Category: 10602-04-7

Timelthaler, Daniel; Topf, Christoph published the artcile< Chromium-catalyzed transfer hydrogenation of aromatic aldehydes facilitated by a simple metal carbonyl complex>, SDS of cas: 10602-04-7, the main research area is aryl aldehyde transfer hydrogenation chromium metal carbonyl complex; alc preparation.

Authors communicate a simple method for the transfer hydrogenation of aromatic aldehydes in i-PrOH effected by the cost-effective and easy-to-handle [Cr(CO)6]. The reactions are readily carried in Ar-flushed tubes without further need of special equipment. Functional groups are widely tolerated and, if desired, the catalytic transformations can be further promoted through the addition of trimethylamine N-oxide (TMAO). This paves the way for processing thermo-labile substrates under mild reaction conditions. In addition, the introduced method is suitable for the deuteration of benzyl alc. derivatives

Journal of Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, SDS of cas: 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pingitore, Valeria; Martinez-Bailen, Macarena; Carmona, Ana T.; Meszaros, Zuzana; Kulik, Natalia; Slamova, Kristyna; Kren, Vladimir; Bojarova, Pavla; Robina, Inmaculada; Moreno-Vargas, Antonio J. published the artcile< Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars>, SDS of cas: 10602-04-7, the main research area is mol modeling docking pyrrolidine iminosugar preparation hexosaminidase human acetylglucosaminidase; click alkyne azide triazole cycloaddition catalyst preparation thiourea; enzyme active site human lysosomal hexosaminidase inhibitor; human lysosomal hexosaminidase inhibitor combinatorial library pyrrolidine iminosugar synthesis; Click reaction; Glycosidase inhibitors; Hexosaminidases; Iminosugars; In situ screening; Multivalency.

Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions from the resp. azido/aminohexylpyrrolidine iminosugar precursors. The resulting monomeric and dimeric compounds were screened for inhibition of β-N-acetylglucosaminidase from Jack beans, the plant ortholog of human lysosomal hexosaminidases. A selection of the best inhibitors of these libraries was then evaluated against human lysosomal β-N-acetylhexosaminidase B (hHexB) and human nucleocytoplasmic β-N-acetylglucosaminidase (hOGA). This evaluation identified a potent (nM) and selective monomeric inhibitor of hOGA compound I that showed a 6770-fold higher affinity for this enzyme than for hHexB. The corresponding dimeric derivative II further remarkably improved the selectivity in the inhibition of hOGA (2.7 x 104 times more selective for hOGA over hHexB) and the inhibition potency (by one order of magnitude). Docking studies were performed to explain the selectivity of inhibition observed in I.

Bioorganic Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, SDS of cas: 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Cheng; Wang, Minyan; Lu, Hongjian; Zhao, Binlin; Shi, Zhuangzhi published the artcile< Enabling the Use of Alkyl Thianthrenium Salts in Cross-Coupling Reactions by Copper Catalysis>, Recommanded Product: (4-Ethynylphenyl)methanol, the main research area is internal alkyne chemoselective photochem preparation; terminal alkyne thianthrenium salt Sonogashira copper catalyst; alkane chemoselective preparation; alkyl thianthrenium trifluoromethanesulfonate Grignard reagent Kumada copper catalyst; alkynylation; copper; photoredox reactions; radical; sulfonium salts.

Here, a series of thianthrenium salts was synthesized that act as reliable alkylation reagents and readily engage in copper-catalyzed Sonogashira reactions to build C(sp3)-C(sp) bonds under mild photochem. conditions. Diverse alkyl thianthrenium salts, including Me and disubstituted thianthrenium salts, were employed with great functional breadth, since sensitive Cl, Br, and I atoms, which were poorly tolerated in conventional approaches, were compatible. The generality of developed alkyl reagents had also been demonstrated in copper-catalyzed Kumada reactions.

Angewandte Chemie, International Edition published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Recommanded Product: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tagami, Takuma; Aoki, Yuma; Kawamura, Shintaro; Sodeoka, Mikiko published the artcile< 1,2-Bis-perfluoroalkylations of alkenes and alkynes with perfluorocarboxylic anhydrides via the formation of perfluoroalkylcopper intermediates>, Application In Synthesis of 10602-04-7, the main research area is bis perfluoroalkyl preparation; alkene alkyne perfluorocarboxylic anhydride perfluoroalkylation copper mediator perfluoroalkylcopper intermediate.

A novel, Cu-mediated protocol toward the 1,2-bis-perfluoroalkyaltion of alkenes/alkynes was developed. The method proceeded with perfluorocarboxylic anhydrides as inexpensive and readily available perfluoroalkyl sources. Diacyl peroxide was generated in situ from the perfluorocarboxylic anhydrides and H2O2. The key step in this reaction is the formation of a stable perfluoroalkylcopper intermediate that is achieved with the aid of a bipyridyl ligand. Subsequent reaction of the intermediate with perfluoroalkyl-containing alkyl or vinyl radicals affords the desired products.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application In Synthesis of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bohigues, Benjamin; Rojas-Buzo, Sergio; Moliner, Manuel; Corma, Avelino published the artcile< Coordinatively Unsaturated Hf-MOF-808 Prepared via Hydrothermal Synthesis as a Bifunctional Catalyst for the Tandem N-Alkylation of Amines with Benzyl Alcohol>, Product Details of C9H8O, the main research area is coordinatively unsaturated hafnium MOF808 hydrothermal bifunctional catalyst.

The modulated hydrothermal synthesis (MHT) of an active and selective Hf-MOF-808 material for the N-alkylation reaction of aniline with benzyl alc. under base-free mild reaction conditions is reported. Through kinetic experiments and isotopically labeled NMR spectroscopy studies we have demonstrated that the reaction mechanism occurs via borrowing hydrogen (BH) pathway, in which the alc. dehydrogenation is the limiting step. The high concentration of defective – OH groups generated on the metallic nodes through MHT synthesis enhances the alc. activation, while the unsaturated Hf4+,which acts as Lewis acid site, is able to borrow the hydrogen from the methylene position of benzyl alc. This fact makes this material at least 14 times more active for the N-alkylation reaction than the material obtained via solvothermal synthesis. The methodol. described in this work could be applied to a wide range of aniline and benzyl alc. derivates, showing in all cases high selectivity toward the corresponding N-benzylaniline product. Finally, Hf-MOF-808, which acts as a true heterogeneous catalyst, can be reused at least four consecutive runs without any activity loss.

ACS Sustainable Chemistry & Engineering published new progress about Alkylation. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Product Details of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Zhaoyang; Guo, Jun; Sun, Yufeng; Zheng, Yushan; Zhou, Zhehong; Lu, Zhan published the artcile< Regio-controllable Cobalt-Catalyzed Sequential Hydrosilylation/Hydroboration of Arylacetylenes>, Product Details of C9H8O, the main research area is arylacetylene pinacolborane diphenylailane cobalt catalyst regioselective tandem hydrosilylation hydroboration; aryl diphenylsilylboronate preparation; alkynes; cobalt catalysis; hydroboration; hydrosilylation; regiodivergent synthesis.

A regio-controllable cobalt-catalyzed sequential hydrosilylation/hydroboration of arylacetylenes, delivering all the possible regio-outcomes with high regioselectivities (up to >20/1 rr for all the cases). Each regioisomer of value-added silylboronates were efficiently and regioselectively obtained from the same materials. The adjustment of the ligands of cobalt catalysts combined with dual catalysis relay strategy was the key to achieve regio-chem. control. This regio-controllable research inspired the exploration of the diversity-oriented synthesis that involved multiple additions and provided full sets of regioisomers of other synthetic useful mols.

Angewandte Chemie, International Edition published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Product Details of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Jun Jie; Pan, Houwen Matthew; Goto, Atsushi published the artcile< Synthesis of vinyl iodide chain-end polymers via organocatalyzed chain-end transformation>, Formula: C9H8O, the main research area is vinyl iodide chain end polymer organocatalyzed transformation.

In the presence of alkynes (CH=C-R2), iodide chain-end polymers (Polymer-I) were successfully transformed to vinyl iodide chain-end polymers (polymer-CH=CR2-I) in a single step via organocatalysis. This reaction is completely metal-free and easy to carry out without using special reagents or special conditions. The polymers encompassing polyacrylates and polymethacrylate, and addnl. functionalities (e.g., OH and CF3) were also incorporated into the R2 moiety. The obtained Polymer-CH=CR2-I further served as a useful precursor for copper-catalyzed cross-coupling reactions with various thiols (R3-SH) to yield vinyl sulfide chain-end polymers (polymer-CH=CR2-SR3) with various R3 moieties. Interestingly, under selected conditions, this organocatalysis also offered block-like copolymers containing a conjugated oligo-alkyne segment and a non-conjugated polyacrylate segment. Exploiting the unique structure, the block-like copolymer was used as an efficient dispersant of carbon nanotubes.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cross-coupling reaction. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Bo; Li, Shi-Jun; Wang, Yongdong; Lan, Yu; Zhu, Shifa published the artcile< Hydrogen radical-shuttle (HRS)-enabled photoredox synthesis of indanones via decarboxylative annulation>, Recommanded Product: (4-Ethynylphenyl)methanol, the main research area is phenylglyoxalic acid acetylene iridium photocatalyst regioselective decarboxylative cyclization; dihydroindenone preparation.

In this work, a HRS-enabled decarboxylative annulation of carbonyl compounds via photoredox catalysis for the synthesis of indanones was developed. This protocol features broad substrate scope, excellent functional group tolerance, internal hydrogen radical transfer, atom- and step-economy. Critical to the success of this process is the introduction of water, acting as both HRS and hydrogen source, which was demonstrated by mechanistic experiments and d. functional theory (DFT) calculations Importantly, this mechanistically distinctive HAT provides a complement to that of typical proton-shuttle-promoted, representing a breakthrough in hydrogen radical transfer, especially in the inherently challenging 1,2- or 1,3-HAT.

Nature Communications published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Recommanded Product: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Laiqiang; Hou, Zhong-Wei; Li, Pinhua; Wang, Lei published the artcile< Electrochemical Dearomatizing Spirocyclization of Alkynes with Dimethyl 2-Benzylmalonates to Spiro[4.5]deca-trienones>, Formula: C9H8O, the main research area is alkene dimethyl benzylmalonate ferrocene catalyst electrochem dearomatizing spirocyclization; spiro decatrienone preparation green chem.

An electrochem. dearomatizing spirocyclization of alkynes with di-Me 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones had been developed. This approach adopted ferrocene (Cp2Fe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviated the forthputting of noble-metal reagents, sacrificial chem. oxidants and 2-bromomalonates. A wide variety of spiro compounds were efficiently prepared with satisfactory results under mild conditions.

Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Mingbing; Gagne, Yohann; Hope, Taylor O.; Pannecoucke, Xavier; Frenette, Mathieu; Jubault, Philippe; Poisson, Thomas published the artcile< Copper-Photocatalyzed Hydroboration of Alkynes and Alkenes>, Computed Properties of 10602-04-7, the main research area is copper photocatalyst diphosphinoxanthene diphosphinophenoxazine phenanthroline complex preparation electrochem absorbance; hydroboration alkyne alkene copper photocatalyst preparation stereoselective regioselective mechanism; mol structure optimized boronic ester free energy enthalpy dissociation; boryl radical; continuous flow; copper; hydroboration; photocatalysis.

The photocatalytic hydroboration of alkenes and alkynes is reported. The use of newly-designed copper photocatalysts with B2Pin2 permits the formation a boryl radical, which is used for hydroboration of a large panel of alkenes and alkynes. The hydroborated products were isolated in high yields, with excellent diastereoselectivities and a high functional group tolerance under mild conditions. The hydroboration reactions were developed under continuous flow conditions to demonstrate their synthetic utility. The reaction mechanism was studied and suggested an oxidation reaction between an in situ formed borate and the Cu-photocatalyst in its excited state for the boryl radical formation.

Angewandte Chemie, International Edition published new progress about Activation enthalpy. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Computed Properties of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts