Category: 106-21-8

Novel Tdp1 inhibitors based on adamantane connected with monoterpene moieties via heterocyclic fragments was written by Munkuev, Aldar A.;Mozhaitsev, Evgenii S.;Chepanova, Arina A.;Suslov, Evgeniy V.;Korchagina, Dina V.;Zakharova, Olga D.;Ilina, Ekaterina S.;Dyrkheeva, Nadezhda S.;Zakharenko, Alexandra L.;Reynisson, Johannes;Volcho, Konstantin P.;Salakhutdinov, Nariman F.;Lavrik, Olga I.. And the article was included in Molecules in 2021.SDS of cas: 106-21-8 The following contents are mentioned in the article:

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized and tested against Tdp1. All the derivatives exhibited inhibition at low micromolar or nanomolar concentrations with the most potent inhibitors having IC₅₀ values in the 0.35-0.57 μM range. The cytotoxicity was determined in the HeLa, HCT-116 and SW837 cancer cell lines; moderate CC₅₀ (μM) values were seen from the mid-teens to no effect at 100 μM. Furthermore, citral derivative 20c, α-pinene-derived compounds 20f, 20g and 25c, and the citronellic acid derivative 25b were found to have a sensitizing effect in conjunction with topotecan in the HeLa cervical cancer and colon adenocarcinoma HCT-116 cell lines. The ligands are predicted to bind in the catalytic pocket of Tdp1 and have favorable physicochem. properties for further development as a potential adjunct therapy with Top1 poisons. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8SDS of cas: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 106-21-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

GC-MS and surface characteristics of polyvinyl siloxane-an in vitro analysis was written by Mohamed, K. Kasim;Banu, R. Fathima;Kumar, V. Anand;Sundaram, Lakshmi;Thyagarajan, S. P.. And the article was included in Journal of Chromatographic Science in 2022.Formula: C10H22O The following contents are mentioned in the article:

To assess the surface characteristics, composition and release of components of Polyvinyl siloxane (PVS) impression material and explore the use of the material other than for impressions. Forty samples of 0.5-mm thickness and 8-mm diameter PVS disks, with ew perforations, were prepared and divided into four groups. Group 1 in methanol was analyzed by GC-MS immediately and on 1st, 7th and 14th day. Group 2 and 3 placed in 10 mL of human saliva and in artificial nasal fluid, resp., were analyzed by GC-MS at 24 h. Group 4 was subjected to surface characteristics anal. by placing five PVS disks each in 1 mL of human saliva and 1 mL of artificial nasal fluid, resp. On Day 1, Dodecanoic acid, Me ester, Cyclononasiloxane, octadecamethyl, Cyclodecasiloxane and eicosamethyl (four peaks) were observed in Group 1. At 24 h, Group 2 had addnl. compounds of 2-Decene,7-methyl-(Z)-, 2-Undecene,8-methyl-(Z)- and Lauryl acetate. Group 3 showed release of 32 compounds, but their retention time was less. Surface characteristics on Day 14 revealed no noticeable changes. The study revealed that there was a lack of any adverse component release from PVS for a period of 2 wk based on GC-MS anal. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H22O

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Alcohol – Wikipedia,
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The Role of the 1,2,3-Triazolyl Heterocycle in the Helical Columnar Assembly and Electric Field Response was written by Nguyen, Manh Linh;Byun, Jaeduk;Cho, Byoung-Ki. And the article was included in Journal of Physical Chemistry B in 2021.Safety of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

Here, we have proven the role of the 1,2,3-triazolyl group in the helical assembly and elec. field (E-field) response upon comparing liquid crystal analogs I and II (1 and 2, resp.) based on 1,2,3-triazolyl and 1,3,4-oxadiazolyl linkers, resp. An ordered helical column was only observed in 1, driven by the hydrogen-bonding interactions between the adjacent triazolyl nitrogen and hydrogen atoms. X-ray diffraction and energy simulations indicate that the helical column is a 11₂ helix and the helical axis does not coincide with the center of the mol. long axis. The key for the formation of the helical column is the tilted conformation of 1 originating from the steric repulsion between the triazolyl C-H and C-H of the aromatic core. Anal. of the dynamics in the simple hexagonal columnar phase revealed that the in-plane rotational motion of the triazolyl linker (1) is allowed, while the oxadiazolyl linker of 2 has limited conformational flexibility. A uniform alignment under an E-field only occurs in 1, demonstrating the requirement for conformational flexibility in the polar linker. This alignment enhances the elec. conductance of 1 by approx. two-fold. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Safety of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 3,7-Dimethyloctan-1-ol

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Antioxidant and antibacterial activities of Pelargonium asperum and Ormenis mixta essential oils and their synergistic antibacterial effect was written by Ouedrhiri, Wessal;Balouiri, Mounyr;Bouhdid, Samira;Harki, El Houssaine;Moja, Sandrine;Greche, Hassane. And the article was included in Environmental Science and Pollution Research in 2018.Recommanded Product: 106-21-8 The following contents are mentioned in the article:

In this work, the chem. composition, the antioxidant, and the antibacterial activities of two Moroccan essential oils less studied, extracted from Pelargonium asperum and Ormenis mixta, were investigated. According to the gas chromatog. coupled to mass spectrometry anal., citronellol (25.07%), citronellyl ester (10.52%), geraniol (10.46%), and buthyl anthranilate (5.93%) were found to be the major components of P. asperum, while O. mixta was mainly composed of D-germacrene (11.46%), 1,8-cineole (10.28%), and cis-Me isoeugenol (9.04%). Moreover, O. mixta essential oil exhibited an important antioxidant activity being significantly higher than that exhibited by P. asperum oil (P < 0.001). As regards the antimicrobial activity of both essential oils, the zones of growth inhibition and the min. inhibitory concentration values showed that P. asperum essential oil was more active than that of O. mixta. Thereafter, the impact of the binary combination of essential oils on their antimicrobial effect was investigated against Staphylococcus aureus using the fractional inhibitory concentration index calculation The results showed a promising synergistic antibacterial interaction between essential oils studied. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Recommanded Product: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 106-21-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analysis of aroma components in fruit development period of “muscat” was written by Zhang, Cun-zhi;Liu, Jing;Zhang, Hong;Wei, Peng;Zhang, Hong-sheng;Cheng, Qian. And the article was included in Anhui Nongye Kexue in 2022.Product Details of 106-21-8 The following contents are mentioned in the article:

Headspace solid phase microextraction (HSPME) was used to extract the aroma components from six different development stages of grape, and the components were determined and analyzed by gas chromatog.-mass spectrometry (GC-MS) to reveal the change rule of aroma components and content in different development stages. The results showed that 60 kinds of aroma components were detected in the grape fruits of “Muscat”, and the aroma components and their contents varied greatly in different development stages of the fruit. Among them, the most changed linalool, the relative content increased rapidly from 3.24% in the late color transition period to 55.26% in the maturity period, followed by C₁₃ alkanes, the relative content surged from 1.63% in the pre-color conversion to 18.84% in the late color conversion stage, an increase of 10.56 times, then rapidly decreased, and disappeared in the maturity period, which was neg. correlated with the change of linalool. Terpenoids were the main aroma of “Muscat” grapes, of which linalool was the most important component, and the pre-color transition-the late color transition was the synthesis period of the precursor substances of the aroma components. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Product Details of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Product Details of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Antifungal Activity of Novel Tetrahydrogeranyl Quaternary Ammonium Salts was written by Peng, Yun;Chang, Jiayu;Xiao, Zhuangquan;Huang, Jiazong;Xu, Ting;Chen, Shangxing;Fan, Guorong;Liao, Shengliao;Wang, Zongde;Luo, Hai. And the article was included in Natural Product Communications in 2022.COA of Formula: C10H22O The following contents are mentioned in the article:

Due to the excessive use of antifungal agents, drug resistance and ecol. problems are increasing. Some antifungal agents are difficult to degrade and have high toxicity and several side effects. In this study, 15 novel tetrahydrogeranyl quaternary ammonium salts (8a-8o) were synthesized from the natural compound citral. The structures of the quaternary ammonium salts were characterized by Fourier transform IR, proton NMR, carbon-13 NMR spectroscopy, and mass spectrometry, and the antifungal activities of these compounds at a concentration of 0.25 mg/mL against 10 plant pathogenic fungi were tested. The results showed that compound 8i had the best antifungal activity, and its inhibition rates against Rhizoctonia solani, Phytophthora parasitica var. nicotianae, Sphaeropsis sapinea, Fusarium oxysporum f. sp. niveum, and Poria vaporaria reached 100%. For Fusarium verticillioides, the inhibition rate of compound 8i was 93.28%, which was higher than that of chlorothalonil. In addition, it was found that the inhibition rates of compounds with N,N-di-Pr group (8l, 8m) against R solani, F oxysporum f. sp. niveum, S sapinea, P parasitica var. nicotianae, F verticillioides, Colletotrichum acutatum, and Coriolus versicolor were higher than compounds with N,N-di-Et and N,N-di-Me groups (8a, 8b, 8j, 8k). The inhibition rates of compounds with morpholine groups (8n, 8o) were generally low. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8COA of Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C10H22O

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Alcohol – Wikipedia,
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Spurge (Euphorbia rigida) exhibits anaesthetic effect in rainbow trout (Oncorhynchus mykiss) without altering plasma cortisol levels was written by Alagoz, Kerem;Parug, Senol;Tastan, Yigit;Bilen, Soner;Sonmez, Adem Yavuz. And the article was included in Aquaculture Research in 2021.Name: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

This study was conducted to investigate a potential new organic anesthetic for aquaculture practices. Aqueous macerate of spurge stem (Euphorbia rigida) was obtained by adding 200 g of plant powder to 1.5 L of distilled water and applied to rainbow trout (Oncorhynchus mykiss) at 5 different concentrations (30000, 40000, 50000, 60000 and 70000μL L^-1) to determine induction (loss of equilibrium and deep anesthesia) and recovery (recovery of equilibrium and full recovery) durations. In addition, plasma cortisol levels of fish within 0 h were determined to evaluate stress response. It was determined that there were 4 concentrations that can be used as suitable anesthetics for rainbow trout: 40000, 50000, 60000 and 70000μL L^-1. These concentrations provided deep anesthesia in 196.67±1.45, 173.00±11.24, 138.33±8.29 and 136.33±5.23 s, resp. Plasma cortisol levels of the mentioned groups were measured as 4.49±1.04, 8.64±0.73, 8.18±0.64 and 9.64±0.78 ng mL^-1, resp. On the other hand, the plasma cortisol level of the control group (anesthetized with 2-phenoxyethanol) was 10.95±0.89 ng mL^-1. These findings suggest that 40000-70000μl L^-1 of E. rigida can be used as an alternative anesthetic in rainbow trout. However, further studies need to be conducted to evaluate the long term effects of the plant, especially in consecutive use. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Name: 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: 3,7-Dimethyloctan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Solar assisted catalytic thermochemical processes: pyrolysis and hydropyrolysis of Chlamydomonas reinhardtii microalgae was written by Aparecida da Silveira Rossi, Raissa;Barbosa, Janaina Miranda;Antonio de Souza Barrozo, Marcos;Martins Vieira, Luiz Gustavo. And the article was included in Renewable Energy in 2021.Recommanded Product: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

Thermochem. processes using solar energy are considered promising approaches. To improve the product properties, alternative techniques have also been investigated, including the use of catalyst and hydrogen atm. These techniques individually have proved to be efficient to overcome some inherent challenges of this process. However, they have never been studied as an integrated process. Thus, in this work the solar assisted catalytic hydropyrolysis process using microalgae Chlamydomonas reinhardtii as biomass source and hydrotalcite-derived mixed oxides as catalyst (in an ex-situ approach) was successfully investigated as an integrated approach. The effects of reaction time and catalyst percentage on the product distribution and the bio-oil content produced from distinct processes: ex-situ catalytic solar pyrolysis (CSP) and ex-situ catalytic solar hydropyrolysis (CSH) were investigated. The hydrogen used in CSH has been produced by solar aqueous alk. electrolysis. The results showed that CSH produced higher liquid yields than CSP, reaching 48.83% in its best condition. The content of oxygenated compounds in bio-oil produced by hydropyrolysis was, on average, about 12% lower than that obtained by CSP. However, CSP presented individual tests with less nitrogenated (6.01%) and oxygenated (22.49%) compounds The hydrocarbon production reached 35.58% for CSP and 37.01% for CSH. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Recommanded Product: 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Impact of alkalization conditions on the phytochemical content of cocoa powder and the aroma of cocoa drinks was written by Sioriki, Eleni;Lemarcq, Valerie;Alhakim, Fauzan;Triharyogi, Harry;Tuenter, Emmy;Cazin, Catherine S. J.;Nolan, Steven P.;Pieters, Luc;Van de Walle, Davy;Dewettinck, Koen. And the article was included in LWT–Food Science and Technology in 2021.Quality Control of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

Alkalization is an important process in cocoa powder production that affects color and flavor. In this study, the impact of alkalization temperature (60, 70, 80, 90, 100°C), NaOH concentration (0.59, 1.17, 2.34, 3.59% weight/weight of cocoa powder) and alkalization time (1 and 10 min) on the physicochem. properties (pH, color) and phytochem. profile (theobromine, caffeine, epicatechin, catechin) of cocoa powder were investigated, while the aroma was studied on the corresponding cocoa drinks. High-performance liquid chromatog. coupled to an ultra-violet detector (HPLC-UV) was used for screening the non-volatiles and headspace solid – phase microextraction – gas chromatog. – mass spectrometry (HS-SPME-GC-MS) for the aromatic compounds Major changes of the cocoa properties occurred during the first minute of alkalization. Increase of temperature and alkali concentration generally reduced the levels of epicatechin and the lightness (L*), while the pH of the cocoa powder was affected by changing the alkali concentration On the other hand, the reddish (a*) and yellowish (b*) color component values and theobromine levels were not significantly affected by varying temperature and alkali concentration A higher temperature did not affect the concentration of the volatile compounds, while a decrease in certain chem. classes was observed by increasing the alkali concentration This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Quality Control of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of 3,7-Dimethyloctan-1-ol

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Alcohol – Wikipedia,
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Antifungal Activity of Monoterpenes against Botryosphaeria dothidea was written by Zhang, Zhilin;Xie, Yongjian;Hu, Xian;Shi, Hongan;Wei, Mi;Lin, Zhufeng. And the article was included in Natural Product Communications in 2018.Related Products of 106-21-8 The following contents are mentioned in the article:

The development of natural plant extracts and essential oils will assist to decrease the neg. effects of synthetic chems. The antifungal activity of 20 pure monoterpenes was assessed their efficacy against Botryosphaeria dothidea. 20 compounds were investigated the antifungal activity against B. dothidea at the concentration of 400μg·mL^-1. And components were used to the future test, which of the antifungal rate is greater than 50% against B. dothidea. Results from antifungal tests revealed that cuminaldehyde, β-citronellol, nerol, geraniol, citral and α-terpineol exhibited strong antifungal effect against B. dothidea. In addition, the antifungal activity of cuminaldehyde, β-citronellol, and geraniol had a highest effect toward B. dothidea with LC₅₀ values of 105.15, 135.73, 132.69μg·mL^-1, resp. In addition to the antagonistic effect of geraniol/β-citronellol (1/2) mixture, the combination of other compounds has synergistic effect on B. dothidea. The present results indicated that cuminaldehyde, geraniol, and β-citronellol are promising antifungal effect against B. dothidea and could be useful in the search for new natural fungicide. Several high activity monoterpenes and some combined with two monoterpenes were identified, and provided a rationale for pursuing further research on the fungicide and enhanced efficacy by the combined of fungicide. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Related Products of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts