Category: 104-38-1

Synthetic Route of 104-38-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.104-38-1, name is 1,4-Bis(2-hydroxyethoxy)benzene, molecular formula is C10H14O4, molecular weight is 198.2158, as common compound, the synthetic route is as follows.

General procedure: Chromonecarbonyl chloride was prepared by the reaction ofacid with thionyl chloride. After a toluene solution of 2-chromoniccarboxylic acid (1.4 g, 7.6 mmol) and thionyl chloride (1.1 g,9.1 mmol) was stirred at 90C for 2e3 h, thionyl chloride wasremoved under reduced pressure. The toluene solution of the cor-responding polyethers 4a-4c (0.5 g, 2.5 mmol) and chromone-carbonyl chloride was stirred at 120C overnight. After baseextraction, the solvent was removed under reduced pressure, andthe residue was separated by silica gel column chromatography(hexane/ethyl acetate) to obtain the corresponding chromone de-rivatives 5a-i in 30e92% yields.

Statistics shows that 104-38-1 is playing an increasingly important role. we look forward to future research findings about 1,4-Bis(2-hydroxyethoxy)benzene.

Reference:
Article; Ishikawa, Hiroki; Uemura, Naohiro; Taira, Ryo; Sano, Kento; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami; Tetrahedron; vol. 75; 29; (2019); p. 3911 – 3916;,
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Synthetic Route of 104-38-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 104-38-1, name is 1,4-Bis(2-hydroxyethoxy)benzene. This compound has unique chemical properties. The synthetic route is as follows.

Example 13 {2-[4-(2-Carboxymethoxy-ethoxy)-phenoxy]-ethoxy}-acetic acid To a suspension of sodium hydride (60%, 132 grams, 3.30 moles) in anhydrous dimethylformamide (600 mL) under nitrogen atmosphere at 0 C. was added hydroquinone bis ethanol (150 grams, 756.7 mmoles) in small for hour, later stirred at room temperature for one hour. To the above mixture was added a solution of chloro acetic acid (195 grams, 2.06 moles) in anhydrous dimethylformamide (300 mL) very cautiously drop wise as the reaction is exothermic. Later the reaction is maintained at 80 C. for one hour and left at room temperature for 16 hours. Reaction mixture carefully poured onto ice (3 kg), extracted with ethyl acetate (2*500 mL) and organic phase discarded. The pH of the aqueous layer was adjusted to 2 with 3N-hydrochloric acid and extracted into ethyl acetate. The ethyl acetate extract was dried over sodium sulphate followed by distillation to yield crude 13 (120 grams, 50.5%) which was carried over to next stage. 1H NMR (CDCl3) delta 3.84 (m, 2H, CH2), 4.06 (m, 4H, CH2*2), 6.82 (s, 2H, Ar).

According to the analysis of related databases, 104-38-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bezwada Biomedical, LLC; US8053591; (2011); B2;,
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Electric Literature of 104-38-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.104-38-1, name is 1,4-Bis(2-hydroxyethoxy)benzene, molecular formula is C10H14O4, molecular weight is 198.2158, as common compound, the synthetic route is as follows.

Example 120 2-[4-(2-{[3-(1-Piperazinyl)-2-pyrazinyl]oxy}ethoxy)phenoxy]ethanol, Maleate The title product was prepared from 1,4-bis(2-hydroxyethoxy)benzene. Yield of free base of the title compound 51%. The maleate salt was prepared: mp 127-129 C. MS m/z 361 (M+H). Anal. (C18H24N4O4.C4H4O4) C, H, N.

The chemical industry reduces the impact on the environment during synthesis 104-38-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Biovitrum AB; US6465467; (2002); B1;,
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Adding a certain compound to certain chemical reactions, such as: 104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

EXAMPLE 125 Sulfamic acid 2-[4-[2-[(aminosulfonyl)oxy]ethoxy]phenoxy]ethyl ester A mixture of 19.8 g (0.1 mole) of hydroquinone bis (2-hydroxyethyl)ether (98%, Aldrich) and 41.4 g (0.41 mole) of triethylamine in 350 ml of acetonitrile was added to a cooled (acetone-ice bath, temp?15 C.) solution of 130 ml of sulfamoyl chloride solution (3.14 M solution in acetonitrile) and 100 ml of acetonitrile. The mixture was mechanically stirred at ambient temperature overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between 400 ml of water and 800 ml of ethyl acetate. The aqueous layer was extracted with two 400 ml portions of ethyl acetate and the combined ethyl acetate extracts (1.61) were washed with two 400 ml portions of water, dried (magnesium sulfate) and the solvent evaporated under reduced pressure to give a viscous residue which was triturated with 100 ml of methylene chloride and let stand at ambient temperature for two days. The resulting solid was collected by filtration and then washed with water until the filtrate was neutral to pH paper and dried (air). The solid was recrystallized from acetonitrile to yield 9.9 g (29%) of a white solid containing a small amount of acetonitrile, mp 162-164 C. Analysis: Calculated for C10 H16 N2 O8 S2: C, 33.70; H, 4.53; N, 7.86. Found: C, 34.30; H, 4.62, N, 8.03.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; A. H. Robins Co., Inc.; US5025031; (1991); A;,
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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, SMILES is OCCOC1=CC=C(OCCO)C=C1, in an article , author is Hu, Bei, once mentioned of 104-38-1, Name: 1,4-Bis(2-hydroxyethoxy)benzene.

Osteopontin (OPN) is a multifunctional protein present in different tissues, body fluids and milk. Different milk has different level of OPN content. To determine the amount of osteopontin in bovine, buffalo, yak, sheep and goat milk, we developed an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLCMS/MS) method to detect an osteopontin signature peptide. The signature peptides selected by searching Uniprot database for trypsin digested osteopontin. The sample preparation procedure includes trypsin digestion, dimethyl labeling of tryptic peptides, purification and concentration of labeled tryptic peptide with solid phase extraction. The limit of detection and limit of quantification are 0.5 mg L-1 and 2.0 mg L-1, respectively. The method has satisfactory analytical performance with a linearity of R-2 >= 0.998, recoveries of 103.7-111.0%, and precision of 1.8-6.2%. It is also validated and successfully applied to quantifying osteopontin content in bovine, buffalo, yak, sheep and goat milk.

Interested yet? Read on for other articles about 104-38-1, you can contact me at any time and look forward to more communication. Name: 1,4-Bis(2-hydroxyethoxy)benzene.

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Application of 104-38-1, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, SMILES is OCCOC1=CC=C(OCCO)C=C1, belongs to alcohols-buliding-blocks compound. In a article, author is Peterson, Cora, introduce new discover of the category.

Assessment of Annual Cost of Substance Use Disorder in US Hospitals

IMPORTANCE A persistently high US drug overdose death toll and increasing health care use associated with substance use disorder (SUD) create urgency for comprehensive estimates of attributable direct costs, which can assist in identifying cost-effective ways to prevent SUD and help people to receive effective treatment. OBJECTIVE To estimate the annual attributable medical cost of SUD in US hospitals from the health care payer perspective. DESIGN, SETTING, AND PARTICIPANTS This economic evaluation of observational data used multivariable regression analysis and mathematical modeling of hospital encounter costs, controlling for patient demographic, clinical, and insurance characteristics, and compared encounters with and without secondary SUD diagnosis to statistically identify the total attributable cost of SUD. Nationally representative hospital emergency department (ED) and inpatient encounters from the 2017 Healthcare Cost and Utilization Project Nationwide Emergency Department Sample and National Inpatient Sample were studied. Statistical analysis was performed from March to June 2020. EXPOSURES International Statistical Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) principal or secondary SUD diagnosis on the hospital discharge record according to the Clinical Classifications Software categories (disorders related to alcohol, cannabis, hallucinogens, inhalants, opioids, sedatives, stimulants, and other substances). MAIN OUTCOMES AND MEASURES Annual attributable SUD medical cost in hospitals overall and by substance type (eg, alcohol). The number of encounters (ED and inpatient) with SUD diagnosis (principal or secondary) and the mean cost attributable to SUD per encounter by substance type are also reported. RESULTS This study examined a total of 124 573 175 hospital ED encounters and 33 648 910 hospital inpatient encounters from the 2017 Healthcare Cost and Utilization Project Nationwide Emergency Department Sample and National Inpatient Sample. Total annual estimated attributable SUD medical cost in hospitals was $13.2 billion. By substance type, the cost ranged from $4 million for inhalantrelated disorders to $7.6 billion for alcohol-related disorders. CONCLUSIONS AND RELEVANCE This study’s results suggest that the cost of effective prevention and treatment may be substantially offset by a reduction in the high direct medical cost of SUD hospital care. The findings of this study may inform the treatment of patients with SUD during hospitalization, which presents a critical opportunity to engage patients who are at high risk for overdose. Aligning incentives such that prevention cost savings accrue to payers and practitioners that are otherwise responsible for SUD-related medical costs in hospitals and other health care settings may encourage prevention investment.

Application of 104-38-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 104-38-1 is helpful to your research.

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Application of 104-38-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, SMILES is OCCOC1=CC=C(OCCO)C=C1, belongs to alcohols-buliding-blocks compound. In a article, author is Ding, Yongjie, introduce new discover of the category.

Development of bio oil and bio asphalt by hydrothermal liquefaction using lignocellulose

Bio asphalt is an organic polymer derived from biomass resources, which has the potential to partially or completely replace petroleum asphalt. This study used lignocellulose to prepare bio oil by hydrothermal liquefaction method. A mixed solvent of ethanol and ethylene glycol was introduced to increase the oil yield and decrease the reaction temperature. The oil yield reached the highest when solvent mixing ratio of 1:1, liquid-solid ratio of 6:1, catalyst dosage of 3%, and reaction temperature of 250 degrees C respectively. The bio oil and 50# asphalt were mixed in proportion sheared for 30 min (1000 rpm) under the condition of 135 degrees C to produce bio asphalt. The chemical structures and rheological properties of bio oil and bio asphalt were investigated and compared with petroleum asphalt. Fourier transform infrared spectroscopy (FTIR) and Nuclear Magnetic Resonance analysis indicate that the bio oil expressed a lower H/C ratio, higher O content and more light components including liquid compounds comparing to the petroleum asphalt. The content of the polar group including O-H and C-O of bio oil was higher than that of petroleum asphalt. Gas Chromatography-Mass Spectrometry (GC-MS) was used to prove the presence of olefins and alcohols in bio oil. Thermogravimetric analysis showed that the bio oil expressed better thermal stability than that of petroleum asphalt, which expressed a potential of using as a pavement material. The dynamic shear rheometer (DSR) results showed that the complex shear modulus, G* decreased as the content of bio oil. The Glass transition temperature Tg indicated that the bio asphalt with 10% bio oil content showed similar performance with that of 70# asphalt. (C) 2020 Published by Elsevier Ltd.

Application of 104-38-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 104-38-1.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, molecular formula is C10H14O4. In an article, author is Luo, Xingguang,once mentioned of 104-38-1, SDS of cas: 104-38-1.

Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence

The gray matter volume (GMV) of the putamen has been reported to be regulated by kinectin 1 gene (KTN1). As a hub of the dopaminergic circuit, the putamen is widely implicated in the etiological processes of substance use disorders (SUD). Here, we aimed to identify robust and reliable associations between KTN1 SNPs and SUD across multiple samples. We examined the associations between SUD and KTN1 SNPs in four independent population-based or family-based samples (n = 10,209). The potential regulatory effects of the risk alleles on the putamen GMVs, the effects of alcohol, nicotine, marijuana and cocaine on KTN1 mRNA expression, and the relationship between KTN1 mRNA expression and SUD were explored. We found that a total of 23 SNPs were associated with SUD across at least two independent samples (1.4 x 10(-4) <= p <= 0.049), including one SNP (rs12895072) across three samples (8.8 x 10(-3) <= p <= 0.049). Four other SNPs were significantly or suggestively associated with SUD only in European-Australians (4.8 x 10(-4) <= p <= 0.058). All of the SUD-risk alleles of these 27 SNPs increased (beta > 0) the putamen GMVs and represented major alleles (f > 0.5) in Europeans. Twenty-two SNPs were potentially biologically functional. Alcohol, nicotine and cocaine significantly affected the KTN1 mRNA expression, and the KTN1 mRNA was differentially expressed between nicotine or cocaine dependent and control subjects. We concluded that there was a replicable and robust relationship among the KTN1 variants, KTN1 mRNA expression, putamen GMVs, molecular effects of substances, and SUD, suggesting that some risk KTN1 alleles might increase kinectin 1 expression in the putamen, altering putamen structures and functions, and leading to SUD.

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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, molecular formula is C10H14O4, belongs to alcohols-buliding-blocks compound, is a common compound. In a patnet, author is Yang, Tian, once mentioned the new application about 104-38-1, Category: alcohols-buliding-blocks.

Selective electrooxidation of 2-propanol on Pt nanoparticles supported on Co3O4: an in-situ study on atomically defined model systems

2-Propanol and its dehydrogenated counterpart acetone can be used as a rechargeable electrofuel. The concept involves selective oxidation of 2-propanol to acetone in a fuel cell coupled with reverse catalytic hydrogenation of acetone to 2-propanol in a closed cycle. We studied electrocatalytic oxidation of 2-propanol on complex model Pt/Co3O4(111) electrocatalysts prepared in ultra-high vacuum and characterized by scanning tunneling microscopy. The electrocatalytic behavior of the model electrocatalysts has been investigated in alkaline media (pH 10, phosphate buffer) by means of electrochemical infrared reflection absorption spectroscopy and ex-situ emersion synchrotron radiation photoelectron spectroscopy as a function of Pt particle size and compared with the electrocatalytic behavior of Pt(111) and pristine Co3O4(111) electrodes under similar conditions. We found that the Co3O4(111) film is inactive towards electrochemical oxidation of 2-propanol under the electrochemical conditions (0.3-1.1 V-RHE). The electrochemical oxidation of 2-propanol readily occurs on Pt(111) yielding acetone at an onset potential of 0.4 V-RHE. The reaction pathway does not involve CO but yields strongly adsorbed acetone species leading to a partial poisoning of the surface sites. On model Pt/Co3O4(111) electrocatalysts, we observed distinct metal support interactions and particle size effects associated with the charge transfer at the metal/oxide interface. We found that ultra-small Pt particles (around 1 nm and below) consist of partially oxidized Pt-delta(+) species which show minor activity towards 2-propanol oxidation. In contrast, conventional Pt particles (particle size of a few nm) are mainly metallic and show high activity toward 2-propanol oxidation.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 104-38-1. The above is the message from the blog manager. Category: alcohols-buliding-blocks.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, molecular formula is C10H14O4. In an article, author is Lin, Qing,once mentioned of 104-38-1, Recommanded Product: 104-38-1.

4-Methoxybenzylalcohol protects brain microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced injury via activation of the PI3K/AKT signaling pathway

Damage to the blood-brain barrier (BBB) during the process of cerebral ischemic injury is a key factor that affects the treatment of this condition. The present study aimed to assess the potential effects of 4-methoxybenzyl alcohol (4-MA) on brain microvascular endothelial cells (bEnd.3) against oxygen-glucose deprivation/reperfusion (OGD/Rep) using an in vitro model that mimics in vivo ischemia/reperfusion injury. In addition, the present study aimed to explore whether this underlying mechanism was associated with the inhibition of pro-inflammatory factors and the activation status of the PI3K/Akt signaling pathway. bEnd.3 cells were subjected to OGD/Rep-induced injury before being treated with 4-MA, following which cell viability, lactate dehydrogenase (LDH) release and levels of nitric oxidase (NO) were detected by colorimetry, pro-inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-6, were detected by ELISA. The expression levels of occluding and claudin-5were evaluated by immunofluorescence staining. The expression levels of AKT, phosphorylated (p)-Akt, endothelial nitric oxide synthase (eNOS) and p-eNOS were also measured by western blot analysis. After bEnd.3 cells were subjected to OGD/Rep-induced injury, cell viability and NO levels were significantly decreased, whilst LDH leakage and inflammatory factor (TNF-alpha, IL-1 beta and IL-6) levels were significantly increased. Treatment with 4-MA significantly ameliorated cell viability, LDH release and the levels of NO and pro-inflammatory factors TNF-alpha, IL-1 beta and IL-6 as a result of OGD/Rep. Furthermore, treatment with 4-MA upregulated the expression of occludin, claudin-5, Akt and eNOS, in addition to increasing eNOS and AKT phosphorylation in bEnd.3 cells. These results suggest that 4-MA can alleviate OGD/Rep-induced injury in bEnd.3 cells by inhibiting inflammation and by activating the PI3K/AKT signaling pathway as a possible mechanism. Therefore, 4-MA can serve as a potential candidate for treating OGD/Rep-induced injury.

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