Category: 10488-69-4

Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Example 21 : pH profiles of enzymatic and nonenzymatic test reactions of ethyl 4-chloro- 3-hydroxybutyrate with cyanide Aqueous solutions containing 25 MG/ML sodium cyanide were prepared at pH 5.0, 6.0, 7.0, 7.5, 8. 0, 8. 5, and 9.0 by the addition of 85percent phosphoric acid while monitoring with pH meter. 5 mL of each solution was charged to a SEPARATE 20 ML screw cap vial. Halohydrin dehalogenase SEQ ID NO: 38 (20 mg) was added to each vial, followed by ethyl (S)-4-chloro-3-hydroxybutyrate (50 mg, 0.30 mmoles). For nonenzymatic reactions experiments, the procedure was identical with the exception that the enzyme was omitted. The vials were capped and heated in an oil bath at 55 °C for 3 hrs, then removed and cooled to room temperature. A 0.4 mL sample of each reaction mixture was extracted with 1 mL butyl acetate and the extracts were analyzed by gas chromatography. The analyzed amounts of substrate and products in each vial are given in Table I, and graphed vs. pH in Figure 1. IN BOTH, CHLOROHYDRIN means ethyl (S)-4-chloro-3- hydroxybutyrate, cyanohydrin means ethyl (R)-4-CYANO-3-HYDROXYBUTYRATE, and crotonate means ethyl 4-hydroxycrotonate. In the Table, ND means not detected. Table I : Millimoles CHLOROHYDRIN, cyanohydrin and crotonate by-product analyzed in test reactions with and without HALOHYDHN dehalogenase. See Example 21 without halohydrin dehalogenase with halohydrin dehalogenase mmol mmol mmol mmol mmol mmol PH chlorohydrin cyanohydrin crotonate chlorohydrin cyanohydrin crotonate 5.0 0. 33 ND ND 0. 27 ND ND 6. 0 0. 29 ND ND 0. 07 0. 20 ND 7. 0 0. 30 ND ND 0. 01 0. 28 ND 7.5 0.3 ND ND 0. 004 0. 30 ND 8. 0 0.30 0.01 ND 0.002 0.29 ND 8. 5 0. 21 0. 05 0. 001 0. 001 0. 24 ND 9. 0 0.11 0.10 0.002 0.001 0.21 ND The pHs of the final test reaction mixtures were remeasured. For the mixtures including halohydrin dehalogenase with initial pHs of 7 or above (being the mixtures in which near complete conversion of the CHLOROHYDRIN to the cyanohydrin occurred, the final mixture pHs were 0.4 to 0.6 pH units below the initial pHs. The other mixtures showed much lesser changes in pH from their initial values. These data show that under these reaction conditions and time, no measurable nonenzymatic reaction of the ethyl 4-CHLORO-3-HYDROXYBUTYRATE with cyanide occurred at any tested pH less than 8. At pH 8 and above, increasing nonenzymatic reaction with cyanide to form ethyl 4-cyano-3-hydroxybutyrate occurred with increasing pH and was accompanied by increasing formation of ethyl 4-hydroxycrotonate by-product. In contrast, the enzymatic reaction with halohydrin dehalogenase occurred at all the tested pH’s greater than 5 and with no detectable formation of ethyl 4-hydroxycrotonate at any tested pH. Additionally, for both enzymatic and nonenzymatic test reactions at pH greater than 8, the mole total of the GC- analyzed products decreased from the initial 0.30 MMOLES provided (as ethyl 4-chloro-3- hydroxybutyrate reactant) indicating the increasing formation of non-analyzable by-products with increasing pH greater than 8. It was separately established that the ester group of the reactant and product are increasingly HYDROLYZED to carboxylic acid groups at pHs greater than 8 and that the resulting carboxylic acids are not extracted in to the extracts of reaction mixture samples that are analyzed by GC. See Example 22.

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CODEXIS, INC.; WO2005/18579; (2005); A2;,
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Synthetic Route of 10488-69-4 , The common heterocyclic compound, 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1; [60] 61.5 g (1.626 mol) of sodium borohydride was dissolved in 694 mL of toluene, and52 g (1.626 mol) of methanol was added drop wise at room temperature for 1 hour. Subsequently, 300 g (1.807 mol, 99.3percent ee) of ethyl (S)-4-chloro-3-hydroxybutyrate was added, and stirring was performed at room temperature for 12 hours. The reaction mixture was cooled below 100C and, after adding 183 g of 36percent HCl dropwise, the solvent was removed by distillation under reduced pressure below 400C. Using 800 mL of methanol, concentration under reduced pressure was performed for 3 times below 40 C. 800 mL of dichloromethane was added to the resultant residue. After filtering off solid inorganic materials and removing the solvent under reduced pressure, 220 g of (S )-4-chloro-l,3-butanediol was obtained as oil (yield = 98percent).

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RSTECH CORPORATION; WO2008/93955; (2008); A1;,
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Related Products of 10488-69-4 , The common heterocyclic compound, 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1; [60] 61.5 g (1.626 mol) of sodium borohydride was dissolved in 694 mL of toluene, and52 g (1.626 mol) of methanol was added drop wise at room temperature for 1 hour. Subsequently, 300 g (1.807 mol, 99.3percent ee) of ethyl (S)-4-chloro-3-hydroxybutyrate was added, and stirring was performed at room temperature for 12 hours. The reaction mixture was cooled below 100C and, after adding 183 g of 36percent HCl dropwise, the solvent was removed by distillation under reduced pressure below 400C. Using 800 mL of methanol, concentration under reduced pressure was performed for 3 times below 40 C. 800 mL of dichloromethane was added to the resultant residue. After filtering off solid inorganic materials and removing the solvent under reduced pressure, 220 g of (S )-4-chloro-l,3-butanediol was obtained as oil (yield = 98percent).

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RSTECH CORPORATION; WO2008/93955; (2008); A1;,
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Reference of 10488-69-4, Adding some certain compound to certain chemical reactions, such as: 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate,molecular formula is C6H11ClO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10488-69-4.

Example 1 Preparation of (S)-Ethyl-3-hydroxy-4-(1-phenyl-1H-tetrazol-5-ylthio)butanoate (11a) 121.2 g of triethylamine and 100 g of (S)-4-chloro-3-hydroxybutyric acid ester were added to the solution of 96.2 g of 1-phenyl-1H-terazole-5-thiol in 750 mL toluene at 25° C. The reaction mixture was heated to 80° C. to 85° C. for completion of reaction on TLC. The reaction mixture was cooled to 25° C. and treated with 200 mL of water and stirred to separate the layers. The separated aqueous layer was twice extracted with 100 mL toluene. The combined organic layer was treated with 300 mL HCl solution followed by washing with 200 ml water. The organic layer was distilled under vacuum below 50° C. The residue was treated with 200 ml hexane and stirred for 30 minutes. The solution was distilled under vacuum below 50° C. to remove hexane and obtain (S)-Ethyl-3-hydroxy-4-(1-phenyl-1H-tetrazol-5-ylthio)butanoate (11a) as an oil.

According to the analysis of related databases, 10488-69-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dwivedi, Shriprakash Dhar; Patel, Dhimant Jasubhai; Rupapara, Mahesh Laljibhai; US2013/158263; (2013); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Ethyl 4-chloro-3-hydroxybutanoate

To 1 L of a 3-necked round bottom flask equipped with a thermometer, a pH meter and a stirrer, 64.8 g of glycinamide hydrochloride, 98.5 g of sodium bicarbonate and 500 mL of ethyl alcohol were successively added and stirred at a room temperature for 1 hour. To the solution, 97.7 g of ethyl- (S)-4-chloro-3-hydroxybutyric was dropwisely added. The reaction solution was further stirred at 80°C for 20 hours. Work-up procedures were performed in the same manner as mentioned in the Example 7. Recrystallization with methyl alcohol and acetone gave 52.5 g of the targeted (S)-4-hydroxy-2-oxo- I -pyrrolidine acetamide.

With the rapid development of chemical substances, we look forward to future research findings about 10488-69-4.

Reference:
Patent; AHN-GOOK PHARMACEUTICAL CO., LTD.; RSTECH CORPORATION; WO2005/115978; (2005); A1;,
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Synthetic Route of 10488-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound B obtained in Example 1 was dissolved in 200 ml of dichloromethane, was added sodium carbonate (37.2 g, 0.35 mol) the reaction solution was cooled to 0 to 5 ° C, acetyl chloride (23.5 g, 0.30 mol) was added dropwise,I insulation reaction 5h, after adding 200 ml of water, the organic layer was washed with water and then with saturated brine, dried and filtered. The solvent was distilled off under reduced pressure to obtain 53.5 g (0.256 mol) of the crude product of Compound C, the molar yield was 95percent.

According to the analysis of related databases, 10488-69-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Yang, Yong; Qiao, Zhitao; Chen, Anfeng; Zhou, Bingcheng; Liu, Bingxian; Zhou, Junan; Ge, Xu; (10 pag.)CN105566242; (2016); A;,
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Electric Literature of 10488-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Take raw materialsS-4-chloro-3-hydroxybutyric acid ethyl ester 5 g,Add a bottle of bottles,Add 10 ml of methanol,Add 5 g of sodium azide to stir,The reaction was carried out at a temperature of about 50 ° C for 4 hours to stop the reaction to obtain a yellow solution.20 ml of water was added, and the mixture was extracted with 20 ml of ethyl acetate, and the ethyl acetate was concentrated to obtain a yellow oil as an intermediate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate.

Reference:
Patent; Chongqing Runze Pharmaceutical Co., Ltd.; Ye Lei; (12 pag.)CN107011235; (2017); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, the common compound, a new synthetic route is introduced below. Safety of Ethyl 4-chloro-3-hydroxybutanoate

(1) Ethyl S-4-chloro-3-hydroxybutyrate was stirred with 60percent by weight of DMSO and 1-fold by weight of sodium azide at 60 ° C for 5 hours, The solvent is DMF, n-propanol, isopropanol, n-butanol, tert-butanol, toluene or cyclopentanol and so on to get the intermediate I, and the reaction is complete, stop the reaction, direct concentration to remove the solvent,

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chongqing East Ze Pharmaceutical Technology Development Co., Ltd.; Yuan, Huajie; Dai, Liping; Xie, Lingling; Ye, Lei; (24 pag.)CN105330581; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10488-69-4, blongs to alcohols-buliding-blocks compound. Recommanded Product: Ethyl 4-chloro-3-hydroxybutanoate

S(-)-4-chloro-3-hydroxybutyric acid ethyl ester (100g) andL-2-Aminobutyramide is the starting material (61.3g),With chloroform as solvent,Add acid agent potassium carbonate (81.3g),While stirring at reflux, the reaction was incubated for 4 hours.After confirming that the reaction of raw materials is completed, the reaction solution is washed twice with 150 mL of dichloromethane, and the organic phase is dried.It is reduced to no fractions and purified by column to give product intermediate I, namely (S)-2-((S)-4-hydroxy-2-oxopyrrolidin-1-yl)butyrylAmine, 96.3 g, purity 98.4percent, yield 86.3percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10488-69-4, its application will become more common.

Reference:
Patent; Emeishan Hongsheng Pharmaceutical Co., Ltd.; Lu Chengxian; Tian Jianhong; Tian Yangyang; Che Shangze; Tian Jinyuan; (10 pag.)CN107513032; (2017); A;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 10488-69-4, blongs to alcohols-buliding-blocks compound. Recommanded Product: 10488-69-4

In a three-necked flask, 200 mL of tetrahydrofuran and 19 g of diisopropylamine were added and cooled to -10 ° C. 134 mL of n-butyllithium was added slowly while keeping the temperature, and the mixture was stirred for 30 minutes. The internal temperature of the reactor was maintained at -40 to -30 , 36 mL of tert-butyl acetate was slowly added dropwise, and the mixture was stirred for 1 hour while maintaining the temperature of the reaction solution. (S) -ethyl 4-chloro-3-hydroxybutanoate was added dropwise at -40 to -30 ° C for 30 minutes and stirred for 30 minutes. The inner temperature of the reaction solution was raised naturally to -20 to -10 ° C The reaction was then completed by further stirring for 2 hours. When the reaction is complete, waterAnd the reaction was quenched. To the reaction solution was added 300 mL of ethyl acetate. The reaction mixture was stirred for 30 minutes to extract the product. The organic layer was extracted and separated. The organic layer was treated with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure The obtained oily product (12.3 gr) was obtained.

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nebula Pharma PVT. LTD; Jang, Myung Sik; Jang, Rae Kyu; Mo, Gil Wung; Jung, In Hwa; Lee, In Kyu; Han, Ka Ram; (25 pag.)KR101528359; (2015); B1;,
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