Category: 10602-04-7

Application of 10602-04-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10602-04-7, name is (4-Ethynylphenyl)methanol, molecular formula is C9H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The corresponding alkyne (1.1e2.2 mmol) was added to a solutionof azide ester (¡À)-2 (1 mmol), Na ascorbate (0.5 mmol) andCuSO4.5H2O (0.05 mmol) in t-BuOH (1 mL)/H2O (1 mL) underargon. The reaction mixture was transferred to the microwavesystem and was irradiated for 10e160 min between 70 and 90 C,using an irradiation power of 100 W. Removal of solvents underreduced pressure afforded a solid residue, which was purified byrecrystallization or by column chromatography on silica gel

According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ferreira Da Costa, Joana; Garcia-Mera, Xerardo; Caamano, Olga; Brea, Jose Manuel; Loza, Maria Isabel; European Journal of Medicinal Chemistry; vol. 98; (2015); p. 212 – 220;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10602-04-7, name is (4-Ethynylphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H8O

Example 13; {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl-phenoxy}-acetic acid; General procedure (A); Step B:; 7-(2,6-Dibromo-pyridin-4-ylsulfanyl)-2-methyl-phenoxy}-acetic acid methyl ester (0.3 g; 0.67 mmol, prepared as described in example 6), cupper iodide (3.8 mg; 0.02 mmol), 4- ethynylbenzylalcohol (266 mg; 2,01 mmol) and bis (triphenylphosphine) (II) chloride (18.8 mg; 0,027 mmol) were added to a dry reaction flask under an atmosphere of nitrogen. Triethylamine (2 ml) and DMF (2 ml) was added and the reaction mixture was reacted at 70 ¡ãC for 10 min in a microwave oven. The reaction mixture was purified by preparative HPLC (method B) to give {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl- phenoxy}-acetic acid methyl ester. Yied: 260 mg; 70 percent. LC-MS (system 1): Rt: 3.02 min.; Mw: 576.4.

The synthetic route of 10602-04-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVO NORDISK A/S; WO2005/105726; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts