H), 6.94 (dd, J = 2.6, 8.7 Hz, 1H), 7.04 (d, J = 2.6 Hz, 1H), 7.56 (d, J = 3.9 Hz, 1H), 8.01 (d, J = 8.7 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. name: 2-(Ethylamino)ethanol

A mixture of 1-(6-hydroxy-2-naphthyl)ethanone (744 mg, 3.92 mmol), sodium hydrogen sulfate(IV) (1.66 g, 16 mmol), 2-ethylaminoethanol (2 mL) and water (5 mL) was heated in a steel bomb at 130-140 C. for 3 days. After cooling, the mixture was distributed between water and ethyl acetate, and the organic layer was washed with brine, dried and evaporated. The residue was dissolved in acetone and loaded onto a 4 mm dry silica plate for radial chromatography. The plate was eluted with a 1:1 mixture of petroleum ether and ethyl acetate. Appropriate fractions were collected and evaporated to give 125 mg (12%)of 1-{6-[ethyl-(2-hydroxylethyl)-amino]-2-naphthyl}ethanone.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Regents of the Univ. of California; US6274119; (2001); B1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. name: 2-(Ethylamino)ethanol

A mixture of 1-(6-hydroxy-2-naphthyl)ethanone (744 mg, 3.92 mmol), sodium hydrogen sulfate(IV) (1.66 g, 16 mmol), 2-ethylaminoethanol (2 mL) and water (5 mL) was heated in a steel bomb at 130-140 C. for 3 days. After cooling, the mixture was distributed between water and ethyl acetate, and the organic layer was washed with brine, dried and evaporated. The residue was dissolved in acetone and loaded onto a 4 mm dry silica plate for radial chromatography. The plate was eluted with a 1:1 mixture of petroleum ether and ethyl acetate. Appropriate fractions were collected and evaporated to give 125 mg (12%)of 1-{6-[ethyl-(2-hydroxylethyl)-amino]-2-naphthyl}ethanone.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Regents of the Univ. of California; US6274119; (2001); B1;,
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Synthetic Route of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

in a four-necked flask of 300ml, formula dye intermediate 34.3 parts obtained in step 5-1, put the NMP146 parts of 2- (ethylamino) ethanol 16.3 parts, 90 in it stirred 1.5 hours.The reaction mixture was poured into 2N aqueous hydrochloric acid, the precipitated crystals were collected by filtration, washed, and dried to give Intermediate 34.9 parts of the dye represented by the following formula (104).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; (16 pag.)JP2016/65220; (2016); A;,
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Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 100mL 1-neck round bottom flask[A-1] (Benzenesulfonate Dichlorosulfofluorescein) (3 g, 7.40 mmol, 1 eq), [A-2] (2-(Ethylamino)ethanol) (5.28g, 59.22mmol, 8eq) and 50 g of DI-water were added thereto, followed by stirring at 100 C. Then stirred for 20 hours. The reaction was terminated by quenching in 1M HCl Solution, and the reaction was precipitated by the addition of sodium chloride (NaCl).The resulting precipitate was filtered under reduced pressure and dried at 80 C Oven. After drying, the resultant was dissolved in DMF (Dimethylformamide) to remove NaCl between the products, filtered, and the filtrate was quenched with diethyl ether, filtered under reduced pressure, and dried to obtain Compound [A] (2.98 g, 5.84 mmol, 78.9%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Lee Da-mi; Choi Sang-a; Yang Seung-jin; Lee Jae-yong; Kim Hye-jin; Kim Ji-seon; Kim Yeong-ung; Park Jong-ho; (27 pag.)KR2020/7157; (2020); A;,
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Related Products of 110-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below.

In a 100 mL 1-neck round bottom flask [A-1] (Benzenesulfonate Dichlorosulfofluorescein) (3g, 7.40mmol, 1eq), [A-2] (2-(Ethylamino)ethanol) (5.28g, 59.22mmol, 8eq), After adding 50 g of di-water, the mixture was stirred at 100C. Thereafter, the reaction was performed overnight (overnight, 12 hours). The reaction was terminated by quenching in 1M HCl solution, NaCl (sodium chloride) was added to precipitate the reaction. The resulting precipitate was filtered under reduced pressure and dried in an oven at 80C. DMF (Dimethylformamide) to remove NaCl between products after drying After dissolving in filtration, the filtrate was diethyl ether Quenching on The mixture was filtered under reduced pressure and dried to obtain Compound A (2.88 g, 5.64 mmol, 76%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110-73-6, 2-(Ethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; LG Chem, Ltd.; Choi Sang-a; Lee Da-mi; Yang Seung-jin; Lee Jae-yong; Kim Hye-jin; Kim Yeong-ung; (47 pag.)KR2020/46212; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C4H11NO

Stage 1: Ethyl-(2-hydroxyethyl)carbamic acid tert-butyl ester: A solution is prepared from 15.2 g of Boc2O and 30 ml of dichloromethane. This solution is added dropwise to a mixture containing 7.36 g of 2-ethylaminoethanol and 30 ml of dichloromethane in the cold state. The reaction medium is allowed to stand for 24 hours at room temperature. After concentrating to dryness, the reaction medium is taken up in an NaCl solution. The medium is extracted three times with ethyl acetate and then washed with a saturated NaCl solution. The organic phase is dried over sodium sulfate and then concentrated to dryness using a vane pump in order to give 12 g of expected product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; sanofi-aventis; US2008/269170; (2008); A1;,
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Application of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of compound 3a or 3b (1 mmol),benzene (50 ml), Et3N (1 ml) and morpholine (1 ml) was stirred for 5 h at80C. The solvents were evaporated in vacuo and the residues werechromatographed on a column with Al2O3 (hexane-diethyl ether, 3 :1) toafford products 8a or 8b, respectively

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Chirinos Flores, Denis E.; Klimova, Elena I.; Mendeleev Communications; vol. 27; 1; (2017); p. 26 – 28;,
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Alcohols – Chemistry LibreTexts

Related Products of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step -1: Synthesis of Compound 2: TBSCI ^ 0C-rt, 30 min <, [0094] Alcohol (8,92 mmol) was added into a round bottom flask followed by OT (36 rriL) and cooled to 0 (. Imidazole ( 1 .04 mmol) was added and allowed to stir for 5 minutes. FBSCi (8,92 mmol) was added in portion wise and continued the stirring for 30 min. The reaction was quenched with 20 niL water. Organic layer was separated and dried over anhydrous ajSO* Concentration in vacuo and purification by flash column chromatography gave silyi ether 2. While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol. Reference:
Patent; KANDULA, Mahesh; WO2013/168023; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Ethylamino)ethanol

Reference Example 19 tert-Butyl ethyl(2-hydroxyethyl)carbamate (0438) (0439) To a mixture of 2-(ethylamino)ethanol (8.91 g) and ethyl acetate (100 mL) was added di-tert-butyl dicarbonate (21.8 g) under ice-cooling. After stirring at room temperature for 3 days, the mixture was washed with saturated brine (100 mL), and dried over anhydrous magnesium sulfate. Concentration under reduced pressure gave the title compound (19.0 g) as a colorless oil. (0440) 1H-NMR (CDCl3): 1.11 (3H, t, J=7.0 Hz), 1.47 (9H, s), 3.27 (2H, q, J=7.0 Hz), 3.37 (2H, t, J=5.2 Hz), 3.73 (2H, q, J=5.2 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AKIYAMA, Yohko; KURASAWA, Takashi; BANDO, Hiroto; NAGAHARA, Naoki; (88 pag.)US2016/128945; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts