Category: 110-03-2

Kim, Da-Som;Kim, Hoe Sung;Lee, Jookyeong;Pan, Jeong Hoon;Kim, Young Jun;Kim, Jae Kyeom;Woo, Seongmin;Shin, Eui-Cheol published 《Wasabia koreana Nakai: a preliminary study on nutrients and chemical compounds that may impact sensory properties》. The research results were published in《Molecules》 in 2018.Category: alcohols-buliding-blocks The article conveys some information:

In this study, the nutritional, functional, and chem. measurements of sensory attributes of different parts of wasabi, namely, leaf, petiole, and rhizome, were investigated. Proximate composition anal. showed the presence of high amounts of carbohydrates in the rhizome and amino acid composition anal. confirmed high proportions of glutamic acid and aspartic acid in all three parts. While proximate composition showed low lipid content in wasabi, ω-3 fatty acids accounted for a high proportion (>44%) of the total lipids. Wasabi leaves had high vitamin C and total phenolic contents, and thus demonstrated antioxidant capacity. Allyl isothiocyanate, which gives wasabi its characteristic pungent taste, was identified by gas chromatog./mass spectrometry and an electronic nose. On an electronic tongue, wasabi leaves showed compounds associated with sourness and saltiness while the petiole had high content of compounds associated with sweetness and bitterness. This study provides basic data for the utilization of wasabi parts as food materials based on their nutritional, functional, and chem. measure of sensory attributes. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Category: alcohols-buliding-blocks

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Formula: C8H18O2In 2021, Tailor, Sanita B.;Manzotti, Mattia;Smith, Gavin J.;Davis, Sean A.;Bedford, Robin B. published 《Cobalt-Catalyzed Coupling of Aryl Chlorides with Aryl Boron Esters Activated by Alkoxides》. 《ACS Catalysis》published the findings. The article contains the following contents:

The cobalt-catalyzed Suzuki biaryl cross-coupling of aryl chloride substrates with aryl boron reagents, activated with more commonly used bases, remained a significant unmet challenge in the race to replace platinum group metal catalysts with Earth-abundant metal alternatives. This highly desirable process can be realized using alkoxide bases, provided the right counterion is employed, strict stoichiometric control of the base is maintained with respect to the aryl boron reagent, and the correct boron ester is selected. Potassium tert-butoxide works well, but any excess of the base first inhibits and then poisons the catalyst. Lithium tert-butoxide performs very poorly, while even catalytic amounts of lithium additives also poison the catalyst. Meanwhile, a neopentane diol-based boron ester is required for best performance. As well as delivering this sought-after transformation, a detailed mechanistic and computational investigations to probe the possible mechanism of the reaction has been discussed and explains the unexpected exptl. observations. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Formula: C8H18O2

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Product Details of 110-03-2《Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates》 was published in 2021. The authors were Ye, Yang;Ma, Guobin;Yao, Ken;Gong, Hegui, and the article was included in《Synlett》. The author mentioned the following in the article:

A general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions was described. The reduction method was suitable for an array of structural motifs derived from tertiary alcs. that beared diverse functional groups, included the synthesis of a key intermediate en route to estrone. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Product Details of 110-03-2

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HPLC of Formula: 110-03-2《Cyclization of alkanediols in high-temperature liquid water with high-pressure carbon dioxide》 was published in 2012. The authors were Yamaguchi, Aritomo;Hiyoshi, Norihito;Sato, Osamu;Shirai, Masayuki, and the article was included in《Catalysis Today》. The author mentioned the following in the article:

Dehydration of 1,4-butanediol to THF, 2R,5R-hexanediol to 2,5-dimethyltetrahydrofuran, and 2,5-dimethyl-2,5-hexanediol to 2,2,5,5-tetramethyltetrahydrofuran proceeded in high-temperature liquid water at 523 K. The formation rates of cyclic ethers were enhanced by high-pressure carbon dioxide (16.2 MPa). The order of dehydration rates in high-temperature water with carbon dioxide was tertiary > secondary > primary alc., which was the same order as the stability of corresponding carbocation species. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.HPLC of Formula: 110-03-2

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Product Details of 110-03-2In 2012, Siebert, Joerg Max;Baier, Grit;Landfester, Katharina published 《Thermal and acid labile polyurethanes as a new class of responsive materials in polymeric nanoparticles and nanocapsules》. 《Journal of Polymer Science, Part A: Polymer Chemistry》published the findings. The article contains the following contents:

A new class of polyurethanes has been designed, containing tertiary carbamate groups in the main chain of the polymer, which enable the resulting polymer to degrade completely under acid and thermal treatment. The decomposition temperatures of the polymers were determined by measuring the evolution of carbon dioxide and other decomposition products using TGA-MS. Until decomposition of the polymer, no glass transition was found. The polymers exhibit excellent solubility in common organic solvents like chloroform and THF, making them to suitable materials for film formation. From the obtained polymers, nanoparticles were synthesized by the solvent evaporation method combined with the miniemulsion technique. The resulting nanoparticles can be used as intelligent fillers in films and sensors, since they degrade at temperatures of above 180°, which can be detected by a color change reaction with ninhydrin. Polymeric nanocapsules were prepared by an interfacial polyaddition reaction from 2,4-toluene diisocyanate and tertiary diols performed at the droplet’s interface in inverse (water-in-oil) miniemulsions. These nanocapsules with an encapsulated photoacid generator can act as a release system, whereby an acidic release through irradiation with UV light can be triggered. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Product Details of 110-03-2

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Su, Nana;Ye, Ziyang;Li, Jinglei;Yang, Liuqing;Hou, Guohua;Ye, Ming published 《Effect of the addition of roselle (Hibiscus sabdariffa L.) extracts on the rheological, textural, and antioxidant activity of fermented milks》. The research results were published in《Flavour and Fragrance Journal》 in 2020.Category: alcohols-buliding-blocks The article conveys some information:

The study aims to evaluate the rheol., textural, and antioxidant activity of fermented milks with the addition of roselle (Hibiscus sabdariffa L.) extracts at concentrations of 0.0, 0.1, 0.2, and 0.3% (CFM, RFM₁, RFM₂, and RFM₃). The chem. composition of the fermented milks, including crude protein, fat, ash, total solids and non-fat solids, were also determined Gas chromatog.-mass spectroscopy (GC-MS) detected 42, 46, 47, and 49 kinds of volatile flavor compounds in CFM, RFM₁, RFM₂, and RFM₃, resp. The antioxidant activity of fermented milks was measured using ferric reducing antioxidant power and scavenging capacities for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals during 28 days of refrigerated storage. The results of this study are of great significance to improve the understanding and application of roselle extracts in the food industry. Both roselle and fermented milk are beneficial to human health, with many biol. activities, such as antioxidant, hypoglycemic, liver-protecting, and antihypertensive properties; however, no attention has been paid to the combined effects of roselle and fermented milks. The study created a novel fermented milk and the results indicate that 0.3% roselle extracts can play the most important role in affecting the rheol., textural properties, and antioxidant activity of fermented milks, so this modification of fermented milk shows promise for potential application in the food industry. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Category: alcohols-buliding-blocks

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COA of Formula: C8H18O2《Facile synthesis of macrocyclic tetrazoles by regioselective cycloalkylation of bistetrazoles with 2,5-dimethylhexane-2,5-diol in perchloric acid》 was published in 2012. The authors were Voitekhovich, Sergei V.;Lyakhov, Alexander S.;Ivashkevich, Ludmila S.;Gaponik, Pavel N., and the article was included in《Tetrahedron Letters》. The author mentioned the following in the article:

Alkylation of 1,5-bis(tetrazol-5-yl)-3-oxapentane with 2,5-dimethylhexane-2,5-diol in 65% aqueous perchloric acid was found to proceed selectively on the N2 atoms of both tetrazole rings generating a 15-membered macrocycle with tetrazol-2,5-diyl moieties incorporated (yield ca. 80%). Under analogous alkylation conditions 1,5-bis(1-methyltetrazol-5-yl)-3-oxapentane undergoes quaternization resulting in a macrocyclic tetrazolium perchlorate containing two 1-methyltetrazolium-3,5-diyl units linked by 3-oxapentane-1,5-diyl and 2,5-dimethylhexane-2,5-diyl bridges. Crystal structures of the macrocyclic compounds obtained, determined by single crystal X-ray anal., are described. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.COA of Formula: C8H18O2

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Kelley, Keven M.;Stenson, Alexandra C.;Dey, Rajarashi;Whelton, Andrew J. published 《Release of drinking water contaminants and odor impacts caused by green building cross-linked polyethylene (PEX) plumbing systems》. The research results were published in《Water Research》 in 2014.COA of Formula: C8H18O2 The article conveys some information:

Green buildings are increasingly being plumbed with crosslinked polyethylene (PEX) potable water pipe. Tap water quality was investigated at a six month old plumbing system and chem. and odor quality impacts of six PEX pipe brands were examined Eleven PEX related contaminants were found in the plumbing system; one regulated (toluene) and several unregulated: Antioxidant degradation products, resin solvents, initiator degradation products, or manufacturing aides. Water chem. and odor quality was monitored for new PEX-a, -b and -c pipes with (2 mg/L free chlorine) and without disinfectant over 30 days. Odor and total organic carbon (TOC) levels decreased for all pipes, but odor remained greater than the USA’s Environmental Protection Agency’s (USEPA) secondary maximum contaminant level. Odors were not attributed to known odorants ethyl-tert-Bu ether (ETBE) or methyl-tert-Bu ether (MTBE). Free chlorine caused odor levels for PEX-a1 pipe to increase from 26 to 75 threshold odor number (TON) on day 3 and affected the rate at which TOC changed for each brand over 30 days. As TOC decreased, the UV absorbance at 254 nm increased. Pipes consumed as much as 0.5 mg/L as Cl₂ during each 3 day stagnation period. Sixteen organic chems. were identified, including toluene, pyridine, methylene trichloroacetate and 2,4-di-tert-butylphenol. Some were also detected during the plumbing system field investigation. Six brands of PEX pipes sold in the USA and a PEX-a green building plumbing system impacted chem. and drinking water odor quality. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.COA of Formula: C8H18O2

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Chacon, Manuel;Vazquez, Natalia;Persinal-Medina, Mairobi;Alonso-Alonso, Sergio;Alcalde, Ignacio;Merayo-Lloves, Jesus;Meana, Alvaro published 《In-house performance assessment of 3D QobuR-Reconstructed Human Cornea-Like Epithelium (RhCE) for the evaluation of eye hazard》 in 2022. The article was appeared in 《Toxicology In Vitro》. They have made some progress in their research.Application of 110-03-2 The article mentions the following:

To replace the Draize eye irritation test (OECD Test Guideline 404), several test methods based on reconstructed cornea-like epithelium (RhCE) have been developed and adopted in the OECD TG 492. The objective of this study was to establish the exptl. procedures and evaluate the performance assessment of QobuR-RhCE, an inhouse RhCE model to be used for the evaluation of eye hazard. We define the essential structural, functional and procedural elements of the test method components to help assuring that the proposed test method is based on the same concepts as the validated reference methods. Performance assessment was evaluated in accordance with the revised performance standards for the assessment of proposed similar or modified in vitro reconstructed human cornea-like epithelium and the min. list of reference chems. was evaluated. As result, the proposed method scored 93.3% sensibility, 60% specificity, 76.7% accuracy and 96.7% within-laboratory reproducibility (WLR), providing a similar performance in comparison to the validated reference methods. Addnl., we describe a secondary endpoint based on Transepithelial Elec. Resistance (TEER) that could be of use to better discriminate between irritants and non-irritants. Taken together the results indicate that the QobuR-RhCE test method is an accurate screening tool that can be used as a standalone alternative to evaluate ocular irritation. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Application of 110-03-2

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Schroter, Ariane;Peter, Sonja;Mahler, Hanns-Christian;Zerr, Andreas;Danton, Ombeline;Chalus, Pascal;Koulov, Atanas V.;Huwyler, Jorg;Jahn, Michael published 《Identification of an Oxidizing Leachable from a Clinical Syringe Rubber Stopper》. The research results were published in《Journal of Pharmaceutical Sciences (Philadelphia, PA, United States)》 in 2021.Name: 2,5-Dimethyl-2,5-hexanediol The article conveys some information:

Leaching of toxic or reactive chems. from polymeric materials can adversely affect the quality and safety of biopharmaceuticals. It was therefore the aim of the present study to analyze leachables from a disposable clin. administration syringe using a polysorbate-containing surrogate solution and to assess their chem. reactivity. Anal. methods did include (headspace) GC-MS, Fourier-transform-IR spectroscopy, a ferrous oxidation-xylenol orange assay, and NMR anal. In the syringe leachables solution, the carcinogenic 1,1,2,2-tetrachloroethane (TCE) was detected in concentrations above the ICH M7-derived anal. evaluation threshold. TCE was shown to be an oxidation product of dichloromethane used during sample preparation Since TCE was only isolated from incubations with the contained rubber stopper, we hypothesized that a stopper-derived leachable acted as a reactive oxidant promoting this chem. reaction. Subsequently, the leachable was identified to be the polymerization initiator Luperox 101. Combining different anal. approaches led to the structural elucidation of a chem. reactive oxidant, which has the potential to interact and alter drug products. We conclude that chem. reactive compounds, such as the newly identified rubber stopper leachable Luperox 101, may be of concern and therefore should be routinely considered if a prolonged exposure of polymers with drug products can be anticipated. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Name: 2,5-Dimethyl-2,5-hexanediol

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