Category: 105-30-6

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105-30-6, name is 2-Methylpentan-1-ol, molecular formula is C6H14O, molecular weight is 102.18, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Methylpentan-1-ol

(R)-methyl 2-(ter?-butoxycarbonylamino)-2-(4-hydroxyphenyl)acetate (23.00 g, 82 mmol), 2-methylpentan-l-ol (16.70 g, 163 mmol), and triphenylphosphine (36.46 g, 139 mmol) were combined in tetrahydrofuran (600 mL). After stirring 10 min, diethylazodicarboxylate (21.9 mL, 138 mmol) was added via syringe at room temperature. The reaction was mildly exothermic resulting in the temperature rising to the mid thirties C during the addition. Intermittent cooling with a tap water bath was used to prevent the reaction mixture temperature from rising higher than this, but it was not cooled down to room temperature during the addition. After the addition was complete, the mixture was stirred at room temperature for 18 h. The reaction mixture was transferred to a separatory funnel containing water (400 mL). The aqueous layer was extracted with ether (3 x 400 mL). The combined organic layers were washed with brine (250 mL), dried over MgS04, filtered and concentrated. The crude product was taken up in ether (ca. 800 mL) and was stirred for 30 min. The mixture was filtered through a pad of diatomaceous earth (Celite) to remove most of the triphenylphosphine oxide and the filtrate was concentrated. The residue was purified by column chromatography on silica gel (20% ethyl acetate in hexanes) to afford (2R)-methyl 2-(tert-butoxycarbonylamino)-2-(4-(2- methylpentyloxy)phenyl)acetate (29.43 g, 98% yield) as a colorless oil: XH NMR (400 MHz, CDC13) delta 7.20-7.29 (m, 2 H), 6.84 (d, J= 8.6 Hz, 2 H), 5.45 (d, J= 6.5 Hz, 1 H), 5.22 (d, J= 7.3 Hz, 1 H), 3.77 (dd, J= 9.1, 5.8 Hz, 1 H), 3.69 (s, 3 H),3.65-3.70 (m, 1 H), 1.85-1.96 (m, 1 H), 1.41 (s, 9 H), 1.14-1.50 (m, 4 H), 0.98 (d, J = 6.8 Hz, 3 H), 0.90 (t, J= 7.1 Hz, 3 H); LRMS (ESI) mle 366.4 [(M + H)+, calcd for C20H32NO5366.2].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105-30-6, 2-Methylpentan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LEXICON PHARMACEUTICALS, INC.; DZIERBA, Carolyn, Diane; HARTZ, Richard, A.; BI, Yingzhi; AHUJA, Vijay T.; BRONSON, Joanne J.; CARSON, Kenneth; CIANCHETTA, Giovanni; GREEN, Michael; KIMBALL, David; KIMURA, S. Roy; KWON, Soojin; MACOR, John E.; ZHANG, Yulian; ZIPP, Greg; WO2011/44225; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 105-30-6, 2-Methylpentan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 105-30-6, blongs to alcohols-buliding-blocks compound. Product Details of 105-30-6

General procedure: Isonicotinic acid (1a) or nicotinic acid (1b, 3.08 g, 0.025 mol) and thionyl chloride (20.5 g, 0.17mol, 12.5mL) were stirred at reflux for 2 h (the end of SO2 evolution). Excess of thionyl chloride was distilled off under normal pressure, and then under reduced pressure. To the residue (white precipitate) methylene chloride (50mL) was added. The solution of the appropriate 2-metylalkyl alcohol (0.025mol) in methylene chloride (10 mL) was added dropwise. The reaction was stirred for 2 h at reflux to complete the evolution of hydrogen chloride. The reaction mixture was adjusted to pH 12 with aqueous potassium carbonate. After layers were separated, the organic layer was dried over anhydrous calcium chloride. Evaporation of the solvent gave a crude product. Purity of 4a, 4b, 5a, 5b was satisfactory (TLC). 4c, 4d, 5c, 5d were purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,105-30-6, its application will become more common.

Reference:
Article; Huras, Bogumi?a; Zakrzewski, Jerzy; Krawczyk, Maria; Bombi?ska, Danuta; Cieniecka-Ros?onkiewicz, Anna; Michalczyk, Alicja; Medicinal Chemistry Research; vol. 26; 3; (2017); p. 509 – 517;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

105-30-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105-30-6, name is 2-Methylpentan-1-ol, molecular formula is C6H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Methyl-1-iodopentane Triphenylphosphine (1.93 g, 7.358 mmol) and imidazole (0.5 g, 7.344 mmol) were dissolved in dichloromethane (5.0 ml), and the solution was stirred for 5 minutes. Then, iodine (1.86 g, 7.328 mmol) was added thereto, and the mixture was stirred for 10 minutes. A dichloromethane (2.0 ml) solution of 2-methyl-1-pentanol (0.5 g, 5.672 mmol) was added dropwise thereto, and the mixture was stirred at room temperature for 1.5 hours. After the reaction was confirmed by TLC to be complete, the reaction solution was filtered through celite, and a 5% aqueous sodium thiosulfate solution was added to the filtrate to remove iodine. The organic layer was washed twice with brine and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and then, the residue was purified by silica gel column chromatography (hexane) to obtain 2-methyl-1-iodopentane (0.56 g, yield: 54%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105-30-6, 2-Methylpentan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TOHOKU UNIVERSITY; KAKE EDUCATIONAL INSTITUTION; KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION KANAGAWA CHILRDEN’S MEDICAL CENTER; ABE, Takaaki; TOMINAGA, Teiji; HAYASHI, Kenichiro; OSAKA, Hitoshi; US2015/353489; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

105-30-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105-30-6, name is 2-Methylpentan-1-ol, the common compound, a new synthetic route is introduced below.

2-Methyl-1-iodopentane Triphenylphosphine (1.93 g, 7.358 mmol) and imidazole (0.5 g, 7.344 mmol) were dissolved in dichloromethane (5.0 ml), and the solution was stirred for 5 minutes. Then, iodine (1.86 g, 7.328 mmol) was added thereto, and the mixture was stirred for 10 minutes. A dichloromethane (2.0 ml) solution of 2-methyl-1-pentanol (0.5 g, 5.672 mmol) was added dropwise thereto, and the mixture was stirred at room temperature for 1.5 hours. After the reaction was confirmed by TLC to be complete, the reaction solution was filtered through celite, and a 5% aqueous sodium thiosulfate solution was added to the filtrate to remove iodine. The organic layer was washed twice with saturated saline and dehydrated over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and then, the residue was purified using silica gel column chromatography (hexane) to obtain 2-methyl-1-iodopentane (0.56 g, yield: 54%).

Statistics shows that 105-30-6 is playing an increasingly important role. we look forward to future research findings about 2-Methylpentan-1-ol.

Reference:
Patent; Tohoku University; Kake Educational Institution; Abe, Takaaki; Katori, Yukio; Honkura, Yohei; Nanto, Fumika; Hayashi, Kenichiro; (77 pag.)US2019/224165; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105-30-6, name is 2-Methylpentan-1-ol, the common compound, a new synthetic route is introduced below. 105-30-6

Example 2 – Bis(2-methylpentyl) Octadecanedioate. [0129] Octadecanedioic acid (ODDA, 5.00 g) was added to a 100-mL three- necked round-bottom flask. A Dean-Stark condenser was attached, followed by the addition of toluene to the ODDA and to the trap. 2-Methylpentyl alcohol (5.90 mL) was added to the ODDA mixture. The flask was immediately purged with nitrogen gas and p-toluenesulfonic acid (0.17 g) was added. The reaction mixture was heated to 1 15 C and the reaction proceeded for 5 hours. Heat was then removed and the reaction mixture was allowed to cool to 60 C, at which point aqueous NaHC03 (saturated) was added to achieve a neutral pH. After vigorous stirring, the organic layer was separated and dried over Na2S04. The dried product was then subjected to a vacuum treatment to remove any residual solvent. A yellow oil was obtained. Analysis by 1H NMR provided the following chemical shifts: (400MHz, CDCIs) delta 0.90-0.85 (m), 1 .10-1 .20 (m), 1 .21 -1 .50 (m), 1 .55-1 .7 (t), 1 .77 (0), 2.30 (t), 3.85 (dd), 3.95 (dd). Anaylsis by 13C NMR provided the following chemical shifts: (400MHz, CDCI3) delta C 173.947; CH 32.366; CH2 69.200, 35.691 , 34.438, 29.701 , 29.684, 29.641 , 29.516, 29.319, 29.220, 25.095, 19.975; CH3 16.885, 14.258.

The synthetic route of 105-30-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELEVANCE RENEWABLE SCIENCES, INC.; PALS, Tessa; COHEN, Steven A.; SNEAD, Thomas E.; BEUHLER, Allyson; HATEGAN, Georgeta; BERTIN, Paul A.; WO2015/142584; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

105-30-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105-30-6, name is 2-Methylpentan-1-ol, molecular formula is C6H14O, molecular weight is 102.18, as common compound, the synthetic route is as follows.

General procedure: Isonicotinic acid (1a) or nicotinic acid (1b, 3.08 g, 0.025 mol) and thionyl chloride (20.5 g, 0.17mol, 12.5mL) were stirred at reflux for 2 h (the end of SO2 evolution). Excess of thionyl chloride was distilled off under normal pressure, and then under reduced pressure. To the residue (white precipitate) methylene chloride (50mL) was added. The solution of the appropriate 2-metylalkyl alcohol (0.025mol) in methylene chloride (10 mL) was added dropwise. The reaction was stirred for 2 h at reflux to complete the evolution of hydrogen chloride. The reaction mixture was adjusted to pH 12 with aqueous potassium carbonate. After layers were separated, the organic layer was dried over anhydrous calcium chloride. Evaporation of the solvent gave a crude product. Purity of 4a, 4b, 5a, 5b was satisfactory (TLC). 4c, 4d, 5c, 5d were purified by column chromatography.

Statistics shows that 105-30-6 is playing an increasingly important role. we look forward to future research findings about 2-Methylpentan-1-ol.

Reference:
Article; Huras, Bogumi?a; Zakrzewski, Jerzy; Krawczyk, Maria; Bombi?ska, Danuta; Cieniecka-Ros?onkiewicz, Anna; Michalczyk, Alicja; Medicinal Chemistry Research; vol. 26; 3; (2017); p. 509 – 517;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts