Category: 1072-52-2

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1072-52-2

Example 15 (Table 1, entry 8 and Scheme 11): Preparation of methyl 3-[(2-bromoethyl)- 2-[(methylsulfonyloxy)ethyl]amino]-2,6-dinitrobenzoate (27b); A solution of methyl 3- chloro-2,6-dinitrobenzoate (25) (1.15 g, 5.0 mmol) in dry DMF (10 mL) was treated with aziridineethanol (1.3 g, 15.0 mmol) and LiBr (4.35 g, 50 mmol)and stirred at room temperature for 6 h. The mixture was diluted with brine (40 mL) and extracted with EtOAc (2×60 mL). The combined organic fractions were washed with brine dried and concentrated under reduced pressure. Chromatography of the residue on silica gel, eluting with EtOAc/petroleum ether gave methyl 3-[(2-chloroethyl)(2-hydroxyethyl)amino]-2,6-dinitrobenzoate (26b) (0.40 g, 36% based on consumed starting material) as a yellow oil: 1H NMR [(CD3)2SO] delta 8.24 (d, / = 9.4 Hz, 1 H), 7.62 (dj = 9.4 Hz, 1 H), 4.79 (vbr s, 1 H), 3.78 (s, 3 H), 3.77 (t, / = 6.2 Hz, 2 H), 3.65 (t, / = 6.1 Hz, 2 H), 3.53 (t, / = 5.4 Hz, 2 H), 3.36 (t, / = 5.3 Hz, 2 H); 13C NMR delta163.2, 147.6, 136.4, 134.5, 128.1, 126.3, 121.9, 58.1, 53.8, 53.6, 52.5, 29.7. 38b: HRMS (FAB) calcd for C12H1579BrN3O7 [M+H]+ m/z 392.0093; found 392.0093.

With the rapid development of chemical substances, we look forward to future research findings about 1072-52-2.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1072-52-2, 2-(Aziridin-1-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H9NO, blongs to alcohols-buliding-blocks compound. Computed Properties of C4H9NO

2-Methyl-3,4-dihydro-2H-spiro[isoquinoline-1 ,4?-piperidine] (compound obtained in example 65 step a, 268 mg, 1.23 mmol) and 2-(aziridin-1-yl)ethanol (43 jtL, 0.49mmol) were dissolved in dichioromethane in a process vial. The reaction was stirredfor few minutes and then the solvent was removed with a stream of nitrogen.Amberlyst (6 mg) was added, the vial was sealed with a septum and the reaction mixture was subjected to microwave irradiation for 3 h at 1000 C. After cooling back to r.t., the reaction was diluted with dichloromethane, and NaHCO3 was added. The phases were separated and the aqueous phase additionally extracted with DCM. The aqueous phase was then basified with NaOH solution and again extracted twice withDCM. The combined organic fractions were dried over sodium sulphate, filtered and the solvent removed to give a crude product which was purified under preparative HPLC (Column X-Bridge C18, H20+ 0.05% formic acid : ACN + 0.05% formic acid from (98:2 to 5:95), flow 20 mI/mm, rt).HPLC-MS (Method H): Ret, 1.23 mm; ESl-MS m/z, 304.2 (M+i).

The synthetic route of 1072-52-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; ALMANSA-ROSALES, Carmen; GARCIA-LOPEZ, Monica; CAAMANO-MOURE, Ana-Maria; (282 pag.)WO2016/78770; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1072-52-2 ,Some common heterocyclic compound, 1072-52-2, molecular formula is C4H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 5 (Table 1, entry 2, and Scheme 6). Preparation of 2-[2-(aminocarbonyl)(2- bromoethyl)-4,6-dinitroanilino] ethyl methanesulfonate (13b); A slurry of 2-chloro-3,5- dinitrobenzamide (U) (237 mg, 1.1 mmol) in dry 3-methyl-2-butanone (20 mL) was cooled to below 5 0C, and LiBr (1.5 g) was added, keeping the temperature below 15 0C. Aziridineethanol (240 mg, 2.76 mmol) was added to the stirred mixture, which was then kept at 20 0C overnight. Water (50 mL) was added, followed by EtOAc (100 mL). The organic layer was washed with water, 10% aqueous NaBr, and then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5- dinitrobenzamide (12b) (360 mg, 87%) as a yellow solid: mp (EtOAc/petroleum ether) 138- 140 C; 1H NMR [(CD3)2SO] delta 8.69 (dj = 2.8 Hz, 1 H), 8.43 (s, 1 H), 8.35 (dj = 2.8 Hz, 1 H), 8.10 (s, 1 H), 5.15 (t, / = 5.6 Hz, 1 H), 3.61 (m, 4 H), 3.53 (m, 2 H), 3.14 (m, 2 H); 13C NMR delta 167.6, 146.4, 143.8, 139.8, 134.2, 128.2, 123.0, 57.8, 54.1, 53.6, 29.8; Anal. Calcd for C11H13BrN4O6: C, 35.0; H, 3.5; N, 14.9. Found: C, 35.0; H, 3.5; N, 14.6%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-52-2, 2-(Aziridin-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

Example 16 (Table 1, entry 8 and Scheme 11): Preparation of methyl 3-[N-(2- iodoethyl)-N- [2- [(methylsulfonyl)oxy] ethyl] amino] -2,6-dinitrobenzoate (27c); A stirred5 solution of methyl 3-chloro-2,6-dinitrobenzoate (25) (140 mg, 0.54 mmol) in DMF (1.5 mL) at» , room temperature was treated with NaI (405 mg, 2.7 mmol) for 5 min, then cooled to 0 0C and treated with aziridineethanol (0.15 mL, 1.87 mmol). The mixture was stirred at 30 0C for 16 h, then diluted with IN aqueous AcOH (15 mL) and extracted with EtOAc (2×15 mL). The combined organic phases were washed with water (2x), dried, and concentrated under10 reduced pressure. The residue was chromatographed on silica gel, eluting with EtOAc/petroleum ether (1:1). The middle fractions were combined and concentrated to small volume, then hexane was added to precipitate methyl 3-[N-(2-hydroxyethyl)-N-2- (iodoethyl)amino]-2,6-dinitrobenzoate (26c) (138 mg, 58%) as a yellow gum: 1H NMR [(CDj)2SO] delta 8.24 (d, J = 9.7 Hz, 1 H), 7.59 (d, J = 9.7 Hz, 1 H), 4.79 (tj = 5.2 Hz, 1 H), 3.8715 (s, 3 H), 3.71 (t, / = 7.2 Hz, 2 H), 3.53 (q, / = 5.1 Hz, 2 H), 3.40-3.33 (m, 4 H). HRMS(FAB) calcd. for C12H15IN3O7 [MH+] m/* 439.9955; found 439.9960.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-52-2, 2-(Aziridin-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol, molecular formula is C4H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2-(Aziridin-1-yl)ethanol

(1) Preparation of 1-[2-(2-hydroxyethylamino)ethyl]-4-(4-nitrophenyl)piperazine (compound 75) In 20 ml of chloroform was dissolved 4 g of 1-(4-nitrophenyl)piperazine (compound 66) and 0.52 ml of 1-(2-hydroxyethyl)aziridine, and the solvent was distilled off from the resulting reaction mixture under reduced pressure. To the residue was added 10 mg of Amberlist 15 (trade name; made by Rohm & Haas Co.), and the mixture was then heated with stirring at 100 C. for 3 hour. Afterward, the temperature of the reaction mixture was returned to room temperature. To the reaction mixture was added 20 ml of chloroform, and insoluble matters were then removed therefrom by filtration. The filtrate was concentrated, and the resulting residue (concentrate) was purified through a silica gel column chromatograph (chloroform/methanol=100/1 to 25/1 in terms of volume ratio), thereby preparing 1 g of 1-[2-(2-hydroxyethylamino)ethyl]-4-(4-nitrophenyl)piperazine (compound 75).

With the rapid development of chemical substances, we look forward to future research findings about 1072-52-2.

Reference:
Patent; Mitsui Toatsu Chemicals, Incorporated; US5008267; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1072-52-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. A new synthetic method of this compound is introduced below.

Example 10 (Table 1, entry 4 and Scheme 7): Preparation of 2- [(2-iodoethyl)-2,4- dinitro-6-({[2-(tetrahydro-2/£pyran-2-yloxy)ethyl]amino}carbonyl)anih’no]ethyl methanesulfonate (17c); A slurry of 15 (520 mg, 1.4 mmol) in dry 3-methyl-2-butanone (20 mL) and NaI (3.1 g) was cooled to below 5 0C, and aziridineethanol (240 mg, 2.76 mmol) was added. The reaction was kept at 20 0C overnight, then water (100 mL) was added, and the mixture was extracted with EtOAc (3×50 mL). The combined organic layer was washed with water, dried and concentrated under pressure, then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 2-[(2-hydroxyethyl)(2-iodoethyl)amino]-3,5- dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (16c) (630 mg, 82%) as a yellow foam; 1H NMR (CDCl3) delta 8.63 (d, / = 2.8 Hz, 1 H), 8.56 (dj = 2.8 Hz, 1 H), 8.24 (br, 1 H), 4.54 (m, 1 H), 4.48 (m, 1 H), 3.93 (m, 2 H), 3.84 (m, 1 H), 3.70 (m, 6 H), 3.54 (m, 1 H), 3.30 (m, 2 H), 3.18 (m, 2 H), 1.90-1.40 (m, 6 H); 13C NMR delta 165.7, 146.7, 144.4, 140,9, 134.5, 129.2, 123.5, 101.6, 67.0, 65.4, 58.0, 55.0, 53.7, 40.7, 31.3, 25.1, 21.2, 0.3; HRMS (FAB) calcd for C18H26IN4O8 [MH]+ m/z 553.0795; found 533.0797.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-52-2, 2-(Aziridin-1-yl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 4 (Table 1, entry 2, and Scheme 6): Preparation 2-[2-(aminocarbonyl)(2- chloroethyl)-4,6-dinitroanilino] ethyl methanesulfonate (13a); A solution of 2-chloro-3,5- dinitrobenzamide (11) (250 mg, 1.15 mmol) in THF (20 mL) was cooled to below 5 0C, and aziridineethanol (240 mg, 2.76 mmol) was added over 10 min to the stirred mixture, which was then kept at 20 0C overnight. Water (50 mL) was added, followed by EtOAc (50 mL). The mixture was separated and aqueous phase was extracted with EtOAc (2×60 mL). The combined organic fractions were washed with brine, dried and concentrated under reduced pressure, chromatography on silica gel and elution with EtOAc/petroleum ether (1:1), to give 2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzamide (12a) (350 mg, 92%) as a yellow solid: mp (EtOAc/petroleum ether) 96-100 C; 1H NMR [(CD3)2SO] delta 8.69 (d, / = 2.8 Hz, 1 H), 8.43 (s, 1 H, CONH), 8.35 (dj = 2.8 Hz, 1 H), 8.10 (s, 1 H), 5.15 (tj = 5.6 Hz, 1 H), 3.77 (m, 2 H), 3.54 (m, 4 H), 3.14 (m, 2 H); 13C NMR delta 167.6, 146.7, 143.8, 139.7, 134.1, 128.2, 123.1, 57.8, 54.3, 53.6, 41.4; Anal. Calcd. for C11H13ClN4O6: C, 39.7; H, 3.9, N, 16.8. Found: C, 38.4; H, 4.4; N, 15.7%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-52-2, 2-(Aziridin-1-yl)ethanol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. A new synthetic method of this compound is introduced below., Quality Control of 2-(Aziridin-1-yl)ethanol

Example 19 (Scheme 14): Preparation of 2-[(2-bromoethyl)-2-[[[2-(beta-D- gulopyranosyloxy)ethyl] amino] carbonyl] -4.6-dinitroanilino] ethyl methanesulfonate(48); Reaction of 37 as in Scheme 14, and chromatography on silica gel, eluting with EtOAc/petroleum ether (2:1) gave a product that was precipitated from a CH2Cl2 solution with i-Pr2O to give 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2,3,4,6-tetra-O-acetyl-beta-D- gulopyranosyl)oxy] ethyl] amino] carbonyl] anilino] ethyl methanesulfonate (47) (2.04 g, 82%) as a yellow solid: mp 70-73 0C; 1H NMR [(CD3)2SO] delta 8.84 (t, / = 5.5 Hz, 1 H), 8.75 (d, / = 2.8 Hz, 1 H), 8.31 (dj = 2.8 Hz, 1 H), 5.27 (d, J = 3.2 Hz, 1 H), 5.17 ‘(ddj = 10.4, 3.5 Hz, 1 H), 4.99 (ddj = 10.3, 8.0 Hz, 1 H), 4.78 (dj = 8.0 Hz, 1 H), 4.28 (tj = 5.4 Hz, 1 H), 4.22 (tj = 6.5 Hz, 1 H), 4.11-3.99 (m, 2 H), 3.94-3.84 (m, 1 H), 3.77-3.68 (m, 1 H), 3.63-3.37 (m, 8 H), 3.13 (s, 3 H), 2.13 (s, 3 H), 2.01 (s, 3 H), 1.97 (s, 3 H), 1.92 (s, 3 H. 13C NMR [(CD3)2SO] delta 169.8, 169.7, 169.4, 169.1, 165.4, 145.8, 145.3, 140.8, 135.8, 127.4, 122.3, 100.1, 70.2, 69.9, 68.5, 67.4, 67.3 (2), 61.2, 54.3, 51.1, 39.4, 36.4, 29.7, 20.4, 20.3, 20.2 (2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-52-2, 2-(Aziridin-1-yl)ethanol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-(Aziridin-1-yl)ethanol

Example 45(4-chlorophenyl)[4-chloro-3-phenyl-2-(2,2,2-trifluoroethoxy)quinolin-6-yl](1-methyl-1H-imidazol-5-yl)methanol TFA(100 mg, 0.202 rnniol, Example 65), 2,2,2 -trifluoroethanol (14,5 L, 0.202 mmol), toluene (2 ml), and sodium hydride (60% dispersion in mineral oil, 20 mg, 0.51 mmol) were combined in a round bottom flask under an N2atmosphere. The reaction solution was heated to reflux and reflux ed overnight. The reaction solution was cooled to room temperature then transferred to a separatory tunnel with EtOAc dilution, and extracted with saturated, aqueous NH4CI then saturated, aqueous NaHCOi solutions. The organic phase was separated then dried over MgS04, filtered and concentrated under reduced pressure. The crude product was purified by flash column chromatography (silica gel, 0-10% DCM / MeOH) then via reverse phase chromatography using acetonitrile with 0.05%) trifluoroacetic acid in water as eluent. The fractions from the purification containing the desired product were transferred to a separatory funnel with EtOAc and extracted with a saturated, aqueous NaHC03solution. The aqueous layer was separated, extracted with EtOAc, then the combined organic phases were dried over Mg804, filtered and concentrated under reduced pressure to provide the title compound. MS (ESS): mass caicd. for C28H20CI2F3N3O2, 557.1 ; m/z found, 558.3 [M+Hf; NMR (600 MHz, CDCI3) delta ppm 8.38 (s, 1 H), 8.17 (d, J = 2.0 Hz, 1H), 7.87 (d, J —— 8.8 Hz, 1H), 7.60 (dd, J —— 8.8, 2.1 Hz,1 1 1). 7.52 – 7.43 (m, 3H), 7.38 – 7.31 (m, 6H), 6.56 (s, 1 H), 4.92 (q, J —– 8.4 Hz, 21 1). 3.62 (s.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-52-2, 2-(Aziridin-1-yl)ethanol.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, Kent; EDWARDS, James, P.; KREUTTER, Kevin, D.; KUMMER, David, A.; MAHAROOF, Umar; NISHIMURA, Rachel; URBANSKI, Maud; VENKATESAN, Hariharan; WANG, Aihua; WOLIN, Ronald, L.; WOODS, Craig, R.; FOURIE, Anne; XUE, Xiaohua; CUMMINGS, Maxwell, D.; LEONARD, Kristi, A.; WO2015/57203; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

Into a dry 500 mL distillation flask there was placed 91 mL (1.14 mole) of aziridineethanol to which there was added 495 mg of NaH (60% dispersion in mineral oil). The mixture was stirred for 30 min and the flask was vented. Dimethyl adipate (48 mL, 0.29 mole) was added to the mixture and the flask was connected to a distillation column. The resulting mixture was then heated and methanol was removed at reduced pressure during a period of one hour. Excess aziridineethanol was then removed by heating the mixture to 70 C at a pressure of 0.15 mm Hg. The desired product was then distilled off from the mixture at 130 C at a pressure of 0.15 mm Hg to obtain 49 g (0.18 mole, 60% yield) of di[2-(1-aziridinyl)ethyl]adipate as a colorless oil having the following analysis: 1H NMR (400 MHz, DMSOd6) delta=1.10-1.11(m, 4H, CH2). 1.51-1.55(m, 8H, CH2), 2.28-2.35(m, 8H, CH2), 4.09(t, J=4.0 Hz, 4H, CH2) ppm. 3C NMR (100 MHz, DMSOd6) delta=24.6; 27.0; 33.8; 59.7; 64.2; 173.3 ppm IR: 3064.42; 2952.38; 1731.46; 1454.54; 1264.33; 1174.82 cm-1

According to the analysis of related databases, 1072-52-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gianolio, Diego A.; Calias, Pericles; Miller, Robert J.; US2005/222081; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts