Category: 10160-28-8

Synthetic Route of 10160-28-8, Adding some certain compound to certain chemical reactions, such as: 10160-28-8, name is Non-8-yn-1-ol,molecular formula is C9H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10160-28-8.

General procedure: 300 mg (1 eq, 1.42 mmol) of 7 was suspended in 11 mL of freshly distilled THF under argon. 745 mg (2 eq, 2.84 mmol) of triphenylphosphine was then added, followed by 198 muL (1.5 eq, 2.13 mmol) of 4-pentyn-1-ol. The flask was then placed in an ice bath and stirred for 10 min. 391 muL (1.4 eq, 1.99 mmol) of diisopropylazodicarboxylate (DIAD) was then added drop-wise. The reaction was stirred, allowing it to return to room temperature, for 72 h at which point the reaction appeared done by TLC (EtOAc,KMnO4 stain). The solvent was removed under reduced pressure, giving a viscous oil that was then subjected to high vacuum for 1 h before being dissolved in the minimum amount of ethyl acetate. After purification by flash chromatography (50% EtOAc in hexanes), 350 mg (89% yield) of the product was obtained as a white powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10160-28-8, Non-8-yn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; McBrayer, Dominic; Kerwin, Sean M.; Molecules; vol. 20; 9; (2015); p. 16446 – 16465;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10160-28-8, name is Non-8-yn-1-ol. A new synthetic method of this compound is introduced below., Computed Properties of C9H16O

Example 2Part A: Synthesis of Pentadeca-8,10-diyn-l-olTo a stirred solution of 1-iodo-hex-l-yne (6.2 g, 29.80 mmol) and non-8-yn-l-ol (2.46 g, 17.53 mmol) in pyrrolidine (50 ml) under an argon atmosphere, was added copper(I) iodide (2.98 mmol, 0.57 g). After stirring at room temperature for 30 min, the mixture was hydrolysed with a saturated aqueous solution of ammonium chloride and extracted with diethyl ether. The organic extract was dried over MgSO4 and the solvent was removed in vacuo. Column chromatography (SiO2, EtOAc-hexane: 2:1) gave 3.35 g (15.19 mmol, 87 %) of pure pentadeca-8,10-diyn-l-ol. 1H-NMR (CDCl3, 400 MHz): delta[ppm] = 0.89 (3H, t, J = 7.3 Hz)5 1.26 – 1.62 (14H, m), 2.24 (4H, t, J = 6.6 Hz), 3.62 (2H, t, J = 7.0 Hz)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10160-28-8, Non-8-yn-1-ol.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2008/31157; (2008); A1;,
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Application of 10160-28-8 ,Some common heterocyclic compound, 10160-28-8, molecular formula is C9H16O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of non-8-yn-1-ol (5.00 g, 35.6 mmol, CAS10160-28-8) and TEA (10.8 g, 106 mmol, 14.8 mL) in DCM (100 mL) was added MsCl (6.13 g, 53.4 mmol, 4.14 mL). The reaction mixture was stirred at 25 C. for 2 hours. On completion, the reaction mixture was concentrated in vacuo. The residue was diluted with water (10 mL) and extracted with DCM (3×10 mL). The combined organic layers was dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (7.70 g, 98% yield) as light yellow oil. 1H NMR (400 MHz, CDCl3) delta 4.23 (t, J=6.4 Hz, 2H), 3.01 (s, 3H), 2.22-2.18 (m, 2H), 1.95 (t, J=2.4 Hz, 1H), 1.80-1.73 (m, 2H), 1.58-1.50 (m, 2H), 1.47-1.36 (m, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10160-28-8, its application will become more common.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
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