Category: 105-13-5

In 2021 ASIAN J ORG CHEM published article about CHEMOSELECTIVE DEOXYGENATION; SULFIDES; SELENOXIDES; EFFICIENT; SELENIDES; SULFONES; SELENOLS; THIOLS; MILD in [Sakai, Norio; Shimada, Retsu; Ogiwara, Yohei] Tokyo Univ Sci RIKADAI, Fac Sci & Technol, Dept Pure & Appl Chem, Noda, Chiba 2788510, Japan in 2021, Cited 75. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Formula: C8H10O2

Described herein is that a novel InBr3/PhSiH3 reducing system in a 1,4-dioxane solution smoothly and effectively undertook deoxygenation of a variety of sulfoxides leading to the facile preparation of sulfide derivatives. Also, it was demonstrated that the reducing system shows a higher reactivity towards sulfoxides than that towards commonly reducible functional groups, such as carboxylic acids, esters, amides, and sulfones.

Welcome to talk about 105-13-5, If you have any questions, you can contact Sakai, N; Shimada, R; Ogiwara, Y or send Email.. Formula: C8H10O2

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I found the field of Chemistry very interesting. Saw the article Cu-Mn Bimetallic Complex Immobilized on Magnetic NPs as an Efficient Catalyst for Domino One-Pot Preparation of Benzimidazole and Biginelli Reactions from Alcohols published in 2021. HPLC of Formula: C8H10O2, Reprint Addresses Nasseri, MA (corresponding author), Univ Birjand, Dept Chem, Fac Sci, Birjand 97175615, Iran.. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol

An efficient magnetically recyclable bimetallic catalyst by anchoring copper and manganese complexes on the Fe(3)O(4)NPs was prepared and named as Fe3O4@Cu-Mn. It was founded as a powerful catalyst for the domino one-pot oxidative benzimidazole and Biginelli reactions from benzyl alcohols as a green protocol in the presence of air, under solvent-free and mild conditions. Fe3O4@Cu-Mn NPs were well characterized by FT-IR, XRD, FE-SEM, TEM, VSM, TGA, EDX, DLS, and ICP analyses. The optimum range of parameters such as time, temperature, amount of catalyst, and solvent were investigated for the domino one-pot benzimidazole and Biginelli reactions to find the optimum reaction conditions. The catalyst was compatible with a variety of benzyl alcohols, which provides favorable products with good to high yields for all of derivatives. Hot filtration and Hg poisoning tests from the nanocatalyst revealed the stability, low metal leaching and heterogeneous nature of the catalyst. To prove the synergistic and cooperative effect of the catalytic system, the various homologues of the catalyst were prepared and then applied to a model reaction separately. Finally, the catalyst could be filtered from the reaction mixture simply, and reused for five consecutive cycles with a minimum loss in catalytic activity and performance. Graphic A new magnetically recyclable Cu/Mn bimetallic catalyst has been developed for domino one-pot oxidation-condensation of benzimidazole and Biginelli reactions from alcohols.

HPLC of Formula: C8H10O2. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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Peng, D; Shan, DF; Dai, CC; Li, J; Wang, ZF; Huang, ZY; Peng, R; Zhao, P; Ma, XZ in [Peng, Da; Dai, Chengcheng; Wang, Zifan; Huang, Ziyi; Peng, Rui; Ma, Xuezhen] Qingdao Univ, Affiliated Qingdao Cent Hosp, Dept Oncol, 127 Siliunan Rd, Qingdao 266042, Shandong, Peoples R China; [Shan, Dongfeng] Qingdao Univ, Affiliated Hosp, Qingdao, Shandong, Peoples R China; [Li, Jie] Jiaozhou Cent Hosp, Dept Oncol, Jiaozhou, Peoples R China; [Zhao, Peng] Qingdao Univ, Affiliated Qingdao Cent Hosp, Biotherapy Ctr, Qingdao, Shandong, Peoples R China published Real-World Data on Osimertinib in Chinese Patients with Pretreated, EGFR T790M Mutation Positive, Advanced Non-Small Cell Lung Cancer: A Retrospective Study in 2021, Cited 25. Application In Synthesis of (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.

Purpose: As a third-generation EGFR TKI has been taken orally, Osimertinib effectively inhibits mutant EGFR, including T790M EGFR resistance mutations. Here, we examined real-world efficacy and tolerability of Osimertinib among Chinese patients with advanced EGFR T790M-mutant NSCLC. Patients and Methods: A total of 106 advanced NSCLC patients who were taking Osimertinib following disease progression after EGFR-TKIs or other treatments were retro-spectively recruited in this study. The PFS and OS after Osimertinib treatment were analyzed as the primary endpoints. Results: Osimertinib was used as a second line and >= 3rd line treatment in 22.6% and 77.4% of the patients, respectively. DCR and ORR were 93.4% and 57.5%, respectively. Median PFS was 12.4 12 (95% CI, 10.5-13.5) months. The PFS was 11 (8.0, 14.0) and 12 (10.3,13.7) months (p = 0.373), in patients with and without CNS metastasis, respectively. PFS in 2nd and >= 3rd line treatment was 11 (9.0, 13.0) and 12.4 12 (8.9, 15.1) months (p = 0.799), respectively. In patients with EGFR exon 19 deletion and exon 21 L858 mutation, the median PFS was 11 (9.2, 12.8) and 12 (9.2, 14.8) months, respectively (p = 0.833). Median PFS in the monotherapy group and combined anti-angiogenesis group was 11 (9.9,12.1) and 14 (11.2,16.8) months, respectively. Median OS after Osimertinib initiation was 27 (19.6, 34.4) months: 15 (6.9, 23.1) and 27 (22, 32) months in patients with and without CNS metastasis (p=0.027), 27 (20.3,33.7) months and (undefined) as second line or >= 3rd line of treatment (p = 0.421), respectively. In patients with exon 19 deletion, the median OS was not reached, and in patients with exon 21 L858 mutations, the median OS was 23 (19.1,29.9) months (p=0.027). Median OS in the monotherapy group was 27 (21.7,32.3) months, and in combined anti-angiogenesis group was not reached (p=0.68). Conclusion: Osimertinib can effectively treat advanced NSCLC with T790M mutations independently of previous treatment lines.

Welcome to talk about 105-13-5, If you have any questions, you can contact Peng, D; Shan, DF; Dai, CC; Li, J; Wang, ZF; Huang, ZY; Peng, R; Zhao, P; Ma, XZ or send Email.. Application In Synthesis of (4-Methoxyphenyl)methanol

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I found the field of Chemistry very interesting. Saw the article Switchable Synthesis of alpha,alpha-Dihalomethyl and alpha,alpha,alpha-Trihalomethyl Ketones by Metal-Free Decomposition of Enaminone C=C Double Bond published in 2020. Name: (4-Methoxyphenyl)methanol, Reprint Addresses Liu, YY; Wan, JP (corresponding author), Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China.. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol

The novel free radical-based cleavage of the enaminone C=C double bond is realized by using N-halosuccinimides (NXS) in the presence of benzoyl peroxide (BPO) with mild heating, enabling the tunable synthesis of alpha,alpha-dihalomethyl ketones and alpha,alpha,alpha-trihalomethyl ketones under different reaction conditions. The formation of these divergent products involving featured C=C double bond cleavage requires no any metal reagent, and represents one more practical example on the synthesis of poly halogenated methyl ketones via the functionalization of carbon-carbon bond.

Welcome to talk about 105-13-5, If you have any questions, you can contact Liu, YY; Xiong, J; Wei, L; Wan, JP or send Email.. Name: (4-Methoxyphenyl)methanol

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Recommanded Product: 105-13-5. Authors Luo, NH; Zhong, YH; Wen, HL; Shui, HL; Luo, RS in WILEY-V C H VERLAG GMBH published article about in [Luo, Nianhua; Zhong, Yuhong; Wen, Huiling; Shui, Hongling; Luo, Renshi] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China in 2021, Cited 94. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of alpha-alkylated ketones in high yield (86 %-95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of alpha-alkylated ketones.

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An article Nickel-Copper bimetallic mesoporous nanoparticles: As an efficient heterogeneous catalyst for N-alkylation of amines with alcohols WOS:000586013600001 published article about MCM-41 MOLECULAR-SIEVES; AROMATIC-AMINES; SILICA NANOPARTICLES; SOLVENT-FREE; OXIDATION; IRON; BENZYLATION; RUTHENIUM; AMINATION; SECONDARY in [Nasresfahani, Zahra; Kassaee, Mohamad Z.] Tarbiat Modares Univ, Dept Chem, POB 14155-175, Tehran, Iran in 2021, Cited 43. Name: (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

A bimetallic catalyst (Ni/Cu-MCM-41) is prepared via co-condensation method. The latter is characterized by Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), diffuse reflectance spectroscopy (DRS), and nitrogen adsorption-desorption analysis. Catalytic performance of Ni/Cu-MCM-41 is probed in N-alkylation of amines with alcohols through a hydrogen autotransfer process. Noteworthy, this catalytic system appears very efficient for synthesis of a range of secondary and tertiary amines in good to excellent isolated yields. Moreover, the catalyst is successfully recovered and reused four times without notable decrease in its activity.

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Li, SC; Hou, B; Wang, JB in [Li, Shichao; Hou, Bo; Wang, Jianbo] Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China published Palladium-Catalyzed Oxidative Coupling of the Allenic C-H Bond with alpha-Diazo Esters: Synthesis of [3]Dendralenes in 2021, Cited 40. Category: alcohols-buliding-blocks. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.

A palladium-catalyzed highly regio- and stereoselective allenic C-H oxidative coupling with alpha-diazo esters is developed. The reaction pathway involves allylic palladium carbene as the key intermediate, which is followed by a carbene migratory insertion process. The reaction proceeds efficiently under mild conditions without external base, providing substituted [3]dendralenes bearing various functional groups.

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Recommanded Product: 105-13-5. Authors Sato, K; Tanaka, S; Wang, JZ; Ishikawa, K; Tsuda, S; Narumi, T; Yoshiya, T; Mase, N in AMER CHEMICAL SOC published article about in [Sato, Kohei; Tanaka, Shoko] Shizuoka Univ, Grad Sch Sci & Technol, Hamamatsu, Shizuoka 4328561, Japan; [Wang, Junzhen; Ishikawa, Kenya] Shizuoka Univ, Dept Appl Chem & Biochem Engn, Fac Engn, Hamamatsu, Shizuoka 4328561, Japan; [Tsuda, Shugo; Yoshiya, Taku] Peptide Inst Inc, Ibaraki, Osaka 5670085, Japan; [Narumi, Tetsuo; Mase, Nobuyuki] Shizuoka Univ, Dept Appl Chem & Biochem Engn, Fac Engn,Grad Sch Sci & Technol, Course Appl Chem & Biochem Engn,Dept Engn,Grad Sc, Hamamatsu, Shizuoka 4328561, Japan; [Narumi, Tetsuo; Mase, Nobuyuki] Shizuoka Univ, Res Inst Green Sci & Technol, Hamamatsu, Shizuoka 4328561, Japan; [Sato, Kohei] Shizuoka Univ, Dept Appl Chem & Biochem Engn, Fac Engn, Course Appl Chem & Biochem Engn,Dept Engn,Grad Sc, Hamamatsu, Shizuoka 4328561, Japan in 2021, Cited 52. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

A novel late-stage solubilization of peptides using hydrazides is described. A solubilizing tag was attached through a selective N-alkylation at a hydrazide moiety with the aid of a 2-picoline-borane complex in 50% acetic acid-hexafluoro-2-propanol. The tag, which tolerates ligation and desulfurization conditions, can be detached by a Cu-mediated selective oxidative hydrolysis of the N-alkyl hydrazide. This new method was validated through the synthesis of HIV-1 protease.

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An article Retrospective review of Kawasaki disease at the Women’s and Children’s Hospital, South Australia WOS:000656443500001 published article about INTRAVENOUS IMMUNOGLOBULIN TREATMENT; CORONARY-ARTERY ABNORMALITIES; PREDICTION; RESISTANCE; EFFICACY; THERAPY; PREDNISOLONE; PREVENTION; ANEURYSMS; TRIAL in [Davidson, Hannah; Kelly, Andrew] Univ Adelaide, Womens & Childrens Hosp, Dept Cardiol, Adelaide, SA, Australia; [Agrawal, Rishi] Univ Adelaide, Womens & Childrens Hosp, Dept Gen Paediat Med, Adelaide, SA, Australia; [Kelly, Andrew; Agrawal, Rishi] Univ Adelaide, Fac Hlth & Med Sci, Dept Paediat Adelaide, Adelaide, SA, Australia in , Cited 25. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Recommanded Product: (4-Methoxyphenyl)methanol

Aim Kawasaki disease (KD) is one of the most common causes of acquired cardiac disease in children in high-income countries. The incidence of coronary artery disease (CAD), despite treatment with intravenous immunoglobulin, ranges from 5 to 20%. Determining risk factors for CAD may assist with management and reduce long-term complications. Methods Retrospective data were collected for all patients presenting to the Women’s and Children’s Hospital with a discharge diagnosis of KD over a 10.5-year period, from 2007 to 2018. Results A total of 141 patients were included in the review; 101 patients fulfilled complete criteria for KD; 25 incomplete criteria and 15 did not meet criteria but were treated for KD. CAD was present in 27.7% of all patients, ranging from ectasia to giant aneurysms based on Z-scores and echocardiogram descriptions. Medium to large aneurysms accounted for 8.5% of all patients with suspected KD. Patients with CAD were more likely to: fulfil incomplete criteria (odds ratio (OR) 4.3, 95% confidence interval (CI) 1.7-10.8, P = 0.0027), be less than 12 months of age (OR 11.38, 95% CI 2.94-44.11, P = 0.0001), have CRP > 100 (OR 2.8, 95% CI 1.31-6.02, P = 0.0068) and have a delay in treatment (average day of illness prior to treatment 8.89 vs. 6.78 (OR 1.19, 95% CI 1.05-1.35, P = 0.0055)). Patients with a Kobayashi score >= 4 had a higher rate of re-treatment with intravenous immunoglobulin (OR 3.16, 95% CI 1.27-7.83, P = 0.013). Conclusion Our data are consistent with previously reported risk factors, and high rates of CAD despite standard treatment.

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Category: alcohols-buliding-blocks. Riadi, Y in [Riadi, Yassin] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj, Saudi Arabia published UV Light Mediated Palladium-Catalyzed Synthesis of 2-Substituedpyrido[2,3-d]pyrimidines in 2021, Cited 26. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.

A novel and effective photochemical approach for access to 2-substituted pyrido[2,3-d]pyrimidines is described starting from the corresponding 2-(2-aminopyridin-3-yl)ethenol through a palladium-catalyzed reaction. Our strategy involves an original procedure under UV light as source of energy with reaction times of 24-36 h and yields ranging between 42 and 92%.

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