Category: 109-83-1

Application of 109-83-1 ,Some common heterocyclic compound, 109-83-1, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 4: Preparation of the compound of formula; (a) Alkylating agent; A mixture of 21.5g 2-hydroxyethyl-methylamine are neutralized with hydrochloric acid and evaporated to dryness.The salt is suspended in chloroform and cooled with stirring to O0C and then 41.Og thionyl chloride are added in small amounts maintaining the temperature at O0C by external cooling. After completion of the addition the reaction is finished by heating to reflux and autgassing the mixture.The solution is evaporated to dryness; the 2-chloroethyl-methylamine used as chlorohydrate in the following step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; CIBA SPECIALTY CHEMICALS HOLDING INC.; WO2007/25889; (2007); A2;,
Alcohol – Wikipedia,
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Synthetic Route of 109-83-1 , The common heterocyclic compound, 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION I; N(2-hydroxyethyl)-4-methoxy-N,2,6-trimethylbenzene-sulphonamide; A solution of 1.76 g (23.4 mM) of 2-(methylamino)ethanol is prepared in 100 ml of DCM and 5.4 g (53 mM) of triethylamine are added. The mixture is cooled to 0 C. and a solution of 5 g (21.3 mM) of 2,6 dimethyl-4-methoxybenzenesulphonyl chloride in 50 ml of DCM is added progressively. The mixture is then agitated for 3 hours at ambient temperature, and then poured over 50 ml of 0.5 N hydrochloric acid. The organic phase is separated and then washed with water, dried over magnesium sulphate and concentrated under reduced pressure. 5.8 g of the compound sought after are thus obtained as a colourless oil (yield=100%). 1H NMR (300 MHz, DMSO) delta: 6.80 (s, 2H); 4.70 (t, 1H); 3.80 (s, 3H); 3.48 (q, 2H); 3.09 (t, 2H); 2.69 (s, 3H); 2.54 (s, 6H).

The synthetic route of 109-83-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Laboratoires Fournier S.A.; US2006/178360; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 109-83-1 ,Some common heterocyclic compound, 109-83-1, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 1 N-benzyloxycarbonyl-N-methyl-2-aminoethanol 75 g of 2-methylaminoethanol and 101 g of triethyl amine are mixed with 1000 ml of absolute chloroform. 171 g of chloroformic acid benzyl ester are added dropwise to this solution at about 20 C. The mixture is stirred for 1 hour at room temperature, washed with water, diluted hydrochloric acid and again with water and dried over sodium sulphate. After evaporation of the solvent in vacuo 173 g of oil remain. Infrared (film): 1695 cm-1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; A. Nattermann & Cie GmbH; US4565659; (1986); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 109-83-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 109-83-1 as follows.

Synthesis of the Acid Unit AC-07: 2-[2-[[(4-Methoxy-2,3,6-trimethyl-phenyl)sulfonyl]-methyl-amino]-ethoxy]-acetic acid (AC-07) Stage-1: 2-Methylaminoethanol 1 (1 eq. 79.9 mmol) was dissolved in 500 ml of methylene chloride, and triethylamine (1.2 eq., 95.9 mmol) and the sulfonyl chloride 2 (1.2 eq., 95.9 mmol), dissolved in 60 ml of methylene chloride, were then added in succession. The mixture was stirred at room temperature for 4 h (TLC control). H2O (100 ml) and sat. NaHCO3 solution (100 ml) were then added to the reaction mixture. After separation of the phases, the aqueous phase was extracted 3* with methylene chloride (250 ml). The combined organic phases were dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (silica, diethyl ether/hexane 8:2?9:1) to obtain the alcohol 3 (66.3 mmol, 83% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; Gruenenthal GmbH; US2009/264400; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 109-83-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, molecular weight is 75.1097, as common compound, the synthetic route is as follows.

[Step 2] Fabrication of 2-Acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene 0.4 g (2.1 mmol) of the second compound 2 is obtained to be mixed with 1.8 g (24.0 mmol) of 2-methylaminoethanol (CH3NHCH2CH2OH), 2.0 g (19.2 mmol) of sodium bisulfite (Na2O5S2) and 4 mL of water to be heated to 140 celsius degrees ( C.) with vigorous stirring and refluxed for 76 hrs. After cooling, 50 mL of dichloromethane is added for phase separation after sufficient stirring. Therein, after being dried with anhydrous sodium sulfate, an organic phase is concentrated under reduced pressure and separated and purified by liquid chromatography (SiO2, EtOAc_CH2Cl2=1:3), with 0.15 g (0.81 mmol) of the second compound 2 recycled. Thus, a solid product, 2-acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene 3 (hereinafter referred to as third compound 3), is obtained, which has a weight of 0.276 g and a yield of 88.0%.

Statistics shows that 109-83-1 is playing an increasingly important role. we look forward to future research findings about 2-(Methylamino)ethanol.

Reference:
Patent; INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.; Lin, Wuu-Jyh; Farn, Shiou-Shiow; Tu, Yean-Hung; Huang, Li-Yuan; Chen, Dow-Che; Chu, Kuo-Yuan; Chang, Mao-Hsung; Duh, Ting-Shien; Chen, Jenn-Tzong; Shiue, Chyng-Yann; US9186423; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 109-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 86 2-N-methyl-benzyloxycarbonylaminoethanol. To N-methylethanolamine (149 mmol) in methylene chloride (100 ml) at 0C was added benzyl chloroformate (10.0 ml, 70 mmol). The mixture was stirred at 0C for 30 min, then at room temperature for 1 h, poured into ethyl acetate, washed with 2 M HCl, saturated NaHCO3 solution, and brine, then dried over Na2SO4 and evaporated to provide 12.91 g (94%) of the desired compound. 1H NMR (CDCl3,TMS) delta 7.36 (m,5H), 5.14 (s,2H), 3.78 (m,2H), 3.47 (m,2H), 3.01(s, 3H).

According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBOTT LABORATORIES; EP341602; (1989); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 109-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4.15 g (55.5 mmol) NaHSO3, 8 mL of water, 0.78 g (4.19 mmol) of 1-(6-hydroxy-2-naphthyl)-1-ethanone (prepared as described in Example 1(b)), and 8 mL of 2-methylaminoethanol was heated and stirred in a steel bomb at 140 C. for 28 hours. After cooling, the mixture was distributed between ethyl acetate and water (500 mL and 200 mL, respectively). The organic layer was dried and evaporated to leave raw 1-(6-(2-hydroxyethyl-methylamino)-2-naphthyl)-1-ethanone (0.749 g, 73%) of which was further purified by radial chromatography (4 mm SiO3, CH2Cl2).

According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Regents of the Univ. of California; US6274119; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C3H9NO

A soln. of 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (2.29 g, 9.19 mmol) in THF (30 ml) was added dropwise to a soln. of 2-methylaminoethanol (0.89 g, 0.95 ml, 11.8 mmol) and Et3N (5 ml) in THF (15 ml) at 0 C. The mixture was subsequently stirred at RT for 5 h and then concentrated i. vac., the residue was taken up in NaHCO3 soln. and the mixture was extracted with EtOAc (3¡Á30 ml). The combined organic phases were dried with Na2SO4 and concentrated i. vac.Yield: 2.38 g (90%)

With the rapid development of chemical substances, we look forward to future research findings about 109-83-1.

Reference:
Patent; Gruenenthal GmbH; US2008/306084; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

109-83-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N-Methylethanolamine (2.0 g, 26.63 mmol) was added to a solution of sodium methoxide (1.44 g, 26.63 mmol, 6.0 mL of a 25% w/v solution in methanol) and ether (30 mL) with stirring at 25 C. The flask was evacuated and then charged with nitric oxide (NO) (40 psi internal pressure) and stirred at 25 C for 24 hrs. The product was isolated by filtration and then suspended in ether (30 mL) and stirred for 15 min. The suspension was filtered, collected and dried at 25 C under reduced pressure to give (NS-06) as a white fine powder (2.72 g, 65% yield). 1H NMR (400 MHz, D20) delta 3.42-3.40 (m, 2H), 2.95-2.92 (m, 2H), 2.63 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SARMONT LLC; MARTINEZ, Eduardo J.; TALLEY, John J.; JEROME, Kevin D.; BOEHM, Terri L.; WO2015/108835; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts