Category: 1074-16-4

Adding a certain compound to certain chemical reactions, such as: 1074-16-4, 2-(2-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1074-16-4, blongs to alcohols-buliding-blocks compound. Product Details of 1074-16-4

Benzyl bromide (7 ml, 0.05 mol) was added drop wise to a stirred solution 2 bromo phenethyl alcohol (10 g, 0.0496 mol) and anhydrous NaH (2.28 g, 0.05 mol) in 100 ml of dry THF at 40-50 C. The reaction mixture was stirred for 10 h at 50 C., progress of the reaction was monitored using TLC, cooled to RT and evaporated to remove the solvent. An equal volume of distilled water was added to the residue and the mixture was stirred for one hour at ambient. The organic layer was separated, dried and evaporated. To the resulting liquid 100 ml of 5% ethanolic solution of NaOH was added and refluxed for 3 hr. The resulting solution was evaporated and extracted with ether to give the benzyl protected phenethyl alcohol as a clear liquid at 80% yield.1H-NMR (CDCl3, 400 Mhz): 7.5 (d, 1H), 7.3 (m, 7H), 7.08 (d, 1H), 4.53 (s, 2H), 3.7 (t, 2H), 3.07 (t, 2H) ppm. 13C-NMR (CDCl3, 100 Mhz): 138.43, 132.96, 131.37, 129.01, 128.58, 128.20, 127.78, 127.76, 127.57, 124.87, 73.12, 69.56, 36.71 ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-16-4, 2-(2-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NDSU-Research Foundation; US2011/28721; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1074-16-4, 2-(2-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1074-16-4, blongs to alcohols-buliding-blocks compound. Safety of 2-(2-Bromophenyl)ethanol

2-(2-Bromophenyl)acetaldehyde A solution of 9.11 grams (0.045 mole) of 2-(2-bromophenyl)ethanol in 35 milliliters of methylene chloride was added to a stirred suspension of 14.62 grams (0.063 mole) of pyridinium chlorochromate in 75 milliliters of methylene chloride at ambient temperature whereupon a slightly exothermic reaction took place with the formation of a black reaction mixture. Stirring was continued for 15 hours at ambient temperature; then 150 milliliters of ether was added and the mixture filtered through silica gel on a pad of celite. The insoluble residue was washed with 100 milliliters of ether, filtered, the ether solutions combined and the solvents evaporated on a rotary evaporator to recover as residue, 8.0 grams (90 percent) of the desired 2-(2-bromophenyl)acetaldehyde intermediate as an oil. The oil had an Rf of 0.6 on silica gel when eluted with one percent methanol in chloroform.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1074-16-4, its application will become more common.

Reference:
Patent; Merck & Co., Inc.; US4670443; (1987); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

1074-16-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1074-16-4, name is 2-(2-Bromophenyl)ethanol, the common compound, a new synthetic route is introduced below.

A solution of 2-bromophenethylalcohol (10 g, 50 mmol) in thionyl chloride (45 ml_) was treated with dimethylformamide (0.1 ml_) and heated to reflux for 6 hours. The reaction mixture was cooled to 00C, quenched by the addition of H2O (100 ml_), extracted with ethyl ether (250 ml_), dried (Na2SO4), and evaporated to provide 2- bromophenethylchloride (9.0 g, 82%) as a yellow oil:HPLC purity 99.2% at 210-370 nm, 10.4 minutes; Xterra RP18, 3.5u, 150 x 4.6 mm column, 1.2 mL/minutes, 85/15-5/95 (ammonium formate buffer pH = 3.5/ACN+MeOH) for 10 minutes, hold 4 minutes.

Statistics shows that 1074-16-4 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)ethanol.

Reference:
Patent; WYETH; WO2008/73956; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

1074-16-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1074-16-4, name is 2-(2-Bromophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

17.6 g (0.314 mol) KOH in 100 mL DMSO was placed in a flask fitted with dropping funnel and magnetic stirrer placed in water bath at ca. 7 C. A solution of 9.9 mL (22.57 g, 0.159 mol) of iodomethane and 13.94 g (0.0742 mol) of 2-(2-bromophenyl)ethanol in 80 mL DMSO was dropped-in while keeping the temperature 21-22 C. Water bath was removed and the reaction mixture was stirred for 2 h while the temperature raised to 27 C. After cooling to RT reaction mixture was poured into 600 mL of water, than extracted with diethyl ether (300 mL and 2 ¡Á 100 mL). Ether extract was washed with water (2 ¡Á 150 mL) and volatiles were distilled off to give 14.6 g of 2-bromo-(2-methoxyethyl)benzene (0.0679 mol, 91.5%), which was used without further purification. 1H NMR (400 MHz, CDCl3): delta: 3.08 (t, 2H), 3.42 (s, 3H), 3.66 (t, 2H), 7.10-7.14 (m, 1H), 7.26-7.33 (m, 2H), 7.57-7.59 ppm (m, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1074-16-4, 2-(2-Bromophenyl)ethanol.

Reference:
Article; Adamczyk-Wo?niak, Agnieszka; Brzozka, Zbigniew; Da?browski, Marek; Madura, Izabela D.; Scheidsbach, Roy; Tomecka, Ewelina; Zukowski, Kamil; Sporzy?ski, Andrzej; Journal of Molecular Structure; vol. 1035; (2013); p. 190 – 197;,
Alcohol – Wikipedia,
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Adding some certain compound to certain chemical reactions, such as: 1074-16-4, name is 2-(2-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1074-16-4. 1074-16-4

Step 3: 2-(2-bromophenyl)acetaldehydeTo a suspension of PCC (5.9 g, 28 mmol) in DCM (15 mL) was added a solution of 2- (2-bromophenyl)ethanol (3.7 g , 18 mmol) in DCM (20ml_) at room temperature whereupon a slightly exothermic reaction took place with the formation of a black reaction mixture which was kept stirring at room temperature for 15 hours. Then, ethyl ether (150 mL) was added and the mixture was filtered through silica gel on a pad of celite. The residue was washed with ether (50ml_) and the filtrate was concentrated under reduced pressure to afford crude product 2-(2-bromophenyl)acetaldehyde (3.4 g, 17 mmol, 94 % yield) as a light black oil. LCMS (m/z, ES 199 (M+H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1074-16-4.

Reference:
Patent; GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David; WO2012/67663; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A common compound: 1074-16-4, name is 2-(2-Bromophenyl)ethanol,molecular formula is C8H9BrO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 1074-16-4

The 2-bromophenyl ethanol (0.5mmol, 99.9mg) and tert-butanol (5mmol, 370.4mg) was added to a dry 10mL microwave tube, while adding Ph3PAuOTf (0.005mmol, 3.1mg) in 0.5mL toluene solution, and the reaction mixture was heated with a microwave reactor to 120 C, the reaction was stirred for 60 minutes, after the completion of the reaction by flash column chromatography to give the title compound isolated X, yield 86%.

With the rapid development of chemical substances, we look forward to future research findings about 1074-16-4.

Reference:
Patent; Shenyang Pharmaceutical University; LIU, YONG XIANG; CHENG, MAO SHENG; WANG, XIAO YU; SHI, HUI; DU, CHUAN; WANG, YAN SHI; LIU, YANG; (10 pag.)CN104326883; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts