Category: 1074-61-9

Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H10O, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H10O

Using a reaction scheme adapted from O. Shimomura, et al, Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis, Tetrahedron 61 (2005) 12160-12167, phosphorous tribromide (PBr3) (18.4 g, 6.4 ml, 68 mmol) dissolved in ethyl ether (10 ml) was added to 4-vinylbenzyl alcohol (5.9 g, 44.3 mmol) in Et20 (500 ml) at 0C under N2. After 1 hour, additional PBr3 (18.4 g, 6.4 ml, 68 mmol) was added. The reaction mixture was stirred for 1 hour at room temperature and subsequently cooled to 0C. Water (100 ml) was slowly added. The solution was extracted with Et20, and the Et20 layer was washed with aqueous NaHC03, brine and dried with MgS04. The crude product was purified by silica gel column chromatography using a hexane:EtOAc, (70:30) eluent system to obtain product vinyl benzyl bromide. XH NMR (CDC13, 500 MHz) £4.48 (s, 2H), 5.26(d, 1H) 5.76(d, 1H) 6.69-6.75(q, 1H) 7.32(d, 2H) 7.41 (d, 2H). UV-vis [chloroform, max(8)]:215, 260.

The synthetic route of 1074-61-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORTH CAROLINA CENTRAL UNIVERSITY; TAYLOR, Darlene K.; BALAMI, Uddhav; WO2015/73882; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1074-61-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 1074-61-9

Step A 1-Bromomethyl-4-vinyl-benzene Bromine (16.4 g, 103 mmol) was slowly added to a solution of triphenylphosphine (28.87 g, 110.1 mmol) in CH2Cl2 (260 mL) at 0 C. After 10 minutes, 4-vinylbenzyl alcohol (12.5 g, 93.3 mmol) was added and the reaction mixture was stirred at 0 C. for 2 h. The reaction mixture was washed with water (1*) followed by brine (1*). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was triturated with petroleum ether (3*), and the ethereal solution was concentrated in vacuo. The residue was purified by flash chromatography (hexanes) to afford 4-vinyl-benzyl bromide (6.23 g). 1H NMR (400 MHz, CDCl3) delta7.32-7.45 (m, 4H), 6.72 (dd, 1H), 5.77 (d, 1H), 5.28 (d, 1H), 4.50 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-61-9, (4-Vinylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc.; US6344485; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1074-61-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1074-61-9

Using a reaction scheme adapted from literature [32] , phosphorous tribromide (18.4 g, 6.4 mL, 68 mmol) dissolved in diethyl ether (10 mL) was added to alcohol 1 (5.9 g, 44.3 mmol) in Et2O (500 mL) at 0 C under N2. After 1 h, additional phosphorous tribromide (18.4 g, 6.4 mL, 68 mmol) was added. The reaction mixture was stirred for 1 h at room temperature and subsequently cooled to 0 C. Water (100 mL) was slowly added. The solution was extracted with Et2O, and the Et2O layer was washed with saturated NaHCO3, brine and dried over MgSO4. The crude product was purified by silica gel column chromatography using a hexane:EtOAc, (70:30) elutant system to obtain product vinyl benzyl bromide 2. 1H NMR (CDCl3, 500 MHz) delta: 4.48 (s, 2H), 5.26 (dd, J = 11.0, 1.0 Hz, 1H) 5.76 (dd, J = 17.6, 1.0 Hz, 1H) 6.69-6.75 (dd, J = 17.6, 11.0 Hz, 1H), 7.32 (d, J = 8.0 Hz, 2H) 7.41 (d, J = 8.0 Hz, 2H). UV-Vis [chloroform, lambdamax(epsilon)]: 215 nm, 260 nm.

The synthetic route of 1074-61-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Balami, Uddhav; Taylor, Darlene K.; Reactive and functional polymers; vol. 81; 1; (2014); p. 54 – 60;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1074-61-9 , The common heterocyclic compound, 1074-61-9, name is (4-Vinylphenyl)methanol, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step A 1-Bromomethyl-4-vinyl-benzene. Bromine (16.4 g, 103 mmol) was slowly added to a solution of triphenylphosphine (28.87 g, 110.1 mmol) in CH2Cl2 (260 mL) at 0 C. After 10 minutes, 4-vinylbenzyl alcohol (12.5 g, 93.3 mmol) was added and the reaction mixture was stirred at 0 C. for 2 h. The reaction mixture was washed with water (1*) followed by brine (1*). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was triturated with petroleum ether (3*), and the ethereal solution was concentrated in vacuo. The residue was purified by flash chromatography (hexanes) to afford 4-vinyl-benzyl bromide (6.23 g). 1H NMR (400 MHz, CDCl3) delta 7.32-7.45 (m, 4H), 6.72 (dd, 1H), 5.77 (d, 1H), 5.28 (d, 1H), 4.50 (s, 2H).

The synthetic route of 1074-61-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US6288120; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts