Category: 1036260-25-9

Padilla, Fernando published the artcilePyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors, Recommanded Product: 3-Aminocyclobutanol hydrochloride, the main research area is pyrrolopyrazine spleen tyrosine kinase inhibitor preparation physicochem property toxicity.

The authors describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors and the efforts that eventually led to the desired improvements in physicochem. properties and human whole blood potencies. Ultimately, the mouse model revealed unexpected toxicity of compound I that precluded the further advancement of this series.

Journal of Medicinal Chemistry published new progress about Acidity. 1036260-25-9 belongs to class alcohols-buliding-blocks, name is 3-Aminocyclobutanol hydrochloride, and the molecular formula is C4H10ClNO, Recommanded Product: 3-Aminocyclobutanol hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1036260-25-9, 3-Aminocyclobutanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1036260-25-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1036260-25-9

step 1: A mixture of 3-aminocyclobutanol hydrochloride (1.91 g, 15.47 mmol), isobenzofuran-1,3-dione (2.52 g, 17.01 mmol) and DIPEA (6.0 g, 46.40 mmol) in PhMe (100 mL) was stirred at 110 C. for 18 h. The reaction mixture was concentrated and purified by SiO2 chromatography eluting with PE/EA (3:1) to afford 2-(3-hydroxycyclobutyl)isoindoline-1,3-dione as white solid (2.1 g, 62.6%). LCMS (ESI): m/z=218.1 [M+1]+

The synthetic route of 1036260-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts