Category: 10160-24-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10160-24-4, name is 7-Bromo-1-heptanol, the common compound, a new synthetic route is introduced below. Product Details of 10160-24-4

General procedure: The alkyl bromide (1.0 equiv) was added to a solution of mercaptoaceticacid (1.0 equiv) in methanol (10.0 mL) and the resultingsolution stirred. Then a solution of NaOH (2.0 equiv) in methanol(5.0 mL)was added slowly, and the final mixturewas stirred at roomtemperature or heated to reflux until absence of the alkyl bromide(checked by TLC). The reaction mixture was concentrated in vacuo,diluted with H2O, and neutralized with 1 N HCl. Then the obtainedreaction mixture was extracted with EtOAc. The combined organicfractions were washed with brine, dried with Na2SO4, and concentratedin vacuo. Purification of the crude residue by column chromatography(petroleum ether/EtOAc) afforded the title compound.

The synthetic route of 10160-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Ying; Wu, Bolin; Hao, Yameng; Liu, Yunqi; Zhang, Zhili; Tian, Chao; Ning, Xianling; Guo, Ying; Liu, Junyi; Wang, Xiaowei; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 420 – 433;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10160-24-4, name is 7-Bromo-1-heptanol, molecular formula is C7H15BrO, molecular weight is 195.0974, as common compound, the synthetic route is as follows.Recommanded Product: 7-Bromo-1-heptanol

Add 8.4 g (0.1 mol) of methyl propiolate to a 100 mL single-mouth bottle. 30 mL of dry tetrahydrofuran and 4.5 g of gram (0.115 mol) sodium amide, and the mixture was stirred at room temperature for about 15 minutes. then 21.34 g (0.11 mol) of 7-bromoheptanol was added dropwise. after 0.5 h of dropwise addition, the reaction was continued for 3.0 h. After the completion of the reaction, the tetrahydrofuran was removed in vacuo, and the residue was dissolved in dichloromethane, washed with water, and then evaporated. the filtrate was evaporated to give a pale yellow oily liquid product II compound 19.2 g, yield 97%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; Jiaxing College; Li Meng; Zong Qianshou; Liu Xuejun; Wang Lu; Dai Jingjing; Zhang Yajing; Zheng Yannan; Zhou Hongwei; Bao Lin; (7 pag.)CN109942397; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 7-Bromo-1-heptanol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 7-Bromo-1-heptanol

To a stirred solution of (S)-3- (1-CARBAMOYL-1,1-DIPHENYLMETHYL)pyrrolidine (40 g, 142.7 mmol) and triethylamine (59.6 mL, 428 mmol) in acetonitrile (1. 1 L) at 40C under a nitrogen atmosphere was added 7-bromo-1-heptanol (24 mL, 146 mmol) in acetonitrile (100 mL) dropwise. The reaction mixture was heated to 50C for 9 hours. The reaction mixture was allowed to cool before removing the solvent under reduced pressure. The crude residue was dissolved in dichloromethane (500 mL) and the organic layer washed with saturated aqueous sodium bicarbonate (2 x 300 mL), followed by water (300 mL) and saturated aqueous sodium chloride (300 mL), and then dried over magnesium sulfate (10 g). The magnesium sulfate was filtered off and washed with dichloromethane (100 mL). The solvent was then removed in vacuo to give the crude product which was purified on a short column (SIO2) by varying the eluant from 19: 1: 0.1 to 3: 1: 0.1 CH2CL2/MEOH/NH40H to give 31.35 g of the title intermediate as a white solid (56% yield ; >95% purity by HPLC Method A).

The synthetic route of 10160-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE, INC.; WO2004/41806; (2004); A2;,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7-Bromo-1-heptanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7-Bromo-1-heptanol

A method for synthesizing cis-7-tetradecenol acetate, which is the main sex pheromone of the elm moth, comprises the following steps:(1) Preparation of (7-bromoheptyl-1 -) – 2-tetrahydropyranyl ether To a 500 ml four-necked flask equipped with an electromagnetic stirrer, a reflux condenser,Pressure dropping funnel in a 250 mL four-necked flask, 3,4-dihydropyran 8 g was added and 0.03 g of 37% hydrochloric acid was added as a catalyst with stirring. After 10 min, a solution of 7-bromo- Alcohol 17 g, control the dropping rate (the reaction is exothermic reaction, 7-bromo-1-heptanol dropping speed is accelerated, the reaction is accelerated, exothermic increase, to be ice bath cooling), keep the reaction temperature of 40 ~ 60 C, add room temperature after reaction 2 h, stop stirring, instead of distillation device, steamed unreacted 3,4-dihydropyran. After the residue was cooled, 85 g of petroleum ether was added, washed with saturated sodium hydrogencarbonate solution and saturated brine, dried over sodium sulfate for 10 to 15 hours, concentrated and evaporated to give (7-bromoheptyl-1- Tetrahydropyranyl ether 23.5 g, purity 99.2%, the yield was 96.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; Shanxi Agricultural University; Yang, Meihong; Chen, Xupeng; Liu, Jinlong; Liu, Hongxia; Zhang, Jintong; Cao, Chuanjian; Jing, Xiaoyuan; Wang, Shifei; Fan, Lihua; (8 pag.)CN105418418; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H15BrO, blongs to alcohols-buliding-blocks compound. Computed Properties of C7H15BrO

2-(7-Bromoheptyloxy)tetrahydro-2H-pyran2 (3): Dihydropyran (5.20 g, 6.11 mmol) was added to a stirring 0C solution of 7-bromoheptane-l-ol (2) (1 1.0 g, 56.7 mmol) and a catalytic amount of PTSA in CH2C12. After stirring at rt for 12 h, the reaction mixture was diluted with CH2C12 (200 mL), washed with water (100 mL x 2), brine (100 mL chi 3), dried over anhydrous sodium sulphate, and evaporated. The residue was purified by silica gel column chromatography using a gradient of 10-20% ethyl acetate/hexane as eluent to give 2-(7- bromoheptyloxy)tetrahydro-2H-pyran (3) (14.50 g, 92%) as a colorless oil. TLC: 10% EtOAc/hexanes, Rf ~ 0.55; NMR (400 MHz, CDC13) delta 4.58-4.56 (m, 1H), 3.84-3.88 (m, 1H), 3.68-3.77 (m, 1H), 3.46-3.51 (m, 1H), 3.33-3.43 (m, 3H), 1.80-1.81 (m, 2H), 1.30-1.62 (m, 14 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; MCW RESEARCH FOUNDATION, INC.; IMIG, John, David; CAMPBELL, William, B.; FALCK, John, Russell; WO2012/138706; (2012); A1;,
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